메뉴 건너뛰기




Volumn 211, Issue 11, 2014, Pages 2213-2230

Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F

Author keywords

[No Author keywords available]

Indexed keywords

DNA; JANUS KINASE 2; BIOLOGICAL MARKER; LY ANTIGEN; LY6A PROTEIN, MOUSE; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; STEM CELL FACTOR RECEPTOR;

EID: 84908258893     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20131371     Document Type: Article
Times cited : (88)

References (63)
  • 1
    • 79960248721 scopus 로고    scopus 로고
    • DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms
    • Abdel-Wahab, O., A. Pardanani, R. Rampal, T.L. Lasho, R.L. Levine, and A. Tefferi. 2011. DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms. Leukemia. 25:1219-1220. http://dx.doi.org/10.1038/ leu.2011.82
    • (2011) Leukemia. , vol.25 , pp. 1219-1220
    • Abdel-Wahab, O.1    Pardanani, A.2    Rampal, R.3    Lasho, T.L.4    Levine, R.L.5    Tefferi, A.6
  • 2
    • 77951759127 scopus 로고    scopus 로고
    • Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease
    • Akada, H., D. Yan, H. Zou, S. Fiering, R.E. Hutchison, and M.G. Mohi. 2010. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood. 115:3589-3597. http://dx.doi.org/10.1182/blood-2009-04-215848
    • (2010) Blood. , vol.115 , pp. 3589-3597
    • Akada, H.1    Yan, D.2    Zou, H.3    Fiering, S.4    Hutchison, R.E.5    Mohi, M.G.6
  • 5
    • 84857873445 scopus 로고    scopus 로고
    • Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs
    • Benz, C., M.R. Copley, D.G. Kent, S. Wohrer, A. Cortes, N. Aghaeepour, E. Ma, H. Mader, K. Rowe, C. Day, et al. 2012. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell. 10:273-283. http://dx.doi.org/ 10.1016/j.stem.2012.02.007
    • (2012) Cell Stem Cell. , vol.10 , pp. 273-283
    • Benz, C.1    Copley, M.R.2    Kent, D.G.3    Wohrer, S.4    Cortes, A.5    Aghaeepour, N.6    Ma, E.7    Mader, H.8    Rowe, K.9    Day, C.10
  • 8
    • 84866124810 scopus 로고    scopus 로고
    • FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm
    • Chu, S.H., D. Heiser, L. Li, I. Kaplan, M. Collector, D. Huso, S.J. Sharkis, C. Civin, and D. Small. 2012. FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm. Cell Stem Cell. 11:346-358. http://dx.doi.org/10.1016/j.stem.2012.05.027
    • (2012) Cell Stem Cell. , vol.11 , pp. 346-358
    • Chu, S.H.1    Heiser, D.2    Li, L.3    Kaplan, I.4    Collector, M.5    Huso, D.6    Sharkis, S.J.7    Civin, C.8    Small, D.9
  • 9
    • 36448992228 scopus 로고    scopus 로고
    • Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches
    • Czechowicz, A., D. Kraft, I.L. Weissman, and D. Bhattacharya. 2007. Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science. 318:1296-1299. http://dx.doi.org/10.1126/science .1149726
    • (2007) Science. , vol.318 , pp. 1296-1299
    • Czechowicz, A.1    Kraft, D.2    Weissman, I.L.3    Bhattacharya, D.4
  • 13
    • 84880790360 scopus 로고    scopus 로고
    • CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age
    • Gekas, C., and T. Graf. 2013. CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age. Blood. 121:4463-4472. http://dx.doi.org/10.1182/blood-2012-09-457929
    • (2013) Blood. , vol.121 , pp. 4463-4472
    • Gekas, C.1    Graf, T.2
  • 14
  • 15
    • 84886850069 scopus 로고    scopus 로고
    • JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα
    • Hasan, S., C. Lacout, C. Marty, M. Cuingnet, E. Solary, W. Vainchenker, and J.L. Villeval. 2013. JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα. Blood. 122:1464-1477. http://dx.doi.org/10.1182/blood-2013-04-498956
    • (2013) Blood. , vol.122 , pp. 1464-1477
    • Hasan, S.1    Lacout, C.2    Marty, C.3    Cuingnet, M.4    Solary, E.5    Vainchenker, W.6    Villeval, J.L.7
  • 18
    • 84879396181 scopus 로고    scopus 로고
    • Selfrenewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion
    • Kent, D.G., J. Li, H. Tanna, J. Fink, K. Kirschner, D.C. Pask, Y. Silber, T.L. Hamilton, R. Sneade, B.D. Simons, and A.R. Green. 2013. Selfrenewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. PLoS Biol. 11:e1001576. http://dx.doi.org/10.1371/journal.pbio.1001576
    • (2013) PLoS Biol. , vol.11 , pp. e1001576
    • Kent, D.G.1    Li, J.2    Tanna, H.3    Fink, J.4    Kirschner, K.5    Pask, D.C.6    Silber, Y.7    Hamilton, T.L.8    Sneade, R.9    Simons, B.D.10    Green, A.R.11
  • 19
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel, M.J., O.H. Yilmaz, T. Iwashita, O.H. Yilmaz, C. Terhorst, and S.J. Morrison. 2005. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 121:1109-1121. http://dx.doi.org/10.1016/j.cell.2005.05.026
    • (2005) Cell. , vol.121 , pp. 1109-1121
    • Kiel, M.J.1    Yilmaz, O.H.2    Iwashita, T.3    Yilmaz, O.H.4    Terhorst, C.5    Morrison, S.J.6
  • 20
    • 84871182464 scopus 로고    scopus 로고
    • Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells
    • Kim, D., J. Wang, S.B. Willingham, R. Martin, G. Wernig, and I.L. Weissman. 2012. Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells. Leukemia. 26:2538-2545. http://dx.doi.org/10.1038/leu.2012.141
    • (2012) Leukemia. , vol.26 , pp. 2538-2545
    • Kim, D.1    Wang, J.2    Willingham, S.B.3    Martin, R.4    Wernig, G.5    Weissman, I.L.6
  • 23
    • 33747199312 scopus 로고    scopus 로고
    • Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders
    • Kralovics, R., S.S. Teo, S. Li, A. Theocharides, A.S. Buser, A. Tichelli, and R.C. Skoda. 2006. Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders. Blood. 108:1377-1380. http://dx.doi.org/10.1182/blood- 2005-11-009605
    • (2006) Blood. , vol.108 , pp. 1377-1380
    • Kralovics, R.1    Teo, S.S.2    Li, S.3    Theocharides, A.4    Buser, A.S.5    Tichelli, A.6    Skoda, R.C.7
  • 25
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine, R.L., M. Wadleigh, J. Cools, B.L. Ebert, G. Wernig, B.J. Huntly, T.J. Boggon, I. Wlodarska, J.J. Clark, S. Moore, et al. 2005. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 7:387-397. http://dx.doi.org/10.1016/j.ccr.2005.03.023
    • (2005) Cancer Cell. , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3    Ebert, B.L.4    Wernig, G.5    Huntly, B.J.6    Boggon, T.J.7    Wlodarska, I.8    Clark, J.J.9    Moore, S.10
  • 27
    • 77956578342 scopus 로고    scopus 로고
    • JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia
    • Li, J., D. Spensberger, J.S. Ahn, S. Anand, P.A. Beer, C. Ghevaert, E. Chen, A. Forrai, L.M. Scott, R. Ferreira, et al. 2010. JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood. 116:1528- 1538. http://dx.doi.org/10.1182/blood-2009-12-259747
    • (2010) Blood. , vol.116 , pp. 1528- 1538
    • Li, J.1    Spensberger, D.2    Ahn, J.S.3    Anand, S.4    Beer, P.A.5    Ghevaert, C.6    Chen, E.7    Forrai, A.8    Scott, L.M.9    Ferreira, R.10
  • 28
    • 79956096380 scopus 로고    scopus 로고
    • Mouse models of myeloproliferative neoplasms: JAK of all grades
    • Li, J., D.G. Kent, E. Chen, and A.R. Green. 2011. Mouse models of myeloproliferative neoplasms: JAK of all grades. Dis. Model. Mech. 4:311-317. http://dx.doi.org/10.1242/dmm.006817
    • (2011) Dis. Model. Mech. , vol.4 , pp. 311-317
    • Li, J.1    Kent, D.G.2    Chen, E.3    Green, A.R.4
  • 29
    • 84889598519 scopus 로고    scopus 로고
    • Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness
    • Li, Q., N. Bohin, T. Wen, V. Ng, J. Magee, S.C. Chen, K. Shannon, and S.J. Morrison. 2013. Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature. 504:143-147. http:// dx.doi.org/10.1038/nature12830
    • (2013) Nature. , vol.504 , pp. 143-147
    • Li, Q.1    Bohin, N.2    Wen, T.3    Ng, V.4    Magee, J.5    Chen, S.C.6    Shannon, K.7    Morrison, S.J.8
  • 31
    • 67650632683 scopus 로고    scopus 로고
    • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    • Majeti, R., M.P. Chao, A.A. Alizadeh, W.W. Pang, S. Jaiswal, K.D. Gibbs Jr., N. van Rooijen, and I.L. Weissman. 2009. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 138:286-299. http://dx.doi.org/10.1016/j.cell.2009.05.045
    • (2009) Cell. , vol.138 , pp. 286-299
    • Majeti, R.1    Chao, M.P.2    Alizadeh, A.A.3    Pang, W.W.4    Jaiswal, S.5    Gibbs, K.D.6    van Rooijen, N.7    Weissman, I.L.8
  • 32
    • 77956280929 scopus 로고    scopus 로고
    • Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice
    • Marty, C., C. Lacout, A. Martin, S. Hasan, S. Jacquot, M.C. Birling, W. Vainchenker, and J.L. Villeval. 2010. Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice. Blood. 116:783-787. http://dx.doi.org/10.1182/blood-2009-12-257063
    • (2010) Blood. , vol.116 , pp. 783-787
    • Marty, C.1    Lacout, C.2    Martin, A.3    Hasan, S.4    Jacquot, S.5    Birling, M.C.6    Vainchenker, W.7    Villeval, J.L.8
  • 33
    • 0023245271 scopus 로고
    • Numbers and dispersion of repopulating hematopoietic cell clones in radiation chimeras as functions of injected cell dose
    • Micklem, H.S., J.E. Lennon, J.D. Ansell, and R.A. Gray. 1987. Numbers and dispersion of repopulating hematopoietic cell clones in radiation chimeras as functions of injected cell dose. Exp. Hematol. 15:251-257.
    • (1987) Exp. Hematol. , vol.15 , pp. 251-257
    • Micklem, H.S.1    Lennon, J.E.2    Ansell, J.D.3    Gray, R.A.4
  • 34
    • 77953512588 scopus 로고    scopus 로고
    • Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment
    • Morita, Y., H. Ema, and H. Nakauchi. 2010. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J. Exp. Med. 207:1173-1182. http://dx.doi.org/10.1084/jem.20091318
    • (2010) J. Exp. Med. , vol.207 , pp. 1173-1182
    • Morita, Y.1    Ema, H.2    Nakauchi, H.3
  • 35
    • 0028824811 scopus 로고
    • The purification and characterization of fetal liver hematopoietic stem cells
    • Morrison, S.J., H.D. Hemmati, A.M. Wandycz, and I.L. Weissman. 1995. The purification and characterization of fetal liver hematopoietic stem cells. Proc. Natl. Acad. Sci. USA. 92:10302-10306. http://dx.doi.org/ 10.1073/pnas.92.22.10302
    • (1995) Proc. Natl. Acad. Sci. USA. , vol.92 , pp. 10302-10306
    • Morrison, S.J.1    Hemmati, H.D.2    Wandycz, A.M.3    Weissman, I.L.4
  • 36
    • 77953274727 scopus 로고    scopus 로고
    • Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
    • Mullally, A., S.W. Lane, B. Ball, C. Megerdichian, R. Okabe, F. Al-Shahrour, M. Paktinat, J.E. Haydu, E. Housman, A.M. Lord, et al. 2010. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell. 17:584-596. http://dx.doi.org/10.1016/j.ccr.2010.05.015
    • (2010) Cancer Cell. , vol.17 , pp. 584-596
    • Mullally, A.1    Lane, S.W.2    Ball, B.3    Megerdichian, C.4    Okabe, R.5    Al-Shahrour, F.6    Paktinat, M.7    Haydu, J.E.8    Housman, E.9    Lord, A.M.10
  • 37
    • 84863589906 scopus 로고    scopus 로고
    • Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera
    • Mullally, A., L. Poveromo, R.K. Schneider, F. Al-Shahrour, S.W. Lane, and B.L. Ebert. 2012. Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera. Blood. 120:166-172. http://dx.doi.org/10.1182/ blood-2012-01-402396
    • (2012) Blood. , vol.120 , pp. 166-172
    • Mullally, A.1    Poveromo, L.2    Schneider, R.K.3    Al-Shahrour, F.4    Lane, S.W.5    Ebert, B.L.6
  • 38
    • 84879728130 scopus 로고    scopus 로고
    • Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera
    • Mullally, A., C. Bruedigam, L. Poveromo, F.H. Heidel, A. Purdon, T. Vu, R. Austin, D. Heckl, L.J. Breyfogle, C.P. Kuhn, et al. 2013. Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood. 121:3692- 3702. http://dx.doi.org/10.1182/blood-2012-05-432989
    • (2013) Blood. , vol.121 , pp. 3692- 3702
    • Mullally, A.1    Bruedigam, C.2    Poveromo, L.3    Heidel, F.H.4    Purdon, A.5    Vu, T.6    Austin, R.7    Heckl, D.8    Breyfogle, L.J.9    Kuhn, C.P.10
  • 40
    • 79952326353 scopus 로고    scopus 로고
    • The JAK2 V617F somatic mutation, mortality and cancer risk in the general population
    • Nielsen, C., H.S. Birgens, B.G. Nordestgaard, L. Kjaer, and S.E. Bojesen. 2011. The JAK2 V617F somatic mutation, mortality and cancer risk in the general population. Haematologica. 96:450-453. http://dx.doi.org/10.3324/ haematol.2010.033191
    • (2011) Haematologica. , vol.96 , pp. 450-453
    • Nielsen, C.1    Birgens, H.S.2    Nordestgaard, B.G.3    Kjaer, L.4    Bojesen, S.E.5
  • 41
    • 77953485892 scopus 로고    scopus 로고
    • Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
    • Oh, S.T., E.F. Simonds, C. Jones, M.B. Hale, Y. Goltsev, K.D. Gibbs Jr., J.D. Merker, J.L. Zehnder, G.P. Nolan, and J. Gotlib. 2010. Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood. 116:988-992. http:// dx.doi.org/10.1182/blood-2010-02-270108
    • (2010) Blood. , vol.116 , pp. 988-992
    • Oh, S.T.1    Simonds, E.F.2    Jones, C.3    Hale, M.B.4    Goltsev, Y.5    Gibbs, K.D.6    Merker, J.D.7    Zehnder, J.L.8    Nolan, G.P.9    Gotlib, J.10
  • 44
    • 51649087754 scopus 로고    scopus 로고
    • JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders
    • Plo, I., M. Nakatake, L. Malivert, J.P. de Villartay, S. Giraudier, J.L. Villeval, L. Wiesmuller, and W. Vainchenker. 2008. JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders. Blood. 112:1402-1412. http://dx.doi.org/10.1182/blood-2008-01-134114
    • (2008) Blood. , vol.112 , pp. 1402-1412
    • Plo, I.1    Nakatake, M.2    Malivert, L.3    de Villartay, J.P.4    Giraudier, S.5    Villeval, J.L.6    Wiesmuller, L.7    Vainchenker, W.8
  • 45
    • 0030927503 scopus 로고    scopus 로고
    • Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment
    • Randall, T.D., and I.L. Weissman. 1997. Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment. Blood. 89:3596-3606.
    • (1997) Blood. , vol.89 , pp. 3596-3606
    • Randall, T.D.1    Weissman, I.L.2
  • 48
    • 0035894949 scopus 로고    scopus 로고
    • Observation of antigen-dependent CD8+ T-cell/dendritic cell interactions in vivo
    • Schaefer, B.C., M.L. Schaefer, J.W. Kappler, P. Marrack, and R.M. Kedl. 2001. Observation of antigen-dependent CD8+ T-cell/dendritic cell interactions in vivo. Cell. Immunol. 214:110-122. http://dx.doi.org/10.1006/ cimm.2001.1895
    • (2001) Cell. Immunol. , vol.214 , pp. 110-122
    • Schaefer, B.C.1    Schaefer, M.L.2    Kappler, J.W.3    Marrack, P.4    Kedl, R.M.5
  • 49
    • 61849118935 scopus 로고    scopus 로고
    • Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F
    • Schaub, F.X., R. Jäger, R. Looser, H. Hao-Shen, S. Hermouet, F. Girodon, A. Tichelli, H. Gisslinger, R. Kralovics, and R.C. Skoda. 2009. Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F. Blood. 113:2022-2027. http://dx.doi.org/10 .1182/blood-2008-07-167056
    • (2009) Blood. , vol.113 , pp. 2022-2027
    • Schaub, F.X.1    Jäger, R.2    Looser, R.3    Hao-Shen, H.4    Hermouet, S.5    Girodon, F.6    Tichelli, A.7    Gisslinger, H.8    Kralovics, R.9    Skoda, R.C.10
  • 50
    • 77950388949 scopus 로고    scopus 로고
    • Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms
    • Schaub, F.X., R. Looser, S. Li, H. Hao-Shen, T. Lehmann, A. Tichelli, and R.C. Skoda. 2010. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood. 115:2003-2007. http://dx.doi.org/10.1182/blood-2009- 09-245381
    • (2010) Blood. , vol.115 , pp. 2003-2007
    • Schaub, F.X.1    Looser, R.2    Li, S.3    Hao-Shen, H.4    Lehmann, T.5    Tichelli, A.6    Skoda, R.C.7
  • 52
    • 33749358349 scopus 로고    scopus 로고
    • Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia
    • Scott, L.M., M.A. Scott, P.J. Campbell, and A.R. Green. 2006. Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia. Blood. 108:2435-2437. http://dx.doi.org/10.1182/blood-2006-04-018259
    • (2006) Blood. , vol.108 , pp. 2435-2437
    • Scott, L.M.1    Scott, M.A.2    Campbell, P.J.3    Green, A.R.4
  • 53
    • 33747599596 scopus 로고    scopus 로고
    • The JAK2V617F mutation is detectable at very low level in peripheral blood of healthy donors
    • Sidon, P., H. El Housni, B. Dessars, and P. Heimann. 2006. The JAK2V617F mutation is detectable at very low level in peripheral blood of healthy donors. Leukemia. 20:1622. http://dx.doi.org/10.1038/sj.leu.2404292
    • (2006) Leukemia. , vol.20 , pp. 1622
    • Sidon, P.1    El Housni, H.2    Dessars, B.3    Heimann, P.4
  • 54
    • 33644781621 scopus 로고    scopus 로고
    • The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets
    • Sieburg, H.B., R.H. Cho, B. Dykstra, N. Uchida, C.J. Eaves, and C.E. Muller- Sieburg. 2006. The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. Blood. 107:2311-2316. http://dx .doi.org/10.1182/blood-2005-07-2970
    • (2006) Blood. , vol.107 , pp. 2311-2316
    • Sieburg, H.B.1    Cho, R.H.2    Dykstra, B.3    Uchida, N.4    Eaves, C.J.5    Muller-Sieburg, C.E.6
  • 55
    • 0023922373 scopus 로고
    • Purification and characterization of mouse hematopoietic stem cells
    • Spangrude, G.J., S. Heimfeld, and I.L. Weissman. 1988. Purification and characterization of mouse hematopoietic stem cells. Science. 241:58-62. http://dx.doi.org/10.1126/science.2898810
    • (1988) Science. , vol.241 , pp. 58-62
    • Spangrude, G.J.1    Heimfeld, S.2    Weissman, I.L.3
  • 57
    • 79951698622 scopus 로고    scopus 로고
    • Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation
    • Takizawa, H., R.R. Regoes, C.S. Boddupalli, S. Bonhoeffer, and M.G. Manz. 2011. Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation. J. Exp. Med. 208:273-284. http://dx.doi .org/10.1084/jem.20101643
    • (2011) J. Exp. Med. , vol.208 , pp. 273-284
    • Takizawa, H.1    Regoes, R.R.2    Boddupalli, C.S.3    Bonhoeffer, S.4    Manz, M.G.5
  • 58
    • 43249084493 scopus 로고    scopus 로고
    • Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice
    • Tiedt, R., H. Hao-Shen, M.A. Sobas, R. Looser, S. Dirnhofer, J. Schwaller, and R.C. Skoda. 2008. Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood. 111:3931- 3940. http://dx.doi.org/10.1182/blood-2007-08-107748
    • (2008) Blood. , vol.111 , pp. 3931- 3940
    • Tiedt, R.1    Hao-Shen, H.2    Sobas, M.A.3    Looser, R.4    Dirnhofer, S.5    Schwaller, J.6    Skoda, R.C.7
  • 59
    • 55449105991 scopus 로고    scopus 로고
    • Maximal STAT5- induced proliferation and self-renewal at intermediate STAT5 activity levels
    • Wierenga, A.T.J., E. Vellenga, and J.J. Schuringa. 2008. Maximal STAT5- induced proliferation and self-renewal at intermediate STAT5 activity levels. Mol. Cell. Biol. 28:6668-6680. http://dx.doi.org/10.1128/ MCB.01025-08
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 6668-6680
    • Wierenga, A.T.J.1    Vellenga, E.2    Schuringa, J.J.3
  • 61
    • 35948964020 scopus 로고    scopus 로고
    • Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
    • Wong, P., M. Iwasaki, T.C. Somervaille, C.W. So, and M.L. Cleary. 2007. Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev. 21:2762-2774. http://dx.doi.org/10.1101/ gad.1602107
    • (2007) Genes Dev. , vol.21 , pp. 2762-2774
    • Wong, P.1    Iwasaki, M.2    Somervaille, T.C.3    So, C.W.4    Cleary, M.L.5
  • 62
    • 33846012829 scopus 로고    scopus 로고
    • JAK2(V617F): Prevalence in a large Chinese hospital population
    • Xu, X., Q. Zhang, J. Luo, S. Xing, Q. Li, S.B. Krantz, X. Fu, and Z.J. Zhao. 2007. JAK2(V617F): Prevalence in a large Chinese hospital population. Blood. 109:339-342. http://dx.doi.org/10.1182/blood-2006-03-009472
    • (2007) Blood. , vol.109 , pp. 339-342
    • Xu, X.1    Zhang, Q.2    Luo, J.3    Xing, S.4    Li, Q.5    Krantz, S.B.6    Fu, X.7    Zhao, Z.J.8
  • 63
    • 84883428326 scopus 로고    scopus 로고
    • Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells
    • Yamamoto, R., Y. Morita, J. Ooehara, S. Hamanaka, M. Onodera, K.L. Rudolph, H. Ema, and H. Nakauchi. 2013. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Cell. 154:1112-1126. http://dx.doi.org/10 .1016/j.cell.2013.08.007
    • (2013) Cell. , vol.154 , pp. 1112-1126
    • Yamamoto, R.1    Morita, Y.2    Ooehara, J.3    Hamanaka, S.4    Onodera, M.5    Rudolph, K.L.6    Ema, H.7    Nakauchi, H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.