A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1

eLife

Volumn 4, Issue MAY, 2015, Pages 1-46

  Lasagna Reeves, C A ^a,b   Rousseaux, M W C ^a,b   Guerrero Munoz, M J ^c   Park, J ^a,b   Jafar Nejad, P ^a,b   Richman, R ^a,b   Lu, N ^a,b   Sengupta, U ^c   Litvinchuk, A ^a   Orr, H T ^d   Kayed, R ^c   Zoghbi, H Y ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; CAPICUA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ATXN1 PROTEIN, MOUSE; CIC PROTEIN, MOUSE; PEPTIDE; POLYGLUTAMINE; REPRESSOR PROTEIN;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DEGENERATIVE DISEASE; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GEL PERMEATION CHROMATOGRAPHY; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; ROTAROD TEST; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; CEREBELLUM; CHEMISTRY; METABOLISM; PATHOPHYSIOLOGY; SIZE EXCLUSION CHROMATOGRAPHY; SPINOCEREBELLAR DEGENERATION; TOXICITY TESTING;

MUS;

ANALYSIS OF VARIANCE; ANIMALS; ATAXIN-1; BLOTTING, WESTERN; CEREBELLUM; CHROMATOGRAPHY, GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICE; PEPTIDES; REPRESSOR PROTEINS; ROTAROD PERFORMANCE TEST; SPINOCEREBELLAR ATAXIAS; TOXICITY TESTS;

EID: 84930648934     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.07558     Document Type: Article

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