Formate metabolism in fetal and neonatal sheep

American Journal of Physiology - Endocrinology and Metabolism

Volumn 308, Issue 10, 2015, Pages E921-E927

  Washburn, Shannon E ^a   Caudil, Marie A ^b   Malysheva, Olga ^b   Macfarlane, Amanda J ^c   Behan, Nathalie A ^c   Harnett, Brian ^d   Macmillan, Luke ^d   Pongnopparat, Theerawat ^d   Brosnan, John T ^d   Brosnan, Margaret E ^d  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c HEALTH CANADA   (Canada)

^d MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Folate; Milk; Mitochondria; One carbon metabolism; Serine; Vitamin B12

Indexed keywords

CARBON; CYANOCOBALAMIN; DIMETHYLGLYCINE; FOLIC ACID; FORMIC ACID; FORMIC ACID DERIVATIVE; HOMOCYSTEINE;

AMNION FLUID; ANIMAL EXPERIMENT; ARTICLE; CANNULATION; CARBON METABOLISM; CONTROLLED STUDY; FEMALE; LAMB; MATERNAL PLASMA; NONHUMAN; PRIORITY JOURNAL; THIRD TRIMESTER PREGNANCY; VITAMIN DEFICIENCY; ANIMAL; BLOOD; BREEDING; EMBRYOLOGY; FETUS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NEWBORN; PREGNANCY; PUERPERIUM; SHEEP;

AMNIOTIC FLUID; ANIMALS; ANIMALS, NEWBORN; FEMALE; FETUS; FOLIC ACID; FORMATES; HOMOCYSTEINE; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY, ANIMAL; SHEEP; VITAMIN B 12;

EID: 84930833861     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00046.2015     Document Type: Article

References (42)

1. Bazer FW, Spencer TE, Thatcher WW. Growth and development of the ovine conceptus. J Anim Sci 90: 159–170, 2012.
2. Cardellino RA, Benson ME. Lactation curves of commercial ewes rearing lambs. J Anim Sci 80: 23–27, 2002.
3. Cetin I, Fennessey PV, Sparks JW, Meschia G, Battaglia FC. Fetal serine fluxes across fetal liver, hindlimb, and placenta in late gestation. Am J Physiol Endocrinol Metab 263: E786–E793, 1992.
4. Cetin I, Marconi AM, Bozzetti P, Sereni LP, Corbetta C, Pardi G, Battaglia FC. Umbilical amino acid concentrations in appropriate and small for gestational age infants: a biochemical difference present in utero. Am J Obstet Gynecol 158: 120–126, 1988.
5. Cetin I, Marconi AM, Corbetta C, Lanfranchi A, Baggiani AM, Battaglia FC, Pardi G. Fetal amino acids in normal pregnancies and in pregnancies complicated by intrauterine growth retardation. Early Hum Dev 29: 183–186, 1992.
6. Chung M, Teng C, Timmerman M, Meschia G, Battaglia FC. Production and utilization of amino acids by ovine placenta in vivo. Am J Physiol Endocrinol Metab 274: E13–E22, 1998.
7. Dasarathy J, Gruca LL, Bennett C, Parimi PS, Duenas C, Marczewski S, Fierro JL, Kalhan SC. Methionine metabolism in human pregnancy. Am J Clin Nutr 91: 357–365, 2010.
8. De Wals P, Tairou F, Van Allen MI, Uh SH, Lowry RB, Sibbald B, Evans JA, Van den Hof MC, Zimmer P, Crowley M, Fernandez B, Lee NS, Niyonsenga T. Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med 357: 135–142, 2007.
9. Dobbing J, Sands J. Comparative aspects of the brain growth spurt. Early Hum Dev 3: 79–83, 1979.
10. Fan J, Ye J, Kamphorst JJ, Shlomi T, Thompson CB, Rabinowitz JD. Quantitative flux analysis reveals folate-dependent NADPH production. Nature 510: 298–302, 2014.
11. Fox JT, Stover PJ. Folate-mediated one-carbon metabolism. Vitam Horm 79: 1–44, 2008.
12. Gamble MV, Liu X, Ahsan H, Pilsner R, Ilievski V, Slavkovich V, Parvez F, Levy D, Factor-Litvak P, Graziano JH. Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh. Environ Health Perspect 113: 1683–1688, 2005.
13. Holm PI, Ueland PM, Kvalheim G, Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem 49: 286–294, 2003.
14. Horne DW, Patterson D. Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates. Clin Chem 34: 2357–2359, 1988.
15. Koukoura O, Sifakis S, Spandidos DA. DNA methylation in the human placenta and fetal growth (review). Mol Med Rep 5: 883–889, 2012.
16. Krebs HA, Hems R, Tyler B. The regulation of folate and methionine metabolism. Biochem J 158: 341–353, 1976.
17. Lamarre SG, MacMillan L, Morrow GP, Randell E, Pongnopparat T, Brosnan ME, Brosnan JT. An isotope-dilution, GC-MS assay for formate and its application to human and animal metabolism. Amino Acids 46: 1885–1891, 2014.
18. Lamarre SG, Molloy AM, Reinke SN, Sykes BD, Brosnan ME, Brosnan JT. Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. Am J Physiol Endocrinol Metab 302: E61–E67, 2012.
19. Lamarre SG, Morrow G, Macmillan L, Brosnan ME, Brosnan JT. Formate: an essential metabolite, a biomarker, or more? Clin Chem Lab Med 51: 571–578, 2013.
20. MacFarlane AJ, Liu X, Perry CA, Flodby P, Allen RH, Stabler SP, Stover PJ. Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J Biol Chem 283: 25846–25853, 2008.
21. Matthews RG. A love affair with vitamins. J Biol Chem 284: 26217–26228, 2009.
22. McCoard S, Sales F, Wards N, Sciascia Q, Oliver M, Koolaard J, van der Linden D. Parenteral administration of twin-bearing ewes with L-arginine enhances the birth weight and brown fat stores in sheep. Springerplus 2: 684, 2013.
23. Momb J, Lewandowski JP, Bryant JD, Fitch R, Surman DR, Vokes SA, Appling DR. Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice. Proc Natl Acad Sci USA 110: 549–554, 2013.
24. Morrow GP, MacMillan L, Lamarre SG, Young SK, MacFarlane AJ, Brosnan ME, Brosnan JT. In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats. J Biol Chem 290: 2244–2250, 2015.
25. Mudd SH, Brosnan JT, Brosnan ME, Jacobs RL, Stabler SP, Allen RH, Vance DE, Wagner C. Methyl balance and transmethylation fluxes in humans. Am J Clin Nutr 85: 19–25, 2007.
26. Narkewicz MR, Moores RR Jr, Battaglia FC, Frerman FF. Ontogeny of serine hydroxymethyltransferase isoenzymes in fetal sheep liver, kidney, and placenta. Mol Genet Metab 68: 473–480, 1999.
27. Pai YJ, Leung KY, Savery D, Hutchin T, Prunty H, Heales S, Brosnan ME, Brosnan JT, Copp AJ, Greene ND. Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. Nat Commun 6: 6388, 2015.
28. Petrossian TC, Clarke SG. Uncovering the human methyltransferasome. Mol Cell Proteomics 10: M110.000976, 2011.
29. Pike ST, Rajendra R, Artzt K, Appling DR. Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial onecarbon units into the methyl cycle in embryos. J Biol Chem 285: 4612–4620, 2010.
30. Prasannan P, Pike S, Peng K, Shane B, Appling DR. Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls. J Biol Chem 278: 43178–43187, 2003.
31. Sawant OB, Ramadoss J, Hankins GD, Wu G, Washburn SE. Effects of L-glutamine supplementation on maternal and fetal hemodynamics in gestating ewes exposed to alcohol. Amino Acids 46: 1981–1996, 2014.
32. Shields DC, Kirke PN, Mills JL, Ramsbottom D, Molloy AM, Burke H, Weir DG, Scott JM, Whitehead AS. The “thermolabile” variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother. Am J Hum Genet 64: 1045–1055, 1999.
33. Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab 281: E1095–E1100, 2001.
34. Thorburn GD, Harding R. Textbook of Fetal Physiology: Oxford University, 1994.
35. Vester B, Rasmussen K. High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur J Clin Chem Clin Biochem 29: 549–554, 1991.
36. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472: 57–63, 2011.
37. Washburn SE, Sawant OB, Lunde ER, Wu G, Cudd TA. Acute alcohol exposure, acidemia or glutamine administration impacts amino acid homeostasis in ovine maternal and fetal plasma. Amino Acids 45: 543–554, 2013.
38. Wu G, Meininger CJ. Analysis of citrulline, arginine, and methylarginines using high-performance liquid chromatography. Methods Enzymol 440: 177–189, 2008.
39. Xue GP, Snoswell AM. Developmental changes in the activities of enzymes related to methyl group metabolism in sheep tissues. Comp Biochem Physiol B 83: 115–120, 1986.
40. Yan J, Jiang X, West AA, Perry CA, Malysheva OV, Brenna JT, Stabler SP, Allen RH, Gregory JF 3rd, Caudill MA. Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women. Am J Clin Nutr 98: 1459–1467, 2013.
41. Yan J, Jiang X, West AA, Perry CA, Malysheva OV, Devapatla S, Pressman E, Vermeylen F, Stabler SP, Allen RH, Caudill MA. Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. Am J Clin Nutr 95: 1060–1071, 2012.
42. Yan J, Wang W, Gregory JF 3rd, Malysheva O, Brenna JT, Stabler SP, Allen RH, Caudill MA. MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline. Am J Clin Nutr 93: 348–355, 2011.