The diagnosis and management of recurrent aphthous stomatitis: A consensus approach

Journal of the American Dental Association

Volumn 134, Issue 2, 2003, Pages 200-207

  Scully, Crispian ^a   Gorsky, Meir ^b   Lozada Nur, Francina ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b TEL AVIV UNIVERSITY   (Israel)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ALPHA INTERFERON; AMELEXANOX; ANTIINFECTIVE AGENT; AZELASTINE; CHLORHEXIDINE; COLCHICINE; CORTICOSTEROID; CYANOACRYLATE; DAPSONE; DICLOFENAC; DOXYCYCLINE; HEAT SHOCK PROTEIN; HYALURONIC ACID; IRSOGLADINE MALEATE; LEVAMISOLE; NICOTINE; PENTOXIFYLLINE; SUCRALFATE; THALIDOMIDE; TRICLOSAN; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; GLUCOCORTICOID; IMMUNOLOGICAL ADJUVANT; STEROID;

APHTHOUS STOMATITIS; CLINICAL TRIAL; CYANOCOBALAMIN DEFICIENCY; DIARRHEA; DISEASE PREDISPOSITION; EUPATORIUM; FOLIC ACID DEFICIENCY; FOOD ALLERGY; HELIUM NEON LASER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGENETICS; INFERTILITY; IRON DEFICIENCY; LEISURE; MEDLINE; METHEMOGLOBINEMIA; MOOD DISORDER; MOUTH DISEASE; NAUSEA; POLYNEUROPATHY; PRIMARY MEDICAL CARE; PUVA; REVIEW; SIDE EFFECT; STREPTOCOCCUS SANGUIS; STRESS; TERATOGENICITY; ULTRASOUND; DIFFERENTIAL DIAGNOSIS; GENETICS; IMMUNOLOGY; RECURRENT DISEASE; RISK FACTOR; STREPTOCOCCUS SANGUINIS;

ADJUVANTS, IMMUNOLOGIC; ANTI-INFLAMMATORY AGENTS; DIAGNOSIS, DIFFERENTIAL; DISEASE SUSCEPTIBILITY; GLUCOCORTICOIDS; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOGENETICS; RECURRENCE; RISK FACTORS; STEROIDS; STOMATITIS, APHTHOUS; STREPTOCOCCUS SANGUIS;

EID: 0037607607     PISSN: 00028177     EISSN: None     Source Type: Journal    
DOI: 10.14219/jada.archive.2003.0134     Document Type: Article

References (50)

1. Miller MF, Ship II. A retrospective study of the prevalence and incidence of recurrent aphthous ulcers in a professional population, 1958-1971. Oral Surg Oral Med Oral Pathol 1977;43(4):532-7.
2. Rogers RS 3rd. Recurrent aphthous stomatitis: clinical characteristics and associated systemic disorders. Semin Cutan Med Surg 1997;16:278-83.
3. Eversole LR. Immunopathology of oral mucosal ulcerative, desquamative, and bullous diseases: selective review of the literature. Oral Surg Oral Med Oral Pathol 1994;77:555-71.
4. Scully C, Porter S. Recurrent aphthous stomatitis: current concepts of etiology, pathogenesis and management. J Oral Pathol Med 1989;18(1):21-7.
5. Shohat-Zabarski R, Kalderon S, Klein T, Weinberger A. Close association of HLA-B51 in persons with recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1992;74:455-8.
6. Ship II. Epidemiologic aspects of recurrent aphthous ulcerations. Oral Surg Oral Med Oral Pathol 1972;33:400-6.
7. Ship II. Inheritance of aphthous ulcers of the mouth. J Dent Res 1965;44:837-44.
8. Natah SS, Hayrinen-Immonen R, Hietanen J, Malmstrom M, Konttinen YT. Immunolocalization of tumor necrosis factor-alpha expressing cells in recurrent aphthous ulcer lesions (RAU). J Oral Pathol Med 2000;29(1):19-25.
9. Sampaio EP, Sarno EN, Galilly R, Cohn ZA, Kaplan G. Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 1991;173:699-703.
10. Sun A, Chu CT, Liu BY, Wang JT, Leu JS, Chiang CP. Expression of interleukin-2 receptor by activated peripheral blood lymphocytes upregulated by the plasma level of interleukin-2 in patients with recurrent aphthous ulcers. Proc Natl Sci Counc Repub China B 2000;24(3):116-22.
11. Buno IJ, Huff JC, Weston WL, Cook DT, Brice SL. Elevated levels of interferon gamma, tumor necrosis factor alpha, interleukins 2, 4, and 5, but not interleukin 10, are present in recurrent aphthous stomatitis. Arch Dermatol 1998;134:827-31.
12. Sun A, Chu CT, Wu YC, Yuan JH. Mechanisms of depressed natural killer cell activity in recurrent aphthous ulcers. Clin Immunol Immunopathol 1991;60(1):83-92.
13. Pedersen A. Psychologic stress and recurrent aphthous ulceration. J Oral Pathol Med 1989;18(2):119-22.
14. Hay KD, Reade PC. The use of an elimination diet in the treatment of recurrent aphthous ulceration of the oral cavity. Oral Surg Oral Med Oral Pathol 1984;57:504-7.
15. Eversole LR, Shopper TP, Chambers DW. Effects of suspected foodstuff challenging agents in the etiology of recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1982;54(1):33-8.
16. Nolan A, Lamey PJ, Milligan KA, Forsyth A. Recurrent aphthous ulceration and food sensitivity. J Oral Pathol Med 1991;20:473-5.
17. Ferguson MM, McKay Hart D, Lindsay R, Stephen KW. Progestin therapy for menstrual related aphthae. Int J Oral Surg 1978;7:463-70.
18. Tuzun B, Wolf R, Tuzun Y, Serdaroglu S. Recurrent aphthous stomatitis and smoking. Int J Dermatol 2000;39:358-60.
19. Axell T, Henricsson V. Association between recurrent aphthous ulcers and tobacco habits. Scand J Dent Res 1985;93:239-42.
20. Dorsey C. More observations on relief of aphthous stomatitis on resumption of cigarette smoking. Calif Med 1964;101:377-8.
21. Grady D, Ernster VL, Stillman L, Greenspan J. Smokeless tobacco use prevents aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1992;74:463-5.
22. Bittoun R. Recurrent aphthous ulcers and nicotine. Med J Aust 1991;154:471-2.
23. Shotts RH, Scully C, Avery CM, Porter SR. Nicorandil-induced severe oral ulceration: a newly recognized drug reaction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87:706-7.
24. Cribier B, Marquart-Elbaz C, Lipsker D, Alt M, Grosshans E. Chronic buccal ulceration induced by nicorandil. Br J Dermatol 1998;138:372-3.
25. Healy CM, Thornhill MH. An association between recurrent orogenital ulceration and non-steroidal anti-inflammatory drugs. J Oral Pathol Med 1995;24(1):46-8.
26. Boulinguez S, Cornee-Leplat I, Bouyssou-Gauthier ML, Bedane C, Bonnetblanc JM. Analysis of the literature about drug-induced aphthous ulcers. Ann Dermatol Venereol 2000;127(2):155-8.
27. Muzyka BC, Glick M. Major aphthous ulcers in patients with HIV disease. Oral Surg Oral Med Oral Pathol 1994;77(2):116-20.
28. MacPhail LA, Greenspan D, Feigal DW, Lennette ET, Greenspan JS. Recurrent aphthous ulcers in association with HIV infection: description of ulcer types and analysis of T-lymphocyte subsets. Oral Surg Oral Med Oral Pathol 1991;71:678-83.
29. Porter SR, Scully C. Orofacial manifestations in primary immunodeficiencies: common variable immunodeficiencies. J Oral Pathol Med 1993;22(4):157-8.
30. Flint SR, Sugerman P, Scully C, Smith JG, Smith MA. The myelodysplastic syndromes: case report and review. Oral Surg Oral Med Oral Pathol 1990;70:579-83.
31. Vanderhoof JA, Rich KC, Stiehm ER, Ament ME. Esophageal ulcers in immunodeficiency with elevated levels of IgM and neutropenia. Am J Dis Child 1977;131:551-2.
32. Wright DG, Dale DC, Fauci AS, Wolff SM. Human cyclic neutropenia: clinical review and long-term follow-up of patients. Medicine (Baltimore) 1981;60(1):1-13.
33. Olson JA, Feinberg I, Silverman S Jr., Abrams D, Greenspan JS. Serum vitamin B12, folate, and iron levels in recurrent aphthous ulceration. Oral Surg Oral Med Oral Pathol 1982;54:517-20.
34. Wray D, Ferguson MM, Mason DK, Hutcheon RI, Lee FD. Recurrent aphthae: treatment with vitamin B12, folic acid and iron. Br Med J 1975;2:490-3.
35. Porter S, Flint S, Scully C, Keith O. Recurrent aphthous stomatitis: the efficacy of replacement therapy in patients with underlying hematinic deficiencies. Ann Dent 1992;51:14-6.
36. Ferguson MM, Wray D, Carmichael HA, et al. Coeliac disease associated with recurrent aphthae. Gut 1980;21:223-6.
37. Wray D. Gluten-sensitive recurrent aphthous stomatitis. Dig Dis Sci 1981;26:737-40.
38. Hunter IP, Ferguson MM, Scully C, Galloway AR, Main AN, Russell RI. Effect of dietary gluten elimination in patients with recurrent minor aphthous stomatitis and no detectable gluten enteropathy. Oral Surg Oral Med Oral Pathol 1993;75:595-8.
39. Veloso FT, Carvalho J, Magro F. Immune-related systemic manifestations of inflammatory bowel disease: a prospective study of 792 patients. J Clin Gastroenterol 1996;23(1):29-34.
40. Schwartz T, Langevitz P, Zemer D, Gazit E, Pras M, Livnen A. Behcet's disease in familial mediterranean fever: characterization of the association between the two diseases. Semin Arthritis Rheum 2000;29:286-95.
41. Marshall GS, Edwards KM, Butler J, Lawton AR. Syndrome of periodic fever, pharyngitis, and aphthous stomatitis. J Pediatr 1987;110(1):43-6.
42. Notani K, Kobayashi S, Kondoh K, Shindoh M, Ferguson MM, Fukuda H. A case of Sweet's syndrome (acute febrile neutrophilic dermatosis) with palatal ulceration. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89:477-9.
43. Paydas S, Sahin B, Zorludemir S. Sweet's syndrome accompanying leukemia: seven cases and review of the literature. Leuk Res 2000;24(1):83-6.
44. Porter SR, Kingsmill V, Scully C. Audit of diagnosis and investigations in patients with recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1993;76:449-52.
45. Woo SB, Sonis ST. Recurrent aphthous ulcers: a review of diagnosis and treatment. JADA 1996;127:1202-13.
46. MacPhail L. Topical and systemic therapy for recurrent aphthous stomatitis. Semin Cutan Med Surg 1997;16:301-7.
47. Ship JA. Recurrent aphthous stomatitis: an update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;81(2):141-7.
48. Porter SR, Scully C. Aphthous ulcers: recurrent. Clin Evidence 2002;3:606-12.
49. Lozada-Nur F, Miranda C, Maliksi R. Double-blind clinical trial of 0.05% clobetasol propionate ointment in orabase and 0.05% fluocinonide ointment in orabase in the treatment of patients with oral vesiculoerosive diseases. Oral Surg Oral Med Oral Pathol 1994;77: 598-604.
50. Eisen D, Lynch DP. Selecting topical and systemic agents for recurrent aphthous stomatitis. Cutis 2001;68:201-6.