메뉴 건너뛰기




Volumn 1, Issue 8, 2009, Pages 1415-1427

Natural product scaffolds as leads to drugs

Author keywords

[No Author keywords available]

Indexed keywords

9 ACETYLIMINO 3 DEHEXAPYRANOSYLOXY 9 DEOXO 3 OXO 6 O,11 O [2 [6 (1 PYRAZOLYL) 3 PYRIDINYLMETHOXYIMINO]PROPYLENE]ERYTHROMYCIN; 9,10 DIDEHYDROEPOTHILONE D; ACICLOVIR; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; ATORVASTATIN; BETA LACTAM; CEM 101; CEPHALOSPORIN; CETHROMYCIN; CHLORDIAZEPOXIDE; CHLORTETRACYCLINE; COMPACTIN; DEFOROLIMUS; DIAZEPAM; EPOTHILONE DERIVATIVE; ERYTHROMYCIN; EVEROLIMUS; GEMCITABINE; HYPOCHOLESTEROLEMIC AGENT; MACROLIDE; MEVINOLIN; MINOCYCLINE; MONOBACTAM; NATURAL PRODUCT; OXYTETRACYCLINE; PENICILLIN G; RAPAMYCIN; SAGOPILONE; TETRACYCLINE; THIENAMYCIN; TIGECYCLINE; TOMAYMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE;

EID: 77953434492     PISSN: 17568919     EISSN: None     Source Type: Journal    
DOI: 10.4155/fmc.09.113     Document Type: Short Survey
Times cited : (89)

References (88)
  • 1
    • 0025300402 scopus 로고
    • Towards a natural system of organisms: Proposal for the domains archaea, bacteria and eucarya
    • Woese CR, Kandler O, Wheelis ML. Towards a natural system of organisms: proposal for the domains archaea, bacteria and eucarya. Proc. Natl Acad. Sci. USA 87, 4576-4579 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 4576-4579
    • Woese, C.R.1    Kandler, O.2    Wheelis, M.L.3
  • 2
    • 0024239320 scopus 로고
    • Methods for drug discovery: Development of potent, selective, orally effective cholecystokinin antagonists
    • Evans BE, Rittle KE, Bock MG et al. Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. J. Med. Chem. 31, 2235-2246 (1988).
    • (1988) J. Med. Chem , vol.31 , pp. 2235-2246
    • Evans, B.E.1    Rittle, K.E.2    Bock, M.G.3
  • 3
    • 0000740137 scopus 로고
    • Quinazoline 3-oxide structure of compounds previously described in the literature as 3.1.4-benzoxadiazepines
    • Sternbach LH, Kaiser S, Reeder E. Quinazoline 3-oxide structure of compounds previously described in the literature as 3.1.4-benzoxadiazepines. J. Am. Chem. Soc. 82, 475-480 (1960).
    • (1960) J. Am. Chem. Soc , vol.82 , pp. 475-480
    • Sternbach, L.H.1    Kaiser, S.2    Reeder, E.3
  • 4
    • 0038761719 scopus 로고
    • Quinazolines and 1,4 benzodiazepines. VI. Halo-, methyl-, and methoxy-substituted 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin- 2-ones
    • Sternbach LH, Fryer RI, Metlesics W et al. Quinazolines and 1,4 benzodiazepines. VI. Halo-, methyl-, and methoxy-substituted 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin- 2-ones. J. Org. Chem. 27, 3788-3796 (1962).
    • (1962) J. Org. Chem , vol.27 , pp. 3788-3796
    • Sternbach, L.H.1    Fryer, R.I.2    Metlesics, W.3
  • 5
    • 0028720443 scopus 로고
    • The discovery of librium
    • Sternbach LH. The discovery of librium. Agents Actions 43, 82-85 (1994).
    • (1994) Agents Actions , vol.43 , pp. 82-85
    • Sternbach, L.H.1
  • 6
    • 77953386310 scopus 로고
    • Condensation of O-phenylene diamine with benzaldehyde
    • Marcinkowska H, Weil S. Condensation of O-phenylene diamine with benzaldehyde. Roczniki Chemii 14, 1312-1319 (1934).
    • (1934) Roczniki Chemii , vol.14 , pp. 1312-1319
    • Marcinkowska, H.1    Weil, S.2
  • 7
    • 0015377787 scopus 로고
    • Tomaymycin, a new antibiotic I. Isolation and properties of tomaymycin
    • Arima K, Kohsaka M, Tamura G, Imanaka H, Sakai H. Tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin. J. Antibiot. 25, 437-444 (1972).
    • (1972) J. Antibiot. , vol.25 , pp. 437-444
    • Arima, K.1    Kohsaka, M.2    Tamura, G.3    Imanaka, H.4    Sakai, H.5
  • 8
    • 67650675111 scopus 로고    scopus 로고
    • Impact of natural products on developing new anti-cancer agents
    • Cragg GM, Grothaus PG, Newman DJ. Impact of natural products on developing new anti-cancer agents. Chem. Revs. 109, 3012-3043 (2009).
    • (2009) Chem. Revs , vol.109 , pp. 3012-3043
    • Cragg, G.M.1    Grothaus, P.G.2    Newman, D.J.3
  • 9
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: An old process or the new hope for drug discovery
    • Newman DJ. Natural products as leads to potential drugs: an old process or the new hope for drug discovery. J. Med. Chem. 51, 2589-2599 (2008).
    • (2008) J. Med. Chem , vol.51 , pp. 2589-2599
    • Newman, D.J.1
  • 10
    • 64549150542 scopus 로고    scopus 로고
    • Triggering cryptic natural product biosynthesis in microorganisms
    • Scherlach K, Hertweck C. Triggering cryptic natural product biosynthesis in microorganisms. Org. Biomol. Chem. 7, 1753-1760 (2009).
    • (2009) Org. Biomol. Chem , vol.7 , pp. 1753-1760
    • Scherlach, K.1    Hertweck, C.2
  • 11
    • 69249202590 scopus 로고    scopus 로고
    • The biosynthetic logic of polyketide diversity
    • Hertweck C. The biosynthetic logic of polyketide diversity. Angew. Chem. Int. Ed. 48, 4688-4716 (2009).
    • (2009) Angew. Chem. Int. Ed , vol.48 , pp. 4688-4716
    • Hertweck, C.1
  • 12
    • 72849166867 scopus 로고
    • The structure of cephalosporin C
    • Abraham EP, Newton GGF. The structure of cephalosporin C. Biochem. J. 79, 377-393 (1961).
    • (1961) Biochem. J , vol.79 , pp. 377-393
    • Abraham, E.P.1    Newton, G.G.F.2
  • 13
    • 0017305032 scopus 로고
    • Nocardicin A and B, monocyclic b-lactam antibiotics from a Nocardia species
    • Hashimoto M, Komori T, Kamiya T. Nocardicin A and B, monocyclic b-lactam antibiotics from a Nocardia species. J. Am. Chem. Soc. 98, 3023-3025 (1976).
    • (1976) J. Am. Chem. Soc , vol.98 , pp. 3023-3025
    • Hashimoto, M.1    Komori, T.2    Kamiya, T.3
  • 14
    • 0032510318 scopus 로고    scopus 로고
    • Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4- fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4- hydroxyphenyl)-2-azetidinone (SCH 58235): A designed, potent, orally active inhibitor of cholesterol absorption
    • Rosenblum SB, Huynh T, Afonso A et al. Discovery of 1-(4-fluorophenyl)- (3R)-[3-(4- fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4- hydroxyphenyl)-2- azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption. J. Med. Chem. 41, 973-980 (1998).
    • (1998) J. Med. Chem , vol.41 , pp. 973-980
    • Rosenblum, S.B.1    Huynh, T.2    Afonso, A.3
  • 15
    • 0027749399 scopus 로고
    • A novel asymmetric synthesis of cis-3-hydroxy-4-arylazetidin-2- ones
    • Holton RA, Liu JH. A novel asymmetric synthesis of cis-3-hydroxy-4- arylazetidin-2- ones. Bioorg. Med. Chem. Lett. 3 2475-2478 (1993).
    • (1993) Bioorg. Med. Chem. Lett , vol.3 , pp. 2475-2478
    • Holton, R.A.1    Liu, J.H.2
  • 16
    • 0034973583 scopus 로고    scopus 로고
    • Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance
    • Chopra I, Roberts M. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol. Mol. Biol. Rev. 65, 232-260 (2001).
    • (2001) Microbiol. Mol. Biol. Rev , vol.65 , pp. 232-260
    • Chopra, I.1    Roberts, M.2
  • 17
    • 0036206050 scopus 로고    scopus 로고
    • Development, validation, and application of PCR primers for detection of tetracycline efflux genes of Gram-negative bacteria
    • Aminov RI, Chee-Sanford JC, Garrigues N et al. Development, validation, and application of PCR primers for detection of tetracycline efflux genes of Gram-negative bacteria. Appl. Environ. Microbiol. 68, 1786-1793 (2002).
    • (2002) Appl. Environ. Microbiol , vol.68 , pp. 1786-1793
    • Aminov, R.I.1    Chee-Sanford, J.C.2    Garrigues, N.3
  • 19
    • 54549112250 scopus 로고    scopus 로고
    • Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: A systematic review of the evidence from microbiological and clinical studies
    • Kelesidis T, Karageorgopoulos DE, Kelesidis I, Falagas ME. Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies. J. Antimicrob. Chemother. 62, 895-904 (2008).
    • (2008) J. Antimicrob. Chemother , vol.62 , pp. 895-904
    • Kelesidis, T.1    Karageorgopoulos, D.E.2    Kelesidis, I.3    Falagas, M.E.4
  • 20
    • 40049106190 scopus 로고    scopus 로고
    • Tigecycline for the treatment of patients with severe sepsis or septic shock: A drug use evaluation in a surgical intensive care unit
    • Swoboda S, Ober M, Hainer C et al. Tigecycline for the treatment of patients with severe sepsis or septic shock: a drug use evaluation in a surgical intensive care unit. J. Antimicrob. Chemother. 61, 729-733 (2008).
    • (2008) J. Antimicrob. Chemother , vol.61 , pp. 729-733
    • Swoboda, S.1    Ober, M.2    Hainer, C.3
  • 22
    • 30744446209 scopus 로고    scopus 로고
    • Total synthesis of selected bioactive natural products: Illustration of strategy and design
    • Tatsuta K, Hosokawa S. Total synthesis of selected bioactive natural products: illustration of strategy and design. Chem. Revs. 105, 4707-4729 (2005).
    • (2005) Chem. Revs , vol.105 , pp. 4707-4729
    • Tatsuta, K.1    Hosokawa, S.2
  • 24
    • 58249107405 scopus 로고    scopus 로고
    • A robust platform for the synthesis of new tetracycline antibiotics
    • Sun C, Wang Q, Brubaker JD et al. A robust platform for the synthesis of new tetracycline antibiotics. J. Am. Chem. Soc. 130, 17913-17927 (2008).
    • (2008) J. Am. Chem. Soc , vol.130 , pp. 17913-17927
    • Sun, C.1    Wang, Q.2    Brubaker, J.D.3
  • 25
    • 28144441826 scopus 로고    scopus 로고
    • The bacterial ribosome as a target for antibiotics
    • Poehlsgaard J, Douthwaite S. The bacterial ribosome as a target for antibiotics. Nat. Rev. Microbiol. 3, 870-881 (2005).
    • (2005) Nat. Rev. Microbiol , vol.3 , pp. 870-881
    • Poehlsgaard, J.1    Douthwaite, S.2
  • 26
    • 0037334850 scopus 로고    scopus 로고
    • Structural basis for the antibiotic activity of ketolides and azalides
    • Schlünzen F, Harms J, Franceschi F et al. Structural basis for the antibiotic activity of ketolides and azalides. Structure 11, 329-338 (2003).
    • (2003) Structure , vol.11 , pp. 329-338
    • Schlünzen, F.1    Harms, J.2    Franceschi, F.3
  • 27
    • 10044284273 scopus 로고    scopus 로고
    • Synthesis of novel 6,11-O-bridged bicyclic ketolides via a palladium-catalyzed bis-allylation
    • Wang G, Niu D, Qiu YL et al. Synthesis of novel 6,11-O-bridged bicyclic ketolides via a palladium-catalyzed bis-allylation. Org. Lett. 6, 4455-4458 (2004).
    • (2004) Org. Lett , vol.6 , pp. 4455-4458
    • Wang, G.1    Niu, D.2    Qiu, Y.L.3
  • 28
    • 11244307407 scopus 로고    scopus 로고
    • Binding site of the bridged macrolides in the Escherichia coli ribosome
    • Xiong L, Korkhin Y, Mankin AS. Binding site of the bridged macrolides in the Escherichia coli ribosome. Antimicrob. Agents Chemother. 49, 281-288 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 281-288
    • Xiong, L.1    Korkhin, Y.2    Mankin, A.S.3
  • 29
    • 34248384306 scopus 로고    scopus 로고
    • EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium
    • Bermudez LE, Motamedi N, Chee C et al. EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. Antimicrob. Agents Chemother. 51, 1666-1670 (2007).
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 1666-1670
    • Bermudez, L.E.1    Motamedi, N.2    Chee, C.3
  • 30
    • 55249099741 scopus 로고    scopus 로고
    • Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs
    • Lewis CA, Merkel J, Miller SJ. Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs. Bioorg. Med. Chem. Lett. 18, 6007-6011 (2008).
    • (2008) Bioorg. Med. Chem. Lett , vol.18 , pp. 6007-6011
    • Lewis, C.A.1    Merkel, J.2    Miller, S.J.3
  • 31
    • 78651002523 scopus 로고
    • Aureomycin; A product of the continuing search for new antibiotics
    • Duggar BM. Aureomycin; a product of the continuing search for new antibiotics. Ann. NY Acad. Sci. 51, 177-181 (1948).
    • (1948) Ann. NY Acad. Sci , vol.51 , pp. 177-181
    • Duggar, B.M.1
  • 32
    • 60849089895 scopus 로고    scopus 로고
    • Decoding and engineering tetracycline biosynthesis
    • Pickens LB, Tang Y. Decoding and engineering tetracycline biosynthesis. Metab. Eng. 11, 69-75 (2009).
    • (2009) Metab. Eng , vol.11 , pp. 69-75
    • Pickens, L.B.1    Tang, Y.2
  • 33
    • 33947449827 scopus 로고
    • The isolation of a new thymine pentoside from sponges
    • Bergmann W, Feeney RJ. The isolation of a new thymine pentoside from sponges. J. Am. Chem. Soc. 72, 2809-2810 (1950).
    • (1950) J. Am. Chem. Soc , vol.72 , pp. 2809-2810
    • Bergmann, W.1    Feeney, R.J.2
  • 34
    • 0000719402 scopus 로고
    • Contributions to the study of marine products. XXXII. The nucleosides of sponges i
    • Bergmann W, Feeney RJ. Contributions to the study of marine products. XXXII. The nucleosides of sponges I. J. Org. Chem. 16, 981-987 (1951).
    • (1951) J. Org. Chem , vol.16 , pp. 981-987
    • Bergmann, W.1    Feeney, R.J.2
  • 35
    • 0000833362 scopus 로고
    • Contributions to the study of marine products. XL. The nucleosides of sponges. IV. Spongosine
    • Bergmann W, Burke DC. Contributions to the study of marine products. XL. The nucleosides of sponges. IV. Spongosine. J. Org. Chem. 21, 226-228 (1956).
    • (1956) J. Org. Chem , vol.21 , pp. 226-228
    • Bergmann, W.1    Burke, D.C.2
  • 36
    • 0026361983 scopus 로고
    • Chemical approaches to the discovery of new drugs
    • Suckling CJ. Chemical approaches to the discovery of new drugs. Sci. Prog. 75, 323-359 (1991).
    • (1991) Sci. Prog , vol.75 , pp. 323-359
    • Suckling, C.J.1
  • 37
    • 0001211744 scopus 로고
    • Potential anticancer agents. XL. Synthesis of the earlier-anomer of 9-(d-arabinofuranosyl) adenine
    • Lee WW, Benitez A, Goodman L, Baker BR. Potential anticancer agents. XL. Synthesis of the earlier-anomer of 9-(d-arabinofuranosyl) adenine. J. Am. Chem. Soc. 82, 2648-2649 (1960).
    • (1960) J. Am. Chem. Soc , vol.82 , pp. 2648-2649
    • Lee, W.W.1    Benitez, A.2    Goodman, L.3    Baker, B.R.4
  • 38
    • 0021261895 scopus 로고
    • Antiviral agents from a gorgonian, Eunicella cavolini
    • Cimino G, de Rosa S, de Stefano S. Antiviral agents from a gorgonian, Eunicella cavolini. Experientia 40, 339-340 (1984).
    • (1984) Experientia , vol.40 , pp. 339-340
    • Cimino, G.1    De Rosa, S.2    De Stefano, S.3
  • 39
    • 53549101905 scopus 로고    scopus 로고
    • A gift from nature: The birth of the statins
    • Endo A. A gift from nature: the birth of the statins. Nat. Med. 14, 1050-1052 (2008).
    • (2008) Nat. Med , vol.14 , pp. 1050-1052
    • Endo, A.1
  • 40
    • 0021999958 scopus 로고
    • Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase
    • Endo A. Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase. J. Med. Chem. 28, 401-405 (1975).
    • (1975) J. Med. Chem , vol.28 , pp. 401-405
    • Endo, A.1
  • 41
    • 0017043554 scopus 로고
    • Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity
    • Endo A, Kuroda M, Tanzawa K. Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. FEBS Lett. 72, 323-326 (1976).
    • (1976) FEBS Lett , vol.72 , pp. 323-326
    • Endo, A.1    Kuroda, M.2    Tanzawa, K.3
  • 42
    • 0017055252 scopus 로고
    • ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinum
    • Endo A, Kuroda M, Tsujita Y. ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J. Antibiot. 29, 1346-1348 (1976).
    • (1976) J. Antibiot , vol.29 , pp. 1346-1348
    • Endo, A.1    Kuroda, M.2    Tsujita, Y.3
  • 43
    • 0016913421 scopus 로고
    • Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum
    • Brown AG, Smale TC, King TJ, Hasenkamp R, Thompson RH. Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum. J. Chem. Soc. Perkin Trans. 1, 1165-1170 (1976).
    • (1976) J. Chem. Soc. Perkin Trans , vol.1 , pp. 1165-1170
    • Brown, A.G.1    Smale, T.C.2    King, T.J.3    Hasenkamp, R.4    Thompson, R.H.5
  • 44
    • 33746042622 scopus 로고    scopus 로고
    • An interpretive history of the cholesterol controversy V. The discovery of the statins and the end of the controversy
    • Steinberg D. An interpretive history of the cholesterol controversy. V. The discovery of the statins and the end of the controversy. J. Lipid Res. 47, 1339-1351 (2006).
    • (2006) J. Lipid Res. , vol.47 , pp. 1339-1351
    • Steinberg, D.1
  • 45
    • 0018592266 scopus 로고
    • A new hypocholesterolemic agent
    • Endo A. Monacolin K. A new hypocholesterolemic agent. J. Antibiot. 32, 852-854 (1979).
    • (1979) J. Antibiot , vol.32 , pp. 852-854
    • Endo, A.1    Monacolin, K.2
  • 46
    • 0019195217 scopus 로고
    • A new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase
    • Endo A. Monacolin K. A new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. J. Antibiot. 33, 334-336 (1980).
    • (1980) J. Antibiot , vol.33 , pp. 334-336
    • Endo, A.1    Monacolin, K.2
  • 47
    • 0026328896 scopus 로고
    • Are prescription drug prices too high?
    • Vagelos RP. Are prescription drug prices too high? Science 252, 1080-1084 (1991).
    • (1991) Science , vol.252 , pp. 1080-1084
    • Vagelos, R.P.1
  • 48
    • 0021997673 scopus 로고
    • 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives
    • Stokker GE, Hoffman WF, Alberts AA et al. 3-hydroxy-3-methylglutaryl- coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives. J. Med. Chem. 28, 347-358 (1985).
    • (1985) J. Med. Chem. , vol.28 , pp. 347-358
    • Stokker, G.E.1    Hoffman, W.F.2    Alberts, A.A.3
  • 49
    • 0022643559 scopus 로고
    • 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors 2. Structural modification of 7-(substituted aryl)-3,5- dihydroxy-6-heptenoic acids and their lactone derivatives
    • Hoffman WF, Alberts AA, Cragoe Jr EJ et al. 3-hydroxy-3-methylglutaryl- coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5- dihydroxy-6-heptenoic acids and their lactone derivatives. J. Med. Chem. 29, 159-169 (1986).
    • (1986) J. Med. Chem. , vol.29 , pp. 159-169
    • Hoffman, W.F.1    Alberts, A.A.2    Cragoe Jr., E.J.3
  • 50
    • 0022648502 scopus 로고
    • 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors 3. 7-3,5-disubstituted [1,1́-biphenyl]-2-yl)-3,5-dihydroxy-6- heptenoic acids and their lactone derivatives
    • Stokker GE, Alberts AA, Anderson PS et al. 3-hydroxy-3-methylglutaryl- coenzyme A reductase inhibitors. 3. 7-(3,5-disubstituted [1,1́-biphenyl]- 2-yl)-3,5-dihydroxy-6- heptenoic acids and their lactone derivatives. J. Med. Chem. 29, 170-181 (1986).
    • (1986) J. Med. Chem , vol.29 , pp. 170-181
    • Stokker, G.E.1    Alberts, A.A.2    Anderson, P.S.3
  • 51
    • 0025174155 scopus 로고
    • Inhibitors of cholesterol biosynthesisi 1. trans-6-(2-pyrrol-1-ylethyl)- 4-hydroxypyran-2- ones, a novel series of HMG-CoA reductase inhibitors 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus
    • Roth BD, Ortwine DF, Hoefle ML et al. Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2- ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus. J. Med. Chem. 33, 21-31 (1990).
    • (1990) J. Med. Chem. , vol.33 , pp. 21-31
    • Roth, B.D.1    Ortwine, D.F.2    Hoefle, M.L.3
  • 52
    • 0025122258 scopus 로고
    • Inhibitors of cholesterol biosynthesis 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy- 2-oxopyran-6-yl)ethyl]pyrazoles
    • Sliskovic DR, Roth BD, Wilson MW, Hoefle ML, Newton RS. Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy- 2-oxopyran-6-yl)ethyl]pyrazoles. J. Med. Chem. 33, 31-38 (1990).
    • (1990) J. Med. Chem. , vol.33 , pp. 31-38
    • Sliskovic, D.R.1    Roth, B.D.2    Wilson, M.W.3    Hoefle, M.L.4    Newton, R.S.5
  • 53
    • 0023038220 scopus 로고
    • The synthesis of mevinic acids
    • Rosen T, Heathcock CH. The synthesis of mevinic acids. Tetrahedron 42, 4909-4951 (1986).
    • (1986) Tetrahedron , vol.42 , pp. 4909-4951
    • Rosen, T.1    Heathcock, C.H.2
  • 54
    • 0036986060 scopus 로고    scopus 로고
    • The discovery and development of atorvastatin, a potent hypolipidemic agent
    • Roth BD. The discovery and development of atorvastatin, a potent hypolipidemic agent. Prog. Med. Chem. 40, 1-22 (2002).
    • (2002) Prog. Med. Chem , vol.40 , pp. 1-22
    • Roth, B.D.1
  • 55
    • 42949151357 scopus 로고    scopus 로고
    • (3R5SE) -7-(4-(4-fluorophenyl)-6-isopropyl- 2-(methyl(1-methyl-1h-1, 2,4-triazol-5-yl) amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6- enoic acid (BMS-644950): A rationally designed orally efficacious 3-hydroxy-3- methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential
    • Ahmad S, Madsen CS, Stein PD et al. (3R,5S,E)-7-(4-(4-fluorophenyl)-6- isopropyl- 2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl) amino)pyrimidin-5-yl)-3,5- dihydroxyhept-6- enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3- methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential. J. Med. Chem. 51, 2722-2733 (2008).
    • (2008) J. Med. Chem. , vol.51 , pp. 2722-2733
    • Ahmad, S.1    Madsen, C.S.2    Stein, P.D.3
  • 56
    • 0016713286 scopus 로고
    • Rapamycin (AY-22, 989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
    • Sehgal SN, Baker H, Vezina C. Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J. Antibiot. 28, 727-732 (1975).
    • (1975) J. Antibiot. , vol.28 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 57
    • 0018101547 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. III in vitro and in vivo evaluation
    • Baker H, Sidorowicz A, Sehgal SN, Vezina C. Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. J. Antibiot. 31, 539-545 (1978).
    • (1978) J. Antibiot , vol.31 , pp. 539-545
    • Baker, H.1    Sidorowicz, A.2    Sehgal, S.N.3    Vezina, C.4
  • 58
    • 0021164348 scopus 로고
    • Activity of rapamycin (AY-22, 989) against transplanted tumors
    • Eng CP, Sehgal SN, Vezina C. Activity of rapamycin (AY-22,989) against transplanted tumors. J. Antibiot. 37, 1231-1237 (1984).
    • (1984) J. Antibiot. , vol.37 , pp. 1231-1237
    • Eng, C.P.1    Sehgal, S.N.2    Vezina, C.3
  • 59
    • 33751226567 scopus 로고    scopus 로고
    • Therapeutic potential of natural product signal transduction agents
    • Koehn FE. Therapeutic potential of natural product signal transduction agents. Curr. Opin. Biotech. 17, 631-637 (2006).
    • (2006) Curr. Opin. Biotech , vol.17 , pp. 631-637
    • Koehn, F.E.1
  • 60
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • Tsang CK, Qi H, Liu LF, Zheng XFS. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov. Today 12, 112-124 (2007).
    • (2007) Drug Discov. Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.S.4
  • 61
    • 66149164593 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors and their potential role in leukaemia and other haematological malignancies
    • Teachey DT, Grupp SA, Brown VI. Mammalian target of rapamycin inhibitors and their potential role in leukaemia and other haematological malignancies. Brit. J. Haematol. 145, 569-580 (2009)
    • (2009) Brit. J. Haematol , vol.145 , pp. 569-580
    • Teachey, D.T.1    Grupp, S.A.2    Brown, V.I.3
  • 62
    • 65949113601 scopus 로고    scopus 로고
    • Targeting mTor with rapamycin: One dose does not fit all
    • Foster DA, Toschi A. Targeting mTor with rapamycin: one dose does not fit all. Cell Cycle 8, 1026-1029 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 1026-1029
    • Foster, D.A.1    Toschi, A.2
  • 63
    • 47749105733 scopus 로고    scopus 로고
    • Protein-proten interaction detection in vitro and in cells by proximity biotinylation
    • Fernandez-Suarez M, Chen TS, Ting AY. Protein-proten interaction detection in vitro and in cells by proximity biotinylation. J. Am. Chem. Soc. 130, 9251-9253 (2008).
    • (2008) J. Am. Chem. Soc , vol.130 , pp. 9251-9253
    • Fernandez-Suarez, M.1    Chen, T.S.2    Ting, A.Y.3
  • 64
    • 38349090475 scopus 로고    scopus 로고
    • Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
    • Ruan B, Pong K, Jow F et al. Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc. Natl Acad. Sci. USA 105, 33-38 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 33-38
    • Ruan, B.1    Pong, K.2    Jow, F.3
  • 65
    • 59449103521 scopus 로고    scopus 로고
    • Discovery of innovative small molecule therapeutics
    • Abou-Gharbia M. Discovery of innovative small molecule therapeutics. J. Med. Chem. 52, 2-9 (2009).
    • (2009) J. Med. Chem , vol.52 , pp. 2-9
    • Abou-Gharbia, M.1
  • 66
    • 65349190615 scopus 로고    scopus 로고
    • Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs
    • Graziani EI. Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs. Nat. Prod. Rep. 26, 602-609 (2009).
    • (2009) Nat. Prod. Rep , vol.26 , pp. 602-609
    • Graziani, E.I.1
  • 67
    • 34548485298 scopus 로고    scopus 로고
    • The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation
    • Chambraud B, Belabes H, Fontaine-Lenoir V, Fellous A, Baulieu EE. The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation. Faseb J. 21, 2787-2797 (2007).
    • (2007) Faseb J , vol.21 , pp. 2787-2797
    • Chambraud, B.1    Belabes, H.2    Fontaine-Lenoir, V.3    Fellous, A.4    Baulieu, E.E.5
  • 68
    • 84937419962 scopus 로고    scopus 로고
    • Epothilone, a myxobacterial metabolite with promising antitumor activity
    • Cragg GM, Kingston DGI, Newman DJ (Eds),Taylor and Francis, Oxford, UK
    • Hoefle G, Reichenbach H. Epothilone, a myxobacterial metabolite with promising antitumor activity. In: Anticancer Agents from Natural Products. Cragg GM, Kingston DGI, Newman DJ (Eds). Taylor and Francis, Oxford, UK 413-450 (2005).
    • (2005) Anticancer Agents from Natural Products , pp. 413-450
    • Hoefle, G.1    Reichenbach, H.2
  • 69
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubulestabilizing agents with a taxol-like mechanism of action
    • Bollag DM, McQueney PA, Zhu J et al. Epothilones, a new class of microtubulestabilizing agents with a taxol-like mechanism of action. Cancer Res. 55, 2325-2333 (1995).
    • (1995) Cancer Res , vol.55 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3
  • 70
    • 12944277104 scopus 로고    scopus 로고
    • A common pharmacophore for epothilones and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
    • Giannakakou R, Gussio R, Nogales E et al. A common pharmacophore for epothilones and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proc. Natl Acad. Sci. USA 97, 2904-2909 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 2904-2909
    • Giannakakou, R.1    Gussio, R.2    Nogales, E.3
  • 71
    • 0034636084 scopus 로고    scopus 로고
    • A common pharmacophore or taxol and the epothilones based on the biological activity of a taxane molecule lacking C-13 side chain
    • He LF, Jagtap PJ, Kingston DGI, Shen HJ, Orr GA, Horwitz SB. A common pharmacophore or taxol and the epothilones based on the biological activity of a taxane molecule lacking C-13 side chain. Biochemistry 39, 3972-3978 (2000).
    • (2000) Biochemistry , vol.39 , pp. 3972-3978
    • He, L.F.1    Jagtap, P.J.2    Kingston, D.G.I.3    Shen, H.J.4    Orr, G.A.5    Horwitz, S.B.6
  • 72
    • 33845486692 scopus 로고    scopus 로고
    • Total synthesis and antitumor activity of ZK-EPO: The first fully synthetic epothilone in clinical development
    • Klar U, Buchmann B, Schwede W, Skuballa W, Hoffmann J, Lichtner RB. Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development. Angew. Chem. Int. Ed. 45, 7942-7948 (2006).
    • (2006) Angew. Chem. Int. Ed , vol.45 , pp. 7942-7948
    • Klar, U.1    Buchmann, B.2    Schwede, W.3    Skuballa, W.4    Hoffmann, J.5    Lichtner, R.B.6
  • 73
    • 33947717002 scopus 로고    scopus 로고
    • Anticancer drugs from nature-natural products as a unique source of new microtubule-stabilizing agents
    • Altmann KH, Gertsch J. Anticancer drugs from nature-natural products as a unique source of new microtubule-stabilizing agents. Nat. Prod. Rep. 24, 327-357 (2007).
    • (2007) Nat. Prod. Rep , vol.24 , pp. 327-357
    • Altmann, K.H.1    Gertsch, J.2
  • 75
    • 38949121627 scopus 로고    scopus 로고
    • Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization
    • Feyen F, Cachoux F, Gertsch J, Wartmann M, Altmann K-H. Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization. Acc. Chem. Res. 41, 21-31 (2008).
    • (2008) Acc. Chem. Res , vol.41 , pp. 21-31
    • Feyen, F.1    Cachoux, F.2    Gertsch, J.3    Wartmann, M.4    Altmann, K.-H.5
  • 76
    • 42949142153 scopus 로고    scopus 로고
    • Epothilones as lead structures for new anticancer drugs - Pharmacology, fermentation, and structure - Activity relationships
    • Altmann KH, Memmert K. Epothilones as lead structures for new anticancer drugs - pharmacology, fermentation, and structure - activity relationships. Prog. Drug Res. 66, 275-334 (2006).
    • (2006) Prog. Drug Res , vol.66 , pp. 275-334
    • Altmann, K.H.1    Memmert, K.2
  • 77
    • 33746581932 scopus 로고    scopus 로고
    • C-15 thiazol-4-yl analogues of (E)-9,10- didehydroepothilone D: Synthesis and cytotoxicity
    • Hearn BR, Zhang D, Li Y, Myles DC. C-15 thiazol-4-yl analogues of (E)-9,10- didehydroepothilone D: synthesis and cytotoxicity. Org. Lett. 8, 3057-3059 (2006).
    • (2006) Org. Lett , vol.8 , pp. 3057-3059
    • Hearn, B.R.1    Zhang, D.2    Li, Y.3    Myles, D.C.4
  • 78
    • 27644559079 scopus 로고    scopus 로고
    • Second-generation epothilones: Discovery of fludelone and its extraordinary antitumor properties
    • Cho YS, Wu KD, Moore MAS, Chou TC, Danishefsky SJ. Second-generation epothilones: discovery of fludelone and its extraordinary antitumor properties. Drugs Fut. 30, 737-745 (2005).
    • (2005) Drugs Fut , vol.30 , pp. 737-745
    • Cho, Y.S.1    Wu, K.D.2    Moore, M.A.S.3    Chou, T.C.4    Danishefsky, S.J.5
  • 79
    • 71249084857 scopus 로고    scopus 로고
    • Iso-oxazole-fludelone (KOS-1803) as a potent and efficacious microtubule-stablization epothilone against xenograft tumors
    • Chou TC, Zhang XG, Dong H et al. Iso-oxazole-fludelone (KOS-1803) as a potent and efficacious microtubule-stablization epothilone against xenograft tumors. Proc. Am. Assoc. Cancer Res. 1402 (2008).
    • (2008) Proc. Am. Assoc. Cancer Res , pp. 1402
    • Chou, T.C.1    Zhang, X.G.2    Dong, H.3
  • 80
    • 51349140042 scopus 로고    scopus 로고
    • Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones
    • Chou TC, Zhang X, Zhong Z et al. Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones. Proc. Natl Acad. Sci. USA 105, 13157-13162 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 13157-13162
    • Chou, T.C.1    Zhang, X.2    Zhong, Z.3
  • 81
    • 57349100779 scopus 로고    scopus 로고
    • Folate-targeted drug strategies for the treatment of cancer
    • Leamon CP. Folate-targeted drug strategies for the treatment of cancer. Curr. Opin. Investig. Drugs 9, 1277-1286 (2008).
    • (2008) Curr. Opin. Investig. Drugs , vol.9 , pp. 1277-1286
    • Leamon, C.P.1
  • 82
    • 38149003837 scopus 로고    scopus 로고
    • Neue wirkstoffe aus myxobakterien: Wie mikroorganismen den krebs bekämpfen helfen
    • Frank B, Müller R. Neue wirkstoffe aus myxobakterien: wie mikroorganismen den krebs bekämpfen helfen. Pharmaz. Zeit. 152, 64-67 (2007).
    • (2007) Pharmaz. Zeit , vol.152 , pp. 64-67
    • Frank, B.1    Müller, R.2
  • 83
    • 35948983363 scopus 로고    scopus 로고
    • Complete genome sequence of the myxobacterium Sorangium cellulosum
    • Schneiker S, Perlova O, Kaiser O et al. Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat. Biotech. 25, 1281-1289 (2007).
    • (2007) Nat. Biotech , vol.25 , pp. 1281-1289
    • Schneiker, S.1    Perlova, O.2    Kaiser, O.3
  • 84
    • 36348982083 scopus 로고    scopus 로고
    • Myxobacterial natural product assembly lines: Fascinating examples of curious biochemistry
    • Wenzel SC, Müller R. Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry. Nat. Prod. Rep. 24, 1211-1224 (2007).
    • (2007) Nat. Prod. Rep , vol.24 , pp. 1211-1224
    • Wenzel, S.C.1    Müller, R.2
  • 85
    • 23744472955 scopus 로고    scopus 로고
    • Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissolute
    • Schimer A, Gadkari R, Reeves CD, Ibrahim F, de Long EF, Hutchinson CR. Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta. Appl. Environ. Microbiol. 71, 4840-4849 (2005).
    • (2005) Appl. Environ. Microbiol , vol.71 , pp. 4840-4849
    • Schimer, A.1    Gadkari, R.2    Reeves, C.D.3    Ibrahim, F.4    De Long, E.F.5    Hutchinson, C.R.6
  • 86
    • 67651183637 scopus 로고    scopus 로고
    • Cultivation-independent approach to investigate the chemistry of marine symbiotic bacteria
    • Uria A, Piel J. Cultivation-independent approach to investigate the chemistry of marine symbiotic bacteria. Phytochem. Revs. 2009, 401-414 (2009).
    • (2009) Phytochem. Revs. , pp. 401-414
    • Uria, A.1    Piel, J.2
  • 87
    • 70349923903 scopus 로고    scopus 로고
    • An environmental DNA-derived type II polyketide biosynthetic pathway encodes the biosynthesis of the pentacyclic polyketide erdacin
    • King RW, Bauer, JD, Brady SF. An environmental DNA-derived type II polyketide biosynthetic pathway encodes the biosynthesis of the pentacyclic polyketide erdacin. Angew. Chem. Int. Ed. 48, 6257-6261 (2009).
    • (2009) Angew. Chem. Int. Ed , vol.48 , pp. 6257-6261
    • King, R.W.1    Bauer, J.D.2    Brady, S.F.3
  • 88
    • 61449113023 scopus 로고    scopus 로고
    • Metabolites from symbiotic bacteria
    • Piel J. Metabolites from symbiotic bacteria. Nat. Prod. Rep. 26, 338-362 (2009).
    • (2009) Nat. Prod. Rep , vol.26 , pp. 338-362
    • Piel, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.