In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats

Journal of Cardiovascular Pharmacology

Volumn 60, Issue 2, 2012, Pages 150-157

  Garcia Espinosa, Maria A ^a   Shaltout, Hossam A ^a   Gallagher, Patricia E ^a   Chappell, Mark C ^a   Diz, Debra I ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

(mRen2) 27; angiotensin (1 7); baroreflex; hypertension; phosphatases

Indexed keywords

ANGIOTENSIN (1-7) FUSION PROTEIN; ANGIOTENSIN 1A RECEPTOR; ANGIOTENSIN[1-7]; HYBRID PROTEIN; MEMBRANE METALLOENDOPEPTIDASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; RENIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; HEART RATE VARIABILITY; HIGH FREQUENCY ALPHA INDEX; HYPERTENSION; IN VIVO STUDY; MALE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSGENIC RAT;

ANGIOTENSIN I; ANIMALS; ARTERIAL PRESSURE; AUTONOMIC NERVOUS SYSTEM; BAROREFLEX; BRAIN; DISEASE MODELS, ANIMAL; DUAL SPECIFICITY PHOSPHATASE 1; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; HEART RATE; HYPERTENSION; INJECTIONS; MALE; MICE; NEPRILYSIN; PEPTIDE FRAGMENTS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; RATS, TRANSGENIC; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN; RENIN-ANGIOTENSIN SYSTEM; RNA, MESSENGER; TIME FACTORS;

EID: 84865577246     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3182588b32     Document Type: Article

References (52)

1. Mullins JJ, Peters J, Ganten D. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature. 1990;344:541-544.
2. Barrett GL, Mullins JJ. Studies on blood pressure regulation in hypertensive Ren-2 transgenic rats. Kidney Int. 1992;41(suppl 37):S125-S128.
3. Moriguchi A, Brosnihan KB, Kumagai H, et al. Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene. Am J Physiol. 1994;266:R1273-R1278.
4. Senanayake PD, Moriguchi A, Kumagai H, et al. Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats. Peptides. 1994;15:919-926.
5. Moriguchi A, Tallant EA, Matsumura K, et al. Opposing actions of Angiotensin-(1-7) and Angiotensin II in the brain of transgenic hypertensive rats. Hypertension. 1995;25:1260-1265.
6. Dobruch J, Paczwa P, Lon S, et al. Hypotensive function of the brain angiotensin-(1-7) in Sprague Dawley and renin transgenic rats. J Physiol Pharmacol. 2003;54:371-381.
7. Diz DI, Arnold AC, Nautiyal M, et al. Angiotensin peptides and central autonomic regulation. Curr Opin Pharmacol. 2011;11:131-137.
8. Diz DI, Garcia-Espinosa MA, Gallagher PE, et al. Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats. J Cardiovasc Pharmacol. 2008;51:542-548.
9. Seyedabadi M, Goodchild AK, Pilowsky PM. Differential role of kinases in brain stem of hypertensive and normotensive rats. Hypertension. 2001;38:1087-1092.
10. Logan EM, Aileru AA, Shaltout HA, et al. The functional role of PI3K in maintenance of blood pressure and baroreflex suppression in (mRen2)27 and mRen2. Lewis rat. J Cardiovasc Pharmacol. 2011;58:367-373.
11. Owens DM, Keyse SM. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene. 2007;26: 3203-3213.
12. Dickinson RJ, Keyse SM. Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci. 2006;119: 4607-4615.
13. Camps M, Nichols A, Arkinstall S. Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J. 2000;14:6-16.
14. Pearson G, Robinson F, Gt Beers, et al. MAPK pathways: regulation and physiological functions. Endocr Rev. 2001;22:153-183.
15. Tallant EA, Gallagher PE. Angiotensin-(1-7) upregulates the mitogen activated phosphatase DUSP1 in vascular smooth muscle cells. Hypertension. 2007;50:E77. Abstract.
16. Methot D, LaPointe MC, Touyz RM, et al. Tissue targeting of angiotensin peptides. J Biol Chem. 1997;272:12994-12999.
17. van Kats JP, Methot D, Paradis P, et al. Use of a biological peptide pump to study chronic peptide hormone action in transgenic mice. Direct and indirect effects of angiotensin II on the heart. J Biol Chem. 2001;276: 44012-44017.
18. Botelho-Santos GA, Sampaio WO, Reudelhuber TL, et al. Expression of an angiotensin-(1-7)-producing fusion protein in rats induced marked changes in regional vascular resistance. Am J Physiol Heart Circ Physiol. 2007;292:H2485-H2490.
19. Ferreira AJ, Pinheiro SV, Castro CH, et al. Renal function in transgenic rats expressing an angiotensin-(1-7)-producing fusion protein. Regul Pept. 2006;137:128-133.
20. Santos RA, Ferreira AJ, Nadu AP, et al. Expression of an angiotensin- (1-7)-producing fusion protein produces cardioprotective effects in rats. Physiol Genomics. 2004;17:292-299.
21. Wang Y, Qian C, Roks AJ, et al. Circulating rather than cardiac angiotensin- (1-7) stimulates cardioprotection after myocardial infarction. Circ Heart Fail. 2010;3:286-293.
22. Botelho-Santos GA, Sampaio WO, Reudelhuber TL, et al. Expression of an angiotensin-(1-7)-producing fusion protein in rats induced marked changes in regional vascular resistance. Am J Physiol Heart Circ Physiol. 2007;292:H2485-H2490.
23. Mancia G, Omboni S, Parati G. Assessment of antihypertenisve treatment by ambulatory blood pressure. J Hypertens. 1997;15:S43-S50.
24. Shaltout HA, Chappell MC, Rose JC, et al. Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure. Am J Physiol Endocrinol Metab. 2011;300:E979-E985.
25. Chaves GZ, Caligiorne SM, Santos RAS, et al. Evidence that endogenous angiotensin-(1-7) participates in the modulation of the baroreflex at the nucleus tractus solitarii [abstract] Chaves GZ, Caligiorne SM, Santos RAS, Khosla MC, Campagnoles-Santos MJ. Hypertension. 1995;25:1389.
26. Campagnole-Santos MJ, Heringer SB, Batista EN, et al. Differential baroreceptor reflex modulation by centrally infused angiotensin peptides. Am J Physiol. 1992;263:R89-R94.
27. Isa K, Arnold AC, Westwood BM, et al. Angiotensin-converting enzyme inhibition, but not AT(1) receptor blockade, in the solitary tract nucleus improves baroreflex sensitivity in anesthetized transgenic hypertensive (mRen2)27 rats. Hypertens Res. 2011;34:1257-1262.
28. Gilliam-Davis S, Gallagher PE, Payne VS, et al. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011;43:829-835.
29. Garcia-Espinoza MA, Gallagher PE, Ferrario CM, et al. Increase in neprilysin activity in the hypothalamus of the (mRen2)27 transgenic rat. [Abstract]. FASEB J. 2006;20:A360.
30. Mitchell KD, Bagatell SJ, Miller CS, et al. Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats. J Renin Angiotensin Aldosterone Syst. 2006;7:74-86.
31. Parati G, Frattola A, Di RM, et al. Effects of aging on 24-h dynamic baroreceptor control of heart rate in ambulant subjects. Am J Physiol. 1995;268:H1606-H1612.
32. Shaltout HA, Abdel-Rahman AA. Mechanism of fatty acids induced suppression of cardiovascular reflexes in rats. J Pharmacol Exp Ther. 2005;314:1328-1337.
33. Wang YP, Cheng YJ, Huang CL. Spontaneous baroreflex measurement in the assessment of cardiac vagal control. Clin Auton Res. 2004;14: 189-193.
34. Parati G, Di RM, Mancia G. Dynamic modulation of baroreflex sensitivity in health and disease. Ann N Y Acad Sci. 2001;940:469-487.
35. Stein PK, Bosner MS, Kleiger RE, et al. Heart rate variability: a measure of cardiac autonomic tone. Am Heart J. 1994;127:1376-1381.
36. Sgoifo A, De Boer SF, Westenbroek C, et al. Incidence of arrhythmias and heart rate variablitly in wild-type rats exposed to social stress. Am J Physiol Cell Physiol. 2011;273:H1754-H1760.
37. Chaves GZ, Caligiorne SM, Santos RAS, et al. Modulation of the baroreflex control of heart rate by angiotensin-(1-7) at the nucleus tractus solitarii of normotensive and spontaneously hypertensive rats. J Hypertens. 2000;18:1841-1848.
38. Laitinen T, Hartikainen J, Niskanen L, et al. Sympathovagal balance is major determinant of short-term blood pressure variability in healthy subjects. Am J Physiol. 1999;276:H1245-H1252.
39. Benter IF, Ferrario CM, Morris M, et al. Antihypertensive actions of angiotensin-(I-7) in spontaneously hypertensive rats. Am J Physiol. 1995;269:H313-H319.
40. Daniels D, Yee DK, Fluharty SJ. Angiotensin II receptor signalling. Exp Physiol. 2007;92:523-527.
41. Hunyady L, Catt KJ. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Mol Endocrinol. 2006;20:953-970.
42. Mehta PK, Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 2007;292:C82-C97.
43. Veerasingham SJ, Yamazato M, Berecek KH, et al. Increased PI3-kinase in presympathetic brain areas of the spontaneously hypertensive rat. Circ Res. 2005;96:277-279.
44. Gallagher PE, Ferrario CM, Tallant EA. MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides. Am J Physiol Cell Physiol. 2008;295:C1169-C1174.
45. Tallant EA, Landrum MH, Gallagher PE. Angiotensin-(1-7) attenuates mitogen activated protein kinase activation. FASEB J. 2001;15:A778. Abstract.
46. Gava E, Samad-Zadeh A, Zimpelmann J, et al. Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells. Nephrol Dial Transplant. 2009;25:1766-1773.
47. Sampaio WO, Henrique de CC, Santos RA, et al. Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells. Hypertension. 2007;50:1093-1098.
48. Arnold AC, Nautiyal M, Diz DI. Protein phosphatase 1b in the solitary tract nucleus is necessary for normal baroreflex function. J Card Pharm. 2012;59:472-478.
49. Cheng A, Dube N, Gu F, et al. Coordinated action of protein tyrosine phosphatases in insulin signal transduction. Eur J Biochem. 2002;269: 1050-1059.
50. Clark MA, Tommasi EN, Bosch SM, et al. Angiotensin-(1-7) reduces renal angiotensin II receptors through a cyclooxygenase dependent pathway. J Cardiovasc Pharmacol. 2003;41:276-283.
51. Pinheiro SV, Ferreira AJ, Kitten GT, et al. Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria. Kidney Int. 2009;75:1184-1193.
52. Rice GI, Thomas DA, Grant PJ, et al. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J. 2004;383:45-51.