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Volumn 34, Issue 7, 2014, Pages 1059-1069

Pre-Clinical Analysis of Changes in Intra-cellular Biochemistry of Glioblastoma Multiforme (GBM) Cells Due to c-Myc Silencing

Author keywords

Akt; Autophagy; Bcl 2; c Myc; Glioblastoma multiforme; Glycogen; Lipid

Indexed keywords

(+)-JQ1 COMPOUND; AZEPINE DERIVATIVE; GLYCOGEN; MYC PROTEIN; TRIAZOLE DERIVATIVE;

EID: 84930278597     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-014-0083-4     Document Type: Article
Times cited : (13)

References (40)
  • 1
    • 73149118890 scopus 로고    scopus 로고
    • Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications
    • PID: 19934302, COI: 1:CAS:528:DC%2BD1MXhsFSnu7%2FJ
    • Alcantara Llaguno SR, Chen J, Parada LF (2009) Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications. Clin Cancer Res 15:7124–7129. doi:10.1158/1078-0432.ccr-09-0433
    • (2009) Clin Cancer Res , vol.15 , pp. 7124-7129
    • Alcantara Llaguno, S.R.1    Chen, J.2    Parada, L.F.3
  • 2
    • 84896714612 scopus 로고    scopus 로고
    • BET-bromodomain inhibition of MYC-amplified medulloblastoma
    • Bandopadhayay P et al (2013) BET-bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer. doi:10.1158/1078-0432.ccr-13-2281
    • (2013) Clin Cancer
    • Bandopadhayay, P.1
  • 3
    • 84899482050 scopus 로고    scopus 로고
    • The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis
    • PID: 24319289
    • Belkina AC, Blanton WP, Nikolajczyk BS, Denis GV (2013) The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis. J Leukoc Biol. doi:10.1189/jlb.1112588
    • (2013) J Leukoc Biol
    • Belkina, A.C.1    Blanton, W.P.2    Nikolajczyk, B.S.3    Denis, G.V.4
  • 4
    • 84877097843 scopus 로고    scopus 로고
    • Inhibition of BET bromodomain targets genetically diverse glioblastoma
    • PID: 23403638, COI: 1:CAS:528:DC%2BC3sXlsVCmsLo%3D
    • Cheng Z et al (2013) Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin Cancer Res 19:1748–1759. doi:10.1158/1078-0432.ccr-12-3066
    • (2013) Clin Cancer Res , vol.19 , pp. 1748-1759
    • Cheng, Z.1
  • 5
    • 0033118755 scopus 로고    scopus 로고
    • Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation
    • PID: 10197581, COI: 1:CAS:528:DyaK1MXisVWrsrg%3D
    • Cory S, Vaux DL, Strasser A, Harris AW, Adams JM (1999) Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation. Cancer Res 59:1685s–1692s
    • (1999) Cancer Res , vol.59 , pp. 1685s-1692s
    • Cory, S.1    Vaux, D.L.2    Strasser, A.3    Harris, A.W.4    Adams, J.M.5
  • 6
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: roles in cell survival and oncogenesis
    • PID: 14634621, COI: 1:CAS:528:DC%2BD3sXptFOmtb0%3D
    • Cory S, Huang DC, Adams JM (2003) The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22:8590–8607. doi:10.1038/sj.onc.1207102
    • (2003) Oncogene , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.2    Adams, J.M.3
  • 7
    • 0032905924 scopus 로고    scopus 로고
    • c-Myc target genes involved in cell growth
    • COI: 1:CAS:528:DyaK1MXhvFOgsw%3D%3D
    • Dang CV (1999) c-Myc target genes involved in cell growth. Apoptosis Metab Mol Cell Biol 19:1–11
    • (1999) Apoptosis Metab Mol Cell Biol , vol.19 , pp. 1-11
    • Dang, C.V.1
  • 8
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • PID: 22549953, COI: 1:CAS:528:DC%2BC38XmslOgtrk%3D
    • Dang CV (2012) Links between metabolism and cancer. Genes Dev 26:877–890. doi:10.1101/gad.189365.112
    • (2012) Genes Dev , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 9
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy nature reviews
    • PID: 12360277, COI: 1:CAS:528:DC%2BD38XnsVGrtbo%3D
    • Darnell JE Jr (2002) Transcription factors as targets for cancer therapy nature reviews. Cancer 2:740–749. doi:10.1038/nrc906
    • (2002) Cancer , vol.2 , pp. 740-749
    • Darnell, J.E.1
  • 10
    • 79955602767 scopus 로고    scopus 로고
    • Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells
    • PID: 21405945
    • De Salvo M et al (2011) Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells. Int J Radiat Biol 87:518–533. doi:10.3109/09553002.2011.556173
    • (2011) Int J Radiat Biol , vol.87 , pp. 518-533
    • De Salvo, M.1
  • 11
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-Myc
    • PID: 21889194, COI: 1:CAS:528:DC%2BC3MXhtF2ht7fF
    • Delmore JE et al (2011) BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146:904–917. doi:10.1016/j.cell.2011.08.017
    • (2011) Cell , vol.146 , pp. 904-917
    • Delmore, J.E.1
  • 12
    • 80052872000 scopus 로고    scopus 로고
    • Effect of naringenin on metabolic markers, lipid profile and expression of GFAP in C6 glioma cells implanted rat’s brain
    • PID: 25205946, COI: 1:CAS:528:DC%2BC3MXhtlSrtb3K
    • Devan S, Janardhanam VA (2011) Effect of naringenin on metabolic markers, lipid profile and expression of GFAP in C6 glioma cells implanted rat’s brain. Ann Neurosci 18:151–155
    • (2011) Ann Neurosci , vol.18 , pp. 151-155
    • Devan, S.1    Janardhanam, V.A.2
  • 13
    • 0032575705 scopus 로고    scopus 로고
    • A matter of life and cell death
    • PID: 9721090, COI: 1:CAS:528:DyaK1cXlvVegsLY%3D
    • Evan G, Littlewood T (1998) A matter of life and cell death. Science 281:1317–1322
    • (1998) Science , vol.281 , pp. 1317-1322
    • Evan, G.1    Littlewood, T.2
  • 14
    • 77951233410 scopus 로고    scopus 로고
    • Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition
    • PID: 20018866, COI: 1:CAS:528:DC%2BC3cXisFaks7s%3D
    • Fan Y, Dickman KG, Zong WX (2010) Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition. J Biol Chem 285:7324–7333. doi:10.1074/jbc.M109.035584
    • (2010) J Biol Chem , vol.285 , pp. 7324-7333
    • Fan, Y.1    Dickman, K.G.2    Zong, W.X.3
  • 15
    • 0026722655 scopus 로고
    • Cooperative interaction between c-myc and bcl-2 proto-oncogenes
    • PID: 1406976, COI: 1:CAS:528:DyaK38XmtlWhtbw%3D
    • Fanidi A, Harrington EA, Evan GI (1992) Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature 359:554–556. doi:10.1038/359554a0
    • (1992) Nature , vol.359 , pp. 554-556
    • Fanidi, A.1    Harrington, E.A.2    Evan, G.I.3
  • 16
    • 84870507227 scopus 로고    scopus 로고
    • Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells
    • PID: 23177934, COI: 1:CAS:528:DC%2BC38XhslWqur7I
    • Favaro E et al (2012) Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells. Cell Metab 16:751–764. doi:10.1016/j.cmet.2012.10.017
    • (2012) Cell Metab , vol.16 , pp. 751-764
    • Favaro, E.1
  • 17
    • 78650847770 scopus 로고    scopus 로고
    • Selective inhibition of BET bromodomains
    • PID: 20871596, COI: 1:CAS:528:DC%2BC3MXotlGmtA%3D%3D
    • Filippakopoulos P et al (2010) Selective inhibition of BET bromodomains. Nature 468:1067–1073. doi:10.1038/nature09504
    • (2010) Nature , vol.468 , pp. 1067-1073
    • Filippakopoulos, P.1
  • 18
    • 84861302910 scopus 로고    scopus 로고
    • Mitochondrial structure, function and dynamics are temporally controlled by c-Myc
    • PID: 22629444, COI: 1:CAS:528:DC%2BC38XnvFGlsrs%3D
    • Graves JA et al (2012) Mitochondrial structure, function and dynamics are temporally controlled by c-Myc. PLoS One 7:e37699. doi:10.1371/journal.pone.0037699
    • (2012) PLoS One , vol.7 , pp. e37699
    • Graves, J.A.1
  • 19
    • 33751159640 scopus 로고    scopus 로고
    • Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor γ agonist treatment
    • PID: 16887936, COI: 1:CAS:528:DC%2BD28XhtFygsbnM
    • Grommes C et al (2006) Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor γ agonist treatment. Mol Pharmacol 70:1524–1533. doi:10.1124/mol.106.022194
    • (2006) Mol Pharmacol , vol.70 , pp. 1524-1533
    • Grommes, C.1
  • 21
    • 84884171936 scopus 로고    scopus 로고
    • iNOS: a potential therapeutic target for malignant glioma
    • PID: 23590833, COI: 1:CAS:528:DC%2BC3sXhsV2itLzN
    • Jahani-Asl A, Bonni A (2013) iNOS: a potential therapeutic target for malignant glioma. Curr Mol Med 13:1241–1249
    • (2013) Curr Mol Med , vol.13 , pp. 1241-1249
    • Jahani-Asl, A.1    Bonni, A.2
  • 22
    • 0031980869 scopus 로고    scopus 로고
    • Down-regulation of c-myc and bcl-2 gene expression in PU.1-induced apoptosis in murine erythroleukemia cells international journal of cancer
    • COI: 1:CAS:528:DyaK1cXjtVWnt78%3D
    • Kihara-Negishi F et al (1998) Down-regulation of c-myc and bcl-2 gene expression in PU.1-induced apoptosis in murine erythroleukemia cells international journal of cancer. J Int cancer 76:523–530
    • (1998) J Int cancer , vol.76 , pp. 523-530
    • Kihara-Negishi, F.1
  • 23
    • 46349099384 scopus 로고    scopus 로고
    • Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo
    • PID: 18335064
    • Kim J, Lee JH, Iyer VR (2008) Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. PloS one 3:e1798. doi:10.1371/journal.pone.0001798
    • (2008) PloS one , vol.3 , pp. e1798
    • Kim, J.1    Lee, J.H.2    Iyer, V.R.3
  • 24
    • 67650417891 scopus 로고    scopus 로고
    • c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry
    • PID: 19448666, COI: 1:CAS:528:DC%2BD1MXmtVOrt78%3D
    • Morrish F, Isern N, Sadilek M, Jeffrey M, Hockenbery DM (2009) c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry. Oncogene 28:2485–2491. doi:10.1038/onc.2009.112
    • (2009) Oncogene , vol.28 , pp. 2485-2491
    • Morrish, F.1    Isern, N.2    Sadilek, M.3    Jeffrey, M.4    Hockenbery, D.M.5
  • 25
    • 78449243673 scopus 로고    scopus 로고
    • Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entry
    • PID: 20813845, COI: 1:CAS:528:DC%2BC3cXhsVWgsr7M
    • Morrish F et al (2010) Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entry. J Biol Chem 285:36267–36274. doi:10.1074/jbc.M110.141606
    • (2010) J Biol Chem , vol.285 , pp. 36267-36274
    • Morrish, F.1
  • 26
    • 46449115281 scopus 로고    scopus 로고
    • Stem cell-related “self-renewal” signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma
    • PID: 18565887, COI: 1:CAS:528:DC%2BD1cXoslOqsLs%3D
    • Murat A et al (2008) Stem cell-related “self-renewal” signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J Clin Oncol 26:3015–3024. doi:10.1200/jco.2007.15.7164
    • (2008) J Clin Oncol , vol.26 , pp. 3015-3024
    • Murat, A.1
  • 27
    • 70449711757 scopus 로고    scopus 로고
    • Genetic alterations and signaling pathways in the evolution of gliomas
    • PID: 19737147, COI: 1:CAS:528:DC%2BD1MXhsFOltrvN
    • Ohgaki H, Kleihues P (2009) Genetic alterations and signaling pathways in the evolution of gliomas. Cancer Sci 100:2235–2241. doi:10.1111/j.1349-7006.2009.01308.x
    • (2009) Cancer Sci , vol.100 , pp. 2235-2241
    • Ohgaki, H.1    Kleihues, P.2
  • 28
    • 77950523330 scopus 로고    scopus 로고
    • Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1
    • PID: 20300197
    • Pescador N et al (2010) Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. PLoS ONE 5:e9644. doi:10.1371/journal.pone.0009644
    • (2010) PLoS ONE , vol.5 , pp. e9644
    • Pescador, N.1
  • 30
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • PID: 21127245, COI: 1:CAS:528:DC%2BC3cXhsVyrsbbE
    • Rabinowitz JD, White E (2010) Autophagy and metabolism. Science 330:1344–1348. doi:10.1126/science.1193497
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 31
    • 0034306997 scopus 로고    scopus 로고
    • Multiple ras-dependent phosphorylation pathways regulate Myc protein stability
    • PID: 11018017, COI: 1:CAS:528:DC%2BD3cXntlOqt7k%3D
    • Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR (2000) Multiple ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14:2501–2514. doi:10.1101/gad.836800
    • (2000) Genes Dev , vol.14 , pp. 2501-2514
    • Sears, R.1    Nuckolls, F.2    Haura, E.3    Taya, Y.4    Tamai, K.5    Nevins, J.R.6
  • 32
    • 79955631150 scopus 로고    scopus 로고
    • Autophagy in the cellular energetic balance
    • PID: 21531332, COI: 1:CAS:528:DC%2BC3MXlsFalsr4%3D
    • Singh R, Cuervo AM (2011) Autophagy in the cellular energetic balance. Cell Metab 13:495–504. doi:10.1016/j.cmet.2011.04.004
    • (2011) Cell Metab , vol.13 , pp. 495-504
    • Singh, R.1    Cuervo, A.M.2
  • 33
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • PID: 15549107, COI: 1:CAS:528:DC%2BD2cXpvVCjtbY%3D
    • Singh SK et al (2004) Identification of human brain tumour initiating cells. Nature 432:396–401. doi:10.1038/nature03128
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1
  • 34
    • 84871599585 scopus 로고    scopus 로고
    • BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis
    • PID: 23115324, COI: 1:CAS:528:DC%2BC3sXhsFKitLc%3D
    • Tang X et al (2013) BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis. Mol Pharmacol 83:283–293. doi:10.1124/mol.112.081661
    • (2013) Mol Pharmacol , vol.83 , pp. 283-293
    • Tang, X.1
  • 35
    • 84874451397 scopus 로고    scopus 로고
    • Metabolic modulation of epigenetics in gliomas
    • PID: 23432648, COI: 1:CAS:528:DC%2BC3sXmsValtLs%3D
    • Venneti S, Thompson CB (2013) Metabolic modulation of epigenetics in gliomas. Brain Pathol 23:217–221. doi:10.1111/bpa.12022
    • (2013) Brain Pathol , vol.23 , pp. 217-221
    • Venneti, S.1    Thompson, C.B.2
  • 36
    • 84890330912 scopus 로고    scopus 로고
    • Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) tax protein-mediated tumorigenesis by inhibiting nuclear factor kappab (NF-kappaB) signaling
    • PID: 24189064, COI: 1:CAS:528:DC%2BC3sXhvFarsbbN
    • Wu X, Qi J, Bradner JE, Xiao G, Chen LF (2013) Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) tax protein-mediated tumorigenesis by inhibiting nuclear factor kappab (NF-kappaB) signaling. J Biol Chem 288:36094–36105. doi:10.1074/jbc.M113.485029
    • (2013) J Biol Chem , vol.288 , pp. 36094-36105
    • Wu, X.1    Qi, J.2    Bradner, J.E.3    Xiao, G.4    Chen, L.F.5
  • 37
    • 33845187907 scopus 로고    scopus 로고
    • Global mapping of c-Myc binding sites and target gene networks in human B cells
    • PID: 17093053, COI: 1:CAS:528:DC%2BD28Xht1Knu77O
    • Zeller KI et al (2006) Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci 103:17834–17839. doi:10.1073/pnas.0604129103
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 17834-17839
    • Zeller, K.I.1
  • 38
    • 84874949245 scopus 로고    scopus 로고
    • Dysregulated lipid metabolism in cancer
    • PID: 22937213
    • Zhang F, Du G (2012) Dysregulated lipid metabolism in cancer. World j Biol Chem 3:167–174. doi:10.4331/wjbc.v3.i8.167
    • (2012) World j Biol Chem , vol.3 , pp. 167-174
    • Zhang, F.1    Du, G.2
  • 39
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
    • PID: 19359588, COI: 1:CAS:528:DC%2BD1MXktFals7g%3D
    • Zhao S et al (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 324:261–265. doi:10.1126/science.1170944
    • (2009) Science , vol.324 , pp. 261-265
    • Zhao, S.1
  • 40
    • 84879289434 scopus 로고    scopus 로고
    • MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
    • PID: 23733953, COI: 1:CAS:528:DC%2BC3sXhtFOrtLrN
    • Zirath H et al (2013) MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells. Proc Natl Acad Sci U S A 110:10258–10263. doi:10.1073/pnas.1222404110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 10258-10263
    • Zirath, H.1


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