A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/- mice

Neurobiology of Disease

Volumn 82, Issue , 2015, Pages 32-45

  Zhang, Jingzhong ^a,g   Götz, Sebastian ^a   Vogt Weisenhorn, Daniela M ^a,b,c   Simeone, Antonio ^d,e   Wurst, Wolfgang ^a,b,c,f   Prakash, Nilima ^a,b,h  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^e IRCCS NEUROMED   (Italy)

^f UNIVERSITY OF MUNICH   (Germany)

^g MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^h UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

Bdnf; Dkk3; Dopamine neuron; Fgf20; Lef1; Lmx1a; Neuroprotection; Parkinson's disease; Pitx3; Survival

Indexed keywords

BETA CATENIN; BRAIN DERIVED NEUROTROPHIC FACTOR; GLYCOPROTEIN; LYMPHOID ENHANCER FACTOR 1; PROTEIN DKK3; TRANSCRIPTION FACTOR PITX3; UNCLASSIFIED DRUG; VELAFERMIN; WNT1 PROTEIN; DKK3 PROTEIN, MOUSE; EN1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; SIGNAL PEPTIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BDNF GENE; CELL PROTECTION; CONTROLLED STUDY; DEVELOPMENTAL GENE; DKK3 GENE; DOPAMINERGIC NERVE CELL; FEMALE; FGF20 GENE; GENE INDUCTION; GENE TARGETING; LEF1 GENE; LMX1A GENE; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PITX3 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VENTRAL TEGMENTUM; ANIMAL; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; SUBSTANTIA NIGRA; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DIFFERENTIATION; DOPAMINERGIC NEURONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; PARKINSON DISEASE; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; UP-REGULATION; VENTRAL TEGMENTAL AREA; WNT1 PROTEIN;

EID: 84930941082     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.05.015     Document Type: Article

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