Herbal formula Astragali Radix and Rehmanniae Radix exerted wound healing effect on human skin fibroblast cell line Hs27 via the activation of transformation growth factor (TGF-β) pathway and promoting extracellular matrix (ECM) deposition

Phytomedicine

Volumn 20, Issue 1, 2012, Pages 9-16

  Zhang, Qi ^a   Fong, Chi Chun ^a   Yu, Wai Kin ^a   Chen, Yao ^a   Wei, Fan ^a   Koon, Chi Man ^b   Lau, Kit Man ^b   Leung, Ping Chung ^b   Lau, Clara Bik San ^b   Fung, Kwok Pui ^b   Yang, Mengsu ^a  

^a CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Astragali Radix; Human skin fibroblast cells Hs27; Rehmanniae Radix; Transformation growth factor; Wound healing

Indexed keywords

ASTRAGALI RADIX; BONE MORPHOGENETIC PROTEIN 6; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; GELATINASE B; HERBACEOUS AGENT; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; REHMANNIAE RADIX; SMAD PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; CELL MIGRATION; DOWN REGULATION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; UPREGULATION; WESTERN BLOTTING; WOUND HEALING;

EID: 84870437888     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.09.006     Document Type: Article

References (33)

1. E.P. Amento, and L.S. Beck TGF-beta and wound healing Ciba Foundation Symposium 157 1991 115 123 (discussion 123-129)
2. R.F. Clark Wound repair Current Opinion in Cell Biology 1 1989 1000 1008
3. J.A. Eble, and S. Niland The extracellular matrix of blood vessels Current Pharmaceutical Design 15 2009 1385 1400
4. B.L. Eppley, J.E. Woodell, and J. Higgins Platelet quantification and growth factor analysis from kplatelet-rich plasma: implications for wound healing Ophthalmic Plastic & Reconstructive Surgery 114 2004 1502 1508 (Pubitemid 40361959)
5. K. Haukipuro, J. Melkko, L. Risteli, M. Kairaluoma, and J. Risteli Synthesis of type I collagen in healing wounds in humans Annals of Surgery 213 1991 75 80
6. T.W. Lau, Y.W. Chan, C.P. Lau, C.M. Chan, B.S. Lau, K.P. Fung, P.C. Leung, and Y.Y. Ho Investigation of the effects of Chinese medicine on fibroblast viability: implications in wound healing Phytotherapy Research 21 2007 938 947 (Pubitemid 47582767)
7. T.W. Lau, D.S. Sahota, C.H. Lau, C.M. Chan, F.C. Lam, Y.Y. Ho, K.P. Fung, C.B.S. Lau, and P.C. Leung An in vivo investigation on the wound-healing effect of two medicinal herbs using an animal model with foot ulcer Eur. Surg. Res. 41 2008 15 23 (Pubitemid 351951479)
8. K.W. Lau, K.K. Lai, C.L. Liu, C.W. Tam, M.H. To, H.F. Kwok, C.P. Lau, C.H. Ko, P.C. Leung, K.P. Fung, K.S. Poon, and B.S. Lau Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing Journal of Ethnopharmacology 141 2012 250 256
9. P.C. Leung, W.N. Wong, and W.C. Wong Limb salvage in extensive diabetic foot ulceration: an extended study using a herbal supplement Hong Kong Medical Journal 14 2008 29 33
10. H. Liu, B. Chen, and B. Lilly Fibroblasts potentiate blood vessel formation partially through secreted factor TIMP-1 Angiogenesis 11 2008 223 234
11. J.D. Lovelock, A.H. Baker, F. Gao, J.F. Dong, A.L. Bergeron, W. McPheat, N. Sivasubramanian, and D.L. Mann Heterogeneous effects of tissue inhibitors of matrix metalloproteinases on cardiac fibroblasts American Journal of Physiology: Heart and Circulatory Physiology 288 2005 H461 H468
12. H. Mani, G.S. Sidhu, R. Kumari, J.P. Gaddipati, P. Seth, and R.K. Maheshwari Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing BioFactors (Oxford, England) 16 2002 29 43 (Pubitemid 36098726)
13. W.A. Marston, J. Hanft, P. Norwood, and R. Pollak The efficacy and safety of dermagraft in improving the healing of chronic diabetic foot ulcers Diabetes Care 26 2003 1701 1705 (Pubitemid 36929107)
14. T.Q. Nguyen, H. Chon, F.A. van Nieuwenhoven, B. Braam, M.C. Verhaar, and R. Goldschmeding Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: a novel clue to adverse tissue remodelling? Diabetologia 49 2006 1039 1048
15. Y.W. Niu, T. Xie, K. Ge, Y. Lin, and S.L. Lu Effects of extracellular matrix glycosylation on proliferation and apoptosis of human dermal fibroblasts via the receptor for advanced glycosylated end products American Journal of Dermatopathology 30 2008 344 351
16. P.M.Y. Or, F.F.Y. Lam, Y.W. Kwan, C.H. Cho, C.P. Lau, H. Yu, G. Lin, C.B.S. Lau, K.P. Fung, P.C. Leung, and J.H.K. Yeung Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms Phytomedicine 19 2012 535 544
17. W.C. Parks, and R.P. Mecham Matrix Metalloproteinases 2008 Acad. Press San Diego, CA pp. 299-356
18. L.A. Repesh, T.J. Fitzgerald, and L.T. Furcht Fibronectin involvement in granulation tissue and wound healing in rabbits Journal of Histochemistry & Cytochemistry 30 1982 351 358 (Pubitemid 13217563)
19. K.J. Rolfe, J. Richardson, C. Vigor, L.M. Irvine, A.O. Grobbelaar, and C. Linge A role for TGF-beta1-induced cellular responses during wound healing of the non-scarring early human fetus Journal of Investigative Dermatology 127 2007 2656 2667 (Pubitemid 47585069)
20. M. Schiller, D. Javelaud, and A. Mauviel TGF-β-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing Journal of Dermatological Science 35 2004 83 92 (Pubitemid 38969031)
21. G.A. Secker, A.J. Shortt, E. Sampson, Q.P. Schwarz, G.S. Schultz, and J.T. Daniels TGF beta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signaling Experimental Cell Research 314 2008 131 142 (Pubitemid 350180781)
22. R. Stratton, V. Rajkumar, M. Ponticos, B. Nichols, X. Shiwen, C.M. Black, D.J. Abraham, and A. Leask Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway FASEB Journal 16 2002 1949 1951
23. G.E. Spyrou, D.A.L. Watt, and I. Naylor The origin and mode of fibroblast migration and proliferation in granulation tissue British Journal of Plastic Surgery 51 1998 455 461 (Pubitemid 28444806)
24. C.W. Tam, K.M. Lau, C.L. Liu, M.H. To, H.F. Kwok, K.L. Kwok, C.P. Lau, C.H. Ko, C.P. Leung, K.P. Fung, and B.S. Lau The in vivo and in vitro diabetic wound healing effects of a 2-herb formula and its mechanisms of action Journal of Ethnopharmacology 134 2011 831 838
25. J.N. Topper, M.R. DiChiara, J.D. Brown, A.J. Williams, D. Falb, T. Collins, and M.A. Gimbrone CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells Proceedings of the National Academy of Sciences of the United States of America 95 1998 9506 9511 (Pubitemid 28506261)
26. S. Vukicevic, and L. Grgurevic BMP-6 and mesenchymal stem cell differentiation Cytokine & Growth Factor Reviews 20 2009 441 448
27. F. Verrecchia, M.L. Chu, and A. Mauviel Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach Journal of Biological Chemistry 276 2001 17058 17062
28. R.G. Wells Fibrogenesis V. TGF-b signaling pathways American Journal of Physiology: Gastrointestinal and Liver Physiology 279 2000 G845 G850
29. S. Werner, and R. Grose Regulation of wound healing by growth factors and cytokines Physiological Reviews 83 3 2003 835 870 (Pubitemid 36828927)
30. W.N. Wong, P.C. Leung, and W.C. Wong Limb salvage in extensive diabetic foot ulceration - a preliminary clinical study using simple debridement and herbal drinks Hong Kong Medical Journal 7 2001 403 407
31. K.M. Yamada, S. Aota, S.K. Akiyam a, and S.E. LaFlamme Mechanisms of fibronectin and integrin function during cell adhesion and migration Cold Spring Harbor Symposia on Quantitative Biology 57 1992 203 212 (Pubitemid 23174393)
32. J.C. Yarrow, Z.E. Perlman, N.J. Westwood, and T.J. Mitchison A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods BMC Biotechnology 4 21 2004 doi:10.1186/1472- 6750-4-21 (Pubitemid 40195466)
33. Q. Zhang, F. Wei, C.C. Fong, W.K. Yu, Y. Chen, C.H. Koon, K.M. Lau, C.P. Leung, C.B.S. Lau, K.P. Fung, and M.S. Yang Transcriptional profiling of human skin fibroblast cell line Hs27 induced by herbal formula Astragali Radix and Rehmanniae Radix Journal of Ethnopharmacology 138 2011 668 675