Plasma nuclear and mitochondrial DNA levels as predictors of outcome in severe sepsis patients in the emergency room

Journal of Translational Medicine

Volumn 10, Issue 1, 2012, Pages

  Kung, Chia Te ^a   Hsiao, Sheng Yuan ^a   Tsai, Tsung Cheng ^a   Su, Chih Min ^a   Chang, Wen Neng ^a   Huang, Chi Ren ^a   Wang, Hung Chen ^a   Lin, Wei Che ^a   Chang, Hsueh Wen ^b   Lin, Yu Jun ^a,b   Cheng, Ben Chung ^a,b   Su, Ben Y ^a   Tsai, Nai Wen ^a   Lu, Cheng Hsien ^a,b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Hospital mortality; Mitochondrial DNA; Nucleus DNA; Severe sepsis

Indexed keywords

CELL NUCLEUS DNA; LACTIC ACID; MITOCHONDRIAL DNA;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; BLOOD LEVEL; CONTROLLED STUDY; EMERGENCY WARD; FATALITY; FEMALE; HOSPITAL ADMISSION; HUMAN; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PREDICTION; PROGNOSIS; PROSPECTIVE STUDY; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SEPSIS; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE;

AGED; BASE SEQUENCE; CASE-CONTROL STUDIES; CELL NUCLEUS; DNA; DNA PRIMERS; DNA, MITOCHONDRIAL; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROGNOSIS; PROSPECTIVE STUDIES; SEPSIS;

EID: 84862492838     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-10-130     Document Type: Article

References (21)

1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554. 10.1056/NEJMoa022139, 12700374.
2. Leon SA, Shapiro B, Sklaroff DM, Yaros MJ. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 1977, 37:646-650.
3. Jiang N, Pisetsky DS. The effect of inflammation on the generation of plasma DNA from dead and dying cell in the peritoneum. J Leukoc Biol 2005, 77:1-7.
4. Jahr S, Hentze H, English S, Hardt D, Fackelmayer FO, Hesch RD, Knippers R. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 2001, 61:1659-1665.
5. Tsumita T, Iwanagam M. Fate of injected deoxyribonucleic acid in mice. Nature 1963, 198:1088-1089. 10.1038/1981088a0, 13994595.
6. Lo YM, Rainer TH, Chan LY, Hjelm NM, Cocks RA. Plasma DNA as a prognostic marker in trauma patients. Clin Chem 2000, 46:319-323.
7. Chang CP, Chia RH, Wu TL, Tsao KC, Sun CF, Wu JT. Elevated cell-free serum DNA detected in patients with myocardial infarction. Clin Chim Acta 2003, 327:95-101. 10.1016/S0009-8981(02)00337-6, 12482623.
8. Rainer TH, Wong LK, Lam W, Yuen E, Lam NY, Metreweli C, Lo YM. Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke. Clin Chem 2003, 49:562-569. 10.1373/49.4.562, 12651807.
9. Saukkonen K, Lakkisto P, Pettila V, Varpula M, Karlsson S, Ruokonen E, Pulkki K. Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock. Clin Chem 2008, 54:1000-1007. 10.1373/clinchem.2007.101030, 18420731.
10. Huang CH, Tsai MS, Hsu CY, Chen HW, Wang TD, Chang WT, Ma MH, Chien KL, Chen SC, Chen WJ. Circulating cell-free DNA levels correlate with post-resuscitation survival rates in out-of-hospital cardiac arrest patients. Resuscitation 2012, 83:213-218. 10.1016/j.resuscitation.2011.07.039, 21864482.
11. Okkonen M, Lakkisto P, Korhonen AM, Parviai-nen I, Reinikainen M, Varpula T, Pettilä V. Plasma cell-free DNA in patients needing mechanical ventilation. Crit Care 2011, 15:R196. 10.1186/cc10357, 3387638, 21838858.
12. Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in the sepsis. Nat Rev Immunol 2006, 6:813-822. 10.1038/nri1943, 17039247.
13. Martins GA, Kawamura MT, Carvalho Mda G. Detection of DNA in the plasma of septic patients. Ann NY Acad Sci 2000, 906:134-140.
14. Zeerleder S, Zwart B, Wuillemin WA, Aarden LA, Groeneveld AB, Caliezi C, van Nieuwenhuijze A, van Mierlo GJ, Eerenberg AJ, Lammle B, Hack CE. Elevated nucleosome levels in systemic inflammation and sepsis. Crit Care Med 2003, 31:1947-1951. 10.1097/01.CCM.0000074719.40109.95, 12847387.
15. Rhodes A, Wort SJ, Thomas H, Collinson P, Bennett ED. Plasma DNA concentration as predictor of mortality and sepsis in critically ill patients. Crit Care 2006, 10:R60. 10.1186/cc4894, 1550922, 16613611.
16. American College of Chest Physicians/ Society of Critical Care Medicine Consensus Committee Definition for sepsis and organ failures and guidelines for the use of innovative therapies in sepsis. Chest 1992, 101:1658-1662. American College of Chest Physicians/ Society of Critical Care Medicine Consensus Committee.
17. Lo YM, Tein MS, Lau TK, Haines CJ, Leung TN, Poon PM, Wainscoat JS, Johnson PJ, Chang AM, Hjelm NM. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for non-invasive pre-natal diagnosis. Am J Hum Genet 1998, 62:768-775. 10.1086/301800, 1377040, 9529358.
18. Chiu RW, Chan LY, Lam NY, Tsui NB, Ng EK, Rainer TH, Lo YM. Quantitative analysis of circulating mitochondrial DNA in plasma. Clin Chem 2003, 49:719-726. 10.1373/49.5.719, 12709361.
19. Brunelle JK, Chandel NS. Oxygen deprivation induced cell death: an update. Apoptosis 2002, 7:475-482. 10.1023/A:1020668923852, 12370489.
20. Huttunen R, Kuparinen T, Jylhava J. Fatal outcome in bacteremia is characterized by high plasma cell free DNA concentration and apoptotic DNA fragmentation: A prospective cohort study. PLoS One 2011, 6:e21700. 10.1371/journal.pone.0021700, 3128600, 21747948.
21. Labbeand K, Saleh M. Cell death in the host response to infection. Cell Death Differ 2008, 15:1339-1349. 10.1038/cdd.2008.91, 18566602.