Proinflammatory cytokine-induced NF-κB activation in human mesangial cells is mediated through intracellular calcium but not ROS: Effects of silymarin

Nephron - Experimental Nephrology

Volumn 103, Issue 4, 2006, Pages

  Jai, Won Chang ^a   Choung, Soo Kim ^a   Soon, Bae Kim ^a   Su, Kil Park ^a   Jung, Sik Park ^a   Sang, Koo Lee ^a,b  

^a University of Ulsan College of Medicine   (South Korea)

^b Asan Medical Center   (South Korea)

Author keywords

Calcium; Monocyte chemoattractant protein 1; Nuclear factor B; Proinflammatory cytokines; Reactive oxygen species; Silymarin

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CALCIUM CHELATING AGENT; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; SILYMARIN; TIRON; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; MESANGIUM CELL; NORTHERN BLOTTING; PRIORITY JOURNAL;

ANTIOXIDANTS; BLOTTING, NORTHERN; CALCIUM; CELL CULTURE TECHNIQUES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERLEUKIN-1; MESANGIAL CELLS; NF-KAPPA B; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SILYMARIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33746332006     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000092906     Document Type: Article

References (26)

1. Hoare GS, Marczin N, Chester AH, Yacoub MH: Role of oxidant stress in cytokine-induced activation of NF-κin human aortic smooth muscle cells. Am J Physiol 1999;277:H1975-H1984.
2. Schreck R, Albermann K, Baeuerle PA: Nuclear factor-κB: an oxidative stress-responsive transcription factor of eukaryotic cells. Free Radic Res Commun 1992;17:221-237.
3. Brennan P, O'Neill LA: Effects of oxidants and antioxidants on nuclear factor-κB activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals. Biochim Biophys Acta 1995;1260:167-175.
4. Bonizzi G, Dejardin E, Piret B, Piette J, Merville MP, Bours V: Interleukin-1β induces nuclear factor-κB in epithelial cells independently of the production of reactive oxygen intermediates. Eur J Biochem 1996;242:544-549.
5. Hayakawa M, Miyashita H, Sakamoto I, Kitagawa M, Tanaka H, Yasuda H, Karn M, Kikugawa K: Evidence that reactive oxygen species do not mediate NF-κB activation. EMBO J 2003;22:3356-3366.
6. 2+ influx. J Immunol 1996;157:5277-5283.
7. Hayashi M, Yamaji Y, Nakazato Y, Saruta T: The effect of calcium channel blockers on nuclear factor-κB activation in the mesangium cells. Hypertens Res 2000;23:521-525.
8. De La Puerta R, Martinez E, Bravo L, Ahumada MC: Effect of silymarin on different acute inflammation models and on leukocyte migration. J Pharm Pharmacol 1996;48:968-970.
9. Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB: Silymarin suppresses TNF-induced activation of NF-κB, c-Jun, N-terminal kinase, and apoptosis. J Immunol 1999;163:6800-6809.
10. Lee SK, Kim CS, Yang WS, Kim SB, Park SK, Park JS: Exogenous nitric oxide inhibits tumor necrosis factor-α or interleukin-1β-induced monocyte chemoattractant protein-1 expression in human mesangial cells. Nephron 2002;92:780-787.
11. Tyagi AK, Agarwal C, Singh RP, Shroyer KR, Glode LM, Agarwal R: Silibinin down-regulates surviving protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional cell papilloma RT4 cells. Biochem Biophys Res Commun 2003;312:1178-1184.
12. Li LH, Wu LJ, Zhou B, Wu Z, Tashiro S, Onodera S, Uchiumi F, Ikejima T: Silymarin prevents UV irradiation-induced A375-S2 cell apoptosis. Biol Pharm Bull 2004;27:1031-1036.
13. Matsuda T, Ferreri K, Todorov I, Kuroda Y, Smith CV, Kandeel F, Mullen Y: Silymarin protects pancreatic β cells against cytokine-mediated toxicity: implication of c-Jun NH2-terminal kinase and Janus kinase/signal transducer and activator of transcription pathways. Endocrinology 2005;146:175-185.
14. Thelen P, Jarry H, Ringert RH, Wuttke W: Silibinin down-regulates prostate epithelium-derived Ets transcription factor in LNCap prostate cancer cells. Planta Med 2004;70:397-400.
15. Yasuoka H, Yoshizumi M, Inui D, Okishima N, Houchi H, Kirima K, Oshita S, Kido H, Tamaki T: Effect of endothelin-1 on intracellular free calcium in cultured human mesangial cells. Life Sci 1999;65:PL267-P272.
16. Radeke HH, Meier B, Topley N, Floege J, Habermehl GG, Resch K: Interleukin-1α and tumor necrosis factor-α induce oxygen radical production in mesangial cells. Kidney Int 1990;37:767-775.
17. Woods JS, Ellis ME, Dieguez-Acuna FJ, Corral J: Activation of NF-κB in normal rat kidney epithelial (NRK52E) cells is mediated via a redox-insensitive, calcium-dependent pathway. Toxicol Appl Pharmacol 1999;154:219-227.
18. Kang JS, Jeon YJ, Kim HM, Han SH, Yang KH: Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages. J Pharmacol Exp Ther 2002;302:138-144.
19. Kang JS, Park SK, Yang KH, Kim HM: Silymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells. FEBS Lett 2003;550:89-93.
20. Jia JD, Bauer M, Cho JJ, Ruehl M, Milani S, Boigk G, Riecken EO, Schuppan D: Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen α1 (I) and TIMP-1. J Hepatol 2001;35:392-398.
21. Schumann J, Prockl J, Kiemer AK, Vollmar AM, Bang R, Tiegs G: Silibinin protects mice from T cell-dependent liver injury. J Hepatol 2003;39:333-340.
22. Gaedeke J, Fels LM, Bokemeyer C, Menga U, Stolte H, Lentzen H: Cisplatin nephrotoxicity and protection by silibinin. Nephrol Dial Transplant 1996;11:55-62.
23. Zima T, Kamenikova L, Janebova M, Buchar E, Crkovska J, Tesar V: The effect of silibinin on experimental cyclosporine nephrotoxicity. Ren Fail 1998;20:471-479.
24. Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R: Silibinin inhibits constitutive and TNF-α-induced activation of NF-κB and sensitizes human prostate carcinoma DU 145 cells to TNF-α-induced apoptosis. Oncogene 2002;21:1759-1767.
25. Farghali H, Kamenikova L, Hynie S, Kmonickova E: Silymarin effects on intracellular calcium and cytotoxicity: a study in perfused rat hepatocytes after oxidative stress injury. Pharmacol Res 2000;41:231-237.
26. Middleton E Jr, Kandaswami C, Theoharides TC: The effects of plant flavonoids on mammalian cells: Implication for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751.