Bromodomain and Extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) tax protein-mediated tumorigenesis by inhibiting nuclear factor κB (NF-κB) signaling

Journal of Biological Chemistry

Volumn 288, Issue 50, 2013, Pages 36094-36105

  Wu, Xuewei ^a   Qi, Jun ^b   Bradner, James E ^b   Xiao, Gutian ^c   Chen, Lin Feng ^a,d  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL TRANSFORMATION; CONSTITUTIVELY ACTIVES; HUMAN T CELL LEUKEMIA VIRUS; POLYUBIQUITINATION; PROTEIN INHIBITORS; TARGET GENE EXPRESSION; THERAPEUTIC STRATEGY; TRANSCRIPTIONAL ACTIVATIONS;

ACETYLATION; AMINO ACIDS; CELL PROLIFERATION; CELLS; CYTOLOGY; DISEASES; GENE EXPRESSION; PROTEINS; TAXATION; TISSUE CULTURE; VIRUSES;

CELL SIGNALING;

BRD4 PROTEIN; BROMODOMAIN AND EXTRATERMINAL PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JQ 1; REGULATOR PROTEIN; TAX PROTEIN; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RAT; T CELL LEUKEMIA; TRANSCRIPTION INITIATION; UBIQUITINATION; VIRUS CARCINOGENESIS;

ACETYLATION; BRD4; CANCER; HTLV-1; JQ1; LEUKEMIA; NF-ΚB; SIGNALING; TAX; TRANSCRIPTION;

ACETYLATION; ANIMALS; AZEPINES; CARCINOGENESIS; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LYSINE; MICE; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS; TRIAZOLES;

EID: 84890330912     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.485029     Document Type: Article

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