LFP-20, a porcine lactoferrin peptide, ameliorates LPS-induced inflammation via the MyD88/NF-κB and MyD88/MAPK signaling pathways

Developmental and Comparative Immunology

Volumn 52, Issue 2, 2015, Pages 123-131

  Zong, Xin ^a   Song, Deguang ^a   Wang, Tenghao ^a   Xia, Xi ^a   Hu, Wangyang ^a   Han, Feifei ^a   Wang, Yizhen ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Inflammation; LFP 20; Lipopolysaccharide; MAPK; MyD88; NF B

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTOFERRIN; LFP 20 PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; LFP-20 PEPTIDE, PORCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CELL FUNCTION; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; MALE; MOUSE; NONHUMAN; PIG; PRIORITY JOURNAL; RNA INTERFERENCE; ANIMAL; C57BL MOUSE; CELL LINE; CHEMISTRY; GENETICS; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); SUIDAE; SUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYTOKINES; LACTOFERRIN; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MALE; MAP KINASE SIGNALING SYSTEM; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; SUS SCROFA;

EID: 84930637510     PISSN: 0145305X     EISSN: 18790089     Source Type: Journal    
DOI: 10.1016/j.dci.2015.05.006     Document Type: Article

References (35)

1. Balkwill F., Mantovani A. Inflammation and cancer: back to Virchow?. Lancet 2001, 357:539-545.
2. Bellamy W., Takase M., Wakabayashi H., Kawase K., Tomita M. Antibacterial spectrum of lactoferricin-b, a potent bactericidal peptide derived from the n-terminal region of bovine lactoferrin. J. Appl. Bacteriol 1992, 73:472-479.
3. Bellamy W., Wakabayashi H., Takase M., Kawase K., Shimamura S., Tomita M. Killing of candida-albicans by lactoferricin-b, a potent antimicrobial peptide derived from the n-terminal region of bovine lactoferrin. Med. Microbiol. Immunol. (Berl) 1993, 182:97-105.
4. Chen B.C., Lin W.W. PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation. Br. J. Pharmacol 2001, 134:1055-1065.
5. Chen H.L., Yen C.C., Lu C.Y., Yu C.H., Chen C.M. Synthetic porcine lactoferricin with a 20-residue peptide exhibits antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans. J. Agric. Food Chem 2006, 54:3277-3282.
6. Diao Y., Xin Y., Zhou Y., Li N., Pan X., Qi S., et al. Extracellular polysaccharide from Bacillus sp strain LBP32 prevents LPS-induced inflammation in RAW 264.7 macrophages by inhibiting NF-kappa B and MAPKs activation and ROS production. Int. Immunopharmacol 2014, 18:12-19.
7. Du X., Poltorak A., Silva M., Beutler B. Tlr4, transducing subunit of the sole mammalian LPS receptor, is the limiting factor in macrophage endotoxin signaling. Blood 1999, 94:584A.
8. Guo Y.B., Zheng J., Zhou G., Lv G.F., Wang L.X., Wei G., et al. A synthesized cationic tetradecapeptide from hornet venom kills bacteria and neutralizes lipopolysaccharide in vivo and in vitro. Biochem. Pharmacol 2005, 70:209-219.
9. Han F.F., Gao Y.H., Luan C., Xie Y.G., Liu Y.F., Wang Y.Z. Comparing bacterial membrane interactions and antimicrobial activity of porcine lactoferricin-derived peptides. J. Dairy Sci 2013, 96:3471-3487.
10. Hirsch T., Metzig M., Niederbichler A., Steinau H.-U., Eriksson E., Steinstraesser L. Role of host defense peptides of the innate immune response in sepsis. Shock 2008, 30:117-126.
11. Hoebe K., Du X., Georgel P., Janssen E., Tabeta K., Kim S.O., et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003, 424:743-748.
12. Inubushi T., Kawazoe A., Miyauchi M., Kudo Y., Ao M., Ishikado A., et al. Molecular mechanisms of the inhibitory effects of bovine lactoferrin on lipopolysaccharide-mediated osteoclastogenesis. J. Biol. Chem 2012, 287:23527-23536.
13. Joh E.-H., Kim D.-H. A sensitive liquid chromatography-electrospray tandem mass spectrometric method for lancemaside A and its metabolites in plasma and a pharmacokinetic study in mice. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci 2010, 878:1875-1880.
14. Kawai T., Adachi O., Ogawa T., Takeda K., Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999, 11:115-122.
15. Korhonen R., Lahti A., Kankaanranta H., Moilanen E. Nitric oxide production and signaling in inflammation. Curr. Drug Targets Inflamm. Allergy 2005, 4:471-479.
16. Kuhara T., Tanaka A., Yamauchi K., Iwatsuki K. Bovine lactoferrin ingestion protects against inflammation via IL-11 induction in the small intestine of mice with hepatitis. Br. J. Nutr 2014, 111:1801-1810.
17. Kyriakis J.M., Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev 2001, 81:807-869.
18. Lee W., Yoo H., Kim J.A., Lee S., Jee J.-G., Lee M.Y., et al. Barrier protective effects of piperlonguminine in LPS-induced inflammation in vitro and in vivo. Food Chem. Toxicol 2013, 58:149-157.
19. Libby P. Inflammation and cardiovascular disease mechanisms. Am. J. Clin. Nutr 2006, 83:456S-460S.
20. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods 2001, 25:402-408.
21. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol 2001, 1:135-145.
22. Motzkus D., Schulz-Maronde S., Heitland A., Schulz A., Forssmann W.-G., Juebner M., et al. The novel beta-defensin DEFB123 prevents lipopolysaccharide-mediated effects in vitro and in vivo. FASEB J. 2006, 20:1701.
23. Moue M., Tohno M., Shimazu T., Kido T., Aso H., Saito T., et al. Toll-like receptor 4 and cytokine expression involved in functional immune response in an originally established porcine intestinal epitheliocyte cell line. Biochim. Biophys. Acta 2008, 1780:134-144.
24. Moynagh P.N. The NF-kappaB pathway. J. Cell Sci 2005, 118:4589-4592.
25. O'Keefe J.H., Gheewala N.M., O'Keefe J.O. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J. Am. Coll. Cardiol 2008, 51:249-255.
26. Pingel L.C., Kohlgraf K.G., Hansen C.J., Eastman C.G., Dietrich D.E., Burnell K.K., et al. Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response. Immunol. Cell Biol 2008, 86:643-649.
27. Rosenfeld Y., Papo N., Shai Y. Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides - Peptide properties and plausible modes of action. J. Biol. Chem 2006, 281:1636-1643.
28. Scherle P.A., Jones E.A., Favata M.F., Daulerio A.J., Covington M.B., Nurnberg S.A., et al. Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E-2 production in lipopolysaccharide-stimulated monocytes. J. Immunol 1998, 161:5681-5686.
29. Semple F., MacPherson H., Webb S., Cox S.L., Mallin L.J., Tyrrell C., et al. Human beta-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF. Eur. J. Immunol 2011, 41:3291-3300.
30. Tak P.P., Firestein G.S. NF-kappa B: a key role in inflammatory diseases. J. Clin. Invest 2001, 107:7-11.
31. Tomita M., Bellamy W., Takase M., Yamauchi K., Wakabayashi H., Kawase K. Potent antibacterial peptides generated by pepsin digestion of bovine lactoferrin. J. Dairy Sci 1991, 74:4137-4142.
32. Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., Chen Z.J.J. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 2001, 412:346-351.
33. Weingartl H.M., Sabara M., Pasick J., van Moorlehem E., Babiuk L. Continuous porcine cell lines developed from alveolar macrophages: partial characterization and virus susceptibility. J. Virol. Methods 2002, 104:203-216.
34. Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003, 301:640-643.
35. Ye X.Y., Wang H.X., Liu F., Ng T.B. Ribonuclease, cell-free translation-inhibitory and superoxide radical scavenging activities of the iron-binding protein lactoferrin from bovine milk. Int. J. Biochem. Cell Biol 2000, 32:235-241.