Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 47, 2013, Pages 19089-19094

  Kisiela, Dagmara I ^a   Rodriguez, Victoria B ^b   Tchesnokova, Veronika ^a   Avagyan, Hovhannes ^a   Aprikian, Pavel ^a   Liu, Yan ^c   Wu, Xue Ru ^c   Thomas, Wendy E ^b   Sokurenko, Evgeni V ^a  

^a Departments of Microbiology   (United States)

^b University of Washington   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; ANTISERUM; DISULFIDE; EPITOPE; FIMH PROTEIN; LECTIN; MANNOSE; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; BACTERIUM ADHERENCE; BINDING SITE; CONFORMATION; CONTROLLED STUDY; EPITHELIUM CELL; ESCHERICHIA COLI; IMMUNOGENICITY; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; URINARY TRACT INFECTION;

ANTIADHESIVE ANTIBODIES; FIMH ADHESIN;

ADHESINS, ESCHERICHIA COLI; ANIMALS; ANTIBODIES, MONOCLONAL; BACTERIAL ADHESION; BINDING SITES, ANTIBODY; ESCHERICHIA COLI; FIMBRIAE PROTEINS; MANNOSE; MICE; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN CONFORMATION; URINARY BLADDER DISEASES;

EID: 84888102778     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1314395110     Document Type: Article

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