-
1
-
-
4544381198
-
Biochemical mechanisms of drug action: what does it take for success?
-
Swinney DC, (2004) Biochemical mechanisms of drug action: what does it take for success? Nat Rev Drug Discov 3: 801–808. 15340390
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 801-808
-
-
Swinney, D.C.1
-
2
-
-
0036490942
-
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery
-
Christopoulos A, (2002) Allosteric binding sites on cell-surface receptors: novel targets for drug discovery. Nat Rev Drug Discov 1: 198–210. 12120504
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 198-210
-
-
Christopoulos, A.1
-
3
-
-
33646122469
-
Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001–2004: mechanisms leading to optimal efficacy and safety
-
Swinney DC, (2006) Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001–2004: mechanisms leading to optimal efficacy and safety. Curr Top Med Chem 6: 461–478. 16719803
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 461-478
-
-
Swinney, D.C.1
-
4
-
-
0028945986
-
FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae
-
Jones CH, Pinkner JS, Roth R, Heuser J, Nicholes AV, et al. (1995) FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae. Proc Natl Acad Sci U S A 92: 2081–2085. 7892228
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 2081-2085
-
-
Jones, C.H.1
Pinkner, J.S.2
Roth, R.3
Heuser, J.4
Nicholes, A.V.5
-
5
-
-
76049113819
-
Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding
-
Chen SL, Hung CS, Pinkner JS, Walker JN, Cusumano CK, et al. (2009) Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding. Proc Natl Acad Sci U S A 106: 22439–22444. doi: 10.1073/pnas.0902179106 20018753
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 22439-22444
-
-
Chen, S.L.1
Hung, C.S.2
Pinkner, J.S.3
Walker, J.N.4
Cusumano, C.K.5
-
6
-
-
0029840463
-
Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract
-
Connell I, Agace W, Klemm P, Schembri M, Marild S, et al. (1996) Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract. Proc Natl Acad Sci U S A 93: 9827–9832. 8790416
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 9827-9832
-
-
Connell, I.1
Agace, W.2
Klemm, P.3
Schembri, M.4
Marild, S.5
-
7
-
-
0025310329
-
Direct evidence that the FimH protein is the mannose-specific adhesin of Escherichia coli type 1 fimbriae
-
Krogfelt KA, Bergmans H, Klemm P, (1990) Direct evidence that the FimH protein is the mannose-specific adhesin of Escherichia coli type 1 fimbriae. Infect Immun 58: 1995–1998. 1971261
-
(1990)
Infect Immun
, vol.58
, pp. 1995-1998
-
-
Krogfelt, K.A.1
Bergmans, H.2
Klemm, P.3
-
8
-
-
0034659834
-
Type 1 pilus-mediated bacterial invasion of bladder epithelial cells
-
Martinez JJ, Mulvey MA, Schilling JD, Pinkner JS, Hultgren SJ, (2000) Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. Embo J 19: 2803–2812. 10856226
-
(2000)
Embo J
, vol.19
, pp. 2803-2812
-
-
Martinez, J.J.1
Mulvey, M.A.2
Schilling, J.D.3
Pinkner, J.S.4
Hultgren, S.J.5
-
9
-
-
0024315717
-
In vivo expression and variation of Escherichia coli type 1 and P pili in the urine of adults with acute urinary tract infections
-
Kisielius PV, Schwan WR, Amundsen SK, Duncan JL, Schaeffer AJ, (1989) In vivo expression and variation of Escherichia coli type 1 and P pili in the urine of adults with acute urinary tract infections. Infect Immun 57: 1656–1662. 2566580
-
(1989)
Infect Immun
, vol.57
, pp. 1656-1662
-
-
Kisielius, P.V.1
Schwan, W.R.2
Amundsen, S.K.3
Duncan, J.L.4
Schaeffer, A.J.5
-
10
-
-
0033551911
-
X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli
-
Choudhury D, Thompson A, Stojanoff V, Langermann S, Pinkner J, et al. (1999) X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli. Science 285: 1061–1066. 10446051
-
(1999)
Science
, vol.285
, pp. 1061-1066
-
-
Choudhury, D.1
Thompson, A.2
Stojanoff, V.3
Langermann, S.4
Pinkner, J.5
-
11
-
-
77952513211
-
Structural basis for mechanical force regulation of the adhesin FimH via finger trap-like beta sheet twisting
-
Le Trong I, Aprikian P, Kidd BA, Forero-Shelton M, Tchesnokova V, et al. (2010) Structural basis for mechanical force regulation of the adhesin FimH via finger trap-like beta sheet twisting. Cell 141: 645–655. doi: 10.1016/j.cell.2010.03.038 20478255
-
(2010)
Cell
, vol.141
, pp. 645-655
-
-
Le Trong, I.1
Aprikian, P.2
Kidd, B.A.3
Forero-Shelton, M.4
Tchesnokova, V.5
-
12
-
-
34547903425
-
Interdomain interaction in the FimH adhesin of Escherichia coli regulates the affinity to mannose
-
Aprikian P, Tchesnokova V, Kidd B, Yakovenko O, Yarov-Yarovoy V, et al. (2007) Interdomain interaction in the FimH adhesin of Escherichia coli regulates the affinity to mannose. J Biol Chem 282: 23437–23446. 17567583
-
(2007)
J Biol Chem
, vol.282
, pp. 23437-23446
-
-
Aprikian, P.1
Tchesnokova, V.2
Kidd, B.3
Yakovenko, O.4
Yarov-Yarovoy, V.5
-
13
-
-
43149107943
-
Integrin-like allosteric properties of the catch bond-forming FimH adhesin of Escherichia coli
-
Tchesnokova V, Aprikian P, Yakovenko O, Larock C, Kidd B, et al. (2008) Integrin-like allosteric properties of the catch bond-forming FimH adhesin of Escherichia coli. J Biol Chem 283: 7823–7833. doi: 10.1074/jbc.M707804200 18174167
-
(2008)
J Biol Chem
, vol.283
, pp. 7823-7833
-
-
Tchesnokova, V.1
Aprikian, P.2
Yakovenko, O.3
Larock, C.4
Kidd, B.5
-
14
-
-
84869127061
-
Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells
-
Chen W, Lou J, Evans EA, Zhu C, (2012) Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells. J Cell Biol 199: 497–512. doi: 10.1083/jcb.201201091 23109670
-
(2012)
J Cell Biol
, vol.199
, pp. 497-512
-
-
Chen, W.1
Lou, J.2
Evans, E.A.3
Zhu, C.4
-
15
-
-
33746163433
-
Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force
-
Phan UT, Waldron TT, Springer TA, (2006) Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force. Nat Immunol 7: 883–889. 16845394
-
(2006)
Nat Immunol
, vol.7
, pp. 883-889
-
-
Phan, U.T.1
Waldron, T.T.2
Springer, T.A.3
-
16
-
-
77956944744
-
Conformational changes and ligand recognition of Escherichia coli D-xylose binding protein revealed
-
Sooriyaarachchi S, Ubhayasekera W, Park C, Mowbray SL, (2010) Conformational changes and ligand recognition of Escherichia coli D-xylose binding protein revealed. J Mol Biol 402: 657–668. doi: 10.1016/j.jmb.2010.07.038 20678502
-
(2010)
J Mol Biol
, vol.402
, pp. 657-668
-
-
Sooriyaarachchi, S.1
Ubhayasekera, W.2
Park, C.3
Mowbray, S.L.4
-
17
-
-
34548476934
-
Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands
-
Avlani VA, Gregory KJ, Morton CJ, Parker MW, Sexton PM, et al. (2007) Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands. J Biol Chem 282: 25677–25686. 17591774
-
(2007)
J Biol Chem
, vol.282
, pp. 25677-25686
-
-
Avlani, V.A.1
Gregory, K.J.2
Morton, C.J.3
Parker, M.W.4
Sexton, P.M.5
-
18
-
-
84877581910
-
Crystal structure of pre-activated arrestin p44
-
Kim YJ, Hofmann KP, Ernst OP, Scheerer P, Choe HW, et al. (2013) Crystal structure of pre-activated arrestin p44. Nature 497: 142–146. doi: 10.1038/nature12133 23604253
-
(2013)
Nature
, vol.497
, pp. 142-146
-
-
Kim, Y.J.1
Hofmann, K.P.2
Ernst, O.P.3
Scheerer, P.4
Choe, H.W.5
-
19
-
-
84904170635
-
Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis
-
Ma Q, Akhter Y, Wilmanns M, Ehebauer MT, (2014) Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis. Protein Sci 23: 932–939. doi: 10.1002/pro.2475 24723382
-
(2014)
Protein Sci
, vol.23
, pp. 932-939
-
-
Ma, Q.1
Akhter, Y.2
Wilmanns, M.3
Ehebauer, M.T.4
-
20
-
-
71449125748
-
A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors
-
Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, et al. (2009) A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature 462: 602–608. doi: 10.1038/nature08613 19898420
-
(2009)
Nature
, vol.462
, pp. 602-608
-
-
Melcher, K.1
Ng, L.M.2
Zhou, X.E.3
Soon, F.F.4
Xu, Y.5
-
21
-
-
0035141668
-
Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation
-
Wagner DA, Czajkowski C, (2001) Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation. J Neurosci 21: 67–74. 11150321
-
(2001)
J Neurosci
, vol.21
, pp. 67-74
-
-
Wagner, D.A.1
Czajkowski, C.2
-
22
-
-
0030734795
-
Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: evidence that an open pocket conformation is required for ligand interaction
-
Carlson KE, Choi I, Gee A, Katzenellenbogen BS, Katzenellenbogen JA, (1997) Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: evidence that an open pocket conformation is required for ligand interaction. Biochemistry 36: 14897–14905. 9398213
-
(1997)
Biochemistry
, vol.36
, pp. 14897-14905
-
-
Carlson, K.E.1
Choi, I.2
Gee, A.3
Katzenellenbogen, B.S.4
Katzenellenbogen, J.A.5
-
23
-
-
79959564813
-
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
-
Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, et al. (2011) Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature 474: 521–525. doi: 10.1038/nature10136 21593763
-
(2011)
Nature
, vol.474
, pp. 521-525
-
-
Lebon, G.1
Warne, T.2
Edwards, P.C.3
Bennett, K.4
Langmead, C.J.5
-
24
-
-
0035830955
-
Crystal structures of the maltodextrin/maltose-binding protein complexed with reduced oligosaccharides: flexibility of tertiary structure and ligand binding
-
Duan X, Hall JA, Nikaido H, Quiocho FA, (2001) Crystal structures of the maltodextrin/maltose-binding protein complexed with reduced oligosaccharides: flexibility of tertiary structure and ligand binding. J Mol Biol 306: 1115–1126. 11237621
-
(2001)
J Mol Biol
, vol.306
, pp. 1115-1126
-
-
Duan, X.1
Hall, J.A.2
Nikaido, H.3
Quiocho, F.A.4
-
25
-
-
0031571605
-
Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor
-
Quiocho FA, Spurlino JC, Rodseth LE, (1997) Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor. Structure 5: 997–1015. 9309217
-
(1997)
Structure
, vol.5
, pp. 997-1015
-
-
Quiocho, F.A.1
Spurlino, J.C.2
Rodseth, L.E.3
-
26
-
-
0025754301
-
The 2.3-A resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis
-
Spurlino JC, Lu GY, Quiocho FA, (1991) The 2.3-A resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis. J Biol Chem 266: 5202–5219. 2002054
-
(1991)
J Biol Chem
, vol.266
, pp. 5202-5219
-
-
Spurlino, J.C.1
Lu, G.Y.2
Quiocho, F.A.3
-
27
-
-
78651411166
-
Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor
-
Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, et al. (2011) Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor. Nature 469: 175–180. doi: 10.1038/nature09648 21228869
-
(2011)
Nature
, vol.469
, pp. 175-180
-
-
Rasmussen, S.G.1
Choi, H.J.2
Fung, J.J.3
Pardon, E.4
Casarosa, P.5
-
28
-
-
77957231785
-
Induced fit, conformational selection and independent dynamic segments: an extended view of binding events
-
Csermely P, Palotai R, Nussinov R, (2010) Induced fit, conformational selection and independent dynamic segments: an extended view of binding events. Trends Biochem Sci 35: 539–546. doi: 10.1016/j.tibs.2010.04.009 20541943
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 539-546
-
-
Csermely, P.1
Palotai, R.2
Nussinov, R.3
-
29
-
-
84898953700
-
Distinguishing induced fit from conformational selection
-
Gianni S, Dogan J, Jemth P, (2014) Distinguishing induced fit from conformational selection. Biophys Chem 189: 33–39. doi: 10.1016/j.bpc.2014.03.003 24747333
-
(2014)
Biophys Chem
, vol.189
, pp. 33-39
-
-
Gianni, S.1
Dogan, J.2
Jemth, P.3
-
30
-
-
84894264010
-
Single molecule insights on conformational selection and induced fit mechanism
-
Hatzakis NS, (2014) Single molecule insights on conformational selection and induced fit mechanism. Biophys Chem 186C: 46–54.
-
(2014)
Biophys Chem
, vol.186C
, pp. 46-54
-
-
Hatzakis, N.S.1
-
31
-
-
79958136745
-
A role for both conformational selection and induced fit in ligand binding by the LAO protein
-
Silva DA, Bowman GR, Sosa-Peinado A, Huang X, (2011) A role for both conformational selection and induced fit in ligand binding by the LAO protein. PLoS Comput Biol 7: e1002054. doi: 10.1371/journal.pcbi.1002054 21637799
-
(2011)
PLoS Comput Biol
, vol.7
, pp. 1002054
-
-
Silva, D.A.1
Bowman, G.R.2
Sosa-Peinado, A.3
Huang, X.4
-
32
-
-
0027447059
-
Activity modulation of the fast and slow isozymes of human cytosolic low-molecular-weight acid phosphatase (ACP1) by purines
-
Dissing J, Rangaard B, Christensen U, (1993) Activity modulation of the fast and slow isozymes of human cytosolic low-molecular-weight acid phosphatase (ACP1) by purines. Biochim Biophys Acta 1162: 275–282. 8457591
-
(1993)
Biochim Biophys Acta
, vol.1162
, pp. 275-282
-
-
Dissing, J.1
Rangaard, B.2
Christensen, U.3
-
33
-
-
84888102778
-
Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin
-
Kisiela DI, Rodriguez VB, Tchesnokova V, Avagyan H, Aprikian P, et al. (2013) Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin. Proc Natl Acad Sci U S A 110: 19089–19094. doi: 10.1073/pnas.1314395110 24191044
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 19089-19094
-
-
Kisiela, D.I.1
Rodriguez, V.B.2
Tchesnokova, V.3
Avagyan, H.4
Aprikian, P.5
-
34
-
-
48449094247
-
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
-
Brochet X, Lefranc MP, Giudicelli V, (2008) IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res 36: W503–508. doi: 10.1093/nar/gkn316 18503082
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 503-508
-
-
Brochet, X.1
Lefranc, M.P.2
Giudicelli, V.3
-
35
-
-
79958045471
-
IMGT/V-QUEST: IMGT standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences
-
Giudicelli V, Brochet X, Lefranc MP, (2011) IMGT/V-QUEST: IMGT standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences. Cold Spring Harb Protoc 2011: 695–715. doi: 10.1101/pdb.prot5633 21632778
-
(2011)
Cold Spring Harb Protoc
, vol.2011
, pp. 695-715
-
-
Giudicelli, V.1
Brochet, X.2
Lefranc, M.P.3
-
36
-
-
0023958554
-
Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods
-
Ehlert FJ, (1988) Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. Mol Pharmacol 33: 187–194. 2828914
-
(1988)
Mol Pharmacol
, vol.33
, pp. 187-194
-
-
Ehlert, F.J.1
-
37
-
-
4444324531
-
Allosteric modulators: the new generation of receptor antagonist
-
Kenakin T, (2004) Allosteric modulators: the new generation of receptor antagonist. Mol Interv 4: 222–229. 15304558
-
(2004)
Mol Interv
, vol.4
, pp. 222-229
-
-
Kenakin, T.1
-
38
-
-
0036094156
-
Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection
-
Hung CS, Bouckaert J, Hung D, Pinkner J, Widberg C, et al. (2002) Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. Mol Microbiol 44: 903–915. 12010488
-
(2002)
Mol Microbiol
, vol.44
, pp. 903-915
-
-
Hung, C.S.1
Bouckaert, J.2
Hung, D.3
Pinkner, J.4
Widberg, C.5
-
39
-
-
33745201204
-
Catch bond-mediated adhesion without a shear threshold: trimannose versus monomannose interactions with the FimH adhesin of Escherichia coli
-
Nilsson LM, Thomas WE, Trintchina E, Vogel V, Sokurenko EV, (2006) Catch bond-mediated adhesion without a shear threshold: trimannose versus monomannose interactions with the FimH adhesin of Escherichia coli. J Biol Chem 281: 16656–16663. 16624825
-
(2006)
J Biol Chem
, vol.281
, pp. 16656-16663
-
-
Nilsson, L.M.1
Thomas, W.E.2
Trintchina, E.3
Vogel, V.4
Sokurenko, E.V.5
-
40
-
-
46049102171
-
Beyond induced-fit receptor-ligand interactions: structural changes that can significantly extend bond lifetimes
-
Nilsson LM, Thomas WE, Sokurenko EV, Vogel V, (2008) Beyond induced-fit receptor-ligand interactions: structural changes that can significantly extend bond lifetimes. Structure 16: 1047–1058. doi: 10.1016/j.str.2008.03.012 18611378
-
(2008)
Structure
, vol.16
, pp. 1047-1058
-
-
Nilsson, L.M.1
Thomas, W.E.2
Sokurenko, E.V.3
Vogel, V.4
-
41
-
-
38049174343
-
Structural insight into distinct mechanisms of protease inhibition by antibodies
-
Wu Y, Eigenbrot C, Liang WC, Stawicki S, Shia S, et al. (2007) Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc Natl Acad Sci U S A 104: 19784–19789. 18077410
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19784-19789
-
-
Wu, Y.1
Eigenbrot, C.2
Liang, W.C.3
Stawicki, S.4
Shia, S.5
-
42
-
-
84890406288
-
Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor
-
Mukund S, Shang Y, Clarke HJ, Madjidi A, Corn JE, et al. (2013) Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor. J Biol Chem 288: 36168–36178. doi: 10.1074/jbc.M113.496984 24189067
-
(2013)
J Biol Chem
, vol.288
, pp. 36168-36178
-
-
Mukund, S.1
Shang, Y.2
Clarke, H.J.3
Madjidi, A.4
Corn, J.E.5
-
43
-
-
3042602113
-
Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain
-
Luo BH, Strokovich K, Walz T, Springer TA, Takagi J, (2004) Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain. J Biol Chem 279: 27466–27471. 15123676
-
(2004)
J Biol Chem
, vol.279
, pp. 27466-27471
-
-
Luo, B.H.1
Strokovich, K.2
Walz, T.3
Springer, T.A.4
Takagi, J.5
-
44
-
-
56749103466
-
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
-
Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, et al. (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322: 1211–1217. doi: 10.1126/science.1164772 18832607
-
(2008)
Science
, vol.322
, pp. 1211-1217
-
-
Jaakola, V.P.1
Griffith, M.T.2
Hanson, M.A.3
Cherezov, V.4
Chien, E.Y.5
-
45
-
-
70350340728
-
The role of dynamic conformational ensembles in biomolecular recognition
-
Boehr DD, Nussinov R, Wright PE, (2009) The role of dynamic conformational ensembles in biomolecular recognition. Nat Chem Biol 5: 789–796. doi: 10.1038/nchembio.232 19841628
-
(2009)
Nat Chem Biol
, vol.5
, pp. 789-796
-
-
Boehr, D.D.1
Nussinov, R.2
Wright, P.E.3
-
46
-
-
84899472221
-
Protein conformational dynamics dictate the binding affinity for a ligand
-
Seo MH, Park J, Kim E, Hohng S, Kim HS, (2014) Protein conformational dynamics dictate the binding affinity for a ligand. Nat Commun 5: 3724. doi: 10.1038/ncomms4724 24758940
-
(2014)
Nat Commun
, vol.5
, pp. 3724
-
-
Seo, M.H.1
Park, J.2
Kim, E.3
Hohng, S.4
Kim, H.S.5
-
47
-
-
37249032102
-
Dynamic personalities of proteins
-
Henzler-Wildman K, Kern D, (2007) Dynamic personalities of proteins. Nature 450: 964–972. 18075575
-
(2007)
Nature
, vol.450
, pp. 964-972
-
-
Henzler-Wildman, K.1
Kern, D.2
-
48
-
-
1342302339
-
Conformational changes associated with protein-protein interactions
-
Goh CS, Milburn D, Gerstein M, (2004) Conformational changes associated with protein-protein interactions. Curr Opin Struct Biol 14: 104–109. 15102456
-
(2004)
Curr Opin Struct Biol
, vol.14
, pp. 104-109
-
-
Goh, C.S.1
Milburn, D.2
Gerstein, M.3
-
49
-
-
4744343045
-
Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair
-
Wolf-Watz M, Thai V, Henzler-Wildman K, Hadjipavlou G, Eisenmesser EZ, et al. (2004) Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair. Nat Struct Mol Biol 11: 945–949. 15334070
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 945-949
-
-
Wolf-Watz, M.1
Thai, V.2
Henzler-Wildman, K.3
Hadjipavlou, G.4
Eisenmesser, E.Z.5
-
50
-
-
78651405537
-
The structural basis for agonist and partial agonist action on a beta(1)-adrenergic receptor
-
Warne T, Moukhametzianov R, Baker JG, Nehme R, Edwards PC, et al. (2011) The structural basis for agonist and partial agonist action on a beta(1)-adrenergic receptor. Nature 469: 241–244. doi: 10.1038/nature09746 21228877
-
(2011)
Nature
, vol.469
, pp. 241-244
-
-
Warne, T.1
Moukhametzianov, R.2
Baker, J.G.3
Nehme, R.4
Edwards, P.C.5
-
51
-
-
84879069952
-
A single-molecule dissection of ligand binding to a protein with intrinsic dynamics
-
Kim E, Lee S, Jeon A, Choi JM, Lee HS, et al. (2013) A single-molecule dissection of ligand binding to a protein with intrinsic dynamics. Nat Chem Biol 9: 313–318. doi: 10.1038/nchembio.1213 23502425
-
(2013)
Nat Chem Biol
, vol.9
, pp. 313-318
-
-
Kim, E.1
Lee, S.2
Jeon, A.3
Choi, J.M.4
Lee, H.S.5
-
52
-
-
35548976322
-
Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR
-
Tang C, Schwieters CD, Clore GM, (2007) Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR. Nature 449: 1078–1082. 17960247
-
(2007)
Nature
, vol.449
, pp. 1078-1082
-
-
Tang, C.1
Schwieters, C.D.2
Clore, G.M.3
-
53
-
-
84862776818
-
G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
-
Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, et al. (2012) G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody. Nature 482: 237–240. doi: 10.1038/nature10750 22286059
-
(2012)
Nature
, vol.482
, pp. 237-240
-
-
Hino, T.1
Arakawa, T.2
Iwanari, H.3
Yurugi-Kobayashi, T.4
Ikeda-Suno, C.5
-
54
-
-
65649108094
-
Characterization of inhibitory anti-insulin-like growth factor receptor antibodies with different epitope specificity and ligand-blocking properties: implications for mechanism of action in vivo
-
Doern A, Cao X, Sereno A, Reyes CL, Altshuler A, et al. (2009) Characterization of inhibitory anti-insulin-like growth factor receptor antibodies with different epitope specificity and ligand-blocking properties: implications for mechanism of action in vivo. J Biol Chem 284: 10254–10267. doi: 10.1074/jbc.M809709200 19211557
-
(2009)
J Biol Chem
, vol.284
, pp. 10254-10267
-
-
Doern, A.1
Cao, X.2
Sereno, A.3
Reyes, C.L.4
Altshuler, A.5
-
55
-
-
33646115449
-
Elevated shear stress protects Escherichia coli cells adhering to surfaces via catch bonds from detachment by soluble inhibitors
-
Nilsson LM, Thomas WE, Sokurenko EV, Vogel V, (2006) Elevated shear stress protects Escherichia coli cells adhering to surfaces via catch bonds from detachment by soluble inhibitors. Appl Environ Microbiol 72: 3005–3010. 16598008
-
(2006)
Appl Environ Microbiol
, vol.72
, pp. 3005-3010
-
-
Nilsson, L.M.1
Thomas, W.E.2
Sokurenko, E.V.3
Vogel, V.4
-
56
-
-
76649125886
-
Shear-enhanced oral microbial adhesion
-
Ding AM, Palmer RJ, Jr.Cisar JO, Kolenbrander PE, (2010) Shear-enhanced oral microbial adhesion. Appl Environ Microbiol 76: 1294–1297. doi: 10.1128/AEM.02083-09 20023085
-
(2010)
Appl Environ Microbiol
, vol.76
, pp. 1294-1297
-
-
Ding, A.M.1
Palmer, R.J.2
Cisar, J.O.3
Kolenbrander, P.E.4
-
57
-
-
77951178787
-
Shear-enhanced binding of intestinal colonization factor antigen I of enterotoxigenic Escherichia coli
-
Tchesnokova V, McVeigh AL, Kidd B, Yakovenko O, Thomas WE, et al. (2010) Shear-enhanced binding of intestinal colonization factor antigen I of enterotoxigenic Escherichia coli. Mol Microbiol 76: 489–502. doi: 10.1111/j.1365-2958.2010.07116.x 20345656
-
(2010)
Mol Microbiol
, vol.76
, pp. 489-502
-
-
Tchesnokova, V.1
McVeigh, A.L.2
Kidd, B.3
Yakovenko, O.4
Thomas, W.E.5
-
58
-
-
33749054710
-
Staphylococcus aureus adhesion via Spa, ClfA, and SdrCDE to immobilized platelets demonstrates shear-dependent behavior
-
George NP, Wei Q, Shin PK, Konstantopoulos K, Ross JM, (2006) Staphylococcus aureus adhesion via Spa, ClfA, and SdrCDE to immobilized platelets demonstrates shear-dependent behavior. Arterioscler Thromb Vasc Biol 26: 2394–2400. 16857949
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 2394-2400
-
-
George, N.P.1
Wei, Q.2
Shin, P.K.3
Konstantopoulos, K.4
Ross, J.M.5
-
59
-
-
0041856083
-
A novel cyclic peptide immunization strategy for preventing HIV-1/AIDS infection and progression
-
Misumi S, Endo M, Mukai R, Tachibana K, Umeda M, et al. (2003) A novel cyclic peptide immunization strategy for preventing HIV-1/AIDS infection and progression. J Biol Chem 278: 32335–32343. 12771150
-
(2003)
J Biol Chem
, vol.278
, pp. 32335-32343
-
-
Misumi, S.1
Endo, M.2
Mukai, R.3
Tachibana, K.4
Umeda, M.5
-
60
-
-
0029120129
-
Conjugates of synthetic cyclic peptides elicit bactericidal antibodies against a conformational epitope on a class 1 outer membrane protein of Neisseria meningitidis
-
Hoogerhout P, Donders EM, van Gaans-van den Brink JA, Kuipers B, Brugghe HF, et al. (1995) Conjugates of synthetic cyclic peptides elicit bactericidal antibodies against a conformational epitope on a class 1 outer membrane protein of Neisseria meningitidis. Infect Immun 63: 3473–3478. 7543883
-
(1995)
Infect Immun
, vol.63
, pp. 3473-3478
-
-
Hoogerhout, P.1
Donders, E.M.2
van Gaans-van den Brink, J.A.3
Kuipers, B.4
Brugghe, H.F.5
-
61
-
-
84860848762
-
Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap
-
Liu Y, El-Achkar TM, Wu XR, (2012) Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap. J Biol Chem 287: 16365–16378. doi: 10.1074/jbc.M112.348243 22451664
-
(2012)
J Biol Chem
, vol.287
, pp. 16365-16378
-
-
Liu, Y.1
El-Achkar, T.M.2
Wu, X.R.3
-
62
-
-
0032701484
-
Improving biosensor analysis
-
Myszka DG, (1999) Improving biosensor analysis. J Mol Recognit 12: 279–284. 10556875
-
(1999)
J Mol Recognit
, vol.12
, pp. 279-284
-
-
Myszka, D.G.1
-
63
-
-
67650500988
-
CHARMM: the biomolecular simulation program
-
Brooks BR, Brooks CL, 3rdMackerell AD, Jr.Nilsson L, Petrella RJ, et al. (2009) CHARMM: the biomolecular simulation program. J Comput Chem 30: 1545–1614. doi: 10.1002/jcc.21287 19444816
-
(2009)
J Comput Chem
, vol.30
, pp. 1545-1614
-
-
Brooks, B.R.1
Brooks, C.L.2
Mackerell, A.D.3
Nilsson, L.4
Petrella, R.J.5
-
64
-
-
0041784950
-
All-atom empirical potential for molecular modeling and dynamics studies of proteins
-
MacKerell AD, Bashford D, Bellott M, Dunbrack RL, Evanseck JD, et al. (1998) All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B 102: 3586–3616. doi: 10.1021/jp973084f 24889800
-
(1998)
J Phys Chem B
, vol.102
, pp. 3586-3616
-
-
MacKerell, A.D.1
Bashford, D.2
Bellott, M.3
Dunbrack, R.L.4
Evanseck, J.D.5
-
65
-
-
19944433174
-
Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin
-
Bouckaert J, Berglund J, Schembri M, De Genst E, Cools L, et al. (2005) Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin. Mol Microbiol 55: 441–455. 15659162
-
(2005)
Mol Microbiol
, vol.55
, pp. 441-455
-
-
Bouckaert, J.1
Berglund, J.2
Schembri, M.3
De Genst, E.4
Cools, L.5
-
66
-
-
44349121099
-
Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex
-
Wellens A, Garofalo C, Nguyen H, Van Gerven N, Slattegard R, et al. (2008) Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex. PLoS One 3: e2040. doi: 10.1371/journal.pone.0002040 18446213
-
(2008)
PLoS One
, vol.3
, pp. 2040
-
-
Wellens, A.1
Garofalo, C.2
Nguyen, H.3
Van Gerven, N.4
Slattegard, R.5
|