Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity

Journal of Neuroscience

Volumn 35, Issue 23, 2015, Pages 8882-8895

  Mark, Melanie D ^a   Krause, Martin ^a   Boele, Henk Jan ^b   Kruse, Wolfgang ^a   Pollok, Stefan ^a   Kuner, Thomas ^c   Dalkara, Deniz ^d   Koekkoek, Sebastiaan ^b   De Zeeuw, Chris I ^b,e   Herlitze, Stefan ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d INSTITUT DE LA VISION   (France)

^e NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

Author keywords

P Q type calcium channel; Poly glutamine disease; Spinocerebellar ataxia type 6

Indexed keywords

CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; NUCLEIC ACID BINDING PROTEIN; POLYGLUTAMINE; PROTEIN AGGREGATE; SPINOCEREBELLAR ATAXIA TYPE 6 PROTEIN; UNCLASSIFIED DRUG; ACTIN; BACTERIAL PROTEIN; CALCIUM CHANNEL N TYPE; PEPTIDE; PHOTOPROTEIN; VOLTAGE-DEPENDENT CALCIUM CHANNEL (P-Q TYPE); YELLOW FLUORESCENT PROTEIN, BACTERIA;

ADENO ASSOCIATED VIRUS; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS INCLUSION BODY; CONTROLLED STUDY; CRANIOTOMY; ELECTROPHYSIOLOGICAL PROCEDURES; EYELID REFLEX; FEMALE; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LEARNING DISORDER; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; VOLTAGE CLAMP TECHNIQUE; WESTERN BLOTTING; ACTION POTENTIAL; AGE; ANIMAL; CEREBELLUM; CEREBELLUM CORTEX; DISEASE MODEL; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; IN VITRO STUDY; METABOLISM; MOTOR ACTIVITY; NERVE CELL; PATHOLOGY; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; SPINOCEREBELLAR DEGENERATION; TRANSGENIC MOUSE;

ACTINS; ACTION POTENTIALS; AGE FACTORS; ANIMALS; BACTERIAL PROTEINS; CALCIUM CHANNELS, N-TYPE; CEREBELLAR CORTEX; CEREBELLUM; DISEASE MODELS, ANIMAL; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEK293 CELLS; HUMANS; IN VITRO TECHNIQUES; LEARNING DISORDERS; LUMINESCENT PROTEINS; MALE; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; NEURONAL PLASTICITY; NEURONS; PEPTIDES; PROTEIN AGGREGATES; PSYCHOMOTOR PERFORMANCE; SPINOCEREBELLAR ATAXIAS;

EID: 84930894941     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0891-15.2015     Document Type: Article

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