The healing and anti-scar effects of astragaloside IV on the wound repair in vitro and in vivo

Journal of Ethnopharmacology

Volumn 139, Issue 3, 2012, Pages 721-727

  Chen, Xi ^a   Peng, Li Hua ^a   Li, Ni ^a   Li, Qi Mei ^b   Li, Ping ^b   Fung, Kwok Pui ^c   Leung, Ping Chung ^c   Gao, Jian Qing ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Changzhou Nanfang Sanitation Materials Company   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Astragaloside IV; Scar inhibition; Wound healing

Indexed keywords

ASTRAGALOSIDE IV; COLLAGEN TYPE 1; COLLAGEN TYPE 3; TRANSFORMING GROWTH FACTOR BETA1;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; KERATINOCYTE; MALE; NONHUMAN; RAT; SCAR FORMATION; TENSILE STRENGTH; WOUND CLOSURE; WOUND HEALING;

ANIMALS; ASTRAGALUS PLANT; CELL MOVEMENT; CICATRIX; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBROBLASTS; KERATINOCYTES; NEOVASCULARIZATION, PHYSIOLOGIC; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; SAPONINS; SKIN; TRANSFORMING GROWTH FACTOR BETA1; TRITERPENES; WOUND HEALING;

ANIMALIA; RATTUS;

EID: 84856211970     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.11.035     Document Type: Article

References (28)

1. T.P. Amadeu, A.S. Braune, L.C. Porto, and A. Desmouliere Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids Wound Repair and Regeneration 12 2004 169 174 (Pubitemid 38520683)
2. M. Babu, R. Diegelmann, and N. Oliver Fibronectin is overproduced by keloid fibroblasts during abnormal wound-healing Molecular and Cellular Biology 9 1989 1642 1650 (Pubitemid 19095205)
3. J.Y. Chan, P.C. Leung, C.T. Che, and K.P. Fung Protective effects of an herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii on streptozotocin-induced apoptosis in pancreatic beta-cells: an implication for its treatment of diabetes mellitus Phytotherapy Research 22 2008 190 196 (Pubitemid 351363237)
4. A.S. Colwell, T.T. Phan, W. Kong, and M.T. Longaker Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation Plastic and Reconstructive Surgery 116 2005 1387 1390 (Pubitemid 41456511)
5. R.F. Diegelmann, and M.C. Evans Wound healing: an overview of acute, fibrotic and delayed healing Frontiers in Bioscience 9 2004 283 289 (Pubitemid 38925460)
6. X.R. Dong, J.N. Wang, L. Liu, and X. Chen Modulation of radiation-induced tumor necrosis factor-alpha and transforming growth factor beta1 expression in the lung tissue by Shengqi Fuzheng injection Molecular Medicine Reports 3 2010 621 627
7. W.K. Fang, F.Y. Ko, H.L. Wang, and C.H. Kuo The proliferation and migration effects of huangqi on RSC96 Schwann cells American Journal of Chinese Medicine 37 2009 945 959
8. D.W. Friedman, C.D. Boyd, J.W. Mackenzie, and P. Norton Regulation of collagen gene-expression in keloids and hypertrophic scars Journal of Surgical Research 55 1993 214 222 (Pubitemid 23335800)
9. M. Fujiwara, Y. Muragaki, and A. Ooshima Keloid-derived fibroblasts show increased secretion of factors involved in collagen turnover and depend on matrix metalloproteinase for migration British Journal of Dermatology 153 2005 295 300 (Pubitemid 41228425)
10. G.C. Gurtner, S. Werner, Y. Barrandon, and M.T. Longaker Wound repair and regeneration Nature 453 2008 314 321 (Pubitemid 351693137)
11. D.O. Han, H.J. Lee, and D.H. Hahm Wound-healing activity of Astragali Radix in rats Methods and Findings in Experimental and Clinical Pharmacology 31 2009 95 100
12. T.W. Lau, Y.W. Chan, C.P. Lau, and C.M. Chan Investigation of the effects of Chinese medicine on fibroblast viability: implications in wound healing Phytotherapy Research 21 2007 938 947 (Pubitemid 47582767)
13. T.W. Lau, Y.W. Chan, C.P. Lau, and K.M. Lau Radix Astragali and Radix Rehmanniae, the principal components of two antidiabetic foot ulcer herbal formulae, elicit viability-promoting effects on primary fibroblasts cultured from diabetic foot ulcer tissues Phytotherapy Research 23 2009 809 815
14. H.A. Linares From wound to scar Burns 22 1996 339 352 (Pubitemid 26245514)
15. F.Q. Liu, Y.L. Wang, X.X. Zhu, and Y.P. Jing The heart-protective mechanism of Qishaowuwei formula on murine viral myocarditis induced by CVB3 Journal of Ethnopharmacology 127 2010 221 228
16. M.C. Miller, and J. Nanchahal Advances in the modulation of cutaneous wound healing and scarring BioDrugs 19 2005 363 381 (Pubitemid 43060720)
17. A.N. Rashed, F.U. Afifi, and A.M. Disi Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1 Journal of Ethnopharmacology 88 2003 131 136 (Pubitemid 37083437)
18. F. Reno, M. Sabbatini, F. Lombardi, and M. Stella In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars Wound Repair and Regeneration 11 2003 331 336 (Pubitemid 37122564)
19. T. Ryan, and G. Cherry The role of traditional medicine in the treatment of wound healing Journal of Alternative and Complementary Medicine 2 1996 447 448
20. C. Sevimli-Gür, I. Onbasilar, P. Atilla, R. Genc, and N. Cakar In vitro growth stimulatory and in vivo wound healing studies on cycloartane-type saponins of Astragalus genus Journal of Ethnopharmacology 134 2011 844 850
21. M. Shah, D. Revis, S. Herrick, and R. Baillie Role of elevated plasma transforming growth factor-beta1 levels in wound healing American Journal of Pathology 154 1999 1115 1124 (Pubitemid 29169746)
22. Y. Shi, W. Li, and L. Li The application of picrosirius polarization in cutaneous study Journal of Chinese Modern Dermatology 2 2005 32 34
23. J.C. Tam, K.M. Lau, C.L. Liu, and M.H. To The in vivo and in vitro diabetic wound healing effects of a 2-herb formula and its mechanisms of action Journal of Ethnopharmacology 134 2011 831 838
24. T.L. Tuan, J.Y. Zhu, B. Sun, and L.S. Nichter Elevated levels of plasminogen activator inhibitor-1 may account for the altered fibrinolysis by keloid fibroblasts Journal of Investigative Dermatology 106 1996 1007 1011 (Pubitemid 26153504)
25. C. Wang, Y.H. Rong, F.G. Ning, and G.A. Zhang The content and ratio of type I and III collagen in skin differ with age and injury African Journal of Biotechnology 10 2011 2524 2529
26. Z. Wang, Z. Gao, Y. Shi, and Y. Sun Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts Journal of Plastic Reconstructive and Aesthetic Surgery 60 2007 1193 1199 (Pubitemid 47570828)
27. L. Yang, T. Chan, J. Demare, and T. Iwashina Healing of burn wounds in transgenic mice overexpressing transforming growth factor-beta 1 in the epidermis American Journal of Pathology 159 2001 2147 2157 (Pubitemid 33104269)
28. L.X. Yang, D.W. Wei, and Y.D. Li Experimental study on stimulating angiogenesis of astragalus membranaceus injection in chorioallantoic membrane model Journal of Pediatrics of Traditional Chinese Medicine 36 2006 450 453