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Volumn 125, Issue 22, 2015, Pages 3388-3392

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; JAK2 PROTEIN, HUMAN;

EID: 84930965814     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-01-621110     Document Type: Article
Times cited : (66)

References (41)
  • 1
    • 0001639195 scopus 로고
    • Some speculations on the myeloproliferative syndromes
    • Dameshek W. Some speculations on the myeloproliferative syndromes. Blood. 1951;6(4): 372-375.
    • (1951) Blood , vol.6 , Issue.4 , pp. 372-375
    • Dameshek, W.1
  • 2
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couédic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434(7037):1144-1148.
    • (2005) Nature , vol.434 , Issue.7037 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couédic, J.P.3
  • 3
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005; 352(17):1779-1790.
    • (2005) N Engl J Med , vol.352 , Issue.17 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3
  • 4
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7(4):387-397.
    • (2005) Cancer Cell , vol.7 , Issue.4 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 5
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ, et al; Cancer Genome Project. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005; 365(9464):1054-1061.
    • (2005) Lancet , vol.365 , Issue.9464 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3
  • 6
    • 79956096380 scopus 로고    scopus 로고
    • Mouse models of myeloproliferative neoplasms: JAK of all grades
    • Li J, Kent DG, Chen E, Green AR. Mouse models of myeloproliferative neoplasms: JAK of all grades. Dis Model Mech. 2011;4(3):311-317.
    • (2011) Dis Model Mech , vol.4 , Issue.3 , pp. 311-317
    • Li, J.1    Kent, D.G.2    Chen, E.3    Green, A.R.4
  • 7
    • 84890372480 scopus 로고    scopus 로고
    • Somatic mutations of calreticulin in myeloproliferative neoplasms
    • Klampfl T, Gisslinger H, Harutyunyan AS, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369(25):2379-2390.
    • (2013) N Engl J Med , vol.369 , Issue.25 , pp. 2379-2390
    • Klampfl, T.1    Gisslinger, H.2    Harutyunyan, A.S.3
  • 8
    • 84890328032 scopus 로고    scopus 로고
    • Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
    • Nangalia J, Massie CE, Baxter EJ, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013; 369(25):2391-2405.
    • (2013) N Engl J Med , vol.369 , Issue.25 , pp. 2391-2405
    • Nangalia, J.1    Massie, C.E.2    Baxter, E.J.3
  • 9
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3(7):e270.
    • (2006) PLoS Med , vol.3 , Issue.7 , pp. e270
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3
  • 10
    • 84902589906 scopus 로고    scopus 로고
    • From Janus kinase 2 to calreticulin: The clinically relevant genomic landscape of myeloproliferative neoplasms
    • Cazzola M, Kralovics R. From Janus kinase 2 to calreticulin: the clinically relevant genomic landscape of myeloproliferative neoplasms. Blood. 2014;123(24):3714-3719.
    • (2014) Blood , vol.123 , Issue.24 , pp. 3714-3719
    • Cazzola, M.1    Kralovics, R.2
  • 11
    • 84908258893 scopus 로고    scopus 로고
    • Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F
    • Lundberg P, Takizawa H, Kubovcakova L, et al. Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. J Exp Med. 2014;211(11): 2213-2230.
    • (2014) J Exp Med , vol.211 , Issue.11 , pp. 2213-2230
    • Lundberg, P.1    Takizawa, H.2    Kubovcakova, L.3
  • 12
    • 77953482860 scopus 로고    scopus 로고
    • Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases
    • Haan C, Behrmann I, Haan S. Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases. J Cell Mol Med. 2010;14(3):504-527.
    • (2010) J Cell Mol Med , vol.14 , Issue.3 , pp. 504-527
    • Haan, C.1    Behrmann, I.2    Haan, S.3
  • 13
    • 0033976059 scopus 로고    scopus 로고
    • The Jak-Stat pathway in normal and perturbed hematopoiesis
    • Ward AC, Touw I, Yoshimura A. The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood. 2000;95(1):19-29.
    • (2000) Blood , vol.95 , Issue.1 , pp. 19-29
    • Ward, A.C.1    Touw, I.2    Yoshimura, A.3
  • 14
    • 0027248709 scopus 로고
    • Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction
    • Silvennoinen O, Witthuhn BA, Quelle FW, Cleveland JL, Yi T, Ihle JN. Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc Natl Acad Sci USA. 1993;90(18):8429-8433.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.18 , pp. 8429-8433
    • Silvennoinen, O.1    Witthuhn, B.A.2    Quelle, F.W.3    Cleveland, J.L.4    Yi, T.5    Ihle, J.N.6
  • 15
    • 0027327484 scopus 로고
    • JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    • Witthuhn BA, Quelle FW, Silvennoinen O, et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell. 1993;74(2):227-236.
    • (1993) Cell , vol.74 , Issue.2 , pp. 227-236
    • Witthuhn, B.A.1    Quelle, F.W.2    Silvennoinen, O.3
  • 16
    • 0032076542 scopus 로고    scopus 로고
    • Jak2 is essential for signaling through a variety of cytokine receptors
    • Parganas E, Wang D, Stravopodis D, et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998;93(3): 385-395.
    • (1998) Cell , vol.93 , Issue.3 , pp. 385-395
    • Parganas, E.1    Wang, D.2    Stravopodis, D.3
  • 17
    • 33646865516 scopus 로고    scopus 로고
    • Phosphorylation of Jak2 on ser 523) inhibits Jak2-dependent leptin receptor signaling
    • Ishida-Takahashi R, Rosario F, Gong Y, et al. Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling. Mol Cell Biol. 2006;26(11):4063-4073.
    • (2006) Mol Cell Biol , vol.26 , Issue.11 , pp. 4063-4073
    • Ishida-Takahashi, R.1    Rosario, F.2    Gong, Y.3
  • 18
    • 33646864349 scopus 로고    scopus 로고
    • Phosphorylation of JAK2 at serine 523: A negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor
    • Mazurkiewicz-Munoz AM, Argetsinger LS, Kouadio JL, et al. Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor. Mol Cell Biol. 2006;26(11): 4052-4062.
    • (2006) Mol Cell Biol , vol.26 , Issue.11 , pp. 4052-4062
    • Mazurkiewicz-Munoz, A.M.1    Argetsinger, L.S.2    Kouadio, J.L.3
  • 19
    • 0030953469 scopus 로고    scopus 로고
    • Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
    • Feng J, Witthuhn BA, Matsuda T, Kohlhuber F, Kerr IM, Ihle JN. Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol Cell Biol. 1997;17(5): 2497-2501.
    • (1997) Mol Cell Biol , vol.17 , Issue.5 , pp. 2497-2501
    • Feng, J.1    Witthuhn, B.A.2    Matsuda, T.3    Kohlhuber, F.4    Kerr, I.M.5    Ihle, J.N.6
  • 20
    • 2442642830 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling
    • Feener EP, Rosario F, Dunn SL, Stancheva Z, Myers MG Jr. Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol. 2004;24(11):4968-4978.
    • (2004) Mol Cell Biol , vol.24 , Issue.11 , pp. 4968-4978
    • Feener, E.P.1    Rosario, F.2    Dunn, S.L.3    Stancheva, Z.4    Myers, M.G.5
  • 21
    • 84878232331 scopus 로고    scopus 로고
    • JAK/STAT signaling in hematological malignancies
    • Vainchenker W, Constantinescu SN. JAK/STAT signaling in hematological malignancies. Oncogene. 2013;32(21):2601-2613.
    • (2013) Oncogene , vol.32 , Issue.21 , pp. 2601-2613
    • Vainchenker, W.1    Constantinescu, S.N.2
  • 23
    • 0028938172 scopus 로고
    • An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects
    • Luo H, Hanratty WP, Dearolf CR. An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects. EMBO J. 1995;14(7):1412-1420.
    • (1995) EMBO J , vol.14 , Issue.7 , pp. 1412-1420
    • Luo, H.1    Hanratty, W.P.2    Dearolf, C.R.3
  • 24
    • 0030729823 scopus 로고    scopus 로고
    • Structural and functional basis for JAK3-deficient severe combined immunodeficiency
    • Candotti F, Oakes SA, Johnston JA, et al. Structural and functional basis for JAK3-deficient severe combined immunodeficiency. Blood. 1997; 90(10):3996-4003.
    • (1997) Blood , vol.90 , Issue.10 , pp. 3996-4003
    • Candotti, F.1    Oakes, S.A.2    Johnston, J.A.3
  • 25
    • 0033965488 scopus 로고    scopus 로고
    • Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: Evidence for interactions between the kinase and pseudokinase domains
    • Chen M, Cheng A, Candotti F, et al. Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains. Mol Cell Biol. 2000;20(3): 947-956.
    • (2000) Mol Cell Biol , vol.20 , Issue.3 , pp. 947-956
    • Chen, M.1    Cheng, A.2    Candotti, F.3
  • 26
    • 0034255258 scopus 로고    scopus 로고
    • A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-a signaling
    • Yeh TC, Dondi E, Uzé G, Pellegrini S. A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-a signaling. Proc Natl Acad Sci USA. 2000;97(16):8991-8996.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.16 , pp. 8991-8996
    • Yeh, T.C.1    Dondi, E.2    Uzé, G.3    Pellegrini, S.4
  • 27
    • 0034012330 scopus 로고    scopus 로고
    • Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
    • Saharinen P, Takaluoma K, Silvennoinen O. Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol Cell Biol. 2000;20(10): 3387-3395.
    • (2000) Mol Cell Biol , vol.20 , Issue.10 , pp. 3387-3395
    • Saharinen, P.1    Takaluoma, K.2    Silvennoinen, O.3
  • 28
    • 0038371050 scopus 로고    scopus 로고
    • Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
    • Saharinen P, Vihinen M, Silvennoinen O. Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain. Mol Biol Cell. 2003; 14(4):1448-1459.
    • (2003) Mol Biol Cell , vol.14 , Issue.4 , pp. 1448-1459
    • Saharinen, P.1    Vihinen, M.2    Silvennoinen, O.3
  • 29
    • 0037033012 scopus 로고    scopus 로고
    • The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
    • Saharinen P, Silvennoinen O. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem. 2002;277(49): 47954-47963.
    • (2002) J Biol Chem , vol.277 , Issue.49 , pp. 47954-47963
    • Saharinen, P.1    Silvennoinen, O.2
  • 30
    • 29644439240 scopus 로고    scopus 로고
    • JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: Cross-talk with IGF1 receptor
    • Staerk J, Kallin A, Demoulin JB, Vainchenker W, Constantinescu SN. JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor. J Biol Chem. 2005;280(51): 41893-41899.
    • (2005) J Biol Chem , vol.280 , Issue.51 , pp. 41893-41899
    • Staerk, J.1    Kallin, A.2    Demoulin, J.B.3    Vainchenker, W.4    Constantinescu, S.N.5
  • 31
    • 52449119447 scopus 로고    scopus 로고
    • Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers
    • Jeong EG, Kim MS, Nam HK, et al. Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers. Clin Cancer Res. 2008;14(12): 3716-3721.
    • (2008) Clin Cancer Res , vol.14 , Issue.12 , pp. 3716-3721
    • Jeong, E.G.1    Kim, M.S.2    Nam, H.K.3
  • 32
    • 80052492285 scopus 로고    scopus 로고
    • The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
    • Ungureanu D, Wu J, Pekkala T, et al. The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nat Struct Mol Biol. 2011;18(9): 971-976.
    • (2011) Nat Struct Mol Biol , vol.18 , Issue.9 , pp. 971-976
    • Ungureanu, D.1    Wu, J.2    Pekkala, T.3
  • 34
    • 84885418884 scopus 로고    scopus 로고
    • Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases
    • Toms AV, Deshpande A, McNally R, et al. Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nat Struct Mol Biol. 2013;20(10): 1221-1223.
    • (2013) Nat Struct Mol Biol , vol.20 , Issue.10 , pp. 1221-1223
    • Toms, A.V.1    Deshpande, A.2    McNally, R.3
  • 35
    • 84901840527 scopus 로고    scopus 로고
    • Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
    • Lupardus PJ, Ultsch M, Wallweber H, Bir Kohli P, Johnson AR, Eigenbrot C. Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition. Proc Natl Acad Sci USA. 2014;111(22):8025-8030.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.22 , pp. 8025-8030
    • Lupardus, P.J.1    Ultsch, M.2    Wallweber, H.3    Bir Kohli, P.4    Johnson, A.R.5    Eigenbrot, C.6
  • 36
    • 84890921845 scopus 로고    scopus 로고
    • A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
    • Murphy JM, Zhang Q, Young SN, et al. A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties. Biochem J. 2014;457(2):323-334.
    • (2014) Biochem J , vol.457 , Issue.2 , pp. 323-334
    • Murphy, J.M.1    Zhang, Q.2    Young, S.N.3
  • 37
    • 77955299093 scopus 로고    scopus 로고
    • JAK2 V617F constitutive activation requires JH2 residue F595: A pseudokinase domain target for specific inhibitors
    • Dusa A, Mouton C, Pecquet C, Herman M, Constantinescu SN. JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors. PLoS ONE. 2010;5(6):e11157.
    • (2010) PLoS ONE , vol.5 , Issue.6 , pp. e11157
    • Dusa, A.1    Mouton, C.2    Pecquet, C.3    Herman, M.4    Constantinescu, S.N.5
  • 38
    • 78649289718 scopus 로고    scopus 로고
    • The constitutive activation of Jak2-V617F is mediated by a p stacking mechanism involving phenylalanines 595 and 617
    • Gnanasambandan K, Magis A, Sayeski PP. The constitutive activation of Jak2-V617F is mediated by a p stacking mechanism involving phenylalanines 595 and 617. Biochemistry. 2010; 49(46):9972-9984.
    • (2010) Biochemistry , vol.49 , Issue.46 , pp. 9972-9984
    • Gnanasambandan, K.1    Sayeski, M.A.2
  • 39
    • 84903899364 scopus 로고    scopus 로고
    • Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase
    • Shan Y, Gnanasambandan K, Ungureanu D, et al. Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase. Nat Struct Mol Biol. 2014;21(7):579-584.
    • (2014) Nat Struct Mol Biol , vol.21 , Issue.7 , pp. 579-584
    • Shan, Y.1    Gnanasambandan, K.2    Ungureanu, D.3
  • 40
    • 84900432315 scopus 로고    scopus 로고
    • Mechanism of activation of protein kinase JAK2 by the growth hormone receptor
    • Brooks AJ, Dai W, O'Mara ML, et al. Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science. 2014;344(6185): 1249783.
    • (2014) Science , vol.344 , Issue.6185 , pp. 1249783
    • Brooks, A.J.1    Dai, W.2    O'mara, M.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.