메뉴 건너뛰기




Volumn 22, Issue 7, 2015, Pages 1117-1130

Reprogramming of human pancreatic exocrine cells to β-like cells

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROGENIN 3; STAT3 PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; NERVE PROTEIN; NEUROG3 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

EID: 84930756594     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.193     Document Type: Article
Times cited : (77)

References (39)
  • 1
    • 0030942255 scopus 로고    scopus 로고
    • Proliferation and differentiation in the human fetal endocrine pancreas
    • Bouwens L, Lu WG, De Krijger R. Proliferation and differentiation in the human fetal endocrine pancreas. Diabetologia 1997; 40: 398-404.
    • (1997) Diabetologia , vol.40 , pp. 398-404
    • Bouwens, L.1    Lu, W.G.2    De Krijger, R.3
  • 2
    • 44749088201 scopus 로고    scopus 로고
    • Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans
    • Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A et al. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes 2008; 57: 1584-1594.
    • (2008) Diabetes , vol.57 , pp. 1584-1594
    • Meier, J.J.1    Butler, A.E.2    Saisho, Y.3    Monchamp, T.4    Galasso, R.5    Bhushan, A.6
  • 4
    • 0043268785 scopus 로고    scopus 로고
    • Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture
    • Gao R, Ustinov J, Pulkkinen MA, Lundin K, Korsgren O, Otonkoski T et al. Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes 2003; 52: 2007-2015.
    • (2003) Diabetes , vol.52 , pp. 2007-2015
    • Gao, R.1    Ustinov, J.2    Pulkkinen, M.A.3    Lundin, K.4    Korsgren, O.5    Otonkoski, T.6
  • 5
    • 27744593347 scopus 로고    scopus 로고
    • In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells
    • Gao R, Ustinov J, Korsgren O, Otonkoski T. In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells. Diabetologia 2005; 48: 2296-2304.
    • (2005) Diabetologia , vol.48 , pp. 2296-2304
    • Gao, R.1    Ustinov, J.2    Korsgren, O.3    Otonkoski, T.4
  • 6
    • 0033911990 scopus 로고    scopus 로고
    • Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro
    • Rooman I, Heremans Y, Heimberg H, Bouwens L. Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 2000; 43: 907-914.
    • (2000) Diabetologia , vol.43 , pp. 907-914
    • Rooman, I.1    Heremans, Y.2    Heimberg, H.3    Bouwens, L.4
  • 7
    • 0031914251 scopus 로고    scopus 로고
    • Cytokeratins and cell differentiation in the pancreas
    • Bouwens L. Cytokeratins and cell differentiation in the pancreas. J Pathol 1998; 184: 234-239.
    • (1998) J Pathol , vol.184 , pp. 234-239
    • Bouwens, L.1
  • 8
    • 12944327377 scopus 로고    scopus 로고
    • In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
    • Baeyens L, De Breuck S, Lardon J, Mfopou JK, Rooman I, Bouwens L et al. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 2005; 48: 49-57.
    • (2005) Diabetologia , vol.48 , pp. 49-57
    • Baeyens, L.1    De Breuck, S.2    Lardon, J.3    Mfopou, J.K.4    Rooman, I.5    Bouwens, L.6
  • 9
    • 2542575642 scopus 로고    scopus 로고
    • Plasticity in the adult rat pancreas: Transdifferentiation of exocrine to hepatocyte-like cells in primary culture
    • Lardon J, De Breuck S, Rooman I, Van Lommel L, Kruhøffer M, Orntoft T et al. Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture. Hepatology 2004; 39: 1499-1507.
    • (2004) Hepatology , vol.39 , pp. 1499-1507
    • Lardon, J.1    De Breuck, S.2    Rooman, I.3    Van Lommel, L.4    Kruhøffer, M.5    Orntoft, T.6
  • 10
    • 65249128642 scopus 로고    scopus 로고
    • Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro
    • Baeyens L, Bonné S, Bos T, Rooman I, Peleman C, Lahoutte T et al. Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro. Gastroenterology 2009; 136: 1750-1760 e1713.
    • (2009) Gastroenterology , vol.136 , pp. 1750-1760
    • Baeyens, L.1    Bonné, S.2    Bos, T.3    Rooman, I.4    Peleman, C.5    Lahoutte, T.6
  • 11
    • 27244437951 scopus 로고    scopus 로고
    • Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells
    • Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K et al. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci USA 2005; 102: 15116-15121.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15116-15121
    • Minami, K.1    Okuno, M.2    Miyawaki, K.3    Okumachi, A.4    Ishizaki, K.5    Oyama, K.6
  • 12
    • 33845966354 scopus 로고    scopus 로고
    • Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes
    • Okuno M, Minami K, Okumachi A, Miyawaki K, Yokoi N, Toyokuni S et al. Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes. Am J Physiol Endocrinol Metab 2007; 292: E158-E165.
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , pp. E158-E165
    • Okuno, M.1    Minami, K.2    Okumachi, A.3    Miyawaki, K.4    Yokoi, N.5    Toyokuni, S.6
  • 13
    • 80051521184 scopus 로고    scopus 로고
    • Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas
    • Houbracken I, de Waele E, Lardon J, Ling Z, Heimberg H, Rooman I et al. Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology 2011; 141: 731-741 and 731-734.
    • (2011) Gastroenterology , vol.141
    • Houbracken, I.1    De Waele, E.2    Lardon, J.3    Ling, Z.4    Heimberg, H.5    Rooman, I.6
  • 14
    • 33749590993 scopus 로고    scopus 로고
    • Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway
    • Baeyens L, Bonné S, German MS, Ravassard P, Heimberg H, Bouwens L et al. Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway. Cell Death Differ 2006; 13: 1892-1899.
    • (2006) Cell Death Differ , vol.13 , pp. 1892-1899
    • Baeyens, L.1    Bonné, S.2    German, M.S.3    Ravassard, P.4    Heimberg, H.5    Bouwens, L.6
  • 15
    • 19244372001 scopus 로고    scopus 로고
    • Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3
    • Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl GGuillemot F et al. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol 2000; 20: 4445-4454.
    • (2000) Mol Cell Biol , vol.20 , pp. 4445-4454
    • Jacquemin, P.1    Durviaux, S.M.2    Jensen, J.3    Godfraind, C.4
  • 16
    • 41849151748 scopus 로고    scopus 로고
    • Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
    • Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, Eliazer S et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 2008; 26: 443-452.
    • (2008) Nat Biotechnol , vol.26 , pp. 443-452
    • Kroon, E.1    Martinson, L.A.2    Kadoya, K.3    Bang, A.G.4    Kelly, O.G.5    Eliazer, S.6
  • 17
    • 77957583357 scopus 로고    scopus 로고
    • MafA and MafB regulate genes critical to beta-cells in a unique temporal manner
    • Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J et al. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes 2010; 59: 2530-2539.
    • (2010) Diabetes , vol.59 , pp. 2530-2539
    • Artner, I.1    Hang, Y.2    Mazur, M.3    Yamamoto, T.4    Guo, M.5    Lindner, J.6
  • 18
    • 77956636575 scopus 로고    scopus 로고
    • Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain
    • Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L et al. Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol 2010; 30: 4234-4244.
    • (2010) Mol Cell Biol , vol.30 , pp. 4234-4244
    • Raum, J.C.1    Hunter, C.S.2    Artner, I.3    Henderson, E.4    Guo, M.5    Elghazi, L.6
  • 20
    • 56549118636 scopus 로고    scopus 로고
    • Effect of extracellular matrix and 3D morphogenesis on islet hormone gene expression by Ngn3-infected mouse pancreatic ductal epithelial cells
    • Boretti MI, Gooch KJ. Effect of extracellular matrix and 3D morphogenesis on islet hormone gene expression by Ngn3-infected mouse pancreatic ductal epithelial cells. Tissue Eng Part A 2008; 14: 1927-1937.
    • (2008) Tissue Eng Part A , vol.14 , pp. 1927-1937
    • Boretti, M.I.1    Gooch, K.J.2
  • 21
    • 0032842777 scopus 로고    scopus 로고
    • Extracellular matrix remodelling and cellular differentiation
    • Streuli C. Extracellular matrix remodelling and cellular differentiation. Curr Opin Cell Biol 1999; 11: 634-640.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 634-640
    • Streuli, C.1
  • 22
    • 35349021929 scopus 로고    scopus 로고
    • Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas
    • Rooman I, De Medts N, Baeyens L, Lardon J, De Breuck S, Heimberg H et al. Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Am J Pathol 2006; 169: 1206-1214.
    • (2006) Am J Pathol , vol.169 , pp. 1206-1214
    • Rooman, I.1    De Medts, N.2    Baeyens, L.3    Lardon, J.4    De Breuck, S.5    Heimberg, H.6
  • 23
    • 59649095116 scopus 로고    scopus 로고
    • Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction
    • Klein T, Heremans Y, Heimberg H, Pipeleers D, Madsen OD, Serup P et al. Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction. Pancreas 2009; 38: 36-48.
    • (2009) Pancreas , vol.38 , pp. 36-48
    • Klein, T.1    Heremans, Y.2    Heimberg, H.3    Pipeleers, D.4    Madsen, O.D.5    Serup, P.6
  • 24
    • 27244437951 scopus 로고    scopus 로고
    • Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells
    • Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K et al. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci USA 2005; 102: 15116-15121.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15116-15121
    • Minami, K.1    Okuno, M.2    Miyawaki, K.3    Okumachi, A.4    Ishizaki, K.5    Oyama, K.6
  • 25
    • 42349085980 scopus 로고    scopus 로고
    • Identification of novel mutations and sequence variants in the SOX2 and CHX10 genes in patients with anophthalmia/microphthalmia
    • Zhou J, Kherani F, Bardakjian TM, Katowitz J, Hughes N, Schimmenti LA et al. Identification of novel mutations and sequence variants in the SOX2 and CHX10 genes in patients with anophthalmia/microphthalmia. Mol Vis 2008; 14: 583-592.
    • (2008) Mol Vis , vol.14 , pp. 583-592
    • Zhou, J.1    Kherani, F.2    Bardakjian, T.M.3    Katowitz, J.4    Hughes, N.5    Schimmenti, L.A.6
  • 26
    • 84892173922 scopus 로고    scopus 로고
    • Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
    • Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G et al. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat Biotechnol 2014; 32: 76-83.
    • (2014) Nat Biotechnol , vol.32 , pp. 76-83
    • Baeyens, L.1    Lemper, M.2    Leuckx, G.3    De Groef, S.4    Bonfanti, P.5    Stangé, G.6
  • 27
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G, Dierich A, LeMeur M, Guillemot F. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 2000; 97: 1607-1611.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 28
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002; 129: 2447-2457.
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 30
    • 79954513296 scopus 로고    scopus 로고
    • Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis
    • Pinho AV, Rooman I, Reichert M, De Medts N, Bouwens L, Rustgi AK et al. Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis. Gut 2011; 60:958-966.
    • (2011) Gut , vol.60 , pp. 958-966
    • Pinho, A.V.1    Rooman, I.2    Reichert, M.3    De Medts, N.4    Bouwens, L.5    Rustgi, A.K.6
  • 31
    • 19944431623 scopus 로고    scopus 로고
    • EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade
    • Rescan C, Le Bras S, Lefebvre VH, Frandsen U, Klein T, Foschi M et al. EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade. Lab Invest 2005; 85: 65-74.
    • (2005) Lab Invest , vol.85 , pp. 65-74
    • Rescan, C.1    Le Bras, S.2    Lefebvre, V.H.3    Frandsen, U.4    Klein, T.5    Foschi, M.6
  • 32
    • 0031985552 scopus 로고    scopus 로고
    • Culture of adult human islet preparations with hepatocyte growth factor and 804 G matrix is mitogenic for duct cells but not for beta-cells
    • Lefebvre VH, Otonkoski T, Ustinov J, Huotari MA, Pipeleers DG, Bouwens L et al. Culture of adult human islet preparations with hepatocyte growth factor and 804 G matrix is mitogenic for duct cells but not for beta-cells. Diabetes 1998; 47: 134-137.
    • (1998) Diabetes , vol.47 , pp. 134-137
    • Lefebvre, V.H.1    Otonkoski, T.2    Ustinov, J.3    Huotari, M.A.4    Pipeleers, D.G.5    Bouwens, L.6
  • 33
    • 84891668969 scopus 로고    scopus 로고
    • Suppression of Epithelial to mesenchymal transitioning (EMT) enhances ex vivo reprogramming of human exocrine pancreatic tissue towards functional insulin producing beta-like cells
    • Lima MJ, Muir KR, Docherty HM, Drummond R, McGowan NW, Forbes S et al. Suppression of Epithelial to mesenchymal transitioning (EMT) enhances ex vivo reprogramming of human exocrine pancreatic tissue towards functional insulin producing beta-like cells. Diabetes 2013; 62: 2821-2833.
    • (2013) Diabetes , vol.62 , pp. 2821-2833
    • Lima, M.J.1    Muir, K.R.2    Docherty, H.M.3    Drummond, R.4    McGowan, N.W.5    Forbes, S.6
  • 34
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008; 455: 627-632.
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 35
    • 0037191099 scopus 로고    scopus 로고
    • Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
    • Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O et al. Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol 2002; 159: 303-312.
    • (2002) J Cell Biol , vol.159 , pp. 303-312
    • Heremans, Y.1    Van De Casteele, M.2    In'T Veld, P.3    Gradwohl, G.4    Serup, P.5    Madsen, O.6
  • 36
    • 0028604482 scopus 로고
    • Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas
    • Bouwens L, Wang RN, De Blay E, Pipeleers DG, Kloppel G. Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas. Diabetes 1994; 43: 1279-1283.
    • (1994) Diabetes , vol.43 , pp. 1279-1283
    • Bouwens, L.1    Wang, R.N.2    De Blay, E.3    Pipeleers, D.G.4    Kloppel, G.5
  • 37
    • 0036216386 scopus 로고    scopus 로고
    • Peptidylprolyl isomerase A (PPIA) as a preferred internal control over GAPDH and beta-actin in quantitative RNA analyses
    • Feroze-Merzoug F, Berquin IM, Dey J, Chen YQ. Peptidylprolyl isomerase A (PPIA) as a preferred internal control over GAPDH and beta-actin in quantitative RNA analyses. Biotechniques 2002; 32: 776-778, 780, 782.
    • (2002) Biotechniques , vol.32
    • Feroze-Merzoug, F.1    Berquin, I.M.2    Dey, J.3    Chen, Y.Q.4
  • 39
    • 0032558692 scopus 로고    scopus 로고
    • A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation
    • Robinson MJ, Stippec SA, Goldsmith E, White MA, Cobb MH. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Curr Biol 1998; 8: 1141-1150.
    • (1998) Curr Biol , vol.8 , pp. 1141-1150
    • Robinson, M.J.1    Stippec, S.A.2    Goldsmith, E.3    White, M.A.4    Cobb, M.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.