Hypotensive function of the brain angiotensin-(1-7) in Sprague Dawley and renin transgenic rats

Journal of Physiology and Pharmacology

Volumn 54, Issue 3, 2003, Pages 371-381

  Dobruch, J ^a   Paczwa, P ^a   Lon S ^a   Khosla, M C ^b   Szczepańska Sadowska, Ewa ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Angiotensin peptides; Angiotensin receptors; Hypertension; Hypotension; Renin; Transgenic rats

Indexed keywords

ANGIOTENSIN[1-7]; RENIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLEEDING; CANNULATION; CEREBROSPINAL FLUID; CONTROLLED STUDY; HEART RATE; HEMODYNAMICS; HYPOTENSION; MEAN ARTERIAL PRESSURE; NONHUMAN; RAT; RAT STRAIN; REGULATORY MECHANISM; TRANSGENIC ANIMAL;

ADAPTATION, PHYSIOLOGICAL; ANGIOTENSIN I; ANGIOTENSIN II; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD PRESSURE; CEREBRAL VENTRICLES; CEREBROSPINAL FLUID; HEART RATE; HEMORRHAGE; HYPERTENSION; HYPOTENSION; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; RENIN; SHOCK, HEMORRHAGIC; SPECIES SPECIFICITY;

EID: 0141458359     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Welches WR, Brosnihan KB, Ferrario CM. A comparison of the properties of enzymatic activities of three angiotensin processing enzymes: angiotensin converting enzyme, prolyl endopeptidase and neprilysin. Life Sci. 1993; 52: 1461-1480.
2. Benter IF, Diz DI, Ferrario CM. Cardiovascular actions of angiotensin (1-7), Peptides 1993; 14: 679-684
3. Ferrario CM, Chappell MC, Tallant EA, Brosnihan KB, Diz DI. Counterregulatory actions of angiotensin-(1-7). Hypertension. 1997; 30: 535-541.
4. Kucharewicz I, Pawlak R, Matys T, Chabielska E, Buczko W. Angiotensin-(1-7): an active member of the renin-angiotensin system. J Physiol Pharmacol 2002; 53: 533-540.
5. Jaiswal N, Jaiswal RK, Tallant EA, Diz DI, Ferrario CM. Alterations in prostaglandin production in spontaneously hypertensive rat smooth muscle cells. Hypertension 1993; 21: 900-905.
6. Nakamoto H, Ferrario CM, Fuller SB, Robaczewski DL, Winicov E, Dean RH. Angiotensin-(1-7) and nitric oxide interaction in renovascular hypertension. Hypertension 1995; 25: 796-802.
7. Porsti I, Bara AT, Busse R, Hecker M. Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor. Br J Pharmacol 1994; 111: 652-654.
8. Benter IF, Diz, DI, Ferrario CM. Pressor and reflex sensitivity is altered in spontaneously hypertensive rats treated with angiotensin-(1-7). J Hypertens 1995; 26: 1138-1144.
9. Benter IF, Ferrario CM, Morris M, Diz DI. Antihypertensive actions of angiotensin-(1-7) in spontaneously hypertensive rats. Am J Physiol 1995; 269: H313-H319.
10. Senanayake PD, Moriguchi A, Kumagai H, Ganten D, Ferrario CM, Brosnihan KB. Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats. Peptides. 1994; 15: 919-926.
11. Mullins JJ, Peters J, Ganten D. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 1990; 344: 541-544.
12. Davisson RL, Yang G, Beltz TG, Cassel MD, Johnson AK, Sigmund CD. The brain reninangiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circulation Res 1998; 83: 1047-1058.
13. Moriguchi A, Tallant EA, Matsumura K, Reilly TM, Walton H, Ganten D, Ferrari CM. Opposing actions of angiotensin-(1-7) and angiotensin II in the brain of transgenic hypertensive rats. Hypertension 1995; 25: 1260-1265.
14. Paczwa P, Szczepańska-Sadowska E, Łoń S, Ganten U, Ganten D. Role of central AT1 and V1 receptors in cardiovascular adaptation to hemorrhage in SD and renin TGR rats. Am J Physiol 1999; 276: H1918-H1926.
15. Szczepańska-Sadowska E, Paczwa P, Łoń S, Ganten D. Increased pressor function of central vasopressinergic system in hypertensive renin transgenic rats. J Hypertens 1998; 16: 1505-1514.
16. Schiavone MT, Santos RAS, Brosnihan KB, Khosla MC, Ferrario CM. Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide. Proc Natl Acad Sci 1988; 85: 4095-4098.
17. th Scientific Meeting of the International Society of Hypertension, Chicago, USA, August 20-24, 2000. Abstract P4.31
18. Porter JP. Chronic intracerebroventicular infusion of angiotensin II increases brain AT1 receptor expression in young rats. Developmental Brain Res. 1999; 112: 293-295.
19. Iyer SN, Ferrario CM, Chappell MC. Angiotensin-(1-7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system. Hypertension 1998; 31: 356-361.
20. Santos RAS, Campagnole-Santos MJ, Baracho NCV, Fontes MAP, Silva LCS, Neves LAA, Oliveira DL, Caligiorne SM, Rodrigues ARV, Gropen Jr C, Carvalho WS, Simoes e Silva AC, Khosla MC. Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res Bull 1994; 35: 293-299.
21. Fontes MAP, Silva LCS, Campagnole-Santos MJ, Khosla MC, Guertzenstein PG, Santos RAS. Evidence that angiotensin-(1-7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors. Brain Res 1994; 665: 175-180.
22. Campagnole-Santos MJ, Heringer SB, Batista EN, Khosla MC, Santos RAS. Differential baroreceptor reflex modulation by centrally infused angiotensin peptides. Am J Physiol 1992; 263: R89-R94.
23. Chaves GZ, Caligiorne SM, Santos RAS, Khosla MC, Campagnole-Santos MJ. Modulation of the barorflex control of heart rate by angiotensin-(1-7) at the nucleus tractus solitarii of normotensive and spontaneously hypertensive rats. J Hypertens 2000; 18: 1841-1848.
24. Budzikowski AS, Paczwa P, Szczepańska-Sadowska E. Central VI AVP receptors are involved in cardiovascular adaptation to hypovolemia in WKY but not in SHR. Am J Physiol 1996; 271: H1057-H1064.
25. Paczwa P, Budzikowski A, Szczepańska-Sadowska E. Role of endogenous centrally released NO in cardiovascular adaptation to hypovolemia in WKY and SHR. Am J Physiol 1997; 272: H2282-H2288.
26. Rudichenko VM, Beierwaltes WH. Arginine vasopressin-induced renal vasodilation mediated by nitric oxide. J Vasc Res 1995; 32: 100-105.
27. Łoń S, Szczepańska-Sadowska E, Paczwa P, Ganten D. Enhanced blood pressure buffering role of the brain nitrergic system in renin transgenic rats. Brain Res 1999; 842: 384-391.
28. Paczwa P, Budzikowski AS, Szczepańska-Sadowska E. Enhancement of central pressor effect of AVP in SHR and WKY rats by intracranial NG-nitro-L-arginine. Brain Res 1997; 748: 51-61.