Targeting and function of the mitochondrial fission factor GDAP1 are dependent on its tail-anchor

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Wagner, Konstanze M ^a   Rüegg, Marcel ^a   Niemann, Axel ^a   Suter, Ueli ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYL TERMINAL MEMBRANE TAIL ANCHOR; GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 1; MITOCHONDRIAL PROTEIN; UNCLASSIFIED DRUG; GDAP PROTEIN; NERVE PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA FLANKING REGION; HUMAN; HUMAN CELL; HYDROPHOBICITY; INTRACELLULAR TRANSPORT; NONHUMAN; OUTER MEMBRANE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN TARGETING; CELL LINE; METABOLISM; MITOCHONDRION; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; CELL LINE; HUMANS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS;

EID: 64549145476     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005160     Document Type: Article

References (28)

1. Chan DC (2006) Mitochondria: dynamic organelles in disease, aging, and development. Cell 125: 1241-1252.
2. Niemann A, Berger P, Suter U (2006) Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease. Neuromolecular Med 8: 217-242.
3. Waterham HR, Koster J, van Roermund CW, Mooyer PA, Wanders RJ, et al. (2007) A lethal defect of mitochondrial and peroxisomal fission. N Engl J Med 356: 1736-1741.
4. Rojo M, Legros F, Chateau D, Lombes A (2002) Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J Cell Sci 115: 1663-1674.
5. Borgese N, Colombo S, Pedrazzini E (2003) The tale of tail-anchored proteins: coming from the cytosol and looking for a membrane. J Cell Biol 161: 1013-1019.
6. Borgese N, Gazzoni I, Barberi M, Colombo S, Pedrazzini E (2001) Targeting of a tail-anchored protein to endoplasmic reticulum and mitochondrial outer membrane by independent but competing pathways.Mol Biol Cell 12: 2482-2496.
7. Wattenberg B, Lithgow T (2001) Targeting of C-terminal (tail)-anchored proteins: understanding how cytoplasmic activities are anchored to intracellular membranes. Traffic 2: 66-71.
8. Neupert W, Herrmann JM (2007) Translocation of proteins into mitochondria. Annu Rev Biochem 76: 723-749.
9. Borgese N, Brambillasca S, Colombo S (2007) How tails guide tail-anchored proteins to their destinations. Curr Opin Cell Biol.
10. Gandre-Babbe S, van der Bliek AM (2008) The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells. Mol Biol Cell 19: 2402-2412.
11. Karbowski M, Norris KL, Cleland MM, Jeong SY, Youle RJ (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443: 658-662.
12. Kuroda R, Ikenoue T, Honsho M, Tsujimoto S, Mitoma JY, et al. (1998) Charged amino acids at the carboxyl-terminal portions determine the intracellular locations of two isoforms of cytochrome b5. J Biol Chem 273: 31097-31102.
13. Egan B, Beilharz T, George R, Isenmann S, Gratzer S, et al. (1999) Targeting of tail-anchored proteins to yeast mitochondria in vivo. FEBS Lett 451: 243-248.
14. Brambillasca S, Yabal M, Makarow M, Borgese N (2006) Unassisted translocation of large polypeptide domains across phospholipid bilayers. J Cell Biol 175: 767-777.
15. Abell BM, Rabu C, Leznicki P, Young JC, High S (2007) Post-translational integration of tail-anchored proteins is facilitated by defined molecular chaperones. J Cell Sci 120: 1743-1751.
16. Stefanovic S, Hegde RS (2007) Identification of a targeting factor for posttranslational membrane protein insertion into the ER. Cell 128: 1147-1159.
17. Setoguchi K, Otera H, Mihara K (2006) Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins. Embo J 25: 5635-5647.
18. Habib SJ, Vasiljev A, Neupert W, Rapaport D (2003) Multiple functions of tail-anchor domains of mitochondrial outer membrane proteins. FEBS Lett 555: 511-515.
19. Niemann A, Ruegg M, La Padula V, Schenone A, Suter U (2005) Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease. J Cell Biol 170: 1067-1078.
20. Marco A, Cuesta A, Pedrola L, Palau F, Marin I (2004) Evolutionary and structural analyses of GDAP1, involved in Charcot-Marie-Tooth disease, characterize a novel class of glutathione transferase-related genes. Mol Biol Evol 21: 176-187.
21. Pedrola L, Espert A, Wu X, Claramunt R, Shy ME, et al. (2005) GDAP1, the protein causing Charcot-Marie-Tooth disease type 4A, is expressed in neurons and is associated with mitochondria. Hum Mol Genet 14: 1087-1094.
22. Shield AJ, Murray TP, Board PG (2006) Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase. Biochem Biophys Res Commun 347: 859-866.
23. Olichon A, Emorine LJ, Descoins E, Pelloquin L, Brichese L, et al. (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523: 171-176.
24. Henderson MP, Billen LP, Kim PK, Andrews DW (2007) Cell-free analysis of tail-anchor protein targeting to membranes. Methods 41: 427-438.
25. Isenmann S, Khew-Goodall Y, Gamble J, Vadas M, Wattenberg BW (1998) A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. Mol Biol Cell 9: 1649-1660.
26. Wattenberg BW, Clark D, Brock S (2007) An artificial mitochondrial tail signal/anchor sequence confirms a requirement for moderate hydrophobicity for targeting. Biosci Rep 27: 385-401.
27. de Brito OM, Scorrano L (2008) Mitofusin 2: a mitochondria-shaping protein with signaling roles beyond fusion. Antioxid Redox Signal 10: 621-633.
28. Engelman DM, Steitz TA, Goldman A (1986) Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins. Annu Rev Biophys Biophys Chem 15: 321-353.