4-1BB signaling enhances primary and secondary population expansion of CD8+ T cells by maximizing autocrine IL-2/IL-2 receptor signaling

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Oh, Ho S ^a   Choi, Beom K ^a   Kim, Young H ^a   Lee, Don G ^a   Hwang, Sunhee ^a   Lee, Myoung J ^a   Park, Sang H ^a   Bae, Yong Soo ^b   Kwon, Byoung S ^a,c  

^a National Cancer Center   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD137 ANTIGEN; IMMUNOGLOBULIN G; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; AUTOCRINE EFFECT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DILUTION; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; T LYMPHOCYTE; ANIMAL; DRUG EFFECTS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD137; AUTOCRINE COMMUNICATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION;

EID: 84930659474     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126765     Document Type: Article

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