메뉴 건너뛰기




Volumn 21, Issue 6, 2015, Pages 433-442

Targeting the mammalian target of rapamycin pathway with everolimus: Implications for the management of metastatic breast cancer

Author keywords

everolimus; Mammalian target of rapamycin inhibitor; management of adverse events; metastatic breast cancer; supportive care

Indexed keywords

EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; ANTINEOPLASTIC AGENT; IMMUNOSUPPRESSIVE AGENT; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

EID: 84930360359     PISSN: 10781552     EISSN: 1477092X     Source Type: Journal    
DOI: 10.1177/1078155214540732     Document Type: Review
Times cited : (7)

References (63)
  • 2
    • 70249088410 scopus 로고    scopus 로고
    • A 2009 update on the treatment of patients with hormone receptor-positive breast cancer
    • Cleator SJ, Ahamed E, Coombes RC, et al. A 2009 update on the treatment of patients with hormone receptor-positive breast cancer. Clin Breast Cancer 2009; 9 (Suppl 1): S6-S17.
    • (2009) Clin Breast Cancer , vol.9 , pp. S6-S17
    • Cleator, S.J.1    Ahamed, E.2    Coombes, R.C.3
  • 3
    • 33748573134 scopus 로고    scopus 로고
    • Postmenopausal advanced breast cancer: Options for therapy after tamoxifen and aromatase inhibitors
    • Dodwell D, Wardley A, Johnston S,. Postmenopausal advanced breast cancer: options for therapy after tamoxifen and aromatase inhibitors. Breast 2006; 15 (5): 584-594.
    • (2006) Breast , vol.15 , Issue.5 , pp. 584-594
    • Dodwell, D.1    Wardley, A.2    Johnston, S.3
  • 4
    • 84945317674 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network - Clinical Practice Guidelines in Oncology. Breast Cancer Version 1
    • National Comprehensive Cancer Network - Clinical Practice Guidelines in Oncology. Breast Cancer Version 1. 2014.
    • (2014)
  • 5
    • 77955551055 scopus 로고    scopus 로고
    • American Society of Clinical Oncology clinical practice guideline: Update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer
    • Burstein HJ, Prestrud AA, Seidenfeld J, et al. American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer. J Clin Oncol 2010; 28 (23): 3784-3796.
    • (2010) J Clin Oncol , vol.28 , Issue.23 , pp. 3784-3796
    • Burstein, H.J.1    Prestrud, A.A.2    Seidenfeld, J.3
  • 6
    • 11244296162 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance
    • Ring A, Dowsett M,. Mechanisms of tamoxifen resistance. Endocr Relat Cancer 2004; 11 (4): 643-658.
    • (2004) Endocr Relat Cancer , vol.11 , Issue.4 , pp. 643-658
    • Ring, A.1    Dowsett, M.2
  • 7
    • 33744823312 scopus 로고    scopus 로고
    • Exemestane in metastatic breast cancer: Effective therapy after third-generation non-steroidal aromatase inhibitor failure
    • Steele N, Zekri J, Coleman R, et al. Exemestane in metastatic breast cancer: effective therapy after third-generation non-steroidal aromatase inhibitor failure. Breast 2006; 15 (3): 430-436.
    • (2006) Breast , vol.15 , Issue.3 , pp. 430-436
    • Steele, N.1    Zekri, J.2    Coleman, R.3
  • 8
    • 9644294233 scopus 로고    scopus 로고
    • Response to fulvestrant in heavily pretreated postmenopausal women: A single-center experience
    • Franco S, Perez A, Tan-Chiu E, et al. Response to fulvestrant in heavily pretreated postmenopausal women: a single-center experience. Breast Cancer Res Treat 2004; 88 (2): 103-108.
    • (2004) Breast Cancer Res Treat , vol.88 , Issue.2 , pp. 103-108
    • Franco, S.1    Perez, A.2    Tan-Chiu, E.3
  • 9
    • 17444453765 scopus 로고    scopus 로고
    • Efficacy of tamoxifen following anastrozole ('Arimidex') compared with anastrozole following tamoxifen as first-line treatment for advanced breast cancer in postmenopausal women
    • Thurlimann B, Robertson JF, Nabholtz JM, et al. Efficacy of tamoxifen following anastrozole ('Arimidex') compared with anastrozole following tamoxifen as first-line treatment for advanced breast cancer in postmenopausal women. Eur J Cancer 2003; 39 (16): 2310-2317.
    • (2003) Eur J Cancer , vol.39 , Issue.16 , pp. 2310-2317
    • Thurlimann, B.1    Robertson, J.F.2    Nabholtz, J.M.3
  • 10
    • 84883050535 scopus 로고    scopus 로고
    • Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): A composite, multicentre, phase 3 randomised trial
    • Johnston SR, Kilburn LS, Ellis P, et al. Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): a composite, multicentre, phase 3 randomised trial. Lancet Oncol 2013; 14 (10): 989-998.
    • (2013) Lancet Oncol , vol.14 , Issue.10 , pp. 989-998
    • Johnston, S.R.1    Kilburn, L.S.2    Ellis, P.3
  • 11
    • 80053426842 scopus 로고    scopus 로고
    • Targeted therapies for breast cancer
    • Higgins MJ, Baselga J,. Targeted therapies for breast cancer. J Clin Investig 2011; 121 (10): 3797-3803.
    • (2011) J Clin Investig , vol.121 , Issue.10 , pp. 3797-3803
    • Higgins, M.J.1    Baselga, J.2
  • 12
    • 84868237217 scopus 로고    scopus 로고
    • Mammalian target of rapamycin as a rational therapeutic target for breast cancer treatment
    • LoRusso PM,. Mammalian target of rapamycin as a rational therapeutic target for breast cancer treatment. Oncology 2013; 84 (1): 43-56.
    • (2013) Oncology , vol.84 , Issue.1 , pp. 43-56
    • LoRusso, P.M.1
  • 13
    • 84879404978 scopus 로고    scopus 로고
    • The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancer
    • Lauring J, Park BH, Wolff AC,. The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancer. JNCCN 2013; 11 (6): 670-678.
    • (2013) JNCCN , vol.11 , Issue.6 , pp. 670-678
    • Lauring, J.1    Park, B.H.2    Wolff, A.C.3
  • 14
    • 84861576201 scopus 로고    scopus 로고
    • The landscape of cancer genes and mutational processes in breast cancer
    • Stephens PJ, Tarpey PS, Davies H, et al. The landscape of cancer genes and mutational processes in breast cancer. Nature 2012; 486 (7403): 400-404.
    • (2012) Nature , vol.486 , Issue.7403 , pp. 400-404
    • Stephens, P.J.1    Tarpey, P.S.2    Davies, H.3
  • 15
    • 43249086546 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
    • O'Donnell A, Faivre S, Burris HA 3rd, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J Clin Oncol 2008; 26 (10): 1588-1595.
    • (2008) J Clin Oncol , vol.26 , Issue.10 , pp. 1588-1595
    • O'Donnell, A.1    Faivre, S.2    Burris, H.A.3
  • 16
    • 34547130295 scopus 로고    scopus 로고
    • RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model
    • Mabuchi S, Altomare DA, Cheung M, et al. RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model. Clin Cancer Res 2007; 13 (14): 4261-4270.
    • (2007) Clin Cancer Res , vol.13 , Issue.14 , pp. 4261-4270
    • Mabuchi, S.1    Altomare, D.A.2    Cheung, M.3
  • 17
    • 63449098382 scopus 로고    scopus 로고
    • MTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor
    • Lane HA, Wood JM, McSheehy PM, et al. mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin Cancer Res 2009; 15 (5): 1612-1622.
    • (2009) Clin Cancer Res , vol.15 , Issue.5 , pp. 1612-1622
    • Lane, H.A.1    Wood, J.M.2    McSheehy, P.M.3
  • 18
    • 84890545412 scopus 로고    scopus 로고
    • Everolimus: A new hope for patients with breast cancer
    • Sendur MA, Zengin N, Aksoy S, et al. Everolimus: a new hope for patients with breast cancer. Curr Med Res Opin 2014; 30 (1): 75-87.
    • (2014) Curr Med Res Opin , vol.30 , Issue.1 , pp. 75-87
    • Sendur, M.A.1    Zengin, N.2    Aksoy, S.3
  • 19
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372 (9637): 449-456.
    • (2008) Lancet , vol.372 , Issue.9637 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 20
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • Yao JC, Shah MH, Ito T, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 2011; 364 (6): 514-523.
    • (2011) N Engl J Med , vol.364 , Issue.6 , pp. 514-523
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3
  • 21
    • 84872088946 scopus 로고    scopus 로고
    • Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): A multicentre, randomised, placebo-controlled phase 3 trial
    • Franz DN, Belousova E, Sparagana S, et al. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet 2013; 381 (9861): 125-132.
    • (2013) Lancet , vol.381 , Issue.9861 , pp. 125-132
    • Franz, D.N.1    Belousova, E.2    Sparagana, S.3
  • 22
    • 6944235337 scopus 로고    scopus 로고
    • Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity
    • deGraffenried LA, Friedrichs WE, Russell DH, et al. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity. Clin Cancer Res 2004; 10 (23): 8059-8067.
    • (2004) Clin Cancer Res , vol.10 , Issue.23 , pp. 8059-8067
    • DeGraffenried, L.A.1    Friedrichs, W.E.2    Russell, D.H.3
  • 23
    • 73549115638 scopus 로고    scopus 로고
    • Endocrine resistance associated with activated ERBB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways
    • Ghayad SE, Vendrell JA, Ben Larbi S, et al. Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways. Int J Cancer 2010; 126 (2): 545-562.
    • (2010) Int J Cancer , vol.126 , Issue.2 , pp. 545-562
    • Ghayad, S.E.1    Vendrell, J.A.2    Ben Larbi, S.3
  • 24
    • 22344446415 scopus 로고    scopus 로고
    • Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer
    • Boulay A, Rudloff J, Ye J, et al. Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clin Cancer Res 2005; 11 (14): 5319-5328.
    • (2005) Clin Cancer Res , vol.11 , Issue.14 , pp. 5319-5328
    • Boulay, A.1    Rudloff, J.2    Ye, J.3
  • 25
    • 34548187212 scopus 로고    scopus 로고
    • Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling
    • Beeram M, Tan QT, Tekmal RR, et al. Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling. Ann Oncol 2007; 18 (8): 1323-1328.
    • (2007) Ann Oncol , vol.18 , Issue.8 , pp. 1323-1328
    • Beeram, M.1    Tan, Q.T.2    Tekmal, R.R.3
  • 26
    • 37149020235 scopus 로고    scopus 로고
    • The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: Results of a phase i study with pharmacokinetics
    • Awada A, Cardoso F, Fontaine C, et al. The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: results of a phase I study with pharmacokinetics. Eur J Cancer 2008; 44 (1): 84-91.
    • (2008) Eur J Cancer , vol.44 , Issue.1 , pp. 84-91
    • Awada, A.1    Cardoso, F.2    Fontaine, C.3
  • 27
    • 66849136781 scopus 로고    scopus 로고
    • Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    • Baselga J, Semiglazov V, van Dam P, et al. Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol 2009; 27 (16): 2630-2637.
    • (2009) J Clin Oncol , vol.27 , Issue.16 , pp. 2630-2637
    • Baselga, J.1    Semiglazov, V.2    Van Dam, P.3
  • 28
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study
    • Bachelot T, Bourgier C, Cropet C, et al. Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study. J Clin Oncol 2012; 30 (22): 2718-2724.
    • (2012) J Clin Oncol , vol.30 , Issue.22 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3
  • 29
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012; 366 (6): 520-529.
    • (2012) N Engl J Med , vol.366 , Issue.6 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 30
    • 84945273476 scopus 로고    scopus 로고
    • AG NPS (ed). East Hanover, NJ
    • Affinitor [package insert]. In: AG NPS (ed). East Hanover, NJ, 2013.
    • (2013) Affinitor [Package Insert]
  • 31
    • 84880051527 scopus 로고    scopus 로고
    • Drug interactions and the pharmacist: Focus on everolimus
    • Grabowsky JA,. Drug interactions and the pharmacist: focus on everolimus. Ann Pharmacother 2013; 47 (7-8): 1055-1063.
    • (2013) Ann Pharmacother , vol.47 , Issue.7-8 , pp. 1055-1063
    • Grabowsky, J.A.1
  • 32
    • 84945306594 scopus 로고    scopus 로고
    • Final progression-free survival analysis of BOLERO-2: A phase III trial of everolimus for postmenopausal women with advanced breast cancer
    • San Antonio: AACR
    • Piccart MBJ, Noguchi S, Burris H, et al. Final progression-free survival analysis of BOLERO-2: a phase III trial of everolimus for postmenopausal women with advanced breast cancer. In: Thirty-fifth annual CTRC-AACR San Antonio breast cancer symposium, San Antonio: AACR, 2012.
    • (2012) In: Thirty-fifth Annual CTRC-AACR San Antonio Breast Cancer Symposium
    • Piccart, M.B.J.1    Noguchi, S.2    Burris, H.3
  • 33
    • 84879914608 scopus 로고    scopus 로고
    • Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: Subgroup analysis from the BOLERO-2 study
    • Campone M, Bachelot T, Gnant M, et al. Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: subgroup analysis from the BOLERO-2 study. Eur J Cancer 2013; 49 (12): 2621-2632.
    • (2013) Eur J Cancer , vol.49 , Issue.12 , pp. 2621-2632
    • Campone, M.1    Bachelot, T.2    Gnant, M.3
  • 34
    • 84877575581 scopus 로고    scopus 로고
    • Health-related quality of life of patients with advanced breast cancer treated with everolimus plus exemestane versus placebo plus exemestane in the phase 3, randomized, controlled, BOLERO-2 trial
    • Burris HA 3rd, Lebrun F, Rugo HS, et al. Health-related quality of life of patients with advanced breast cancer treated with everolimus plus exemestane versus placebo plus exemestane in the phase 3, randomized, controlled, BOLERO-2 trial. Cancer 2013; 119 (10): 1908-1915.
    • (2013) Cancer , vol.119 , Issue.10 , pp. 1908-1915
    • Burris, H.A.1    Lebrun, F.2    Rugo, H.S.3
  • 35
    • 84889654398 scopus 로고    scopus 로고
    • Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer: BOLERO-2 final progression-free survival analysis
    • Yardley DA, Noguchi S, Pritchard KI, et al. Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer: BOLERO-2 final progression-free survival analysis. Adv Ther 2013; 30 (10): 870-884.
    • (2013) Adv Ther , vol.30 , Issue.10 , pp. 870-884
    • Yardley, D.A.1    Noguchi, S.2    Pritchard, K.I.3
  • 36
    • 74549192779 scopus 로고    scopus 로고
    • Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients
    • Sonis S, Treister N, Chawla S, et al. Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients. Cancer 2010; 116 (1): 210-215.
    • (2010) Cancer , vol.116 , Issue.1 , pp. 210-215
    • Sonis, S.1    Treister, N.2    Chawla, S.3
  • 37
    • 80053959068 scopus 로고    scopus 로고
    • Clinical presentation and management of mTOR inhibitor-associated stomatitis
    • de Oliveira MA, Martins EMF, Wang Q, et al. Clinical presentation and management of mTOR inhibitor-associated stomatitis. Oral Oncol 2011; 47 (10): 998-1003.
    • (2011) Oral Oncol , vol.47 , Issue.10 , pp. 998-1003
    • De Oliveira, M.A.1    Martins, E.M.F.2    Wang, Q.3
  • 38
    • 11144356545 scopus 로고    scopus 로고
    • Perspectives on cancer therapy-induced mucosal injury: Pathogenesis measurement, epidemiology, and consequences for patients
    • Sonis ST, Elting LS, Keefe D, et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis measurement, epidemiology, and consequences for patients. Cancer 2004; 100 (Suppl 9): 1995-2025.
    • (2004) Cancer , vol.100 , pp. 1995-2025
    • Sonis, S.T.1    Elting, L.S.2    Keefe, D.3
  • 39
    • 84880199344 scopus 로고    scopus 로고
    • Oral ulcers in patients with advanced breast cancer receiving everolimus: A case series report on clinical presentation and management
    • Nicolatou-Galitis O, Nikolaidi A, Athanassiadis I, et al. Oral ulcers in patients with advanced breast cancer receiving everolimus: a case series report on clinical presentation and management. Oral Surg Oral Med Oral Pathol Oral Radiol 2013; 116 (2): e110-e116.
    • (2013) Oral Surg Oral Med Oral Pathol Oral Radiol , vol.116 , Issue.2 , pp. e110-e116
    • Nicolatou-Galitis, O.1    Nikolaidi, A.2    Athanassiadis, I.3
  • 40
    • 84879899632 scopus 로고    scopus 로고
    • Management of adverse events in patients with hormone receptor-positive breast cancer treated with everolimus: Observations from a phase III clinical trial
    • Peterson ME,. Management of adverse events in patients with hormone receptor-positive breast cancer treated with everolimus: observations from a phase III clinical trial. Supportive Care Cancer 2013; 21 (8): 2341-2349.
    • (2013) Supportive Care Cancer , vol.21 , Issue.8 , pp. 2341-2349
    • Peterson, M.E.1
  • 41
    • 80053265601 scopus 로고    scopus 로고
    • Managing stomatitis in patients treated with mammalian target of rapamycin inhibitors
    • Pilotte AP, Hohos MB, Polson KM, et al. Managing stomatitis in patients treated with mammalian target of rapamycin inhibitors. Clin J Oncol Nurs 2011; 15 (5): E83-E89.
    • (2011) Clin J Oncol Nurs , vol.15 , Issue.5 , pp. E83-E89
    • Pilotte, A.P.1    Hohos, M.B.2    Polson, K.M.3
  • 42
    • 84867337737 scopus 로고    scopus 로고
    • Clinical and histopathologic characteristics of rash in cancer patients treated with mammalian target of rapamycin inhibitors
    • Balagula Y, Rosen A, Tan BH, et al. Clinical and histopathologic characteristics of rash in cancer patients treated with mammalian target of rapamycin inhibitors. Cancer 2012; 118 (20): 5078-5083.
    • (2012) Cancer , vol.118 , Issue.20 , pp. 5078-5083
    • Balagula, Y.1    Rosen, A.2    Tan, B.H.3
  • 43
    • 67349127898 scopus 로고    scopus 로고
    • The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents
    • Sankhala K, Mita A, Kelly K, et al. The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents. Targeted Oncol 2009; 4 (2): 135-142.
    • (2009) Targeted Oncol , vol.4 , Issue.2 , pp. 135-142
    • Sankhala, K.1    Mita, A.2    Kelly, K.3
  • 44
    • 0141679203 scopus 로고    scopus 로고
    • Involvement of the Akt/mTOR pathway on EGF-induced cell transformation
    • Nomura M, He Z, Koyama I, et al. Involvement of the Akt/mTOR pathway on EGF-induced cell transformation. Mol Carcinog 2003; 38 (1): 25-32.
    • (2003) Mol Carcinog , vol.38 , Issue.1 , pp. 25-32
    • Nomura, M.1    He, Z.2    Koyama, I.3
  • 45
    • 84878217451 scopus 로고    scopus 로고
    • Practical management of everolimus-related toxicities in patients with advanced solid tumors
    • Grunwald V, Weikert S, Pavel ME, et al. Practical management of everolimus-related toxicities in patients with advanced solid tumors. Onkologie 2013; 36 (5): 295-302.
    • (2013) Onkologie , vol.36 , Issue.5 , pp. 295-302
    • Grunwald, V.1    Weikert, S.2    Pavel, M.E.3
  • 46
    • 84898703037 scopus 로고    scopus 로고
    • Everolimus: Side effect profile and management of toxicities in breast cancer
    • Paplomata E, Zelnak A, O'Regan R,. Everolimus: side effect profile and management of toxicities in breast cancer. Breast Cancer Res Treat 2013; 140 (3): 453-462.
    • (2013) Breast Cancer Res Treat , vol.140 , Issue.3 , pp. 453-462
    • Paplomata, E.1    Zelnak, A.2    O'Regan, R.3
  • 47
    • 79952282127 scopus 로고    scopus 로고
    • Toxicities of targeted therapy and their management in kidney cancer
    • Di Lorenzo G, Porta C, Bellmunt J, et al. Toxicities of targeted therapy and their management in kidney cancer. Eur Urol 2011; 59 (4): 526-540.
    • (2011) Eur Urol , vol.59 , Issue.4 , pp. 526-540
    • Di Lorenzo, G.1    Porta, C.2    Bellmunt, J.3
  • 48
    • 2342630498 scopus 로고    scopus 로고
    • Sirolimus-associated pulmonary toxicity
    • Pham PT, Pham PC, Danovitch GM, et al. Sirolimus-associated pulmonary toxicity. Transplantation 2004; 77 (8): 1215-1220.
    • (2004) Transplantation , vol.77 , Issue.8 , pp. 1215-1220
    • Pham, P.T.1    Pham, P.C.2    Danovitch, G.M.3
  • 49
    • 84862002981 scopus 로고    scopus 로고
    • Pneumonitis associated with mTOR inhibitors therapy in patients with metastatic renal cell carcinoma: Incidence, radiographic findings and correlation with clinical outcome
    • Dabydeen DA, Jagannathan JP, Ramaiya N, et al. Pneumonitis associated with mTOR inhibitors therapy in patients with metastatic renal cell carcinoma: incidence, radiographic findings and correlation with clinical outcome. Eur J Cancer 2012; 48 (10): 1519-1524.
    • (2012) Eur J Cancer , vol.48 , Issue.10 , pp. 1519-1524
    • Dabydeen, D.A.1    Jagannathan, J.P.2    Ramaiya, N.3
  • 50
    • 84885420714 scopus 로고    scopus 로고
    • Phase III, randomized, double blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer (BOLERO-3). Paper presented at
    • May 31-June 4, 2013; Chicago, IL. Abstract 505. J Clin Oncol 31
    • O'Regan R, Ozguroglu M, Andre F, et al. Phase III, randomized, double blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer (BOLERO-3). Paper presented at: ASCO Annual Meeting; May 31-June 4, 2013; Chicago, IL. Abstract 505. J Clin Oncol 31, 2013 (suppl; abstr 505).
    • (2013) ASCO Annual Meeting
    • O'Regan, R.1    Ozguroglu, M.2    Andre, F.3
  • 51
    • 58149352480 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells
    • Schmitz F, Heit A, Dreher S, et al. Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. Eur J Immunol 2008; 38 (11): 2981-2992.
    • (2008) Eur J Immunol , vol.38 , Issue.11 , pp. 2981-2992
    • Schmitz, F.1    Heit, A.2    Dreher, S.3
  • 52
    • 0035884304 scopus 로고    scopus 로고
    • Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients
    • Morelon E, Stern M, Israel-Biet D, et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients. Transplantation 2001; 72 (5): 787-790.
    • (2001) Transplantation , vol.72 , Issue.5 , pp. 787-790
    • Morelon, E.1    Stern, M.2    Israel-Biet, D.3
  • 53
    • 84945289369 scopus 로고    scopus 로고
    • MTOR inhibitor associated noninfectious pneumonitis in patients with renal cell cancer: Management, predictors, and outcomes
    • Epub ahead ofprint 23 August 2013
    • Atkinson BJ, Cauley DH, Ng C, et al. mTOR inhibitor associated noninfectious pneumonitis in patients with renal cell cancer: management, predictors, and outcomes. BJU Int. Epub ahead ofprint 23 August 2013.
    • BJU Int
    • Atkinson, B.J.1    Cauley, D.H.2    Ng, C.3
  • 54
    • 84865074467 scopus 로고    scopus 로고
    • Management of metabolic effects associated with anticancer agents targeting the PI3K-Akt-mTOR pathway
    • Busaidy NL, Farooki A, Dowlati A, et al. Management of metabolic effects associated with anticancer agents targeting the PI3K-Akt-mTOR pathway. J Clin Oncol 2012; 30 (23): 2919-2928.
    • (2012) J Clin Oncol , vol.30 , Issue.23 , pp. 2919-2928
    • Busaidy, N.L.1    Farooki, A.2    Dowlati, A.3
  • 55
    • 0037154264 scopus 로고    scopus 로고
    • Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin
    • Huffman TA, Mothe-Satney I, Lawrence JC Jr,. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Proc Natl Acad Sci U S A 2002; 99 (2): 1047-1052.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.2 , pp. 1047-1052
    • Huffman, T.A.1    Mothe-Satney, I.2    Lawrence, J.C.J.3
  • 56
    • 42449104351 scopus 로고    scopus 로고
    • MTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
    • Fraenkel M, Ketzinel-Gilad M, Ariav Y, et al. mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 2008; 57 (4): 945-957.
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 945-957
    • Fraenkel, M.1    Ketzinel-Gilad, M.2    Ariav, Y.3
  • 57
    • 78651338445 scopus 로고    scopus 로고
    • Diabetes Care 2011; 34 (Suppl 1)
    • Standards of medical care in diabetes - 2011. Diabetes Care 2011; 34 (Suppl 1) S11-S61.
    • (2011) Standards of Medical Care in Diabetes , pp. S11-S61
  • 58
    • 79960613394 scopus 로고    scopus 로고
    • Common toxicities of mammalian target of rapamycin inhibitors
    • Soefje SA, Karnad A, Brenner AJ,. Common toxicities of mammalian target of rapamycin inhibitors. Targeted Oncol 2011; 6 (2): 125-129.
    • (2011) Targeted Oncol , vol.6 , Issue.2 , pp. 125-129
    • Soefje, S.A.1    Karnad, A.2    Brenner, A.J.3
  • 59
    • 79957566962 scopus 로고    scopus 로고
    • Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma
    • Porta C, Osanto S, Ravaud A, et al. Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma. Eur J Cancer 2011; 47 (9): 1287-1298.
    • (2011) Eur J Cancer , vol.47 , Issue.9 , pp. 1287-1298
    • Porta, C.1    Osanto, S.2    Ravaud, A.3
  • 60
    • 38549100593 scopus 로고    scopus 로고
    • NCCN Task Force Report. Prevention and management of mucositis in cancer care
    • quiz S2-S4
    • Bensinger W, Schubert M, Ang KK, et al. NCCN Task Force Report. prevention and management of mucositis in cancer care. JNCCN 2008; 6 (Suppl 1): S1-21. quiz S2-S4.
    • (2008) JNCCN , vol.6 , pp. S1-21
    • Bensinger, W.1    Schubert, M.2    Ang, K.K.3
  • 61
    • 0037607607 scopus 로고    scopus 로고
    • The diagnosis and management of recurrent aphthous stomatitis: A consensus approach
    • Scully C, Gorsky M, Lozada-Nur F,. The diagnosis and management of recurrent aphthous stomatitis: a consensus approach. J Am Dent Assoc 2003; 134 (2): 200-207.
    • (2003) J Am Dent Assoc , vol.134 , Issue.2 , pp. 200-207
    • Scully, C.1    Gorsky, M.2    Lozada-Nur, F.3
  • 62
    • 84864954263 scopus 로고    scopus 로고
    • Incidence and management of mTOR inhibitor-associated pneumonitis in patients with metastatic renal cell carcinoma
    • Albiges L, Chamming's F, Duclos B, et al. Incidence and management of mTOR inhibitor-associated pneumonitis in patients with metastatic renal cell carcinoma. Ann Oncol 2012; 23 (8): 1943-1953.
    • (2012) Ann Oncol , vol.23 , Issue.8 , pp. 1943-1953
    • Albiges, L.1    Chamming'S, F.2    Duclos, B.3
  • 63
    • 84879016199 scopus 로고    scopus 로고
    • Budget impact analysis of everolimus for the treatment of hormone receptor positive, human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer in the United States
    • Xie J, Diener M, De G, et al. Budget impact analysis of everolimus for the treatment of hormone receptor positive, human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer in the United States. J Med Econ 2013; 16 (2): 278-288.
    • (2013) J Med Econ , vol.16 , Issue.2 , pp. 278-288
    • Xie, J.1    Diener, M.2    De, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.