Chronic infusion of angiotensin-(1-7) into the lateral ventricle of the brain attenuates hypertension in DOCA-salt rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 303, Issue 3, 2012, Pages 393-400

  Guimaraes, Priscila S ^a   Santiago, Nivia M ^a   Xavier, Carlos H ^a   Velloso, Elizabeth P P ^a   Fontes, Marco A P ^a   Santos, Robson A S ^a   Campagnole Santos, Maria Jose ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Baroreflex; Collagen; Deoxycorticosterone acetate salt; Renin angiotensin system

Indexed keywords

ANGIOTENSIN[1-7]; COLLAGEN TYPE 1; DEOXYCORTICOSTERONE ACETATE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DRUG EFFECT; HEART LEFT VENTRICLE; HEART RATE; HYPERTENSION; LATERAL BRAIN VENTRICLE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PARASYMPATHETIC TONE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; SYMPATHETIC NERVE; SYMPATHETIC TONE;

EID: 84864858833     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00075.2012     Document Type: Article

References (48)

1. Becker LK, Etelvino GM, Walther T, Santos RA, Campagnole-Santos MJ. Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain. Am J Physiol Heart Circ Physiol 293: H1416-H1424, 2007.
2. Botelho LM, Block CH, Khosla MC, Santos RA. Plasma angioten-sin(1-7) immunoreactivity is increased by salt load, water deprivation, and hemorrhage. Peptides 15: 723-729, 1994.
3. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
4. Britto RR, Santos RA, Fagundes-Moura CR, Khosla MC, Campag-nole-Santos MJ. Role of angiotensin-(1-7) in the modulation of the baroreflex in renovascular hypertensive rats. Hypertension 30: 549-556, 1997.
5. Campagnole-Santos MJ, Diz DI, Ferrario CM. Baroreceptor reflex modulation by angiotensin II at the nucleus tractus solitarii. Hypertension 11: I167-I171, 1988.
6. Campagnole-Santos MJ, Heringer SB, Batista EN, Khosla MC, Santos RA. Differential baroreceptor reflex modulation by centrally infused angiotensin peptides. Am J Physiol Regul Integr Comp Physiol 263: R89-R94, 1992.
7. Campbell DJ, Alexiou T, Xiao HD, Fuchs S, McKinley MJ, Corvol P, Bernstein KE. Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice. Hypertension 43: 854-859, 2004.
8. Chaves GZ, Caligiorne SM, Santos RA, Khosla MC, Campagnole-Santos MJ. Modulation of the baroreflex control of heart rate by angio-tensin-(1-7) at the nucleus tractus solitarii of normotensive and spontaneously hypertensive rats. J Hypertens 18: 1841-1848, 2000.
9. de Souza RR. Aging of myocardial collagen. Biogerontology 3: 325-335, 2002.
10. Diz DI, Arnold AC, Nautiyal M, Isa K, Shaltout HA, Tallant EA. Angiotensin peptides and central autonomic regulation. Curr Opin Pharmacol 11: 131-137, 2011.
11. Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD, Lazartigues E. Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circ Res 106: 373-382, 2010.
12. Fontes MA, Silva LC, Campagnole-Santos MJ, Khosla MC, Guert-zenstein PG, Santos RA. Evidence that angiotensin-(1-7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors. Brain Res 665: 175-180, 1994.
13. Gironacci MM, Valera MS, Yujnovsky I, Pena C. Angiotensin-(1-7) inhibitory mechanism of norepinephrine release in hypertensive rats. Hypertension 44: 783-787, 2004.
14. Gironacci MM, Vatta M, Rodriguez-Fermepin M, Fernandez BE, Pena C. Angiotensin-(1-7) reduces norepinephrine release through a nitric oxide mechanism in rat hypothalamus. Hypertension 35: 1248-1252, 2000.
15. Gironacci MM, Yujnovsky I, Gorzalczany S, Taira C, Pena C. An-giotensin-(1-7) inhibits the angiotensin II-enhanced norepinephrine release in coarcted hypertensive rats. Regul Pept 118: 45-49, 2004.
16. Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). Am J Physiol Heart Circ Physiol 292: H736-H742, 2007.
17. Grobe JL, Mecca AP, Mao H, Katovich MJ. Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension. Am J Physiol Heart Circ Physiol 290: H2417-H2423, 2006.
18. Guyenet PG. The sympathetic control of blood pressure. Nat Rev Neu-rosci 7: 335-346, 2006.
19. Hamza SM, Kaufman S. Effect of mesenteric vascular congestion on reflex control of renal blood flow. Am J Physiol Regul Integr Comp Physiol 293: R1917-R1922, 2007.
20. Heringer-Walther S, Batista EN, Walther T, Khosla MC, Santos RA, Campagnole-Santos MJ. Baroreflex improvement in shr after ace inhibition involves angiotensin-(1-7). Hypertension 37: 1309-1314, 2001.
21. Itaya Y, Suzuki H, Matsukawa S, Kondo K, Saruta T. Central renin-angiotensin system and the pathogenesis of DOCA-salt hypertension in rats. Am J Physiol Heart Circ Physiol 251: H261-H268, 1986.
22. Iwata M, Cowling RT, Yeo SJ, Greenberg B. Targeting the ACE2-Ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure. J Mol Cell Cardiol 51: 542-547, 2011.
23. Julius S, Nesbitt S. Sympathetic overactivity in hypertension. A moving target. Am J Hypertens 9: 113S-120S, 1996.
24. Kandlikar SS, Fink GD. Mild DOCA-salt hypertension: sympathetic system and role of renal nerves. Am J Physiol Heart Circ Physiol 300: H1781-H1787, 2011.
25. Kandlikar SS, Fink GD. Splanchnic sympathetic nerves in the development of mild DOCA-salt hypertension. Am J Physiol Heart Circ Physiol 301: H1965-H1973, 2011.
26. Kar S, Gao L, Belatti DA, Curry PL, Zucker IH. Central angiotensin (1-7) enhances baroreflex gain in conscious rabbits with heart failure. Hypertension 58: 627-634, 2011.
27. Kasama S, Toyama T, Hatori T, Sumino H, Kumakura H, Takayama Y, Ichikawa S, Suzuki T, Kurabayashi M. Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol. Eur Heart J 28: 989-995, 2007.
28. Katz SA, Opsahl JA, Wernsing SE, Forbis LM, Smith J, Heller LJ. Myocardial renin is neither necessary nor sufficient to initiate or maintain ventricular hypertrophy. Am J Physiol Regul Integr Comp Physiol 278: R578-R586, 2000.
29. Li M, Zheng C, Sato T, Kawada T, Sugimachi M, Sunagawa K. Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats. Circulation 109: 120-124, 2004.
30. -δδCT method. Methods 25: 402-408, 2001.
31. Morgan HE, Baker KM. Cardiac hypertrophy: mechanical, neural, and endocrine dependence. Circulation 83: 13-25, 1991.
32. Oliveira DR, Santos RA, Santos GF, Khosla M, Campagnole-Santos MJ. Changes in the baroreflex control of heart rate produced by central infusion of selective angiotensin antagonists in hypertensive rats. Hypertension 27: 1284-1290, 1996.
33. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Amsterdam, Boston: Academic Press/Elsevier, 2007.
34. Sabbah HN, Gupta RC, Imai M, Irwin ED, Rastogi S, Rossing MA, Kieval RS. Chronic electrical stimulation of the carotid sinus baroreflex improves left ventricular function and promotes reversal of ventricular remodeling in dogs with advanced heart failure. Circ Heart Fail 4: 65-70, 2011.
35. Santiago NM, Guimaraes PS, Sirvente RA, Oliveira LA, Irigoyen MC, Santos RA, Campagnole-Santos MJ. Lifetime overproduction of circulating Angiotensin-(1-7) attenuates deoxycorticosterone acetate-salt hypertension-induced cardiac dysfunction and remodeling. Hypertension 55: 889-896, 2010.
36. Santos RA, Ferreira AJ, Simoes ESAC. Recent advances in the angio-tensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp Physiol 93: 519-527, 2008.
37. Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci USA 100: 8258-8263, 2003.
38. Schenk J, McNeill JH. The pathogenesis of DOCA-salt hypertension. J Pharmacol Toxicol Methods 27: 161-170, 1992.
39. Silva AQ, Santos RA, Fontes MA. Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone. Hypertension 46: 341-348, 2005.
40. Silva AQ, Xavier CH, Campagnole-Santos MJ, Caligiorne SM, Bal-tatu OC, Bader M, Santos RA, Fontes MA. Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen. Brain Res 1448: 101-110, 2012.
41. Tallant EA, Ferrario CM, Gallagher PE. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Am J Physiol Heart Circ Physiol 289: H1560-H1566, 2005.
42. Uemura K, Li M, Tsutsumi T, Yamazaki T, Kawada T, Kamiya A, Inagaki M, Sunagawa K, Sugimachi M. Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia-reperfusion injury in rabbit. Am J Physiol Heart Circ Physiol 293: H2254-H2261, 2007.
43. Veerasingham SJ, Raizada MK. Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives. Br J Pharmacol 139: 191-202, 2003.
44. Weber KT, Janicki JS, Shroff SG, Pick R, Chen RM, Bashey RI. Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ Res 62: 757-765, 1988.
45. Wilson KM, Sumners C, Hathaway S, Fregly MJ. Mineralocorticoids modulate central angiotensin II receptors in rats. Brain Res 382: 87-96, 1986.
46. Yamazato M, Yamazato Y, Sun C, Diez-Freire C, Raizada MK. Overexpression of angiotensin-converting enzyme 2 in the rostral ventro-lateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension 49: 926-931, 2007.
47. Yin FC, Spurgeon HA, Rakusan K, Weisfeldt ML, Lakatta EG. Use of tibial length to quantify cardiac hypertrophy: application in the aging rat. Am J Physiol Heart Circ Physiol 243: H941-H947, 1982.
48. Zhang ZH, Yu Y, Kang YM, Wei SG, Felder RB. Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. Am J Physiol Heart Circ Physiol 294: H1067-H1074, 2008.