Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase: Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice

Journal of Biological Chemistry

Volumn 279, Issue 5, 2004, Pages 3434-3438

  Andreola, Fausto ^a   Hayhurst, Graham P ^a   Luo, Gang ^b   Ferguson, Stephen S ^b   Gonzalez, Frank J ^a   Goldstein, Joyce A ^a   De Luca, Luigi M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CATALYSIS; HYDROCARBONS; METABOLISM; PROTEINS; RNA;

RETINOIC ACID (RA);

BIOCHEMISTRY;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON; AROMATIC HYDROCARBON RECEPTOR; COMPLEMENTARY DNA; CYTOCHROME P 450 CYP2C SUBFAMILY; CYTOCHROME P-450 CYP2C SUBFAMILY; CYTOCHROME P450; CYTOCHROME P450 2C; CYTOCHROME P450 C39; ISOPROTEIN; MESSENGER RNA; MIXED FUNCTION OXIDASE; OXYGENASE; PEPTIDE; PRIMER DNA; RECOMBINANT PROTEIN; RETINOIC ACID; RETINOIC ACID 4 HYDROXYLASE; RETINOIC ACID 4-HYDROXYLASE; RETINOL; RETINOL PALMITATE; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CHEMICAL MODEL; CHEMISTRY; CHRONIC TOXICITY; CROSS REACTION; DOWN REGULATION; ENZYME ANALYSIS; ENZYMOLOGY; FIBROSIS; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; LIVER; LIVER METABOLISM; LIVER MICROSOME; MALE; MESSENGER RNA SYNTHESIS; METABOLISM; MOUSE; NONHUMAN; NULL CELL; PHENOTYPE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; DNA, COMPLEMENTARY; DOWN-REGULATION; FIBROSIS; KINETICS; LIVER; MALE; MICE; MICE, TRANSGENIC; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; PEPTIDES; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN ISOFORMS; RATS; RECEPTORS, ARYL HYDROCARBON; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; TRETINOIN;

ANIMALIA; ESCHERICHIA COLI; MURINAE; MUS MUSCULUS;

EID: 0942265563     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305832200     Document Type: Article

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