BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis

Molecular Pharmacology

Volumn 83, Issue 1, 2013, Pages 283-293

  Tang, Xiaoyan ^a   Peng, Ruoqi ^a   Ren, Yonglin ^a   Apparsundaram, Subramanium ^a   Deguzman, Jeremy ^a   Bauer, Carla M ^a   Hoffman, Ann F ^a   Hamilton, Shannon ^a   Liang, Zhenmin ^a   Zeng, Hang ^a   Fuentes, Maria E ^a   DeMartino, Julie A ^a   Kitson, Christopher ^a   Stevenson, Christopher S ^a   Budd, David C ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 (3,5 DIMETHYL 4 ISOXAZOLYL) 1,3 DIHYDRO 8 METHOXY 1 [1 (2 PYRIDINYL)ETHYL] 2H IMIDAZO[4,5 C]QUINOLIN 2 ONE; [4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H 1 THIA 5, 7,8,9 ATETRAAZACYCLOPENT[E]AZULEN 6 YL]ACETIC ACID TERT BUTYL ESTER; BLEOMYCIN; COLLAGEN TYPE 1; FIBRONECTIN; GROWTH FACTOR; INTERLEUKIN 6; JQ 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN; PROTEIN BRD2; PROTEIN BRD4; PROTEIN INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; SB 525334; SMAD2 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; EXPERIMENTAL MODEL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG FIBROSIS; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ACTINS; ADMINISTRATION, ORAL; ANIMALS; BLEOMYCIN; CELL MOVEMENT; CELL PROLIFERATION; CYTOKINES; EPIGENESIS, GENETIC; EXTRACELLULAR MATRIX PROTEINS; FIBROBLASTS; HUMANS; LUNG; MALE; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-SIS; PULMONARY FIBROSIS; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84871599585     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.081661     Document Type: Article

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