N-Palmitoylethanolamide protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress

Pharmacological Research

Volumn 76, Issue , 2013, Pages 67-76

  Mattace Raso, Giuseppina ^a   Simeoli, Raffaele ^a   Russo, Roberto ^a   Santoro, Anna ^a   Pirozzi, Claudio ^a   D'Emmanuele Di Villa Bianca, Roberta ^a   Mitidieri, Emma ^a   Paciello, Orlando ^a   Pagano, Teresa Bruna ^a   Orefice, Nicola Salvatore ^a   Meli, Rosaria ^a   Calignano, Antonio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Angiotensin receptors; Epoxyeicosatrienoic acid; Hydroxyeicosatetraenoic acid; Hypertension; Oxidative stress; Palmitoylethanolamide; Renal damage

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME P450 2C; CYTOCHROME P450 2C23; CYTOCHROME P450 4A; EPOXIDE HYDROLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE; PALMIDROL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG MECHANISM; HYPERTENSION; KIDNEY INJURY; MALE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PERFUSION PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; SPONTANEOUSLY HYPERTENSIVE RAT;

AA; ACE; ANG II; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTORS; ARACHIDONIC ACID; AT; CYP; CYTOCHROME P-450; EET; EPOXYEICOSATRIENOIC ACID; GFR; GLOMERULAR FILTRATION RATE; HEART RATE; HETE; HR; HYDROXYEICOSATETRAENOIC ACID; HYPERTENSION; INDUCIBLE NITRIC OXIDE SYNTHASE; INOS; OXIDATIVE STRESS; PALMITOYLETHANOLAMIDE; PEA; PEROXISOME PROLIFERATOR RESPONSE ELEMENTS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PPAR; PPRE; RAAS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RENAL DAMAGE; RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM; RNS; ROS; SBP; SEH; SHR; SOD; SOLUBLE EPOXIDE HYDROLASE; SPONTANEOUSLY HYPERTENSIVE RATS; SUPEROXIDE DISMUTASE; SYSTOLIC BLOOD PRESSURE; WISTAR KYOTO; WKY;

ALKANE 1-MONOOXYGENASE; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD PRESSURE; CYTOCHROME P-450 ENZYME SYSTEM; ENDOCANNABINOIDS; ETHANOLAMINES; HYPERTENSION; KIDNEY; MALE; OXIDATIVE STRESS; PALMITIC ACIDS; PPAR ALPHA; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, ANGIOTENSIN; RENAL INSUFFICIENCY; RENIN-ANGIOTENSIN SYSTEM;

EID: 84882781906     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.07.007     Document Type: Article

References (60)

1. N.R. Bachur, K. Masek, K.L. Melmon, and S. Udenfriend Fatty acid amides of ethanolamine in mammalian tissues Journal of Biological Chemistry 240 1965 1019 1024
2. S. Conti, B. Costa, M. Colleoni, D. Parolaro, and G. Giagnoni Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat British Journal of Pharmacology 135 2002 181 187 (Pubitemid 34102111)
3. A. Calignano, G. La Rana, and D. Piomelli Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide European Journal of Pharmacology 419 2001 191 198 (Pubitemid 32568218)
4. J. LoVerme, R. Russo, G. La Rana, J. Fu, J. Farthing, and G. Mattace-Raso Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha Journal of Pharmacology and Experimental Therapeutics 319 2006 1051 1061
5. J. Lo Verme, J. Fu, G. Astarita, G. La Rana, R. Russo, and A. Calignano The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide Molecular Pharmacology 67 2005 15 19 (Pubitemid 40069962)
6. G. D'Agostino, G. La Rana, R. Russo, O. Sasso, A. Iacono, and E. Esposito Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice Journal of Pharmacology and Experimental Therapeutics 322 2007 1137 1143 (Pubitemid 47295805)
7. G. D'Agostino, G. La Rana, R. Russo, O. Sasso, A. Iacono, and E. Esposito Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia European Journal of Pharmacology 613 2009 54 59
8. F. Zandbergen, and J. Plutzky PPARalpha in atherosclerosis and inflammation Biochimica et Biophysica Acta 1771 2007 972 982
9. O. Sasso, R. Russo, S. Vitiello, G. Mattace Raso, G. D'Agostino, and A. Iacono Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain Pain 153 2012 33 41
10. G. Mattace Raso, E. Esposito, S. Vitiello, A. Iacono, A. Santoro, and G. D'Agostino Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-α Journal of Neuroendocrinology 23 2011 591 600
11. G. Medina-Gomez, S. Gray, and A. Vidal-Pluig Role of PPARs in the pathogenesis of the metabolic syndrome M. Serrano, J.F. Caro, R. Carraro, J.A. Gutierez Fuentes, The metabolic syndrome at the beginning of the 21st century 2005 Elsevier Madrid, Spain 264 265
12. Y. Guan, and M.D. Breyer Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease Kidney International 60 2001 14 30 (Pubitemid 32587535)
13. O. Braissant, F. Foufelle, C. Scotto, M. Dauca, and W. Wahli Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, -gamma in the adult rat Endocrinology 137 1996 354 366 (Pubitemid 26005011)
14. P. Gelosa, C. Banfi, A. Gianella, M. Brioschi, and A. Pignieri Peroxisome proliferator-activated receptor {alpha} agonism prevents renal damage and the oxidative stress and inflammatory processes affecting the brains of stroke-prone rats Journal of Pharmacology and Experimental Therapeutics 335 2010 324 331
15. S.J. Shin, J.H. Lim, S. Chung, D.Y. Youn, H.W. Chung, and H.W. Kim Peroxisome proliferator-activated receptor-alpha activator fenofibrate prevents high-fat diet-induced renal lipotoxicity in spontaneously hypertensive rats Hypertension Research 32 2009 835 845
16. T. Vera, M. Taylor, Q. Bohman, A. Flasch, R.J. Roman, and D.E. Stec Fenofibrate prevents the development of angiotensin II-dependent hypertension in mice Hypertension 45 2005 730 735 (Pubitemid 40418373)
17. X. Hou, Y.H. Shen, C. Li, F. Wang, C. Zhang, and P. Bu PPARalpha agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity Biochemical and Biophysical Research Communications 394 2010 653 659
18. Q.N. Diep, F. Amiri, R.M. Touyz, J.S. Cohn, M.F. Endemann, and M.F. Neves PPARα activator effects on Ang II-induced vascular oxidative stress and inflammation Hypertension 40 2002 866 871 (Pubitemid 35434908)
19. G.D. Girnun, F.E. Domann, S.A. Moore, and M.E.C. Robbins Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter Molecular Endocrinology 16 2002 2793 2801 (Pubitemid 36020658)
20. S.Z. Duan, C.Y. Ivashchenko, M.G. Usher, and R.M. Mortensen PPAR-γ in the cardiovascular system PPAR Research 2008 2008 745804
21. I.J. Jonkers, F.H. de Man, A. van der Laarse, M. Frölich, J.A. Gevers Leuven, and A.M. Kamper Bezafibrate reduces heart rate and blood pressure in patients with hypertriglyceridemia Journal of Hypertension 19 2001 749 755 (Pubitemid 32289555)
22. P.A. Sarafidis, and G.L. Bakris Protection of the kidney by thiazolidinediones: an assessment from bench to bedside Kidney International 70 2006 1223 1233 (Pubitemid 44435173)
23. G. Mattace Raso, G. Bianco, A. Iacono, E. Esposito, G. Autore, and M.C. Ferrante Maternal adaptations to pregnancy in spontaneously hypertensive rats: leptin and ghrelin evaluation Journal of Endocrinology 194 2007 611 619 (Pubitemid 47471229)
24. C. Montoliu, S. Vallés, J. Renau-Piqueras, and C. Guerri Ethanol-induced oxygen radical formation and lipid peroxidation in rat brain: effect of chronic alcohol consumption Journal of Neurochemistry 63 1994 1855 1862 (Pubitemid 24326230)
25. K.M. Mullane, W. Westlin, and R. Kraemer Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion Annals of the New York Academy of Sciences 524 1988 103 121
26. R.J. Roman P-450 metabolites of arachidonic acid in the control of cardiovascular function Physiological Reviews 82 2002 131 185 (Pubitemid 34654217)
27. Z. Yu, F. Xu, L.M. Huse, C. Morisseau, A.J. Draper, and J.W. Newman Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids Circulation Research 87 2000 992 998
28. M. Hultstrom Development of structural kidney damage in spontaneously hypertensive rats Journal of Hypertension 30 2012 1087 1091
29. C. Chatziantoniou, F.H. Daniels, and W.J. Arendshorst Exaggerated renal vascular reactivity to angiotensin and thromboxane in young genetically hypertensive rats American Journal of Physiology 259 1990 F372 F382
30. S.J. Vyas, and E.K. Jackson Angiotensin II: enhanced renal responsiveness in young genetically hypertensive rats Journal of Pharmacology and Experimental Therapeutics 273 1995 768 777
31. W.J. Arendshorst, C. Chatziantoniou, and F.H. Daniels Role of angiotensin in the renal vasoconstriction observed during the development of genetic hypertension Kidney International Supplements 30 1990 S92 S96
32. R.E. Christiansen, A.B. Roald, O. Tenstad, and B.M. Iversen Renal hemodynamics during development of hypertension in young spontaneously hypertensive rats Kidney and Blood Pressure Research 25 2002 322 328 (Pubitemid 35356754)
33. K. Omata, N.G. Abraham, and M.L. Schwartzman Renal cytochrome P-450-arachidonic acid metabolism: localization and hormonal regulation in SHR American Journal of Physiology 262 1992 F591 F599
34. J.D. Imig, J.R. Falck, D. Gebremedhin, D.R. Harder, and R.J. Roman Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450 Hypertension 22 1993 357 364 (Pubitemid 23254084)
35. D.L. Kroetz, L.M. Huse, A. Thuresson, and M.P. Grillo Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney Molecular Pharmacology 52 1997 362 372 (Pubitemid 27412960)
36. M.H. Wang, F. Zhang, J. Marji, B.A. Zand, A. Nasjletti, and M. Laniado-Schwartzman CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 280 2001 R255 R261
37. M. Laniado-Schwartzman, N.G. Abraham, D. Sacerdoti, B. Escalante, and J.C. McGiff Effect of acute and chronic treatment of tin on blood pressure in spontaneously hypertensive rats Tohoku Journal of Experimental Medicine 166 1992 85 91
38. R.K. Shatara, D.W. Quest, and T.W. Wilson Fenofibrate lowers blood pressure in two genetic models of hypertension Canadian Journal of Physiology and Pharmacology 78 2000 367 371 (Pubitemid 30354459)
39. K.M. Dunn, M. Renic, A.K. Flasch, D.R. Harder, J. Falck, and R.J. Roman Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats American Journal of Physiology. Heart and Circulatory Physiology 295 2008 H2455 H2465
40. J.D. Imig, and B.D. Hammock Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases Nature Reviews Drug Discovery 8 2009 794 805
41. J.D. Imig, X. Zhao, C.Z. Zaharis, J.J. Olearczyk, D.M. Pollock, and J.W. Newman An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension Hypertension 46 2005 975 981
42. A. Sarkis, and R.J. Roman Role of cytochrome p450 metabolites of arachidonic acid in hypertension Current Drug Metabolism 5 2004 245 256 (Pubitemid 38735779)
43. U. Landmesser, H. Cai, S. Dikalov, L. McCann, J. Hwang, and H. Jo Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II Hypertension 40 2002 511 515
44. A. Iacono, G. Bianco, G. Mattace Raso, E. Esposito, R. d'Emmanuele di Villa Bianca, and R. Sorrentino Maternal adaptation in pregnant hypertensive rats: improvement of vascular and inflammatory variables and oxidative damage in the kidney American Journal of Hypertension 22 2009 777 783
45. G. Pearson, F. Robinson, T. Beers Gibson, B. Xu, M. Karandikar, and K. Berman Mitogen-activated protein kinase pathways: regulation and physiological functions Endocrine Reviews 22 2001 153 183 (Pubitemid 32458157)
46. M.C. McDonald, R. d'Emmanuele di Villa Bianca, N.S. Wayman, A. Pinto, M.A. Sharpe, and S. Cuzzocrea A superoxide dismutase mimetic with catalase activity (EUK-8) reduces the organ injury in endotoxic shock European Journal of Pharmacology 466 2003 181 189 (Pubitemid 36385104)
47. A. Whaley-Connell, J. Habibi, R. Nistala, S.A. Cooper, P.R. Karuparthi, and M.R. Hayden Attenuation of Angiotensin II-mediated NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment Hypertension 51 2008 474 480 (Pubitemid 351156435)
48. K.K. Griendling, C.A. Minieri, J.D. Ollerenshaw, and R.W. Alexander Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells Circulation Research 74 1994 1141 1148 (Pubitemid 24176909)
49. Y. Shimamoto, K. Hirota, and A. Fukamizu Effect of peroxisome proliferator-activated receptor α on human angiotensinogen promoter International Journal of Molecular Medicine 13 2004 729 733
50. S. Takai, D. Jin, M. Kimura, K. Kirimura, H. Sakonjo, and K. Tanaka Inhibition of vascular angiotensin-coverting enzyme by telmisartan via the peroxisome proliferator-activated receptor γ agonistic property in rats Hypertension Research 30 2007 1231 1237 (Pubitemid 351176421)
51. L. Ibarra-Lara, E. Hong, E. Soria-Castro, J.C. Torres-Narváez, F. Pérez-Severiano, and L. Del Valle-Mondragón Clofibrate PPARα activation reduces oxidative stress and improves ultrastructure and ventricular hemodynamics in no-flow myocardial ischemia Journal of Cardiovascular Pharmacology 60 2012 323 334
52. M. Ushio-Fukai, A.M. Zafari, T. Fukui, N. Ishizaka, and K.K. Griendling p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells Journal of Biological Chemistry 271 1996 23317 23321 (Pubitemid 26314775)
53. L.G. Navar The intrarenal renin-angiotensin system in hypertension Kidney International 65 2004 1522 1532 (Pubitemid 38407000)
54. Y. Taniyama, and K.K. Griendling Reactive oxygen species in the vasculature: molecular and cellular mechanisms Hypertension 42 2003 1075 1081 (Pubitemid 37549058)
55. M. Ruiz-Ortega, O. Lorenzo, M. Ruperez, S. Konig, B. Wittig, and J. Egido Angiotensin II activates nuclear transcription factor kappaB through AT(1) and AT(2) in vascular smooth muscle cells: molecular mechanisms Circulation Research 86 2000 1266 1272 (Pubitemid 30436668)
56. M. De Gasparo, H.J. Catt, T. Inagami, J.W. Wright, and T.H. Unger International union of pharmacology. XXIII. The angiotensin II receptors Pharmacological Reviews 52 2000 415 472
57. C. Hui-Fang, W. Jun-Ling, P.V. Gavin, and C.R. Raymond Young SHR express increased type I angiotensin II receptors in renal proximal tubule American Journal of Physiology 274 1998 F10 F17
58. S.S. Landgraf, M. Wengert, J.S. Silva, G. Zapata-Sudo, R.T. Sudo, and C.M. Takiya Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats American Journal of Physiology 300 2011 F499 F510
59. T.M. Gwathmey, H.A. Shaltout, J.C. Rose, D.I. Diz, and M.C. Chappell Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney Hypertension 57 2011 620 626
60. H. Okunishi, Y. Oka, N. Shiota, T. Kawamoto, K. Song, and M. Miyazaki Marked species-difference in the vascular angiotensin II-forming pathways: humans versus rodents Japanese Journal of Pharmacology 62 1993 207e10