Activation of angiotensin-(1-7)/Mas axis in the brain lowers blood pressure and attenuates cardiac remodeling in hypertensive transgenic (mRen2)27 rats

Neuropharmacology

Volumn 97, Issue , 2015, Pages 58-66

  Kangussu, Lucas M ^a   Guimaraes, Priscila S ^a   Nadu, Ana Paula ^a   Melo, Marcos B ^a   Santos, Robson A S ^a   Campagnole Santos, Maria Jose ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

(mRen2)27 rats; Angiotensin (1 7); Anti hypertensive; Autonomic nervous system; Cardiac remodeling; Mas receptor

Indexed keywords

ANGIOTENSIN[1-7]; ANGIOTENSIN[1-7][7 DEXTRO ALANINE]; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; COLLAGEN TYPE 1; FIBRONECTIN; TRANSFORMING GROWTH FACTOR BETA; 7-ALA-ANGIOTENSIN (1-7); ANGIOTENSIN I; ANGIOTENSIN I (1-7); ANGIOTENSIN II; ANTIHYPERTENSIVE AGENT; MESSENGER RNA; PEPTIDE FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; HEART FUNCTION; HEART RATE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HYPERTENSION; MALE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSGENIC RAT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD PRESSURE; BRAIN; CARDIAC MUSCLE; DRUG EFFECTS; HEART; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANGIOTENSIN I; ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BAROREFLEX; BLOOD PRESSURE; BRAIN; HEART; HEART RATE; HYPERTENSION; MALE; MYOCARDIUM; PEPTIDE FRAGMENTS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RENIN-ANGIOTENSIN SYSTEM; RNA, MESSENGER;

EID: 84930637358     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.04.036     Document Type: Article

References (44)

1. L.K. Becker, G.M. Etelvino, T. Walther, R.A. Santos, and M.J. Campagnole-Santos Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain Am. J. Physiol. Heart Circ. Physiol. 293 2007 H1416 H1424
2. I.F. Benter, D.I. Diz, and C.M. Ferrario Pressor and reflex sensitivity is altered in spontaneously hypertensive rats treated with angiotensin-(1-7) Hypertension 26 1995 1138 1144
3. S. Bosnyak, E.S. Jones, A. Christopoulos, M.I. Aguilar, W.G. Thomas, and R.E. Widdop Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors Clin. Sci. (Lond.) 121 2011 297 303
4. R.R. Britto, R.A. Santos, C.R. Fagundes-Moura, M.C. Khosla, and M.J. Campagnole-Santos Role of angiotensin-(1-7) in the modulation of the baroreflex in renovascular hypertensive rats Hypertension 30 1997 549 556
5. M.J. Campagnole-Santos, S.B. Heringer, E.N. Batista, M.C. Khosla, and R.A. Santos Differential baroreceptor reflex modulation by centrally infused angiotensin peptides Am. J. Physiol. 263 1992 R89 R94
6. M.C. Chappell, N.T. Pirro, A. Sykes, and C.M. Ferrario Metabolism of angiotensin-(1-7) by angiotensin-converting enzyme Hypertension 31 1998 362 367
7. G.Z. Chaves, S.M. Caligiorne, R.A. Santos, M.C. Khosla, and M.J. Campagnole-Santos Modulation of the baroreflex control of heart rate by angiotensin-(1-7) at the nucleus tractus solitarii of normotensive and spontaneously hypertensive rats J. Hypertens. 18 2000 1841 1848
8. M.M. de Moura, R.A. dos Santos, M.J. Campagnole-Santos, M. Todiras, M. Bader, N. Alenina, and A.S. Haibara Altered cardiovascular reflexes responses in conscious angiotensin-(1-7) receptor Mas-knockout mice Peptides 31 2010 1934 1939
9. D.I. Diz, M.A. Garcia-Espinosa, P.E. Gallagher, D. Ganten, C.M. Ferrario, and D.B. Averill Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats J. Cardiovasc. Pharmacol. 51 2008 542 548
10. J. Dobruch, P. Paczwa, S. Lon, M.C. Khosla, and E. Szczepanska-Sadowska Hypotensive function of the brain angiotensin-(1-7) in Sprague Dawley and renin transgenic rats J. Physiol. Pharmacol. 54 2003 371 381
11. Y. Feng, H. Xia, Y. Cai, C.M. Halabi, L.K. Becker, R.A. Santos, R.C. Speth, C.D. Sigmund, and E. Lazartigues Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension Circ. Res. 106 2010 373 382
12. C.M. Ferrario, S. Ahmad, J. Joyner, and J. Varagic Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7) Adv. Pharmacol. 59 2010 197 233
13. A.J. Ferreira, P.L. Moraes, G. Foureaux, A.B. Andrade, R.A. Santos, and A.P. Almeida The angiotensin-(1-7)/Mas receptor axis is expressed in sinoatrial node cells of rats J. Histochem. Cytochem. 59 2011 761 768
14. A.J. Ferreira, R.A. Santos, and A.P. Almeida Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion Hypertension 38 2001 665 668
15. A.G. Filho, A.J. Ferreira, S.H. Santos, S.R. Neves, E.R. Silva Camargos, L.K. Becker, H.A. Belchior, M.F. Dias-Peixoto, S.V. Pinheiro, and R.A. Santos Selective increase of angiotensin(1-7) and its receptor in hearts of spontaneously hypertensive rats subjected to physical training Exp. Physiol. 93 2008 589 598
16. M. Freund, T. Walther, and O. von Bohlen und Halbach Immunohistochemical localization of the angiotensin-(1-7) receptor Mas in the murine forebrain Cell Tissue Res. 348 2012 29 35
17. M.A. Garcia-Espinosa, H.A. Shaltout, P.E. Gallagher, M.C. Chappell, and D.I. Diz In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats J. Cardiovasc. Pharmacol. 60 2012 150 157
18. M.M. Gironacci, H.P. Adamo, G. Corradi, R.A. Santos, P. Ortiz, and O.A. Carretero Angiotensin (1-7) induces MAS receptor internalization Hypertension 58 2011 176 181
19. M.M. Gironacci, M.S. Valera, I. Yujnovsky, and C. Pena Angiotensin-(1-7) inhibitory mechanism of norepinephrine release in hypertensive rats Hypertension 44 2004 783 787
20. J.L. Grobe, A.P. Mecca, M. Lingis, V. Shenoy, T.A. Bolton, J.M. Machado, R.C. Speth, M.K. Raizada, and M.J. Katovich Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7) Am. J. Physiol. Heart Circ. Physiol. 292 2007 H736 H742
21. P.S. Guimaraes, N.M. Santiago, C.H. Xavier, E.P. Velloso, M.A. Fontes, R.A. Santos, and M.J. Campagnole-Santos Chronic infusion of angiotensin-(1-7) into the lateral ventricle of the brain attenuates hypertension in DOCA-salt rats Am. J. Physiol. Heart Circ. Physiol. 303 2012 H393 H400
22. J.E. Hall Control of blood pressure by the renin-angiotensin-aldosterone system Clin. Cardiol. 14 1991 IV6 21 (discussion IV51-25)
23. S. Heringer-Walther, E.N. Batista, T. Walther, M.C. Khosla, R.A. Santos, and M.J. Campagnole-Santos Baroreflex improvement in SHR after ace inhibition involves angiotensin-(1-7) Hypertension 37 2001 1309 1314
24. T. Jiang, L. Gao, J. Shi, J. Lu, Y. Wang, and Y. Zhang Angiotensin-(1-7) modulates renin-angiotensin system associated with reducing oxidative stress and attenuating neuronal apoptosis in the brain of hypertensive rats Pharmacol. Res. 67 2013 84 93
25. S. Kar, L. Gao, D.A. Belatti, P.L. Curry, and I.H. Zucker Central angiotensin (1-7) enhances baroreflex gain in conscious rabbits with heart failure Hypertension 58 2011 627 634
26. S. Kasama, T. Toyama, T. Hatori, H. Sumino, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol Eur. Heart J. 28 2007 989 995
27. M. Langheinrich, M.A. Lee, M. Bohm, Y.M. Pinto, D. Ganten, and M. Paul The hypertensive Ren-2 transgenic rat TGR (mREN2)27 in hypertension research. Characteristics and functional aspects Am. J. Hypertens. 9 1996 506 512
28. R.Q. Lautner, D.C. Villela, R.A. Fraga-Silva, N. Silva, T. Verano-Braga, F. Costa-Fraga, J. Jankowski, V. Jankowski, F. Sousa, A. Alzamora, E. Soares, C. Barbosa, F. Kjeldsen, A. Oliveira, J. Braga, S. Savergnini, G. Maia, A.B. Peluso, D. Passos-Silva, A. Ferreira, F. Alves, A. Martins, M. Raizada, R. Paula, D. Motta-Santos, F. Klempin, A. Pimenta, N. Alenina, R. Sinisterra, M. Bader, M.J. Campagnole-Santos, and R.A. Santos Discovery and characterization of alamandine: a novel component of the renin-angiotensin system Circ. Res. 112 2013 1104 1111
29. M. Li, C. Zheng, T. Sato, T. Kawada, M. Sugimachi, and K. Sunagawa Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats Circulation 109 2004 120 124
30. E. Liu, Z. Xu, J. Li, S. Yang, W. Yang, and G. Li Enalapril, irbesartan, and angiotensin-(1-7) prevent atrial tachycardia-induced ionic remodeling Int. J. Cardiol. 146 2011 364 370
31. J.J. Mullins, J. Peters, and D. Ganten Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene Nature 344 1990 541 544
32. D.R. Oliveira, R.A. Santos, G.F. Santos, M. Khosla, and M.J. Campagnole-Santos Changes in the baroreflex control of heart rate produced by central infusion of selective angiotensin antagonists in hypertensive rats Hypertension 27 1996 1284 1290
33. B.P. Rowe, D.L. Saylor, R.C. Speth, and D.R. Absher Angiotensin-(1-7) binding at angiotensin II receptors in the rat brain Regul. Pept. 56 1995 139 146
34. H.N. Sabbah, R.C. Gupta, M. Imai, E.D. Irwin, S. Rastogi, M.A. Rossing, and R.S. Kieval Chronic electrical stimulation of the carotid sinus baroreflex improves left ventricular function and promotes reversal of ventricular remodeling in dogs with advanced heart failure Circ. Heart Fail. 4 2011 65 70
35. N.M. Santiago, P.S. Guimaraes, R.A. Sirvente, L.A. Oliveira, M.C. Irigoyen, R.A. Santos, and M.J. Campagnole-Santos Lifetime overproduction of circulating angiotensin-(1-7) attenuates deoxycorticosterone acetate-salt hypertension-induced cardiac dysfunction and remodeling Hypertension 55 2010 889 896
36. R.A. Santos Angiotensin-(1-7) Hypertension 63 2014 1138 1147
37. R.A. Santos, M.J. Campagnole-Santos, N.C. Baracho, M.A. Fontes, L.C. Silva, L.A. Neves, D.R. Oliveira, S.M. Caligiorne, A.R. Rodrigues, and C. Gropen Junior Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors Brain Res. Bull. 35 1994 293 298
38. R.A. Santos, A.J. Ferreira, S.V. Pinheiro, W.O. Sampaio, R. Touyz, and M.J. Campagnole-Santos Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs Expert Opin. Investig. Drugs 14 2005 1019 1031
39. P.D. Senanayake, A. Moriguchi, H. Kumagai, D. Ganten, C.M. Ferrario, and K.B. Brosnihan Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats Peptides 15 1994 919 926
40. A. Shah, Y.B. Oh, S.H. Lee, J.M. Lim, and S.H. Kim Angiotensin-(1-7) attenuates hypertension in exercise-trained renal hypertensive rats Am. J. Physiol. Heart Circ. Physiol. 302 2012 H2372 H2380
41. Z. Tan, J. Wu, and H. Ma Regulation of angiotensin-converting enzyme 2 and Mas receptor by Ang-(1-7) in heart and kidney of spontaneously hypertensive rats J. Renin Angiotensin Aldosterone Syst. 12 2011 413 419
42. K. Uemura, M. Li, T. Tsutsumi, T. Yamazaki, T. Kawada, A. Kamiya, M. Inagaki, K. Sunagawa, and M. Sugimachi Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia-reperfusion injury in rabbit Am. J. Physiol. Heart Circ. Physiol. 293 2007 H2254 H2261
43. H. Xia, S. Suda, S. Bindom, Y. Feng, S.B. Gurley, D. Seth, L.G. Navar, and E. Lazartigues ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function PLoS One 6 2011 e22682
44. B. Xue, Z. Zhang, R.F. Johnson, F. Guo, M. Hay, and A.K. Johnson Central endogenous angiotensin-(1-7) protects against aldosterone/NaCl-induced hypertension in female rats Am. J. Physiol. Heart Circ. Physiol. 305 2013 H699 H705