Sesamol loaded solid lipid nanoparticles: A promising intervention for control of carbon tetrachloride induced hepatotoxicity

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Singh, Neha ^a   Khullar, Neeraj ^a   Kakkar, Vandita ^b   Kaur, Indu Pal ^b  

^a PANJAB UNIVERSITY   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

CCl4; Hepatoprotective; Oxidative stress; Sesamol; SLNs

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; NATURAL PRODUCT; SESAMOL; SILYMARIN; SOLID LIPID NANOPARTICLE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; ANTIOXIDANT; CARBON TETRACHLORIDE; LIPID; NANOPARTICLE; PHENOL DERIVATIVE; PLANT EXTRACT; PROTECTIVE AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG MECHANISM; EMULSION; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; TISSUE REGENERATION; ANIMAL; BLOOD; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; METABOLISM; PHYTOTHERAPY; SESAMUM; WISTAR RAT;

ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; BENZODIOXOLES; CARBON TETRACHLORIDE; DRUG DELIVERY SYSTEMS; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; LIPID PEROXIDATION; LIPIDS; MALE; NANOPARTICLES; OXIDATIVE STRESS; PHENOLS; PHYTOTHERAPY; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS, WISTAR; SESAMUM; SILYMARIN; SUPEROXIDE DISMUTASE;

EID: 84930646090     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0655-y     Document Type: Article

References (57)

1. Rivera-Espinoza Y, Muriel P. Pharmacological actions of curcumin in liver diseases or damage. Liver Int. 2009;29:1457-66.
2. Muriel P, Rivera-Espinoza Y. Beneficial drugs for liver diseases. J Appl Toxicol. 2008;28:93-103.
3. Morisco F, Vitaglione P, Amoruso D, Russo B, Fogliano V, Caporaso N. 144-150: foods and liver health. Mol Aspects Med. 2008;29:144-50.
4. Rechnagel RO, Glende EAJ. Carbon tetrachloride hepatotoxicity: an example of lethal cleavage. CRC Crit Rev Toxicol. 1973;2:263-97.
5. Slater TF. Free-radical mechanisms in tissue injury. Biochem J. 1984;222:1-15.
6. Liu SL, Degli-Esposti S, Yao T, Diehl AMA, Zern MA. Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa β binding. Hepatology. 1995;22:1474-81.
7. Hernandez-Munoz R, Diaz-Munoz M, Chagoya de Sanchez V. Possible role of cell redox state on collagen metabolism in carbon tetrachloride-induced cirrhosis as evidenced by adenosine administration to rats. Biochim Biophys Acta. 1994;1200:93-9.
8. Weber LW, Boll MA, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol. 2003;33:105-39.
9. Elleuch M, Besbes S, Roiseux O, Blecker C, Attia H. Quality. Characteristics of sesame seeds and by- products. Food Chem. 2007;103:641-50.
10. Mohamed HMA, Awatif II. The Use of sesame Oil Unsaponifiable. Matter as a natural antioxidant. Food Chem. 1998;62:269-76.
11. Hemalatha G, Pugalendi KV, Saravanan R. Modulatory effect of sesamol on DOCA-salt-induced oxidative stress in uninephrectomized hypertensive rats. Mol Cell Biochem. 2013;379:255-65.
12. Suja KP, Jayalekshmy A, Arumughan C. Free radical scavenging behavior of antioxidant compounds of sesame (Sesamum indicum L.) in DPPH (*) system. J Agric Food Chem. 2004;52:912-5.
13. Chennuru A, Saleem MTS. Antioxidant, Lipid Lowering, and Membrane Stabilization Effect of Sesamol against Doxorubicin-Induced Cardiomyopathy in Experimental Rats. BioMed Res Int. 2013;2013:934239. doi:10.1155/2013/934239.
14. Kumagai Y, Lin LY, Schmitz DA, Cho AK. Hydroxyl radical mediated demethylenation of (methylenedioxy) phenyl compounds. Chem Res Toxicol. 1991;4:330-4.
15. Jan KC, Ho CT, Hwang LS. Bioavailability and tissue distribution of sesamol in rat. J AgricFood Chem. 2008;56:7032-7.
16. Jan KC, Ho CT, Hwang LS. Elimination and metabolism of sesamol, a bioactive compound in sesame oil, in rats. Mol Nutr Food Res. 2009;53:S36-43.
17. CBBD: http://toxnet.nlm.nih.gov/cpdb/chempages/SESAMOL.html . 2007.
18. Kakkar V, Mishra M, Chuttani K, Chopra K, Kaur IP. Delivery of sesamol loaded solid lipid nanoparticles to the brain for menopause related emotional and cognitive central nervous system derangements. Rejuvenation Res. 2011;14:597-604.
19. Hsu DZ, Chen KT, Li YH, Chuang YC, Liu MY. Sesamol delays mortality and attenuates hepatic injury after cecal ligation and puncture in rats: role of oxidative stress. Shock. 2006;25:528-32.
20. Hsu DZ, Chien SP, Chen KT, Liu MY. The effect of sesamol on systemic oxidative stress and hepatic dysfunction in acutely iron-intoxicated mice. Shock. 2007;28:596-601.
21. Chandrasekaran VRM, Chien SP, Hsu DZ, Liu MY. Anti-hepatotoxic effects of 3,4-methylenedioxyphenol and N-acetylcysteine in acutely acetaminophen-overdosed mice. Hum Exp Toxicol. 2011;30:1609-15.
22. Chandrasekaran VR, Hsu DZ, Liu MY. The protective effect of sesamol against mitochondrial oxidative stress and hepatic injury in acetaminophen-overdosed rats. Shock. 2009;32:89-93.
23. Periasamy S, Hsu DZ, Chen SY, Yang SS, Chandrasekaran VR, Liu MY. Therapeutic sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats by inhibiting matrix metalloproteinase-9. Cell Biochem Biophys. 2011;61:327-36.
24. Jnaneshwari S, Hemshekhar M, Thushara RM, Sundaram MS, Santhosh MS, Sunitha K, et al. Sesamol Ameliorates Cyclophosphamide-Induced Hepatotoxicity by Modulating Oxidative Stress and Inflammatory Mediators. Anticancer Agents Med Chem. 2014;14:975-83.
25. Ohta S, Suzuki M, Sato N, Kamogawa A, Shinoda M. Protective effects of sesamol and its related compounds on carbon tetrachloride induced liver injury in rats. Yakugaku Zasshi. 1994;114:901-10.
26. Uchida M, Nakajin S, Toyoshima S, Shinoda M. Antioxidative effect of sesamol and related compounds on lipid peroxidation. Biol Pharm Bull. 1996;19:623-6.
27. Singh N, Khullar N, Kakkar V, Kaur I P: Hepatoprotective effects of sesamol loaded solid lipid nanoparticles in carbon tetrachloride induced sub-chronic hepatotoxicity in rats. Environ Toxicol. 2014; doi:10.1002/tox.22064.
28. Kakkar V, Singh S, Singla D, Kaur IP. Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Mol Nutr Food Res. 2011;55:495-503.
29. Bhandari R, Kaur IP. Pharmacokinetics, tissue distribution and relative bioavailability of isoniazid-solid lipid nanoparticles. Int J Pharm. 2013;441:202-12.
30. Singh N, Khullar N, Kakkar V, Kaur IP. Attenuation of Carbon Tetrachloride-Induced Hepatic Injurywith Curcumin-Loaded Solid Lipid Nanoparticles. BioDrugs. 2014;28:297-312.
31. Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res. 2006;124:491-504.
32. Manjunath K, Reddy S, Venkateswarlu V. Solid lipid nanoparticles as drug delivery systems. Method Exp Clin. 2005;27:127-44.
33. Kakkar V, Kaur IP. Preparation, characterization and scale-up of sesamol loaded solid lipid nanoparticles. Nanotechnol Dev. 2012;2, e8.
34. Gopal N, Sengottuvelu S. Hepatoprotective activity of Clerodendrum inerme against CCl4 induced hepatic injury in rats. Fitoterapia. 2008;79:24-6.
35. Dong MX, Jia Y, Zhang YB, Li CC, Geng YT, Zhou L, et al. Emodin protects rat liver from CCl4-induced fibrogenesis via inhibition of hepatic stellate cells activation. World J Gastroenterol. 2009;15:4753-62.
36. Reitman S, Frankel SA. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Amer J Clin Pathol. 1957;28:56-63.
37. Wills ED. Mechanisms of lipid peroxide formation in animal tissue. Biochem J. 1966;99:667-76.
38. Kono Y. Generation of superoxide radical during autooxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys. 1978;186:189-95.
39. Jollow D, Mitchell L, Zampaglione N, Gillete J. Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzenoxide as the hepatotoxic intermediate. Pharmacology. 1974;11:151-69.
40. He J, Hou S, Lu W, Zhu L, Feng J. Preparation, Pharmacokinetics and Body Distribution of Silymarin-Loaded Solid Lipid Nanoparticles After Oral Administration. J Biomed Nanotechnol. 2007;3:195-202.
41. Hu Y, Xie J, Tong YW, Wang CH. Effect of PEG conformation and particle size on the cellular uptake efficiency of nanoparticles with the HepG2 cells. J Control Release. 2007;118:7-17.
42. Liang HF, Yang TF, Huang CT, Chen MC, Sung HW. Preparation of nanoparticles composed of poly(gamma-glutamic acid)-poly (lactide) block copolymers and evaluation of their uptake by HepG2 cells. J Control Release. 2005;105:213-25.
43. Hashida M, Takemura S, Nishikawa M, Takakura Y. Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine). J Control Release. 1998;53:301-10.
44. Li L, Wang H, Ong ZY, Xu K, Ee PLR, Zheng S, et al. Polymer- and lipid-based nanoparticle therapeutics for the treatment of liver diseases. Nano Today. 2010;5:296-312.
45. Kuhad A, Sachdeva AK, Chopra K. Attenuation of renoinflammatory cascade in experimental model of diabetic nephropathy by sesamol. J Agric Food Chem. 2009;57:6123-8.
46. Sallie R, Tredger JM, Williams R. Drugs and the liver part 1: testing liver function. Biopharm Drug Dispos. 1991;12:251-9.
47. Ohashi N, Hori T, Chen F, Jermanus S, Eckman CB, Nakao A, et al. Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice. World J Gastroenterol. 2012;18:2320-33.
48. Curtis JJ, Mortiz M. Serum enzymes derived from liver cell fraction and response to carbon tetrachloride intoxication in rats. Gastroenterol. 1972;62:84-92.
49. Geetha T, Bhandari R, Kaur IP. Sesamol: An efficient antioxidant with potential therapeutic benefits. Med Chem. 2009;5:367-71.
50. Feher J, Lengyel G. Silymarin in the Prevention and Treatment of Liver Diseases and Primary Liver Cancer. Curr Pharm Biotechnol. 2012;13:210-7.
51. Javed S, Kohli K, Ali M. Reassessing bioavailability of silymarin. Altern Med Rev. 2011;16:239-49.
52. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004;134:489-92.
53. Blair IA. Endogenous glutathione adducts. Curr Drug Metab. 2006;7:853-72.
54. Shukitt-Hale B, Erat SA, Joseph JA. Spatial learning and memory deficits induced by dopamine administration with decreased glutathione. Free Radic Biol Med. 1998;24:1149-58.
55. Roy S, Sannigrahi S, Majumdar S, Ghosh B, Sarkar B. Resveratrol regulates antioxidant status, inhibits cytokine expression and restricts apoptosis in carbon tetrachloride induced Rat hepatic injury. Oxid Med Cell Longev. 2011;703676:12.
56. Hernandez-Munoz I, Torre PDL, Sanchez-Alcazar JA, Garcia I, Santiago E, Munoz-Yague MT, et al. Tumor necrosis factor αinhibits collagen α1(I) gene expression in rat hepatic stellate cells through a G protein. Gastroenterol. 1997;113:625-40.
57. Berghe TV, Denecker G, Brouckaert G, Vadimovisch D, D'Herde KK, Vandenabeele P. More than one way to die: methods to determine TNF-induced apoptosis and necrosis. Methods Mol Med. 2004;98:101-26.