Autocrine IL-2 is required for secondary population expansion of CD8 + memory T cells

Nature Immunology

Volumn 12, Issue 9, 2011, Pages 908-913

  Feau, Sonia ^a   Arens, Ramon ^a,b   Togher, Susan ^a   Schoenberger, Stephen P ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; INTERLEUKIN 2;

ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ MEMORY T CELL; CD8+ T LYMPHOCYTE; CELL POPULATION; CYTOKINE PRODUCTION; DENDRITIC CELL; HELPER CELL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD40; AUTOCRINE COMMUNICATION; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DENDRITIC CELLS; FLOW CYTOMETRY; IMMUNOLOGIC MEMORY; INTERLEUKIN-2; LISTERIA MONOCYTOGENES; LISTERIOSIS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION;

EID: 80052038585     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2079     Document Type: Article

References (40)

1. Ahmed, R. & Gray, D. Immunological memory and protective immunity: understanding their relation. Science 272, 54-60 (1996). (Pubitemid 26110754)
2. van Stipdonk, M.J. et al. Dynamic programming of CD8+ T lymphocyte responses. Nat. Immunol. 4, 361-365 (2003).
3. van Stipdonk, M.J., Lemmens, E.E. & Schoenberger, S.P. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2, 423-429 (2001). (Pubitemid 33706140)
4. Kaech, S.M. & Ahmed, R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2, 415-422 (2001). (Pubitemid 33706139)
5. Badovinac, V.P., Porter, B.B. & Harty, J.T. Programmed contraction of CD8+ T cells after infection. Nat. Immunol. 3, 619-626 (2002). (Pubitemid 34752470)
6. Masopust, D., Kaech, S.M., Wherry, E.J. & Ahmed, R. The role of programming in memory T-cell development. Curr. Opin. Immunol. 16, 217-225 (2004). (Pubitemid 38328722)
7. Sun, J.C. & Bevan, M.J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300, 339-342 (2003). (Pubitemid 36433727)
8. Shedlock, D.J. & Shen, H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300, 337-339 (2003). (Pubitemid 36433726)
9. Bourgeois, C., Rocha, B. & Tanchot, C. A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 297, 2060-2063 (2002).
10. Janssen, E.M. et al. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 421, 852-856 (2003). (Pubitemid 36254145)
11. Janssen, E.M. et al. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature 434, 88-93 (2005). (Pubitemid 40349390)
12. Badovinac, V.P., Messingham, K.A., Griffith, T.S. & Harty, J.T. TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells. J. Immunol. 177, 999-1006 (2006). (Pubitemid 44036602)
13. Bennett, S.R. et al. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393, 478-480 (1998).
14. Lanzavecchia, A. Immunology. Licence to kill. Nature 393, 413-414 (1998).
15. Ridge, J.P., Di Rosa, F. & Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393, 474-478 (1998).
16. Schoenberger, S.P., Toes, R.E., van der Voort, E.I., Offringa, R. & Melief, C.J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393, 480-483 (1998).
17. Horak, I., Lohler, J., Ma, A. & Smith, K.A. Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance. Immunol. Rev. 148, 35-44 (1995). (Pubitemid 26010541)
18. Keene, J.A. & Forman, J. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J. Exp. Med. 155, 768-782 (1982). (Pubitemid 12187851)
19. Mitchison, N.A. & O'Malley, C. Three-cell-type clusters of T cells with antigen-presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response. Eur. J. Immunol. 17, 1579-1583 (1987). (Pubitemid 18000195)
20. Williams, M.A., Tyznik, A.J. & Bevan, M.J. Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature 441, 890-893 (2006).
21. Kalia, V. et al. Prolonged interleukin-2Rα expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity 32, 91-103 (2010).
22. Pipkin, M.E. et al. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity 32, 79-90 (2010).
23. Malek, T.R. & Bayer, A.L. Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 4, 665-674 (2004). (Pubitemid 39223073)
24. Sadlack, B. et al. Generalized autoimmune disease in interleukin-2- deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur. J. Immunol. 25, 3053-3059 (1995).
25. Kurts, C. et al. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184, 923-930 (1996). (Pubitemid 26313550)
26. Ehst, B.D., Ingulli, E. & Jenkins, M.K. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am. J. Transplant. 3, 1355-1362 (2003). (Pubitemid 37288079)
27. Nikolić-Zugić, J. & Bevan, M.J. Role of self-peptides in positively selecting the T-cell repertoire. Nature 344, 65-67 (1990).
28. Granucci, F., Feau, S., Angeli, V., Trottein, F. & Ricciardi-Castagnoli, P. Early IL-2 production by mouse dendritic cells is the result of microbial-induced priming. J. Immunol. 170, 5075-5081 (2003). (Pubitemid 36554737)
29. Badovinac, V.P., Haring, J.S. & Harty, J.T. Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8+ T cell response to infection. Immunity 26, 827-841 (2007). (Pubitemid 46907668)
30. D'Souza, W.N. & Lefrancois, L. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J. Immunol. 171, 5727-5735 (2003). (Pubitemid 37467187)
31. Kurts, C. et al. CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J. Exp. Med. 186, 2057-2062 (1997). (Pubitemid 28013691)
32. Wilson, E.B. & Livingstone, A.M. Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses. J. Immunol. 181, 7445-7448 (2008).
33. Granucci, F. et al. A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. J. Exp. Med. 200, 287-295 (2004). (Pubitemid 39031248)
34. Clarke, S.R. et al. Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol. Cell Biol. 78, 110-117 (2000). (Pubitemid 30220105)
35. Castellino, F. et al. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440, 890-895 (2006).
36. Kündig, T.M. et al. Immune responses in interleukin-2-deficient mice. Science 262, 1059-1061 (1993). (Pubitemid 24035046)
37. Macintyre, A.N. et al. Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. Immunity 34, 224-236 (2011).
38. Schorle, H., Holtschke, T., Hunig, T., Schimpl, A. & Horak, I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352, 621-624 (1991). (Pubitemid 21912393)
39. Mach, N. et al. Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res. 60, 3239-3246 (2000).
40. Henri, S. et al. The dendritic cell populations of mouse lymph nodes. J. Immunol. 167, 741-748 (2001). (Pubitemid 32660827)