The coupling interface and pore domain codetermine the single-channel activity of the α7 nicotinic receptor

Neuropharmacology

Volumn 95, Issue , 2015, Pages 448-458

  Yan, Hongxia ^a   Pan, Na ^a   Xue, Fenqin ^b   Zheng, Yan ^a   Li, Chaokun ^c   Chang, Yongchang ^d   Xu, Zhiqing ^a   Yang, Hui ^a   Zhang, Jianliang ^a  

^a BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c XINXIANG MEDICAL UNIVERSITY   (China)

^d BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

Channel coupling; Channel gating; Nicotinic receptor; Patch clamp

Indexed keywords

BUNGAROTOXIN RECEPTOR; ACETYLCHOLINE; SERINE; SEROTONIN 3 RECEPTOR;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE CONDUCTANCE; CELL SURFACE; CHANNEL GATING; CHIMERA; CONTROLLED STUDY; COUPLING FACTOR; EXTRACELLULAR SPACE; FLUORESCENCE ANALYSIS; GENE MUTATION; HYDROPHILICITY; LIGAND BINDING; MAMMAL CELL; MICROSCOPY; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; BINDING SITE; CELL MEMBRANE; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CONFOCAL MICROSCOPY; GENETICS; HEK293 CELL LINE; HUMAN; KINETICS; METABOLISM; MUTATION; PHYSIOLOGY; RADIOASSAY;

ACETYLCHOLINE; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; BINDING SITES; CELL MEMBRANE; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MUTATION; PATCH-CLAMP TECHNIQUES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN, 5-HT3; SERINE;

EID: 84930934206     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.04.010     Document Type: Article

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