Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases

Nature Structural and Molecular Biology

Volumn 20, Issue 10, 2013, Pages 1221-1224

  Toms, Angela V ^a,b   Deshpande, Anagha ^a,b   McNally, Randall ^a,b   Jeong, Youngjee ^a   Rogers, Julia M ^b,c   Kim, Chae Un ^d   Gruner, Sol M ^d,e   Ficarro, Scott B ^a,b   Marto, Jarrod A ^a,b   Sattler, Martin ^a,b   Griffin, James D ^a,b   Eck, Michael J ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD UNIVERSITY   (United States)

^d Department of Obstetrics Gynecology   (United States)

^e Cornell University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DELETION MUTANT; ENZYME ACTIVATION; ENZYME STRUCTURE; EXON; GAIN OF FUNCTION MUTATION; HUMAN; POINT MUTATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; T CELL LEUKEMIA;

ENZYME ACTIVATION; HUMANS; JANUS KINASES; MODELS, MOLECULAR; ONCOGENES; PROTEIN CONFORMATION;

EID: 84885418884     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2673     Document Type: Article

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