Astragaloside IV attenuates glutamate-induced neurotoxicity in PC12 cells through Raf-MEK-ERK pathway

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Yue, Rongcai ^a,b   Li, Xia ^a   Chen, Bingyang ^a   Zhao, Jing ^c   He, Weiwei ^d   Yuan, Hu ^b   Yuan, Xing ^a   Gao, Na ^a   Wu, Guozhen ^a   Jin, Huizi ^b   Shan, Lei ^a   Zhang, Weidong ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c Logistical Engineering University of PLA   (China)

^d EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASTRAGALOSIDE IV; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NEUROMODULIN; RAF PROTEIN; VIMENTIN; ASTRAGALOSIDE A; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NEUROPROTECTIVE AGENT; SAPONIN; TRITERPENE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; LIQUID CHROMATOGRAPHY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; RAT; TANDEM MASS SPECTROMETRY; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM; MOLECULAR GENETICS; NERVE CELL; PC12 CELL LINE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION;

ASTRAGALUS MEMBRANACEUS;

ANIMALS; CELL DIFFERENTIATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUTAMIC ACID; HIGH-THROUGHPUT SCREENING ASSAYS; MAP KINASE KINASE KINASES; MOLECULAR SEQUENCE ANNOTATION; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN INTERACTION MAPPING; RAF KINASES; RATS; SAPONINS; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84930629420     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126603     Document Type: Article

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