Peroxisome morphology in pathologies

Molecular Machines Involved in Peroxisome Biogenesis and Maintenance

Volumn , Issue , 2014, Pages 125-151

  Schrader, Michael ^a,b   Castro, Inês ^a   Fahimi, H Dariush ^c   Islinger, Markus ^c  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b UNIVERSITY OF AVEIRO   (Portugal)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Biogenesis disorders; Dynamin; GDAP1; Mff; Organelle dynamics; Peroxisomes; Pex11

Indexed keywords

EID: 84930711430     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-7091-1788-0_7     Document Type: Chapter

References (130)

1. Angermuller S, Fahimi HD. (1986). Ultrastructural cytochemical localization of uricase in peroxisomes of rat liver. J Histochem Cytochem. 34: 159-165
2. Ashrafian H, Docherty L, Leo V, Towlson C, Neilan M, Steeples V, Lygate CA, Hough T, Townsend S, Williams D, Wells S, Norris D, Glyn-Jones S, Land J, Barbaric I, Lalanne Z, Denny P, Szumska D, Bhattacharya S, Griffin JL, Hargreaves I, Fernandez-Fuentes N, Cheeseman M, Watkins H, Dear TN. (2010). A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet. 6: e1001000
3. Belanger AJ, Luo Z, Vincent KA, Akita GY, Cheng SH, Gregory RJ, Jiang C. (2007). Hypoxiainducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-Activated receptor alpha/retinoid X receptor. Biochem Biophys Res Commun. 364: 567-572
4. Benedetti E, Galzio R, D?Angelo B, Ceru MP, Cimini A. (2010). PPARs in human neuroepithelial tumors: PPAR ligands as anticancer therapies for the most common human neuroepithelial tumors. PPAR Res. 2010: 427401
5. Biempica L. (1966). Human hepatic microbodies with crystalloid cores. J Cell Biol. 29: 383-386
6. Bonekamp NA, Schrader M. (2012). Transient complex peroxisomal interactions: A new facet of peroxisome dynamics in mammalian cells commun Integr Biol. 5: 534-537
7. Bonekamp NA, Vormund K, Jacob R, Schrader M. (2010). Dynamin-like protein 1 at the Golgi complex: a novel component of the sorting/targeting machinery en route to the plasma membrane. Exp Cell Res. 316: 3454-3467
8. Bonekamp NA, Sampaio P, de Abreu FV, Luers GH, Schrader M. (2012). Transient complex interactions of mammalian peroxisomes without exchange of matrix or membrane marker proteins. Traffic. 13: 960-978
9. Bonekamp NA, Grille S, Cardoso MJ, Almeida M, Aroso M, Gomes S, Magalhaes AC, Ribeiro D, Islinger M, Schrader M. (2013). Self-interaction of human Pex11pbeta during peroxisomal growth and division. PLoS One. 8: e53424
10. Cablé S, Keller JM, Colin S, Haffen K, Kedinger M, Parache RM, DaucaM(1992) Peroxisomes in human colon carcinomas. A cytochemical and biochemical study. Virchows Arch B 62: 221-226
11. Camões F, Bonekamp NA, Delille HK, Schrader M(2009) Organelle dynamics and dysfunction: a closer link between peroxisomes and mitochondria. J Inherit Metab Dis. 32: 163-180
12. Chang CC, South S, Warren D, Jones J, Moser AB, Moser HW, Gould SJ. (1999). Metabolic control of peroxisome abundance. J Cell Sci. 112: 1579-1590
13. Chang CR, Manlandro CM, Arnoult D, Stadler J, Posey AE, Hill RB, Blackstone C. (2010). A Lethal de Novo Mutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division. J Biol Chem. 285: 32494-32503
14. Cuesta A, Pedrola L, Sevilla T, Garcia-Planells J, Chumillas MJ, Mayordomo F, LeGuern E, Marin I, Vilchez JJ, Palau F. (2002). The gene encoding ganglioside-induced differentiation-Associated protein 1 is mutated in axonal Charcot-Marie-Tooth type. 4A disease. Nat Genet. 30: 22-25
15. De Craemer D. (1995). Secondary alterations of human hepatocellular peroxisomes. J Inherit Metab Dis. 18: 181-213
16. De Craemer D, Pauwels M, Van den Branden C. (1996). Morphometric characteristics of human hepatocellular peroxisomes in alcoholic liver disease. Alcohol Clin Exp Res. 20: 908-913
17. De Craemer D, Van den Branden C, Pauwels M, Vamecq J. (1998). Peroxisome-proliferating effects of fenoprofen in mice. Lipids. 33: 539-543
18. De Duve C, Baudhuin P. (1966). Peroxisomes (microbodies and related particles). Physiol Rev. 46: 323-357
19. del Rio LA (ed). (2013). Peroxisomes and their key role in cellular signaling and metabolism, vol. 69, Subcellular biochemistry. Springer, Heidelberg
20. Delille HK, Alves R, Schrader M. (2009). Biogenesis of peroxisomes and mitochondria: linked by division. Histochem Cell Biol. 131: 441-446
21. Delille HK, Agricola B, Guimaraes SC, Borta H, Luers GH, Fransen M, Schrader M. (2010). Pex11pbeta-mediated growth and division of mammalian peroxisomes follows a maturation pathway. J Cell Sci. 123: 2750-2762
22. Delille HK, Dodt G, Schrader M. (2011). Pex11pbeta-mediated maturation of peroxisomes commun Integr Biol. 4: 51-54
23. Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, Mobbs CV, Yang X, Gao XB, Horvath TL. (2011). Peroxisome proliferation-Associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med. 17: 1121-1127
24. Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC. (2010). Peroxisomes are signaling platforms for antiviral innate immunity cell. 141: 668-681
25. Dreyer C, Keller H, Mahfoudi A, Laudet V, Krey G, Wahli W. (1993). Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-Activated receptors (PPAR). Biol Cell. 77: 67-76
26. Ebberink MS, Csanyi B, Chong WK, Denis S, Sharp P, Mooijer PA, Dekker CJ, Spooner C, Ngu LH, De Sousa C, Wanders RJ, Fietz MJ, Clayton PT, Waterham HR, Ferdinandusse S. (2010). Identification of an unusual variant peroxisome bio-genesis disorder caused by mutations in the PEX16 gene. J Med Genet. 47: 608-615
27. Ebberink MS, Koster J, Visser G, Spronsen F, Stolte-Dijkstra I, Smit GP, Fock JM, Kemp S, Wanders RJ, Waterham HR. (2012). A novel defect of peroxisome division due to a homozygous non-sense mutation in the PEX11beta gene. J Med Genet. 49: 307-313
28. Espeel M, Depreter M, Nardacci R, D?Herde K, Kerckaert I, Stefanini S, Roels F. (1997). Biogenesis of peroxisomes in fetal liver. Microsc Res Tech. 39: 453-466
29. Fahimi HD. (1969) cytochemical localization of peroxidatic activity of catalase in rat hepatic microbodies (peroxisomes). J Cell Biol. 43: 275-288
30. Fahimi HD. (2009). Peroxisomes: 40 years of histochemical staining, personal reminiscences. Histochem Cell Biol. 131: 437-440
31. Fahimi HD, Kino M, Hicks L, Thorp KA, Abelman WH. (1979). Increased myocardial catalase in rats fed ethanol. Am J Pathol. 96: 373-390
32. Fahimi HD, Reinicke A, Sujatta M, Yokota S, Ozel M, Hartig F, Stegmeier K. (1982). The shortand long-Term effects of bezafibrate in the rat. Ann N Y Acad Sci. 386: 111-135
33. Fahimi HD, Baumgart E, Volkl A. (1993). Ultrastructural aspects of the biogenesis of peroxisomes in rat liver. Biochimie. 75: 201-208
34. Ferdinandusse S, Denis S, Mooijer PA, Zhang Z, Reddy JK, Spector AA, Wanders RJ. (2001). Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. J Lipid Res. 42: 1987-1995
35. Fischer M, You M, Matsumoto M, Crabb DW. (2003). Peroxisome proliferator-Activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem. 278: 27997-28004
36. Frederiks WM, Bosch KS, Hoeben KA, van Marle J, Langbein S. (2010). Renal cell carcinoma and oxidative stress: the lack of peroxisomes. Acta Histochem. 112: 364-371
37. Fritz R, Bol J, Hebling U, Angermuller S, Volkl A, Fahimi HD, Mueller S. (2007) compartmentdependent management of H(2)O(2) by peroxisomes. Free Radic Biol Med. 42: 1119-1129
38. Funato M, Shimozawa N, Nagase T, Takemoto Y, Suzuki Y, Imamura Y, Matsumoto T, Tsukamoto T, Kojidani T, Osumi T, Fukao T, Kondo N. (2006). Aberrant peroxisome morphology in peroxisomal beta-oxidation enzyme deficiencies. Brain Dev. 28: 287-292
39. Gandre-Babbe S, van der Bliek AM. (2008). The novel tail-Anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell. 19: 2402-2412
40. Gomes LC, Di Benedetto G, Scorrano L. (2011). During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol. 13: 589-598
41. Gorgas K. (1984). Peroxisomes in sebaceous glands. V complex peroxisomes in the mouse preputial gland: serial sectioning and three-dimensional reconstruction studies. Anat Embryol. 169: 261-270
42. Gorgas K. (1985). Serial section analysis of mouse hepatic peroxisomes. Anat Embryol. 172: 21-32
43. Gorgas K, Volkl A. (1984). Peroxisomes in sebaceous glands. IV. Aggregates of tubular peroxisomes in the mouse Meibomian gland. Histochem J 16: 1079-1098
44. Gorgas K, Zaar K. (1984). Peroxisomes in sebaceous glands. III. Morphological similarities of peroxisomes with smooth endoplasmic reticulum and Golgi stacks in the circumanal gland of the dog. Anat Embryol. 169: 9-20
45. Gould SG, Keller GA, Subramani S. (1987). Identification of a peroxisomal targeting signal at the carboxy terminus of firefly luciferase. J Cell Biol. 105: 2923-2931
46. Grabenbauer M, Satzler K, Baumgart E, Fahimi HD. (2000). Three-dimensional ultrastructural analysis of peroxisomes in HepG2 cells. Absence of peroxisomal reticulum but evidence of close spatial association with the endoplasmic reticulum cell Biochem Biophys. 32: 37-49
47. Hall D, Poussin C, Velagapudi VR, Empsen C, Joffraud M, Beckmann JS, Geerts AE, Ravussin Y, Ibberson M, Oresic M, Thorens B. (2010). Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state. J Biol Chem. 285: 31011-31023
48. Hanker JS, Romanovicz DK. (1977). Phi bodies: peroxidatic particles that produce crystalloidal cellular inclusions. Science. 197: 895-898
49. Hashimoto T, Cook WS, Qi C, Yeldandi AV, Reddy JK, Rao MS. (2000). Defect in peroxisome proliferator-Activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem. 275: 28918-28928
50. Hicks L, Fahimi HD. (1977). Peroxisomes (microbodies) in the myocardium of rodents and primates. A comparative Ultrastructural cytochemical study cell Tissue Res. 175: 467-481
51. Hoepfner D, Schildknegt D, Braakman I, Philippsen P, Tabak HF. (2005) contribution of the endoplasmic reticulum to peroxisome formation cell. 122: 85-95
52. Huber N, Guimaraes S, Schrader M, Suter U, Niemann A. (2013) charcot-Marie-Tooth diseaseassociated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission. EMBO Rep. 14: 545-552
53. Huybrechts SJ, Van Veldhoven PP, Brees C, Mannaerts GP, Los GV, Fransen M. (2009). Peroxisome dynamics in cultured mammalian cells. Traffic. 10: 1722-1733
54. Imoto Y, Kuroiwa H, Yoshida Y, Ohnuma M, Fujiwara T, Yoshida M, Nishida K, Yagisawa F, Hirooka S, Miyagishima SY, Misumi O, Kawano S, Kuroiwa T. (2013). Single-membranebounded peroxisome division revealed by isolation of dynamin-based machinery. Proc Natl Acad Sci USA. 110: 9583-9588
55. Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, Otera H, Nakanishi Y, Nonaka I, Goto Y, Taguchi N, Morinaga H, Maeda M, Takayanagi R, Yokota S, Mihara K. (2009). Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol. 11: 958-966
56. Islinger M, Cardoso MJ, Schrader M. (2010). Be different-The diversity of peroxisomes in the animal kingdom. Biochim Biophys Acta. 1803: 881-897
57. Islinger M, Grille S, Fahimi HD, Schrader M. (2012). The peroxisome: an update on mysteries. Histochem Cell Biol. 137: 547-574
58. Issemann I, Green S. (1990). Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 347: 645-650
59. Itoyama A, Honsho M, Abe Y, Moser A, Yoshida Y, Fujiki Y. (2012). Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division. J Cell Sci. 125: 589-602
60. Itoyama A, Michiyuki S, Honsho M, Yamamoto T, Moser A, Yoshida Y, Fujiki Y. (2013). Mff functions with Pex11pβ and DLP1 in peroxisomal fission. Biol Open. 2: 998-1006
61. Johkura K, Usuda N, Liang Y, Nakazawa A. (1998). Immunohistochemical localization of peroxisomal enzymes in developing rat kidney tissues. J Histochem Cytochem. 46: 1161-1173
62. Kang YH, Morris HP, Criss WE. (1982) correlation between growth rate and cytochemistry in Morris hepatomas. Anat Rec. 202: 209-219
63. Kobayashi S, Tanaka A, Fujiki Y. (2007). Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis. Exp Cell Res. 313: 1675-1686
64. Koch A, Thiemann M, Grabenbauer M, Yoon Y, McNiven MA, Schrader M. (2003). Dynamin-like protein 1 is involved in peroxisomal fission. J Biol Chem. 278: 8597-8605
65. Koch A, Schneider G, Luers GH, Schrader M. (2004). Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein. 1. J Cell Sci. 117: 3995-4006
66. Koch J, Brocard C. (2012). PEX11 proteins attract Mff and human Fis1 to coordinate peroxisomal fission. J Cell Sci. 125: 3813-3826
67. Koch J, Pranjic K, Huber A, Ellinger A, Hartig A, Kragler F, Brocard C. (2010). PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance. J Cell Sci. 123: 3389-3400
68. Lauer C, Volkl A, Riedl S, Fahimi HD, Beier K. (1999). Impairment of peroxisomal biogenesis in human colon carcinoma carcinogenesis. 20: 985-989
69. Laurenti G, Benedetti E, D?Angelo B, Cristiano L, Cinque B, Raysi S, Alecci M, Ceru MP, Cifone MG, Galzio R, Giordano A, Cimini A. (2011). Hypoxia induces peroxisome proliferatoractivated receptor alpha (PPARalpha) and lipid metabolism peroxisomal enzymes in human glioblastoma cells. J Cell Biochem. 112: 3891-3901
70. Legakis JE, Koepke JI, Jedeszko C, Barlaskar F, Terlecky LJ, Edwards HJ, Walton PA, Terlecky SR. (2002). Peroxisome senescence in human fibroblasts. Mol Biol Cell. 13: 4243-4255
71. Li H, Alavian KN, Lazrove E, Mehta N, Jones A, Zhang P, Licznerski P, Graham M, Uo T, Guo J, Rahner C, Duman RS, Morrison RS, Jonas EA. (2013). A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nat Cell Biol. 15: 773-785
72. Li X, Baumgart E, Morrell JC, Jimenez-Sanchez G, Valle D, Gould SJ. (2002). PEX11 beta deficiency is lethal and impairs neuronal migration but does not abrogate peroxisome function. Mol Cell Biol. 22: 4358-4365
73. Li X, Gould SJ. (2003). The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11. J Biol Chem. 278: 17012-17020
74. Litwin JA, Beier K, Volkl A, Hofmann WJ, Fahimi HD. (1999). Immunocytochemical investigation of catalase and peroxisomal lipid beta-oxidation enzymes in human hepatocellular tumors and liver cirrhosis. Virchows Arch. 435: 486-495
75. Misra P, Viswakarma N, Reddy JK. (2013). Peroxisome proliferator-Activated receptor-Alpha signaling in hepatocarcinogenesis. Subcell Biochem. 69: 77-99
76. Mizushima N, Yoshimori T, Ohsumi Y. (2011). The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol. 27: 107-132
77. Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, Fukushima Y, Peters JM, Gonzalez FJ, Aoyama T. (2004). Peroxisome proliferator-Activated receptor alpha protects against alcohol-induced liver damage. Hepatology. 40: 972-980
78. Nanji AA, Dannenberg AJ, Jokelainen K, Bass NM. (2004). Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-Alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation. J Pharmacol Exp Ther. 310: 417-424
79. Narravula S, Colgan SP. (2001). Hypoxia-inducible factor. 1-mediated inhibition of peroxisome proliferator-Activated receptor alpha expression during hypoxia. J Immunol. 166: 7543-7548
80. Nazarko TY, Farre JC, Subramani S. (2009). Peroxisome size provides insights into the function of autophagy-related proteins. Mol Biol Cell. 20: 3828-3839
81. Niemann A, Ruegg M, La Padula V, Schenone A, Suter U. (2005). Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease. J Cell Biol. 170: 1067-1078
82. Niemann A, Berger P, Suter U. (2006). Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease. Neuromolecular Med. 8: 217-242
83. Niemann A, Wagner KM, Ruegg M, Suter U. (2009). GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance. Neurobiol Dis. 36: 509-520
84. Noack R, Frede S, Albrecht P, Henke N, Pfeiffer A, Knoll K, Dehmel T, Meyer Zu Horste G, Stettner M, Kieseier BC, Summer H, Golz S, Kochanski A, Wiedau-Pazos M, Arnold S, Lewerenz J, Methner A. (2012) charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential. Hum Mol Genet. 21: 150-162
85. Nordgren M, Wang B, Apanasets O, Fransen M. (2013). Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives. Front Physiol. 4: 145
86. Novikoff AB, Novikoff PM. (1973). Microperoxisomes. J Histochem Cytochem. 11: 963-966
87. Opalinski L, Kiel JA, Williams C, Veenhuis M, van der Klei IJ. (2011). Membrane curvature during peroxisome fission requires Pex11. EMBO J 30: 5-16
88. Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K. (2010). Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol. 191: 1141-1158
89. Pavelka M, Goldenberg H, Huttinger M, Kramar R. (1976). Enzymic and morphological studies on catalase positive particles from brown fat of cold adapted rats. Histochemistry. 50: 47-55
90. Phipps AN, Connock MJ, Johnson P, Burdett K. (2000). Peroxisome distribution along the cryptvillus axis of the guinea pig small intestine. Mol Cell Biochem. 203: 119-126
91. Pipan N, Psenicnik M. (1975). The development of microperoxisomes in the cells of the proximal tubules of the kidney and epithelium of the small intestine during the embryonic development and postnatal period. Histochemistry. 44: 13-21
92. Platt FM, Boland B, van der Spoel AC. (2012). The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. J Cell Biol. 199: 723-734
93. Praefcke GJ, McMahon HT. (2004). The dynamin superfamily: universal membrane tubulation and fission molecules?. Nat Rev Mol Cell Biol. 5: 133-147
94. Purohit V, Gao B, Song BJ. (2009). Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res. 33: 191-205
95. Rambold AS, Kostelecky B, Elia N, Lippincott-Schwartz J. (2011). Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci USA. 108: 10190-10195
96. Rhodin J. (1954) correlation of ultrastructural organization and function in normal experimentally changed convoluted tubule cells of the mouse kidney. Aktiebolaget Godvil, Stockholm
97. Ribeiro D, Castro I, Fahimi HD, Schrader M. (2012). Peroxisome morphology in pathology. Histol Histopathol. 27: 661-676
98. Roels F, Geerts A, de Prest B, de Coster W, Plum J. (1981). Absence of peroxisome turnover during inhibition of catalase synthesis. Verh Anat Ges. 75: 623-626
99. Sandalio LM, Rodriguez-Serrano M, Romero-Puertas MC, Del Rio LA. (2013). Role of peroxisomes as a source of reactive oxygen species (ROS) signaling molecules. Subcell Biochem. 69: 231-255
100. Santel A, Frank S. (2008). Shaping mitochondria: the complex posttranslational regulation of the mitochondrial fission protein DRP1. IUBMB Life. 60: 448-455
101. Schrader M. (2006). Shared components of mitochondrial and peroxisomal division. Biochim Biophys Acta. 1763: 531-541
102. Schrader M, Fahimi HD. (2006). Growth and division of peroxisomes. Int Rev Cytol. 255: 237-290
103. Schrader M, Fahimi HD. (2006). Peroxisomes and oxidative stress. Biochim Biophys Acta. 1763: 1755-1766
104. Schrader M, Baumgart E, Volkl A, Fahimi HD. (1994). Heterogeneity of peroxisomes in human hepatoblastoma cell line HepG2. Evidence of distinct subpopulations. Eur J Cell Biol. 64: 281-294
105. Schrader M, Burkhardt JK, Baumgart E, Luers G, Spring H, Volkl A, Fahimi HD. (1996). Interaction of microtubules with peroxisomes. Tubular and spherical peroxisomes in HepG2 cells and their alterations induced by microtubule-Active drugs. Eur J Cell Biol. 69: 24-35
106. Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ. (1998). Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli. J Biol Chem. 273: 29607-29614
107. Schrader M, Wodopia R, Fahimi HD. (1999). Induction of tubular peroxisomes by UV irradiation and reactive oxygen species in HepG2 cells. J Histochem Cytochem. 47: 1141-1148
108. Schrader M, King SJ, Stroh TA, Schroer TA. (2000). Real time imaging reveals a peroxisomal reticulum in living cells. J Cell Sci. 113: 3663-3671
109. Schrader M, Thiemann M, Fahimi HD. (2003). Peroxisomal motility and interaction with microtubules. Microsc Res Tech. 61: 171-178
110. Schrader M, Yoon Y. (2007). Mitochondria and peroxisomes: are the ?big brother? and the ?little sister? closer than assumed?. BioEssays. 29: 1105-1114
111. Schrader M, Bonekamp NA, Islinger M. (2012). Fission and proliferation of peroxisomes. Biochim Biophys Acta. 1822: 1343-1357
112. Shamseldin HE, Alshammari M, Al-Sheddi T, Salih MA, Alkhalidi H, Kentab A, Repetto GM, Hashem M, Alkuraya FS. (2012). Genomic analysis of mitochondrial diseases in a consanguineous population reveals novel candidate disease genes. J Med Genet. 49: 234-241
113. Sima AA. (1980). Peroxisomes (microbodies) in human glial tumors. A cytochemical ultrastructural study. Acta Neuropathol. 51: 113-117
114. Sinclair AM, Trobacher CP, Mathur N, Greenwood JS, Mathur J. (2009). Peroxule extension over ER-defined paths constitutes a rapid subcellular response to hydroxyl stress. Plant J 59: 231-242
115. Tanaka A, Kobayashi S, Fujiki Y. (2006). Peroxisome division is impaired in a CHO cell mutant with an inactivating point-mutation in dynamin-like protein 1 gene. Exp Cell Res. 312: 1671-1684
116. Thoms S, Erdmann R. (2005). Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation. FEBS J 272: 5169-5181
117. Titorenko VI, Rachubinski RA. (2004). The peroxisome: orchestrating important developmental decisions from inside the cell. J Cell Biol. 164: 641-645
118. Toyama T, Nakamura H, Harano Y, Yamauchi N, Morita A, Kirishima T, Minami M, Itoh Y, Okanoue T. (2004). PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats. Biochem Biophys Res Commun. 324: 697-704
119. van der Zand A, Braakman I, Geuze HJ, Tabak HF. (2006). The return of the peroxisome. J Cell Sci. 119: 989-994
120. Vasko R, Ratliff BB, Bohr S, Nadel E, Chen J, Xavier S, Chander P, Goligorsky MS. (2013). Endothelial peroxisomal dysfunction and impaired pexophagy promotes oxidative damage in lipopolysaccharide-induced acute kidney injury. Antioxid Redox Signal. 19: 211-230
121. Wagner KM, Ruegg M, Niemann A, Suter U. (2009). Targeting and function of the mitochondrial fission factor GDAP1 are dependent on its tail-Anchor. PLoS One. 4: e5160
122. Wakabayashi J, Zhang Z, Wakabayashi N, Tamura Y, Fukaya M, Kensler TW, Iijima M, Sesaki H. (2009). The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol. 186: 805-816
123. Wanders RJ, Waterham HR. (2006). Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem. 75: 295-332
124. Waterham HR, Ebberink MS. (2012). Genetics and molecular basis of human peroxisome biogenesis disorders. Biochim Biophys Acta. 1822: 1430-1441
125. Waterham HR, Koster J, van Roermund CW, Mooyer PA, Wanders RJ, Leonard JV. (2007). A lethal defect of mitochondrial and peroxisomal fission. N Engl J Med. 356: 1736-1741
126. Yamamoto K, Fahimi HD. (1987). Three-dimensional reconstruction of a peroxisomal reticulum in regenerating rat liver: evidence of interconnections between heterogeneous segments. J Cell Biol. 105: 713-722
127. Yan M, Rayapuram N, Subramani S. (2005). The control of peroxisome number and size during division and proliferation curr Opin Cell Biol. 17: 376-383
128. Yokota S, Fahimi HD. (1978). The peroxisome (microbody) membrane: effects of de-Tergents and lipid solvents on its ultrastructure and permeability to catalase. Histochem J 10: 469-487
129. Zaar K, Fahimi HD. (1990). A freeze-etch study of angular marginal-plate-containing peroxisomes in the proximal tubes of bovine kidney cell Tissue Res. 260: 409-414
130. Zhou J, Zhang S, Xue J, Avery J, Wu J, Lind SE, Ding WQ. (2012). Activation of peroxisome proliferator-Activated receptor alpha (PPARalpha) suppresses hypoxia-inducible factor-1alpha. (HIF-1alpha) signaling in cancer cells. J Biol Chem. 287: 35161-35169