메뉴 건너뛰기




Volumn 38, Issue 4, 2013, Pages 245-256

Discovery and development of natural compounds into medicinal products

Author keywords

Drug discovery; Lead molecules; Natural compounds; New chemical entities

Indexed keywords

ACETYLSALICYLIC ACID; ARTEMETHER; ARTEMISININ; ARTESUNATE; ATORVASTATIN; CAMPTOTHECIN; CASPOFUNGIN; CEPHALOSPORIN C; DIGOXIN; DIHYDROARTEMISININ; DISCODERMOLIDE; EPOTHILONE D; ERIBULIN; FINGOLIMOD; GALANTAMINE; HALICHONDRIN B; HOMOHARRINGTONINE; IRINOTECAN; MORPHINE; NATURAL PRODUCT; PACLITAXEL; PENICILLIN G; PNEUMOCANDIN DERIVATIVE; QUININE; SALICYLIC ACID; TOPOTECAN;

EID: 84930539358     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2013.038.04.1940442     Document Type: Review
Times cited : (6)

References (77)
  • 1
    • 0034082239 scopus 로고    scopus 로고
    • The influence of natural products upon drug discovery
    • DOI 10.1039/a902202c
    • Newman, D.J., Cragg, CM., Snader, K.M. The influence of natural products upon drug discovery. Nat Prod Rep 2000,17(3): 215-34. (Pubitemid 30390787)
    • (2000) Natural Product Reports , vol.17 , Issue.3 , pp. 215-234
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 2
    • 84889486721 scopus 로고    scopus 로고
    • John Wiley & Sons: Chichester, West Sussex, U.K.
    • Sneader, W. Drug Discovery. A History. John Wiley & Sons: Chichester, West Sussex, U.K. 2005.
    • (2005) Drug Discovery. A History
    • Sneader, W.1
  • 3
    • 61849148824 scopus 로고    scopus 로고
    • Natural products and drug discovery
    • Ji, H.-R, Li, X.-J., Zhang, H.-Y. Natural products and drug discovery. EMBO Rep 2009,10(3): 194-200.
    • (2009) EMBO Rep , vol.10 , Issue.3 , pp. 194-200
    • Ji, H.-R.1    Li, X.-J.2    Zhang, H.-Y.3
  • 5
    • 34249811180 scopus 로고    scopus 로고
    • New aspects of natural products in drug discovery
    • DOI 10.1016/j.tim.2007.04.001, PII S0966842X07000686
    • Lam, K.S. New aspects of natural products in drug discovery. Trends Microbiol 2007,15(6): 279-89. (Pubitemid 46856162)
    • (2007) Trends in Microbiology , vol.15 , Issue.6 , pp. 279-289
    • Lam, K.S.1
  • 6
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • DOI 10.1021/np068054v
    • Newman, D.J., Cragg, CM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007, 70(3): 461-77. (Pubitemid 46595760)
    • (2007) Journal of Natural Products , vol.70 , Issue.3 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 7
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman, D.J., Cragg, CM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 2012, 75(3): 311-35.
    • (2012) J Nat Prod , vol.75 , Issue.3 , pp. 311-335
    • Newman, D.J.1    Cragg, C.M.2
  • 8
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
    • DOI 10.1021/jm0704090
    • Newman, D.J. Natural products as leads to potential drugs: An old process or the new hope for drug discovery? J Med Chem 2008, 51(9): 2589-99. (Pubitemid 351620778)
    • (2008) Journal of Medicinal Chemistry , vol.51 , Issue.9 , pp. 2589-2599
    • Newman, D.J.1
  • 10
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • DOI 10.1016/S0169-409X(96)00423-1, PII S0169409X96004231
    • Lipinski, C.A., Lombardo, R, Dominy, B., Feeney, P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Del Rev 1997, 23(1-3): 3-25. (Pubitemid 27046991)
    • (1997) Advanced Drug Delivery Reviews , vol.23 , Issue.1-3 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 11
    • 0142228822 scopus 로고    scopus 로고
    • Rediscovering natural products
    • Rouhi, A.M. Rediscovering natural products. Chem Eng News 2003, 81(41): 77-91.
    • (2003) Chem Eng News , vol.81 , Issue.41 , pp. 77-91
    • Rouhi, A.M.1
  • 12
    • 35748934487 scopus 로고    scopus 로고
    • The influence of drug-like concepts on decision-making in medicinal chemistry
    • DOI 10.1038/nrd2445, PII NRD2445
    • Leeson, P.D., Springthorpe, B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nat Rev Drug Discov 2007, 6(11): 881-90. (Pubitemid 350042396)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.11 , pp. 881-890
    • Leeson, P.D.1    Springthorpe, B.2
  • 14
    • 0035438391 scopus 로고    scopus 로고
    • Is there a difference between leads and drugs? A historical perspective
    • Oprea, T.I., Davis, A.M., Teague, S.J., Leeson, P.D. Is there a difference between leads and drugs? A historical perspective. J Chem Inf Comp Sc 2001, 41(15): 1308-15.
    • (2001) J Chem Inf Comp Sc , vol.41 , Issue.15 , pp. 1308-1315
    • Oprea, T.I.1    Davis, A.M.2    Teague, S.J.3    Leeson, P.D.4
  • 15
    • 2942564021 scopus 로고    scopus 로고
    • Pursuing the leadlikeness concept in pharmaceutical research
    • DOI 10.1016/j.cbpa.2004.04.003, PII S1367593104000493
    • Hann, M.M., Oprea, T.I. Pursuing the leadlikeness concept in pharmaceutical research. Curr Opin Chem Biol 2004, 8(3): 255-63. (Pubitemid 38759400)
    • (2004) Current Opinion in Chemical Biology , vol.8 , Issue.3 , pp. 255-263
    • Hann, M.M.1    Oprea, T.I.2
  • 16
    • 44949211332 scopus 로고    scopus 로고
    • Fragment-based activity space: Smaller is better
    • Hesterkamp, T, Whittaker, M. Fragment-based activity space: Smaller is better. Curr Opin Chem Biol 2008,12(3): 260-8.
    • (2008) Curr Opin Chem Biol , vol.12 , Issue.3 , pp. 260-268
    • Hesterkamp, T.1    Whittaker, M.2
  • 18
    • 9744232909 scopus 로고    scopus 로고
    • Time-related differences in the physical property profiles of oral drugs
    • DOI 10.1021/jm049717d
    • Leeson, P.D., Davis, A.M. Time-related differences in the physical property profiles of oral drugs. J Med Chem 2004, 47(25): 6338-48. (Pubitemid 39587257)
    • (2004) Journal of Medicinal Chemistry , vol.47 , Issue.25 , pp. 6338-6348
    • Leeson, P.D.1    Davis, A.M.2
  • 19
    • 84856449974 scopus 로고    scopus 로고
    • Drug-like properties: Guiding principles for the design of natural product libraries
    • Camp, D, Davis, R.A., Campitelli, M., Ebdon, J., Quinn, R.J. Drug-like properties: Guiding principles for the design of natural product libraries. J Nat Prod 2012, 75(1): 72-85.
    • (2012) J Nat Prod , vol.75 , Issue.1 , pp. 72-85
    • Camp, D.1    Davis, R.A.2    Campitelli, M.3    Ebdon, J.4    Quinn, R.J.5
  • 20
    • 37849027240 scopus 로고    scopus 로고
    • Novel PPAR-gamma agonists identified from a natural product library: A virtual screening, induced-fit docking and biological assay study
    • Salam, N.K., Huang, T.H.-W., Kota, B.P., Kim, M.S., Li, Y., Hibbs, D.E. Novel PPAR-gamma agonists identified from a natural product library: A virtual screening, induced-fit docking and biological assay study. Chem Biol Drug Des 2008, 71(1): 57-70.
    • (2008) Chem Biol Drug des , vol.71 , Issue.1 , pp. 57-70
    • Salam, N.K.1    Huang, T.H.-W.2    Kota, B.P.3    Kim, M.S.4    Li, Y.5    Hibbs, D.E.6
  • 21
    • 77649236726 scopus 로고    scopus 로고
    • In silico search for multi-target antiinflammatories in Chinese herbs and formulas
    • Ehrman, T.M., Barlow, D.J., Hylands, P.J. In silico search for multi-target antiinflammatories in Chinese herbs and formulas. Bioorg Med Chem 2010,18(6): 2204-18.
    • (2010) Bioorg Med Chem , vol.18 , Issue.6 , pp. 2204-2218
    • Ehrman, T.M.1    Barlow, D.J.2    Hylands, P.J.3
  • 22
    • 81355161288 scopus 로고    scopus 로고
    • Molecular docking for virtual screening of natural product databases
    • Ma, D.-L., Chan, D.S.-H., Leung, C.-H. Molecular docking for virtual screening of natural product databases. Chem Sci 2011, 2(9): 1656-65.
    • Chem Sci 2011 , vol.2 , Issue.9 , pp. 1656-1665
    • Ma, D.-L.1    Chan, D.S.-H.2    Leung, C.-H.3
  • 23
    • 59849113232 scopus 로고    scopus 로고
    • Natural product pharmaceuticals: The third generation
    • McCullagh, M. Natural product pharmaceuticals: The third generation. Drug Discovery World 2008, 9(4): 69-73.
    • (2008) Drug Discovery World , vol.9 , Issue.4 , pp. 69-73
    • McCullagh, M.1
  • 24
    • 0000604613 scopus 로고    scopus 로고
    • The Synthesis of a Combinatorial Library Using a Tambjamine Natural Product Template
    • DOI 10.1071/CH01123
    • Davis, R.A., Carroll, A.R., Quinn, R.J. The synthesis of a combinatorial library using a tambjamine natural product template. Aust J Chem 2001, 54(6): 355-9. (Pubitemid 33694052)
    • (2001) Australian Journal of Chemistry , vol.54 , Issue.6 , pp. 355-359
    • Davis, R.A.1    Carroll, A.R.2    Quinn, R.J.3
  • 25
    • 0034684250 scopus 로고    scopus 로고
    • Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of ben-zopyrans
    • Nicolaou, K.C., Pfefferkorn, J.A., Roecker, A.J., Cao, G.-Q., Barluenga, S., Mitchell, H.J. Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of ben-zopyrans. J Am Chem Soc 2000,122(41): 9939-53.
    • (2000) J Am Chem Soc , vol.122 , Issue.41 , pp. 9939-9953
    • Nicolaou, K.C.1    Pfefferkorn, J.A.2    Roecker, A.J.3    Cao, G.-Q.4    Barluenga, S.5    Mitchell, H.J.6
  • 26
    • 0035293182 scopus 로고    scopus 로고
    • Solution- and solid-phase strategies for the design, synthesis and screening of libraries based on natural product templates: A comprehensive survey
    • Hall, D.C, Manku, S., Wang, R Solution- and solid-phase strategies for the design, synthesis and screening of libraries based on natural product templates: A comprehensive survey. J Combin Chem 2001, 3(2): 125-50.
    • (2001) J Combin Chem , vol.3 , Issue.2 , pp. 125-150
    • Hall, D.C.1    Manku, S.2    Wang, R.3
  • 27
    • 2942590399 scopus 로고    scopus 로고
    • Libraries from natural product-like scaffolds
    • DOI 10.1016/j.cbpa.2004.04.010, PII S1367593104000560
    • Boldi, A.M. Libraries from natural product-like scaffolds. Curr Opin Chem Biol 2004, 8(3): 281-6. (Pubitemid 38759403)
    • (2004) Current Opinion in Chemical Biology , vol.8 , Issue.3 , pp. 281-286
    • Boldi, A.M.1
  • 28
    • 77953434492 scopus 로고    scopus 로고
    • Natural product scaffolds as leads to drugs
    • Newman, D.J., Cragg, CM. Natural product scaffolds as leads to drugs. Future Med Chem 2009,1(8): 1415-27.
    • (2009) Future Med Chem , vol.1 , Issue.8 , pp. 1415-1427
    • Newman, D.J.1    Cragg, C.M.2
  • 29
    • 79957972299 scopus 로고    scopus 로고
    • Synthesis of novel molecular probes inspired by harringtonolide
    • Hegde, V., Campitelli, M., Quinn, R.J., Camp, D. Synthesis of novel molecular probes inspired by harringtonolide. Org Biomol Chem 2011, 9(12): 4570-9.
    • (2011) Org Biomol Chem , vol.9 , Issue.12 , pp. 4570-4579
    • Hegde, V.1    Campitelli, M.2    Quinn, R.J.3    Camp, D.4
  • 30
    • 64549110945 scopus 로고    scopus 로고
    • Synthesis of four novel natural product inspired scaffolds for drug discovery
    • Jenkins, I.D., Lacrampe, F, Ripper, J. et al. Synthesis of four novel natural product inspired scaffolds for drug discovery. J Org Chem 2009, 74(3): 1304-13.
    • (2009) J Org Chem , vol.74 , Issue.3 , pp. 1304-1313
    • Jenkins, I.D.1    Lacrampe, F.2    Ripper, J.3
  • 31
    • 79961012396 scopus 로고    scopus 로고
    • Natural product-like synthetic libraries
    • Thomas, G.L., Johannes, C.W. Natural product-like synthetic libraries. Curr Opin Chem Biol 2011,15(4): 516-22.
    • (2011) Curr Opin Chem Biol , vol.15 , Issue.4 , pp. 516-522
    • Thomas, G.L.1    Johannes, C.W.2
  • 32
    • 84871531960 scopus 로고    scopus 로고
    • Drug discovery: Nature's pieces
    • Shoichet, B.K. Drug discovery: Nature's pieces. Nat Chem 2013, 5(1): 9-10.
    • (2013) Nat Chem , vol.5 , Issue.1 , pp. 9-10
    • Shoichet, B.K.1
  • 33
  • 34
    • 0031695495 scopus 로고    scopus 로고
    • Recent natural products based drug development: A pharmaceutical industry perspective
    • DOI 10.1021/np9800102
    • Shu, Y.-Z. Recent natural products based drug development: A pharmaceutical industry perspective. J Nat Prod 1998, 61(8): 1053-71. (Pubitemid 28417273)
    • (1998) Journal of Natural Products , vol.61 , Issue.8 , pp. 1053-1071
    • Shu, Y.-Z.1
  • 35
    • 79959737853 scopus 로고    scopus 로고
    • The relevance of higher plants in lead compound discovery programs
    • Kinghorn, A.D., Pan, L, Fletcher, J.N., Chai, H. The relevance of higher plants in lead compound discovery programs. J Nat Prod 2011, 74(6): 1539-55.
    • (2011) J Nat Prod , vol.74 , Issue.6 , pp. 1539-1555
    • Kinghorn, A.D.1    Pan, L.2    Fletcher, J.N.3    Chai, H.4
  • 36
    • 84859032176 scopus 로고    scopus 로고
    • Natural products and traditional medicine: Turning on a paradigm
    • Cordell, G.A., Colvard, M.D. Natural products and traditional medicine: Turning on a paradigm. J Nat Prod 2012, 75(3): 514-25.
    • (2012) J Nat Prod , vol.75 , Issue.3 , pp. 514-525
    • Cordell, G.A.1    Colvard, M.D.2
  • 37
    • 0021778837 scopus 로고
    • Wilhelm Serturner and the discovery of morphine
    • Schmitz, R.F. Wilhelm Serturner and the discovery of morphine. Pharm Hist 1985, 27(2): 61-74.
    • (1985) Pharm Hist , vol.27 , Issue.2 , pp. 61-74
    • Schmitz, R.F.1
  • 38
    • 43049183607 scopus 로고    scopus 로고
    • Natural products as a robust source of new drugs and drug leads: Past successes and present day issues
    • Rishton, CM. Natural products as a robust source of new drugs and drug leads: Past successes and present day issues. Am J Cardiol 2008,101(10A): 43D-9D.
    • (2008) Am J Cardiol , vol.101 , Issue.10 A
    • Rishton, C.M.1
  • 40
    • 2342501400 scopus 로고    scopus 로고
    • Galanthamine from snowdrop - The development of a modern drug against Alzheimer's disease from local Caucasian knowledge
    • DOI 10.1016/j.jep.2004.02.012, PII S037887410400073X
    • Heinrich, M., Teoh, H.-L. Calanthamine from snowdrop - The development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol 2004, 92(2-3): 147-62. (Pubitemid 38610095)
    • (2004) Journal of Ethnopharmacology , vol.92 , Issue.2-3 , pp. 147-162
    • Heinrich, M.1    Teoh, H.L.2
  • 41
    • 0035882369 scopus 로고    scopus 로고
    • Pure compound libraries; a new perspective for natural product based drug discovery
    • DOI 10.1016/S1359-6446(01)01856-6, PII S1359644601018566
    • Bindseil, K.U., Jakupovic, J., Wolf, D., Lavayre, J., Leboul, J., van der Pyl, D. Pure compound libraries; a new perspective for natural product based drug discovery. Drug Discov Today 2001, 6(16): 840-7. (Pubitemid 32734512)
    • (2001) Drug Discovery Today , vol.6 , Issue.16 , pp. 840-847
    • Bindseil, K.U.1    Jakupovic, J.2    Wolf, D.3    Lavayre, J.4    Leboul, J.5    Van Der Pyl, D.6
  • 45
    • 84862569342 scopus 로고    scopus 로고
    • Guiding principles for natural product drug discovery
    • Camp, D., Davis, R.A., Evans-lllidge, E.A., Quinn, R.J. Guiding principles for natural product drug discovery. Future Med Chem 2012, 4(9): 1067-84.
    • (2012) Future Med Chem , vol.4 , Issue.9 , pp. 1067-1084
    • Camp, D.1    Davis, R.A.2    Evans-Lllidge, E.A.3    Quinn, R.J.4
  • 46
    • 34548295338 scopus 로고    scopus 로고
    • Origin and evolution of high throughput screening
    • DOI 10.1038/sj.bjp.0707373, PII 0707373
    • Pereira, D.A., Williams, J.A. Origin and evolution of high throughput screening. Br J Pharmacol 2007,152(1): 53-61. (Pubitemid 47339909)
    • (2007) British Journal of Pharmacology , vol.152 , Issue.1 , pp. 53-61
    • Pereira, D.A.1    Williams, J.A.2
  • 47
    • 79953240916 scopus 로고    scopus 로고
    • Modem natural products drug discovery and its relevance to biodiversity conservation
    • Kingston, D.G.I. Modem natural products drug discovery and its relevance to biodiversity conservation. J Nat Prod 2011, 74(3): 496-511.
    • (2011) J Nat Prod , vol.74 , Issue.3 , pp. 496-511
    • Kingston, D.G.I.1
  • 48
    • 46749090589 scopus 로고    scopus 로고
    • Pre-fractionated microbial samples - The second generation natural products library at Wyeth
    • Wagenaar, M.M. Pre-fractionated microbial samples - The second generation natural products library at Wyeth. Molecules 2008,13(6): 1406-26.
    • (2008) Molecules , vol.13 , Issue.6 , pp. 1406-1426
    • Wagenaar, M.M.1
  • 49
    • 34547335884 scopus 로고    scopus 로고
    • A simple method for high-throughput extract prefractionation for biological screening
    • Appleton, D.R., Buss, A.D., Butler, M.S. A simple method for high-throughput extract prefractionation for biological screening. Chimia 2007, 61(6): 327-31.
    • (2007) Chimia , vol.61 , Issue.6 , pp. 327-331
    • Appleton, D.R.1    Buss, A.D.2    Butler, M.S.3
  • 50
    • 77958044565 scopus 로고    scopus 로고
    • Observations on screening-based research and some concerning trends in the literature
    • Baell, J.B. Observations on screening-based research and some concerning trends in the literature. Future Med Chem 2010, 2(10): 1529-46.
    • (2010) Future Med Chem , vol.2 , Issue.10 , pp. 1529-1546
    • Baell, J.B.1
  • 51
    • 77950571108 scopus 로고    scopus 로고
    • New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays
    • Baell, J.B., Holloway, G.A. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. J Med Chem 2010, 53(7): 2719-40.
    • (2010) J Med Chem , vol.53 , Issue.7 , pp. 2719-2740
    • Baell, J.B.1    Holloway, G.A.2
  • 53
    • 77951566660 scopus 로고    scopus 로고
    • Automated high-throughput system to fractionate plant natural products for drug discovery
    • Tu, Y, Jeffries, C, Ruan, H. et al. Automated high-throughput system to fractionate plant natural products for drug discovery. J Nat Prod 2010, 73(4): 751-4.
    • (2010) J Nat Prod , vol.73 , Issue.4 , pp. 751-754
    • Tu, Y.1    Jeffries, C.2    Ruan, H.3
  • 54
    • 33745188660 scopus 로고    scopus 로고
    • Screening in a spirit haunted world
    • Shoichet, B.K. Screening in a spirit haunted world. Drug Discov Today 2006,11(13-14): 607-15.
    • (2006) Drug Discov Today , vol.11 , Issue.13-14 , pp. 607-615
    • Shoichet, B.K.1
  • 55
    • 77952545106 scopus 로고    scopus 로고
    • Apparent activity in high-throughput screening: Origins of compound-dependent assay interference
    • Thorne, N., Auld, D.S., Inglese, J. Apparent activity in high-throughput screening: Origins of compound-dependent assay interference. Curr Opin Chem Biol 2010,14(3): 315-24.
    • (2010) Curr Opin Chem Biol , vol.14 , Issue.3 , pp. 315-324
    • Thorne, N.1    Auld, D.S.2    Inglese, J.3
  • 56
    • 46749152580 scopus 로고    scopus 로고
    • Marine natural product libraries for high-throughput screening and rapid drug discovery
    • DOI 10.1021/np800184g
    • Bugni, T.S., Richards, B., Bhoite, L, Cimbora, D., Harper, M.K., Ireland, CM. Marine natural product libraries for high-throughput screening and rapid drug discovery. J Nat Prod 2008, 71(6): 1095-8. (Pubitemid 352008917)
    • (2008) Journal of Natural Products , vol.71 , Issue.6 , pp. 1095-1098
    • Bugni, T.S.1    Richards, B.2    Bhoite, L.3    Cimbora, D.4    Harper, M.K.5    Ireland, C.M.6
  • 57
    • 44949134801 scopus 로고    scopus 로고
    • The impact of natural products upon modern drug discovery
    • Ganesan, A. The impact of natural products upon modern drug discovery. Curr Opin Chem Biol 2008,12(3): 306-17.
    • (2008) Curr Opin Chem Biol , vol.12 , Issue.3 , pp. 306-317
    • Ganesan, A.1
  • 59
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
    • Bollag, D.M., McQueney, P.A., Zhu, J. et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res 1995, 55(11): 2325-33.
    • (1995) Cancer Res , vol.55 , Issue.11 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3
  • 61
    • 0034041275 scopus 로고    scopus 로고
    • Recent advances in the chemistry of taxol
    • DOI 10.1021/np000064n
    • Kingston, D.G.I. Recent advances in the chemistry of taxol. J Nat Prod 2000, 63(5): 726-34. (Pubitemid 30395547)
    • (2000) Journal of Natural Products , vol.63 , Issue.5 , pp. 726-734
    • Kingston, D.G.I.1
  • 62
    • 14944383798 scopus 로고    scopus 로고
    • The evolving role of natural products in drug discovery
    • DOI 10.1038/nrd1657
    • Koehn, F.E., Carter, G.T. The evolving role of natural products in drug discovery. Nat Rev Drug Discov 2005, 4(3): 206-20. (Pubitemid 40372555)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.3 , pp. 206-220
    • Koehn, F.E.1    Carter, G.T.2
  • 63
    • 67650675111 scopus 로고    scopus 로고
    • Impact of natural products on developing new anti-cancer agents
    • Cragg, CM., Grothaus, PC, Newman, D.J. Impact of natural products on developing new anti-cancer agents. Chem Rev 2009,109(7): 3012-43.
    • (2009) Chem Rev , vol.109 , Issue.7 , pp. 3012-3043
    • Cragg, C.M.1    Grothaus, P.C.2    Newman, D.J.3
  • 64
    • 67650436176 scopus 로고    scopus 로고
    • Drug discovery and natural products: End of an era or an endless frontier?
    • Li, J.W.-H., Vederas, J.C. Drug discovery and natural products: End of an era or an endless frontier? Science 2009, 325(5937): 161-5.
    • (2009) Science , vol.325 , Issue.5937 , pp. 161-165
    • Li, J.W.-H.1    Vederas, J.C.2
  • 65
    • 0021061045 scopus 로고
    • Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation
    • Ikeda, Y, Idemoto, H., Hirayama, F, Yamamoto, K., Iwao, K., Asao, T, Munakata, T. Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation. J Antibiot 1983, 36(10): 1279-83. (Pubitemid 14232192)
    • (1983) Journal of Antibiotics , vol.36 , Issue.10 , pp. 1279-1283
    • Ikeda, Y.1    Idemoto, H.2    Hirayama, F.3
  • 66
    • 0034632436 scopus 로고    scopus 로고
    • Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B
    • Cuevas, C, Perez, M., Martin, M.J. et al. Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B. Org Lett 2000, 2(16): 2545-8.
    • (2000) Org Lett , vol.2 , Issue.16 , pp. 2545-2548
    • Cuevas, C.1    Perez, M.2    Martin, M.J.3
  • 67
    • 38849174356 scopus 로고    scopus 로고
    • Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: Combining synthetic chemistry and biosynthetic engineering for diversifying natural products
    • DOI 10.1039/b707678a
    • Kennedy, J. Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products. Nat Prod Rep 2008, 25(1): 25-34. (Pubitemid 351207544)
    • (2008) Natural Product Reports , vol.25 , Issue.1 , pp. 25-34
    • Kennedy, J.1
  • 68
    • 33746616007 scopus 로고    scopus 로고
    • Tigecycline: A critical analysis
    • DOI 10.1086/505494
    • Stein, G.E., Craig, W.A. Tigecycline: A critical analysis. Clin Infect Dis 2006, 43(4): 518-24. (Pubitemid 44157163)
    • (2006) Clinical Infectious Diseases , vol.43 , Issue.4 , pp. 518-524
    • Stein, G.E.1    Craig, W.A.2
  • 74
    • 1542305513 scopus 로고    scopus 로고
    • Scaled-up synthesis of discodermolide
    • Freemantle, M. Scaled-up synthesis of discodermolide. Chem Eng News 2004, 82(9): 33-5.
    • (2004) Chem Eng News , vol.82 , Issue.9 , pp. 33-35
    • Freemantle, M.1
  • 75
    • 79955408396 scopus 로고    scopus 로고
    • Fingolimod (FTY720): A recently approved multiple sclerosis drug based on a fungal secondary metabolite
    • Strader, C.R., Pearce, C.J., Oberlies, N.H. Fingolimod (FTY720): A recently approved multiple sclerosis drug based on a fungal secondary metabolite. J Nat Prod 2011, 74(4): 900-7.
    • (2011) J Nat Prod , vol.74 , Issue.4 , pp. 900-907
    • Strader, C.R.1    Pearce, C.J.2    Oberlies, N.H.3
  • 76
    • 0036149009 scopus 로고    scopus 로고
    • C-10 Ester and ether derivatives of dihydroartemisinin - 10 - A artesunate, preparation of authentic 10-b artesunate, and of other ester and ether derivatives bearing potential aromatic intercalating groups at C-10
    • Haynes, R.K., Chan, H.-W., Cheung, M.-K. etal. C-10 Ester and ether derivatives of dihydroartemisinin - 10-a artesunate, preparation of authentic 10-b artesunate, and of other ester and ether derivatives bearing potential aromatic intercalating groups at C-10. Eur J Org Chem 2002(1): 113-35.
    • (2002) Eur J Org Chem , vol.1 , pp. 113-135
    • Haynes, R.K.1    Chan, H.-W.2    Cheung, M.-K.3
  • 77
    • 0035347869 scopus 로고    scopus 로고
    • Scaffold architecture and pharmacophoric properties of natural products and trade drugs: Application in the design of natural product-based combinatorial libraries
    • DOI 10.1021/cc000097l
    • Lee, M.L., Schneider, G. Scaffold architecture and pharmacophoric properties of natural products and trade drugs: Application in the design of nat-ural product-based combinatorial libraries. J Combin Chem 2001, 3(3): 284-9. (Pubitemid 33616450)
    • (2001) Journal of Combinatorial Chemistry , vol.3 , Issue.3 , pp. 284-289
    • Lee, M.-L.1    Schneider, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.