Quercetin, a bioflavonoid, protects against oxidative stress-related renal dysfunction by cyclosporine in rats

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 23, Issue 4, 2001, Pages 175-181

  Satyanarayana, P S V ^a   Singh, D ^a   Chopra, K ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Bioflavonoid; Cyclosporine; Nephrotoxicity; Oxidative stress; Quercetin

Indexed keywords

BIOFLAVONOID; CREATININE; CYCLOSPORIN; NATURAL PRODUCT; NITROGEN; QUERCETIN; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UREA;

ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERY DISEASE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DRUG EFFECT; DRUG INDUCED DISEASE; FEMALE; FLUID INTAKE; GLOMERULUS BASEMENT MEMBRANE; HISTOPATHOLOGY; KIDNEY DISEASE; KIDNEY FIBROSIS; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; SYSTOLIC BLOOD PRESSURE; UREA NITROGEN BLOOD LEVEL; URINE VOLUME;

EID: 0034808632     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2001.23.4.634641     Document Type: Article

References (41)

1. Cyclosporine
2. Acute effects of cyclosporine on renal function in healthy humans
3. Mechanisms of nephrotoxicity
4. Chronic cyclosporine nephrotoxicity
5. Possible role lipid peroxidation in cyclosporine nephrotoxicity
6. Role of reactive oxygen formation in the cyclosporim-A-mediated impairment of renal functions
7. Evidence that alteration in renal metabolism and lipid peroxidation may contribute to nephrotoxicity
8. Increased urinary excretion of lipid peroxide levels in renal transplant patients
9. Oxygen radical formation during cytochrome P450-catalyzed cyclosporine metabolism in rat and human liver microsomes at varying hydrogen ion concentrations
10. Cyclosporine Ainduced lipid peroxidation and influence on glucose-6-phosphatase in rat hepatic and renal microsomes
11. Cyclosorine produces endothelial dysfunction by increased production of superoxide
12. Reactive oxygen species mediate the effects of cyclosporine A on human culture mesangial cells
13. The effect of mycophenolate mofetil and polyhenolic bioflavonoids on renal ischemia-reperfusion injury and repair
14. Natural antioxidants enhance and prolong the oxyradical/NO-related suppression by dexamethasone of ischemic and histamine paw edema in mice
15. Assay of lipid peroxidation in animal tissues by thiobarbituric acid reaction
16. Cyclosporin A increases hypoxia and free radical production in rat kidneys: Prevention by dietary glycine
17. Intravenous cyclosporine activates afferent and efferent nerves and causes sodium retention in innervated kidneys in rats
18. Effect of cyclosporine administration on renal hemodynamics in conscious rats
19. Mechanisms of cyclosporine A-induced vasoconstriction in the isolated perfused rat kidney
20. Effects of endothelin receptor antagonist on cyclosporine-induced vasoconstriction in isolated rat renal arterioles
21. Sequential agonist activation and site-specific meiation of acute cyclosporine constriction in rat renal arterioles
22. Cyclosporine A up-regulates angiotensin II receptors and calcium responses in human vascular smooth muscle cells
23. Effect of cyclosporin A and analogues on cytosolic calcium and vasoconstriction: Possible lack of relationship to immunosuppressive activity
24. Dietary glycine and renal denervation prevents cyclosporine A-induced hydroxyl radical production in rat kidney
25. On the ability of four flavonoids, baicilein, luteolin, naringenin, and qaercetinto suppress the Fenton reaction of the iron-ATP complex
26. Chelating and free radiacl scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation
27. The correlation between active oxygen scavenging and antioxidative effects of flavonoids
28. Flavonoids are scavengers of superoxide anions
29. Structural damage to proteins caused by free radicals: Assessment, protection by antioxidants, and influence of protein binding
30. Antioxidative activity of flavonoids in stimulated human neutrophils
31. Inhibition of oxidant-induced lipid peroxidation in cultured renal tubular epithelial cells (LLC-PKI) by quercetin
32. Detection of drug-induced, superoxide-mediated cell damage and its prevention by antioxidants
33. Low-dose cyclosporine nephrotoxicity in the rat
34. Induction of renal growth and injury in intact rat kidney by dietary deficiency of antioxidants
35. Involvement of reactive oxygen species in kidney damage
36. Bile acids, oxidative stress, and renal function in biliary obstruction
37. Functional significance of exaggerated renal thromboxane A2 synthesis reduced by cyclosporin A
38. Endothelin receptor antagonism is protective in in vivo acute cycloxporine toxicity
39. Effects of naturally occurring flavonoids and biflavonoids on epidermal cyclooxygenose from guinea pigs
40. Modification of arachidonic acid metabolism by flavonoids
41. Lipid peroxidation