Paliperidone Protects SH-SY5Y Cells Against MK-801-Induced Neuronal Damage Through Inhibition of Ca2+ Influx and Regulation of SIRT1/miR-134 Signal Pathway

Molecular Neurobiology

Volumn 53, Issue 4, 2016, Pages 2498-2509

  Zhu, Dexiao ^a   Zhang, Jing ^a   Wu, Jintao ^a   Li, Guibao ^a   Yao, Wei ^a   Hao, Jing ^a   Sun, Jinhao ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

MK 801; Neuroprotection; Paliperidone; Schizophrenia

Indexed keywords

MICRORNA; MICRORNA 134; PALIPERIDONE; SIRTUIN 1; UNCLASSIFIED DRUG; CALCIUM; CALCIUM CHANNEL; DIZOCILPINE MALEATE; MIRN134 MICRORNA, HUMAN; NEUROPROTECTIVE AGENT; NEUROTOXIN; NICOTINAMIDE;

ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE POTENTIAL; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME REGULATION; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BIOLOGICAL MODEL; CALCIUM SIGNALING; CELL DEATH; CELL SURVIVAL; DOWN REGULATION; DRUG EFFECTS; HUMAN; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL; PATHOLOGY; TUMOR CELL LINE; UPREGULATION;

CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; DIZOCILPINE MALEATE; DOWN-REGULATION; HUMANS; MEMBRANE POTENTIALS; MICRORNAS; MODELS, BIOLOGICAL; NEURONS; NEUROPROTECTION; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NIACINAMIDE; PALIPERIDONE PALMITATE; SIGNAL TRANSDUCTION; SIRTUIN 1; UP-REGULATION;

EID: 84930607152     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9217-z     Document Type: Article

References (45)

1. Rajji TK, Miranda D, Mulsant BH (2014) Cognition, function, and disability in patients with schizophrenia: a review of longitudinal studies. Can J Psychiatry 59(1):13–17
2. Sarkar S, Grover S (2013) Antipsychotics in children and adolescents with schizophrenia: a systematic review and meta-analysis. Indian J Pharmacol 45(5):439–446
3. Kempton MJ, Stahl D, Williams SC, DeLisi LE (2010) Progressive lateral ventricular enlargement in schizophrenia: a meta-analysis of longitudinal MRI studies. Schizophr Res 120(1–3):54–62
4. Vita A, De Peri L, Deste G, Sacchetti E (2012) Progressive loss of cortical gray matter in schizophrenia: a meta-analysis and meta-regression of longitudinal MRI studies. Transl Psychiatry 20(2):116
5. Cannon TD, Chung Y, He G, Sun D, Jacobson A, van Erp TG, McEwen S, Addington J et al (2015) Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk. Biol Psychiatry 77(2):147–157
6. Na KS, Kim CE, Kim YS, Lee JI, Han WS, Kang UG, Park DH, Kim B et al (2013) Effectiveness of paliperidone extended-release for patients with schizophrenia: focus on subjective improvement. Hum Psychopharmacol 28(2):107–116
7. Huang MW, Yang TT, Ten PR, Su PW, Wu BJ, Chan CH, Lan TH, Liu IC et al (2012) Effects of paliperidone extended release on the symptoms and functioning of schizophrenia. BMC Clin Pharmacol 12(1):1472–6904
8. Singh J, Robb A, Vijapurkar U, Nuamah I, Hough D (2011) A randomized, double-blind study of paliperidone extended-release in treatment of acute schizophrenia in adolescents. Biol Psychiatry 70(12):1179–1187
9. Sliwa JK, Bossie CA, Ma YW, Alphs L (2011) Effects of acute paliperidone palmitate treatment in subjects with schizophrenia recently treated with oral risperidone. Schizophr Res 132(1):28–34
10. Yang MC, Lung FW (2011) Neuroprotection of paliperidone on SH-SY5Y cells against beta-amyloid peptide(25–35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. Psychopharmacology 217(3):397–410
11. Gasso P, Mas S, Molina O, Bernardo M, Lafuente A, Parellada E (2012) Neurotoxic/neuroprotective activity of haloperidol, risperidone and paliperidone in neuroblastoma cells. Prog Neuropsychopharmacol Biol Psychiatry 36(1):71–77
12. Berliocchi L, Bano D, Nicotera P (2005) Ca2+ signals and death programmes in neurons. Philos Trans R Soc Lond B Biol Sci 360(1464):2255–2258
13. Duchen MR (2012) Mitochondria, calcium-dependent neuronal death and neurodegenerative disease. Pflugers Arch 464(1):111–121
14. Simms BA, Zamponi GW (2014) Neuronal voltage-gated calcium channels: structure, function, and dysfunction. Neuron 82(1):24–45
15. Yan J, Leal K, Magupalli VG, Nanou E, Martinez GQ, Scheuer T, Catterall WA (2014) Modulation of CaV2.1 channels by neuronal calcium sensor-1 induces short-term synaptic facilitation. Mol Cell Neurosci 63:124–131
16. Hubbard BP, Sinclair DA (2014) Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci 35(3):146–154
17. Rehan L, Laszki-Szczachor K, Sobieszczanska M, Polak-Jonkisz D (2014) SIRT1 and NAD as regulators of ageing. Life Sci 105(1–2):1–6
18. Paraiso AF, Mendes KL, Santos SH (2013) Brain activation of SIRT1: role in neuropathology. Mol Neurobiol 48(3):681–689
19. Tang BL, Chua CE (2008) SIRT1 and neuronal diseases. Mol Aspects Med 29(3):187–200
20. Donmez G (2012) The effects of SIRT1 on Alzheimer’s disease models. Int J Alzheimers Dis 509529(10):3
21. Kishi T, Fukuo Y, Kitajima T, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Inada T et al (2011) SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study. Genes Brain Behav 10(3):257–263
22. Numakawa T, Richards M, Adachi N, Kishi S, Kunugi H, Hashido K (2011) MicroRNA function and neurotrophin BDNF. Neurochem Int 59(5):551–558
23. Santarelli DM, Beveridge NJ, Tooney PA, Cairns MJ (2011) Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia. Biol Psychiatry 69(2):180–187
24. Wen L, Chen Z, Zhang F, Cui X, Sun W, Geary GG, Wang Y, Johnson DA et al (2013) Ca2+/calmodulin-dependent protein kinase kinase beta phosphorylation of Sirtuin 1 in endothelium is atheroprotective. Proc Natl Acad Sci U S A 110(26):10
25. Peng L, Zhu D, Feng X, Dong H, Yue Q, Zhang J, Gao Q, Hao J et al (2013) Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3beta signaling pathway. Schizophr Res 147(1):14–23
26. Ono T, Hashimoto E, Ukai W, Ishii T, Saito T (2010) The role of neural stem cells for in vitro models of schizophrenia: neuroprotection via Akt/ERK signal regulation. Schizophr Res 122(1–3):239–247
27. Klimaviciusa L, Safiulina D, Kaasik A, Klusa V, Zharkovsky A (2008) The effects of glutamate receptor antagonists on cerebellar granule cell survival and development. Neurotoxicology 29(1):101–108
28. Sheng L, Leshchyns’ka I, Sytnyk V (2013) Cell adhesion and intracellular calcium signaling in neurons. Cell Commun Sign 11(94):11–94
29. Frank CA (2014) How voltage-gated calcium channels gate forms of homeostatic synaptic plasticity. Front Cell Neurosci 8 (40)
30. Matute C (2010) Calcium dyshomeostasis in white matter pathology. Cell Calcium 47(2):150–157
31. Liu D, Gharavi R, Pitta M, Gleichmann M, Mattson MP (2009) Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromol Med 11(1):28–42
32. Wang J, Fivecoat H, Ho L, Pan Y, Ling E, Pasinetti GM (2010) The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology. Biochim Biophys Acta 8(4):26
33. Jesus S, Gomez-Garre P, Carrillo F, Caceres-Redondo MT, Huertas-Fernandez I, Bernal-Bernal I, Bonilla-Toribio M, Vargas-Gonzalez L et al (2013) Genetic association of sirtuin genes and Parkinson’s disease. J Neurol 260(9):2237–2241
34. Lalla R, Donmez G (2013) The role of sirtuins in Alzheimer’s disease. Front Aging Neurosci 5 (16)
35. Li Y, Xu W, McBurney MW, Longo VD (2008) SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab 8(1):38–48
36. Sansone L, Reali V, Pellegrini L, Villanova L, Aventaggiato M, Marfe G, Rosa R, Nebbioso M et al (2013) SIRT1 silencing confers neuroprotection through IGF-1 pathway activation. J Cell Physiol 228(8):1754–1761
37. Slomka M, Zieminska E, Salinska E, Lazarewicz JW (2008) Neuroprotective effects of nicotinamide and 1-methylnicotinamide in acute excitotoxicity in vitro. Folia Neuropathol 46(1):69–80
38. Gao J, Wang WY, Mao YW, Graff J, Guan JS, Pan L, Mak G, Kim D et al (2010) A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 466(7310):1105–1109
39. Huang W, Liu X, Cao J, Meng F, Li M, Chen B, Zhang J (2015) miR-134 regulates ischemia/reperfusion injury-induced neuronal cell death by regulating CREB signaling. J Mol Neurosci 55(4):821–829
40. Guan L, Jia N, Zhao X, Zhang X, Tang G, Yang L, Sun H, Wang D et al (2013) The involvement of ERK/CREB/Bcl-2 in depression-like behavior in prenatally stressed offspring rats. Brain Res Bull 99:1–8
41. Ahn YM, Seo MS, Kim SH, Kim Y, Yoon SC, Juhnn YS, Kim YS (2005) Increased phosphorylation of Ser473-Akt, Ser9-GSK-3beta and Ser133-CREB in the rat frontal cortex after MK-801 intraperitoneal injection. Int J Neuropsychopharmacol 8(4):607–613
42. Castren E, da Penha BM, Lindholm D, Thoenen H (1993) Differential effects of MK-801 on brain-derived neurotrophic factor mRNA levels in different regions of the rat brain. Exp Neurol 122(2):244–252
43. Hanson ND, Nemeroff CB, Owens MJ (2011) Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus. J Pharmacol Exp Ther 337(1):180–186
44. Wozniak DF, Dikranian K, Ishimaru MJ, Nardi A, Corso TD, Tenkova T, Olney JW, Fix AS (1998) Disseminated corticolimbic neuronal degeneration induced in rat brain by MK-801: potential relevance to Alzheimer’s disease. Neurobiol Dis 5(5):305–322
45. Hwang JY, Kim YH, Ahn YH, Wie MB, Koh JY (1999) N-Methyl-D-aspartate receptor blockade induces neuronal apoptosis in cortical culture. Exp Neurol 159(1):124–130