Three-dimensional structure of a Kunitz-type inhibitor in complex with an elastase-like enzyme

Journal of Biological Chemistry

Volumn 290, Issue 22, 2015, Pages 14154-14165

  García Fernández, Rossana ^a   Perbandt, Markus ^b   Rehders, Dirk ^b,c   Ziegelmüller, Patrick ^b   Piganeau, Nicolas ^b   Hahn, Ulrich ^b   Betzel, Christian ^b   De Los Ángeles Chávez, María ^a   Redecke, Lars ^b,c  

^a UNIVERSITY OF HAVANA   (Cuba)

^b UNIVERSITY OF HAMBURG   (Germany)

^c UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BINS; COMPLEX NETWORKS; ENZYME INHIBITION; ENZYMES; SCAFFOLDS (BIOLOGY);

BIOTECHNOLOGICAL POTENTIALS; BOVINE PANCREATIC TRYPSIN INHIBITORS; CHRONIC INFLAMMATORY; INTERACTION NETWORKS; SERINE PROTEASE INHIBITOR; SITE-SPECIFIC MUTAGENESIS; SPECIFIC INHIBITORS; THREE-DIMENSIONAL STRUCTURE;

CRYSTAL STRUCTURE;

APROTININ; CHYMOTRYPSIN; ELASTASE; NEUTHROPHIL ELASTASE; SERINE PROTEINASE; UNCLASSIFIED DRUG; PANCREATIC ELASTASE; PROTEIN BINDING; SERINE PROTEINASE INHIBITOR; TRYPSIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STABILITY; HYDROGEN BOND; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ANIMAL; BOVINE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; INFLAMMATION; MOLECULAR CLONING; PIG; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ACTINIARIA; BOVINAE; STICHODACTYLA HELIANTHUS; SUS; TESTUDINES;

ANIMALS; APROTININ; CATTLE; CHYMOTRYPSIN; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; INFLAMMATION; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PANCREATIC ELASTASE; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SERINE PROTEASES; SERINE PROTEINASE INHIBITORS; SWINE; TRYPSIN;

EID: 84930630956     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.647586     Document Type: Article

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