Analysis of development of lesions in mice with serine palmitoyltransferase (SPT) deficiency - Sptlc2 conditional knockout mice -

Experimental Animals

Volumn 58, Issue 5, 2009, Pages 515-524

  Ohta, Etsuko ^a,c   Ohira, Takashi ^a   Matsue, Kenta ^a   Ikeda, Yuika ^a   Fujii, Kenji ^a   Ohwaki, Kenji ^a   Osuka, Sou ^b   Hirabayashi, Yoshio ^b   Sasaki, Minoru ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c EISAI CO LTD   (Japan)

Author keywords

Conditional knockout mouse; Gastrointestinal mucosa; Sphingolipids; SPT; Sptlc2

Indexed keywords

SERINE PALMITOYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL MUCOSA; HISTOPATHOLOGY; INTESTINE EPITHELIUM CELL; INTESTINE NECROSIS; KNOCKOUT MOUSE; LYMPHATIC SYSTEM DISEASE; LYMPHOCYTE COUNT; MALE; MOUSE; NONHUMAN; PROTEIN FUNCTION; RETICULOCYTE COUNT; SPLEEN WEIGHT; THYMUS; WEIGHT REDUCTION;

ANIMALS; ATROPHY; CELL COUNT; CELL PROLIFERATION; CHIMERA; FEMALE; HEMATOPOIESIS; INTESTINAL MUCOSA; INTESTINE, LARGE; INTESTINE, SMALL; LYMPHOCYTES; LYMPHOID TISSUE; MALE; MICE; MICE, KNOCKOUT; NECROSIS; ORGAN SIZE; RETICULOCYTES; SERINE C-PALMITOYLTRANSFERASE; SPHINGOLIPIDS; SPLEEN; TAMOXIFEN; THYMUS GLAND;

MUS;

EID: 73249126943     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.58.515     Document Type: Article

References (24)

1. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. 2008. Membrane Structure. pp. 617-650. In: Molecular Biology of THE CELL (Anderson, M. and Granum, S. eds.), Garland Science, New York, USA and Abingdon, UK.
2. Bouhours, J.F. and Glickman, R.M. 1976. Rat intestinal glycolipids. II. Distribution and biosynthesis of glycolipids and ceramide in villus and crypt cells. Biochim. Biophys. Acta 441: 123-133.
3. Dahiya, R. and Brasitus, T.A. 1986. Distribution of glycosphingolipids and ceramide of rat small intestinal mucosa. Lipids 21: 112-116.
4. Dbaibo, G.S. and Hannun, Y.A. 1998. Signal transduction and the regulation of apoptosis: roles of ceramide. Apoptosis 3: 317-334.
5. Elwell, M.R. and McConnell, E.E. 1990. Small and Large Intestine. pp. 43-69. In: Pathology of the Fischer Rat (Boorman, G.A., Eustis, S.L., Elwell, M.R., Montgomery, C.A.J., and Mackenzie, W.F. eds.), Academic Press, Inc., San Diego.
6. Fukui, Y., Sudo, N., Yu, X.N., Nukina, H., Sogawa, H., and Kubo, C. 1997. The restraint stress-induced reduction in lymphocyte cell number in lymphoid organs correlates with the suppression of in vivo antibody production. J. Neuroimmunol. 79: 211-217.
7. Hanada, K. 2003. Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim. Biophys. Acta 1632: 16-30.
8. Hanada, K., Nishijima, M., Fujita, T., and Kobayashi, S. 2000. Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant. Biochem. Pharmacol. 59: 1211-1216.
9. Hannun, Y.A. and Luberto, C. 2000. Ceramide in the eukaryotic stress response. Trends Cell Biol. 10: 73-80.
10. Hojjati, M.R., Li, Z., and Jiang, X.C. 2005. Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice. Biochim. Biophys. Acta 1737: 44-51.
11. Johnson, V.J., He, Q., Osuchowski, M.F., and Sharma, R.P. 2004. Disruption of sphingolipid homeostasis by myriocin, a mycotoxin, reduces thymic and splenic T-lymphocyte populations. Toxicology 201: 67-75.
12. Mackenzie, W.F. and Eustis, S.L. 1990. Bone Marrow. pp. 395-403. In: Pathology of the Fischer Rat (Boorman, G.A., Eustis, S.L., Elwell, M.R., Montgomery, C.A.J., and Mackenzie, W.F. eds.), Academic Press, Inc., San Diego.
13. Mathias, S., Pena, L.A., and Kolesnick, R.N. 1998. Signal transduction of stress via ceramide. Biochem. J. 335: 465-480.
14. Miyake, Y., Kozutsumi, Y., Nakamura, S., Fujita, T., and Kawasaki, T. 1995. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun. 211: 396-403.
15. Miyoshi, I., Okamura, T., Kasai, N., Kitmot, T., Ichikawa, S., Osuka, S., and Hirabayashi, Y. 2006. Conventional/Conditional Knockout Mice. pp. 443-451. In: Sphingolipid Biology (Igarashi, Y. and Merrill, A.H. eds.), Springer Japan, Tokyo.
16. Sawai, H. and Hannun, Y.A. 1999. Ceramide and sphingomyelinases in the regulation of stress responses. Chem. Phys. Lipids 102: 141-147.
17. Shackelford, C.C. and Elwell, M.R. 1999. Intestines and Mesentery. pp. 81-112. In: Pathology of the Mouse (Maronpot, R.R., Boorman, G.A., and Gaul, B.W. eds.), Cache River Press, Vienna.
18. Spiegel, S. and Merrill, A.H., Jr. 1996. Sphingolipid metabolism and cell growth regulation. FASEB J. 10: 1388-1397.
19. Stefanski, S.A., Elwell, M.R., and Stromberg, P.C. 1990. Spleen, Lymph Nodes, and Thymus. pp. 369-393. In: Pathology of the Fischer Rat (Boorman, G.A., Eustis, S.L., Elwell, M.R., Montgomery, C.A.J., and Mackenzie, W.F. eds.), Academic Press, Inc., San Diego.
20. Ward, J.M., Mann, P.C., Morishima, H., and Frith, C.H. 1999. Thymus, Spleen, and Lymph Nodes. pp. 333-357. In: Pathology of the Mouse (Maronpot, R.R., Boorman, G.A., and Gaul, B.W. eds.), Cache River Press, Vienna.
21. Weiss, B. and Stoffel, W. 1997. Human and murine serinepalmitoyl-CoA transferase - Cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur. J. Biochem. 249: 239-247.
22. Wong, W.M. and Wright, N.A. 1999. Cell proliferation in gastrointestinal mucosa. J. Clin. Pathol. 52: 321-333.
23. Yamaji, T., Nakamura, S., Takematsu, H., Kawasaki, T., and Kozutsumi, Y. 2001. Apoptosis of CTLL-2 cells induced by an immunosuppressant, ISP-I, is caspase-3-like protease-independent. J. Biochem. 129: 521-527.
24. Zhang, H., Fujitani,Y., Wright, C.V., and Gannon, M. 2005. Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis. 42: 210-217.