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Volumn 7, Issue 2, 2015, Pages 341-355

QT Prolongation and Oncology Drug Development

Author keywords

Cancer treatment; Cardio oncology; Cardiotoxicity; Chemotherapy; QT prolongation; Torsades de pointes

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ANTIARRHYTHMIC AGENT; ANTIEMETIC AGENT; ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; CISAPRIDE; CYTOTOXIC AGENT; DASATINIB; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; GREPAFLOXACIN; HISTONE DEACETYLASE INHIBITOR; IMATINIB; MOXIFLOXACIN; NILOTINIB; PANOBINOSTAT; PONATINIB; POTASSIUM; PROTEIN TYROSINE KINASE INHIBITOR; QUINIDINE; RAZOXANE; ROMIDEPSIN; SODIUM; SUNITINIB; TAMOXIFEN; TERFENADINE; UNINDEXED DRUG; VANDETANIB; VORINOSTAT; CARDIOTOXIN;

EID: 84930276825     PISSN: 18779182     EISSN: 18779190     Source Type: Journal    
DOI: 10.1016/j.ccep.2015.03.013     Document Type: Review
Times cited : (40)

References (118)
  • 3
    • 0242494266 scopus 로고    scopus 로고
    • What clinicians should know about the QT interval
    • Al-Khatib S.M., LaPointe N.M., Kramer J.M., et al. What clinicians should know about the QT interval. JAMA 2003, 289(16):2120-2127.
    • (2003) JAMA , vol.289 , Issue.16 , pp. 2120-2127
    • Al-Khatib, S.M.1    LaPointe, N.M.2    Kramer, J.M.3
  • 4
    • 40249094483 scopus 로고    scopus 로고
    • Drug-induced QTc interval prolongation: a proposal towards an efficient and safe anticancer drug development
    • Curigliano G., Spitaleri G., Fingert H.J., et al. Drug-induced QTc interval prolongation: a proposal towards an efficient and safe anticancer drug development. Eur J Cancer 2008, 44(4):494-500.
    • (2008) Eur J Cancer , vol.44 , Issue.4 , pp. 494-500
    • Curigliano, G.1    Spitaleri, G.2    Fingert, H.J.3
  • 5
    • 49749174698 scopus 로고
    • Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death
    • Jervell A., Lange-Nielsen F. Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death. Am Heart J 1957, 54(1):59-68.
    • (1957) Am Heart J , vol.54 , Issue.1 , pp. 59-68
    • Jervell, A.1    Lange-Nielsen, F.2
  • 6
    • 0000387603 scopus 로고
    • Anew familial cardiac syndrome in children
    • Ward O.C. Anew familial cardiac syndrome in children. JIr Med Assoc 1964, 54:103-106.
    • (1964) JIr Med Assoc , vol.54 , pp. 103-106
    • Ward, O.C.1
  • 7
    • 0041737372 scopus 로고    scopus 로고
    • Mechanisms of clinical arrhythmias
    • Zipes D.P. Mechanisms of clinical arrhythmias. JCardiovasc Electrophysiol 2003, 14(8):902-912.
    • (2003) JCardiovasc Electrophysiol , vol.14 , Issue.8 , pp. 902-912
    • Zipes, D.P.1
  • 8
    • 34249330240 scopus 로고    scopus 로고
    • Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes
    • Gupta A., Lawrence A.T., Krishnan K., et al. Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes. Am Heart J 2007, 153(6):891-899.
    • (2007) Am Heart J , vol.153 , Issue.6 , pp. 891-899
    • Gupta, A.1    Lawrence, A.T.2    Krishnan, K.3
  • 9
    • 1442306232 scopus 로고    scopus 로고
    • Drug-induced prolongation of the QTinterval
    • Roden D.M. Drug-induced prolongation of the QTinterval. NEngl J Med 2004, 350(10):1013-1022.
    • (2004) NEngl J Med , vol.350 , Issue.10 , pp. 1013-1022
    • Roden, D.M.1
  • 10
    • 0021972633 scopus 로고
    • Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length
    • Roden D.M., Hoffman B.F. Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length. Circ Res 1985, 56(6):857-867.
    • (1985) Circ Res , vol.56 , Issue.6 , pp. 857-867
    • Roden, D.M.1    Hoffman, B.F.2
  • 11
    • 0027330110 scopus 로고
    • Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalis
    • Sicouri S., Antzelevitch C. Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalis. JCardiovasc Electrophysiol 1993, 4(1):48-58.
    • (1993) JCardiovasc Electrophysiol , vol.4 , Issue.1 , pp. 48-58
    • Sicouri, S.1    Antzelevitch, C.2
  • 12
    • 21144457928 scopus 로고    scopus 로고
    • Inaccurate electrocardiographic interpretation of long QT: the majority of physicians cannot recognize a long QT when they see one
    • Viskin S., Rosovski U., Sands A.J., et al. Inaccurate electrocardiographic interpretation of long QT: the majority of physicians cannot recognize a long QT when they see one. Heart Rhythm 2005, 2(6):569-574.
    • (2005) Heart Rhythm , vol.2 , Issue.6 , pp. 569-574
    • Viskin, S.1    Rosovski, U.2    Sands, A.J.3
  • 13
    • 34547925239 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of short QT interval in a middle-aged Finnish population
    • Anttonen O., Junttila M.J., Rissanen H., et al. Prevalence and prognostic significance of short QT interval in a middle-aged Finnish population. Circulation 2007, 116(7):714-720.
    • (2007) Circulation , vol.116 , Issue.7 , pp. 714-720
    • Anttonen, O.1    Junttila, M.J.2    Rissanen, H.3
  • 14
    • 64549103023 scopus 로고    scopus 로고
    • AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part IV: the ST segment, T and U waves, and the QT interval: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the Internatio
    • Rautaharju P.M., Surawicz B., Gettes L.S., et al. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part IV: the ST segment, T and U waves, and the QT interval: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology. Circulation 2009, 119(10):e241-e250.
    • (2009) Circulation , vol.119 , Issue.10 , pp. e241-e250
    • Rautaharju, P.M.1    Surawicz, B.2    Gettes, L.S.3
  • 15
    • 46349102469 scopus 로고    scopus 로고
    • Accurate electrocardiographic assessment of the QT interval: teach the tangent
    • Postema P.G., De Jong J.S., Van der Bilt I.A., et al. Accurate electrocardiographic assessment of the QT interval: teach the tangent. Heart Rhythm 2008, 5(7):1015-1018.
    • (2008) Heart Rhythm , vol.5 , Issue.7 , pp. 1015-1018
    • Postema, P.G.1    De Jong, J.S.2    Van der Bilt, I.A.3
  • 16
    • 0036847942 scopus 로고    scopus 로고
    • Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management
    • Anderson M.E., Al-Khatib S.M., Roden D.M., et al. Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management. Am Heart J 2002, 144(5):769-781.
    • (2002) Am Heart J , vol.144 , Issue.5 , pp. 769-781
    • Anderson, M.E.1    Al-Khatib, S.M.2    Roden, D.M.3
  • 17
    • 1842789116 scopus 로고    scopus 로고
    • Assessment of prolonged QT and JT intervals in ventricular conduction defects
    • Rautaharju P.M., Zhang Z.M., Prineas R., et al. Assessment of prolonged QT and JT intervals in ventricular conduction defects. Am J Cardiol 2004, 93(8):1017-1021.
    • (2004) Am J Cardiol , vol.93 , Issue.8 , pp. 1017-1021
    • Rautaharju, P.M.1    Zhang, Z.M.2    Prineas, R.3
  • 18
    • 0019983942 scopus 로고
    • The ventricular paced QT interval-the effects of rate and exercise
    • Milne J.R., Ward D.E., Spurrell R.A., et al. The ventricular paced QT interval-the effects of rate and exercise. Pacing Clin Electrophysiol 1982, 5(3):352-358.
    • (1982) Pacing Clin Electrophysiol , vol.5 , Issue.3 , pp. 352-358
    • Milne, J.R.1    Ward, D.E.2    Spurrell, R.A.3
  • 19
    • 77956038870 scopus 로고    scopus 로고
    • QTc prolongation assessment in anticancer drug development: clinical and methodological issues
    • Curigliano G., Spitaleri G., de Braud F., et al. QTc prolongation assessment in anticancer drug development: clinical and methodological issues. Ecancermedicalscience 2009, 3:130.
    • (2009) Ecancermedicalscience , vol.3 , pp. 130
    • Curigliano, G.1    Spitaleri, G.2    de Braud, F.3
  • 20
    • 77958500384 scopus 로고    scopus 로고
    • Drug-induced arrhythmia
    • Heist E.K., Ruskin J.N. Drug-induced arrhythmia. Circulation 2010, 122(14):1426-1435.
    • (2010) Circulation , vol.122 , Issue.14 , pp. 1426-1435
    • Heist, E.K.1    Ruskin, J.N.2
  • 21
    • 38049146378 scopus 로고    scopus 로고
    • Clinical practice. Long-QT syndrome
    • Roden D.M. Clinical practice. Long-QT syndrome. NEngl J Med 2008, 358(2):169-176.
    • (2008) NEngl J Med , vol.358 , Issue.2 , pp. 169-176
    • Roden, D.M.1
  • 22
    • 0026786140 scopus 로고
    • Sex differences in the evolution of the electrocardiographic QT interval with age
    • Rautaharju P.M., Zhou S.H., Wong S., et al. Sex differences in the evolution of the electrocardiographic QT interval with age. Can J Cardiol 1992, 8(7):690-695.
    • (1992) Can J Cardiol , vol.8 , Issue.7 , pp. 690-695
    • Rautaharju, P.M.1    Zhou, S.H.2    Wong, S.3
  • 23
    • 0036399675 scopus 로고    scopus 로고
    • QT interval prolongation as a biomarker for torsades de pointes and sudden death in drug development
    • Sides G.D. QT interval prolongation as a biomarker for torsades de pointes and sudden death in drug development. Dis Markers 2002, 18(2):57-62.
    • (2002) Dis Markers , vol.18 , Issue.2 , pp. 57-62
    • Sides, G.D.1
  • 24
    • 80051506719 scopus 로고    scopus 로고
    • Sex-steroid hormones and electrocardiographic QT-interval duration: findings from the third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis
    • Zhang Y., Ouyang P., Post W.S., et al. Sex-steroid hormones and electrocardiographic QT-interval duration: findings from the third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 2011, 174(4):403-411.
    • (2011) Am J Epidemiol , vol.174 , Issue.4 , pp. 403-411
    • Zhang, Y.1    Ouyang, P.2    Post, W.S.3
  • 25
    • 75049083200 scopus 로고    scopus 로고
    • The association of serum testosterone levels and ventricular repolarization
    • van Noord C., Dorr M., Sturkenboom M.C., et al. The association of serum testosterone levels and ventricular repolarization. Eur J Epidemiol 2010, 25(1):21-28.
    • (2010) Eur J Epidemiol , vol.25 , Issue.1 , pp. 21-28
    • van Noord, C.1    Dorr, M.2    Sturkenboom, M.C.3
  • 26
    • 33645022523 scopus 로고    scopus 로고
    • Evidences of the gender-related differences in cardiac repolarization and the underlying mechanisms in different animal species and human
    • Cheng J. Evidences of the gender-related differences in cardiac repolarization and the underlying mechanisms in different animal species and human. Fundam Clin Pharmacol 2006, 20(1):1-8.
    • (2006) Fundam Clin Pharmacol , vol.20 , Issue.1 , pp. 1-8
    • Cheng, J.1
  • 27
    • 79959330417 scopus 로고    scopus 로고
    • Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis
    • Wu Z.Y., Yu D.J., Soong T.W., et al. Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis. JBiol Chem 2011, 286(25):22186-22194.
    • (2011) JBiol Chem , vol.286 , Issue.25 , pp. 22186-22194
    • Wu, Z.Y.1    Yu, D.J.2    Soong, T.W.3
  • 28
    • 77956178351 scopus 로고    scopus 로고
    • Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts
    • Gaborit N., Varro A., Le Bouter S., et al. Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts. JMol Cell Cardiol 2010, 49(4):639-646.
    • (2010) JMol Cell Cardiol , vol.49 , Issue.4 , pp. 639-646
    • Gaborit, N.1    Varro, A.2    Le Bouter, S.3
  • 29
    • 0036149136 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the long QT syndrome
    • Antzelevitch C., Shimizu W. Cellular mechanisms underlying the long QT syndrome. Curr Opin Cardiol 2002, 17(1):43-51.
    • (2002) Curr Opin Cardiol , vol.17 , Issue.1 , pp. 43-51
    • Antzelevitch, C.1    Shimizu, W.2
  • 30
    • 0036607371 scopus 로고    scopus 로고
    • Torsades de pointes associated with nonantiarrhythmic drugs and observations on gender and QTc
    • Bednar M.M., Harrigan E.P., Ruskin J.N. Torsades de pointes associated with nonantiarrhythmic drugs and observations on gender and QTc. Am J Cardiol 2002, 89(11):1316-1319.
    • (2002) Am J Cardiol , vol.89 , Issue.11 , pp. 1316-1319
    • Bednar, M.M.1    Harrigan, E.P.2    Ruskin, J.N.3
  • 31
    • 0027515633 scopus 로고
    • Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs
    • Makkar R.R., Fromm B.S., Steinman R.T., et al. Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. JAMA 1993, 270(21):2590-2597.
    • (1993) JAMA , vol.270 , Issue.21 , pp. 2590-2597
    • Makkar, R.R.1    Fromm, B.S.2    Steinman, R.T.3
  • 32
    • 0038415858 scopus 로고    scopus 로고
    • Risk stratification in the long-QT syndrome
    • Priori S.G., Schwartz P.J., Napolitano C., et al. Risk stratification in the long-QT syndrome. NEngl J Med 2003, 348(19):1866-1874.
    • (2003) NEngl J Med , vol.348 , Issue.19 , pp. 1866-1874
    • Priori, S.G.1    Schwartz, P.J.2    Napolitano, C.3
  • 33
    • 33748642599 scopus 로고    scopus 로고
    • ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Preventio
    • Zipes D.P., Camm A.J., Borggrefe M., et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). JAm Coll Cardiol 2006, 48(5):e247-e346.
    • (2006) JAm Coll Cardiol , vol.48 , Issue.5 , pp. e247-e346
    • Zipes, D.P.1    Camm, A.J.2    Borggrefe, M.3
  • 34
    • 0030848673 scopus 로고    scopus 로고
    • Normalization of acquired QT prolongation in humans by intravenous potassium
    • Choy A.M., Lang C.C., Chomsky D.M., et al. Normalization of acquired QT prolongation in humans by intravenous potassium. Circulation 1997, 96(7):2149-2154.
    • (1997) Circulation , vol.96 , Issue.7 , pp. 2149-2154
    • Choy, A.M.1    Lang, C.C.2    Chomsky, D.M.3
  • 35
    • 33645302935 scopus 로고    scopus 로고
    • An evaluation ofthe impact of oral magnesium lactate on thecorrected QT interval of patients receiving sotalol or dofetilide to prevent atrial or ventricular tachyarrhythmia recurrence
    • McBride B.F., Min B., Kluger J., et al. An evaluation ofthe impact of oral magnesium lactate on thecorrected QT interval of patients receiving sotalol or dofetilide to prevent atrial or ventricular tachyarrhythmia recurrence. Ann Noninvasive Electrocardiol 2006, 11(2):163-169.
    • (2006) Ann Noninvasive Electrocardiol , vol.11 , Issue.2 , pp. 163-169
    • McBride, B.F.1    Min, B.2    Kluger, J.3
  • 36
    • 0002304545 scopus 로고
    • Quinidine syncope. Paroxysmal ventricular fibrillation occurring during treatment of chronic atrial arrhythmias
    • Selzer A., Wray H.W. Quinidine syncope. Paroxysmal ventricular fibrillation occurring during treatment of chronic atrial arrhythmias. Circulation 1964, 30:17-26.
    • (1964) Circulation , vol.30 , pp. 17-26
    • Selzer, A.1    Wray, H.W.2
  • 37
    • 0013881809 scopus 로고
    • Ventricular tachycardia with 2 variable opposing foci
    • [French]
    • Dessertenne F. Ventricular tachycardia with 2 variable opposing foci. Arch Mal Coeur Vaiss 1966, 59(2):263-272. [in French].
    • (1966) Arch Mal Coeur Vaiss , vol.59 , Issue.2 , pp. 263-272
    • Dessertenne, F.1
  • 38
    • 0030588699 scopus 로고    scopus 로고
    • Sex difference in risk of torsade de pointes with d,l-sotalol
    • Lehmann M.H., Hardy S., Archibald D., et al. Sex difference in risk of torsade de pointes with d,l-sotalol. Circulation 1996, 94(10):2535-2541.
    • (1996) Circulation , vol.94 , Issue.10 , pp. 2535-2541
    • Lehmann, M.H.1    Hardy, S.2    Archibald, D.3
  • 39
    • 0034619437 scopus 로고    scopus 로고
    • Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter: the symptomatic atrial fibrillation investigative research on dofetilide (SAFIRE-D) study
    • Singh S., Zoble R.G., Yellen L., et al. Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter: the symptomatic atrial fibrillation investigative research on dofetilide (SAFIRE-D) study. Circulation 2000, 102(19):2385-2390.
    • (2000) Circulation , vol.102 , Issue.19 , pp. 2385-2390
    • Singh, S.1    Zoble, R.G.2    Yellen, L.3
  • 40
    • 0026671408 scopus 로고
    • Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin
    • Honig P.K., Woosley R.L., Zamani K., et al. Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin. Clin Pharmacol Ther 1992, 52(3):231-238.
    • (1992) Clin Pharmacol Ther , vol.52 , Issue.3 , pp. 231-238
    • Honig, P.K.1    Woosley, R.L.2    Zamani, K.3
  • 41
    • 0025222965 scopus 로고
    • Torsades de pointes occurring in association with terfenadine use
    • Monahan B.P., Ferguson C.L., Killeavy E.S., et al. Torsades de pointes occurring in association with terfenadine use. JAMA 1990, 264(21):2788-2790.
    • (1990) JAMA , vol.264 , Issue.21 , pp. 2788-2790
    • Monahan, B.P.1    Ferguson, C.L.2    Killeavy, E.S.3
  • 42
    • 0029947311 scopus 로고    scopus 로고
    • Drug interactions, cardiac toxicity, and terfenadine: from bench to clinic?
    • Flockhart D.A. Drug interactions, cardiac toxicity, and terfenadine: from bench to clinic?. JClin Psychopharmacol 1996, 16(2):101-103.
    • (1996) JClin Psychopharmacol , vol.16 , Issue.2 , pp. 101-103
    • Flockhart, D.A.1
  • 43
    • 0036242014 scopus 로고    scopus 로고
    • Safety of fluoroquinolones: an update
    • Mandell L., Tillotson G. Safety of fluoroquinolones: an update. Can J Infect Dis 2002, 13(1):54-61.
    • (2002) Can J Infect Dis , vol.13 , Issue.1 , pp. 54-61
    • Mandell, L.1    Tillotson, G.2
  • 44
    • 0029890375 scopus 로고    scopus 로고
    • Cisapride and fatal arrhythmia
    • Wysowski D.K., Bacsanyi J. Cisapride and fatal arrhythmia. NEngl J Med 1996, 335(4):290-291.
    • (1996) NEngl J Med , vol.335 , Issue.4 , pp. 290-291
    • Wysowski, D.K.1    Bacsanyi, J.2
  • 45
    • 0033936124 scopus 로고    scopus 로고
    • Cisapride: limited access and alternatives
    • Richter J.E. Cisapride: limited access and alternatives. Cleve Clin J Med 2000, 67(7):471-472.
    • (2000) Cleve Clin J Med , vol.67 , Issue.7 , pp. 471-472
    • Richter, J.E.1
  • 46
    • 67149117982 scopus 로고    scopus 로고
    • ICH topic S7B: note for guidance on the nonclinical evaluation of the potential for delayed ventricular repolarization
    • (QT interval prolongation) by human pharmaceuticals. (CPMP/ICH/423/02)
    • European Agency for the Evaluation of Medicinal Products (EMEA). ICH topic S7B: note for guidance on the nonclinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. (CPMP/ICH/423/02). 2005.
    • (2005)
  • 47
    • 84877826703 scopus 로고    scopus 로고
    • The role of intratumoral and systemic IL-6 in breast cancer
    • Dethlefsen C., Hojfeldt G., Hojman P. The role of intratumoral and systemic IL-6 in breast cancer. Breast Cancer Res Treat 2013, 138(3):657-664.
    • (2013) Breast Cancer Res Treat , vol.138 , Issue.3 , pp. 657-664
    • Dethlefsen, C.1    Hojfeldt, G.2    Hojman, P.3
  • 48
    • 48149103387 scopus 로고    scopus 로고
    • Principles of safety pharmacology
    • Pugsley M.K., Authier S., Curtis M.J. Principles of safety pharmacology. Br J Pharmacol 2008, 154(7):1382-1399.
    • (2008) Br J Pharmacol , vol.154 , Issue.7 , pp. 1382-1399
    • Pugsley, M.K.1    Authier, S.2    Curtis, M.J.3
  • 49
    • 0035038217 scopus 로고    scopus 로고
    • The canine Purkinje fiber: an invitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis
    • Gintant G.A., Limberis J.T., McDermott J.S., et al. The canine Purkinje fiber: an invitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis. JCardiovasc Pharmacol 2001, 37(5):607-618.
    • (2001) JCardiovasc Pharmacol , vol.37 , Issue.5 , pp. 607-618
    • Gintant, G.A.1    Limberis, J.T.2    McDermott, J.S.3
  • 50
    • 84860376625 scopus 로고    scopus 로고
    • Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome
    • Lu Z., Wu C.Y., Jiang Y.P., et al. Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome. Sci Transl Med 2012, 4(131):131ra150.
    • (2012) Sci Transl Med , vol.4 , Issue.131 , pp. 131ra150
    • Lu, Z.1    Wu, C.Y.2    Jiang, Y.P.3
  • 51
    • 84904573224 scopus 로고    scopus 로고
    • Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current
    • Yang T., Chun Y.W., Stroud D.M., et al. Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current. Circulation 2014, 130(3):224-234.
    • (2014) Circulation , vol.130 , Issue.3 , pp. 224-234
    • Yang, T.1    Chun, Y.W.2    Stroud, D.M.3
  • 52
    • 27744493604 scopus 로고    scopus 로고
    • Role of transmural dispersion of repolarization in the genesis of drug-induced torsades de pointes
    • Antzelevitch C. Role of transmural dispersion of repolarization in the genesis of drug-induced torsades de pointes. Heart Rhythm 2005, 2(2 Suppl):S9-S15.
    • (2005) Heart Rhythm , vol.2 , Issue.2 , pp. S9-S15
    • Antzelevitch, C.1
  • 53
    • 27744472015 scopus 로고    scopus 로고
    • Use of preclinical assays to predict risk of drug-induced torsades de pointes
    • Belardinelli L., Shryock J.C., Wu L., et al. Use of preclinical assays to predict risk of drug-induced torsades de pointes. Heart Rhythm 2005, 2(2 Suppl):S16-S22.
    • (2005) Heart Rhythm , vol.2 , Issue.2 , pp. S16-S22
    • Belardinelli, L.1    Shryock, J.C.2    Wu, L.3
  • 54
    • 74549120726 scopus 로고    scopus 로고
    • The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance
    • Darpo B. The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance. Br J Pharmacol 2010, 159(1):49-57.
    • (2010) Br J Pharmacol , vol.159 , Issue.1 , pp. 49-57
    • Darpo, B.1
  • 55
    • 50349099149 scopus 로고    scopus 로고
    • The effect of moxifloxacin on QTc and implications for the design of thorough QT studies
    • Bloomfield D.M., Kost J.T., Ghosh K., et al. The effect of moxifloxacin on QTc and implications for the design of thorough QT studies. Clin Pharmacol Ther 2008, 84(4):475-480.
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.4 , pp. 475-480
    • Bloomfield, D.M.1    Kost, J.T.2    Ghosh, K.3
  • 57
    • 84875075909 scopus 로고    scopus 로고
    • ICH E14 Q & A (R1) document: perspectives on the updated recommendations on thorough QT studies
    • Shah R.R., Morganroth J. ICH E14 Q & A (R1) document: perspectives on the updated recommendations on thorough QT studies. Br J Clin Pharmacol 2013, 75(4):959-965.
    • (2013) Br J Clin Pharmacol , vol.75 , Issue.4 , pp. 959-965
    • Shah, R.R.1    Morganroth, J.2
  • 58
    • 84930272408 scopus 로고    scopus 로고
    • QT prolongation induced by targeted biotherapies used in clinical practice and under investigation: a comprehensive review
    • Locatelli M., Criscitiello C., Esposito A., et al. QT prolongation induced by targeted biotherapies used in clinical practice and under investigation: a comprehensive review. Target Oncol 2015, 10(1):27-43.
    • (2015) Target Oncol , vol.10 , Issue.1 , pp. 27-43
    • Locatelli, M.1    Criscitiello, C.2    Esposito, A.3
  • 59
    • 0141576728 scopus 로고    scopus 로고
    • Baseline heart rate-corrected QT and eligibility for clinical trials in oncology
    • Varterasian M., Meyer M., Fingert H., et al. Baseline heart rate-corrected QT and eligibility for clinical trials in oncology. JClin Oncol 2003, 21(17):3378-3379.
    • (2003) JClin Oncol , vol.21 , Issue.17 , pp. 3378-3379
    • Varterasian, M.1    Meyer, M.2    Fingert, H.3
  • 60
    • 33745683507 scopus 로고    scopus 로고
    • Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma
    • Piekarz R.L., Frye A.R., Wright J.J., et al. Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma. Clin Cancer Res 2006, 12(12):3762-3773.
    • (2006) Clin Cancer Res , vol.12 , Issue.12 , pp. 3762-3773
    • Piekarz, R.L.1    Frye, A.R.2    Wright, J.J.3
  • 61
    • 84930271479 scopus 로고    scopus 로고
    • version 4.0, DHHS, NIH, NCI. Accessed March 9, 2015.
    • US Department of Health and Human Services: common terminology criteria for adverse events (CTCAE), version 4.0, DHHS, NIH, NCI. 2009. Available at: Accessed March 9, 2015. http://evs.nci.nih.gov/ftp1/CTCAE/Archive/CTCAE_4.02_2009-09-15_QuickReference:8.5x11.pdf.
    • (2009)
  • 62
    • 33645087114 scopus 로고    scopus 로고
    • Safety biomarkers and the clinical development of oncology therapeutics: considerations for cardiovascular safety and risk management
    • Fingert H., Varterasian M. Safety biomarkers and the clinical development of oncology therapeutics: considerations for cardiovascular safety and risk management. AAPS J 2006, 8(1):E89-E94.
    • (2006) AAPS J , vol.8 , Issue.1 , pp. E89-E94
    • Fingert, H.1    Varterasian, M.2
  • 63
    • 4444306383 scopus 로고    scopus 로고
    • Consideration of QT/QTc interval data in a phase I study in patients with advanced cancer
    • [author reply: 5968-9]
    • Varterasian M., Fingert H., Agin M., et al. Consideration of QT/QTc interval data in a phase I study in patients with advanced cancer. Clin Cancer Res 2004, 10(17):5967-5968. [author reply: 5968-9].
    • (2004) Clin Cancer Res , vol.10 , Issue.17 , pp. 5967-5968
    • Varterasian, M.1    Fingert, H.2    Agin, M.3
  • 64
    • 84868113707 scopus 로고    scopus 로고
    • Electrocardiograms (ECGs) in phase I anticancer drug development: the MD Anderson Cancer Center experience with 8518 ECGs
    • Naing A., Veasey-Rodrigues H., Hong D.S., et al. Electrocardiograms (ECGs) in phase I anticancer drug development: the MD Anderson Cancer Center experience with 8518 ECGs. Ann Oncol 2012, 23(11):2960-2963.
    • (2012) Ann Oncol , vol.23 , Issue.11 , pp. 2960-2963
    • Naing, A.1    Veasey-Rodrigues, H.2    Hong, D.S.3
  • 65
    • 84898825699 scopus 로고    scopus 로고
    • Chemotherapy and QT prolongation: overview with clinical perspective
    • Kim P.Y., Ewer M.S. Chemotherapy and QT prolongation: overview with clinical perspective. Curr Treat Options Cardiovasc Med 2014, 16(5):303.
    • (2014) Curr Treat Options Cardiovasc Med , vol.16 , Issue.5 , pp. 303
    • Kim, P.Y.1    Ewer, M.S.2
  • 66
    • 0035031113 scopus 로고    scopus 로고
    • Risk/benefit profile of arsenic trioxide
    • Rust D.M., Soignet S.L. Risk/benefit profile of arsenic trioxide. Oncologist 2001, 6(Suppl 2):29-32.
    • (2001) Oncologist , vol.6 , pp. 29-32
    • Rust, D.M.1    Soignet, S.L.2
  • 67
    • 0025201879 scopus 로고
    • All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results
    • Castaigne S., Chomienne C., Daniel M.T., et al. All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 1990, 76(9):1704-1709.
    • (1990) Blood , vol.76 , Issue.9 , pp. 1704-1709
    • Castaigne, S.1    Chomienne, C.2    Daniel, M.T.3
  • 68
    • 0028008950 scopus 로고
    • All-trans retinoic acid for acute promyelocytic leukemia. Results of the New York Study
    • Frankel S.R., Eardley A., Heller G., et al. All-trans retinoic acid for acute promyelocytic leukemia. Results of the New York Study. Ann Intern Med 1994, 120(4):278-286.
    • (1994) Ann Intern Med , vol.120 , Issue.4 , pp. 278-286
    • Frankel, S.R.1    Eardley, A.2    Heller, G.3
  • 69
    • 0033254499 scopus 로고    scopus 로고
    • Long-term survival and prognostic study in acute promyelocytic leukemia treated with all-trans-retinoic acid, chemotherapy, and As2O3: an experience of 120 patients at a single institution
    • Hu J., Shen Z.X., Sun G.L., et al. Long-term survival and prognostic study in acute promyelocytic leukemia treated with all-trans-retinoic acid, chemotherapy, and As2O3: an experience of 120 patients at a single institution. Int J Hematol 1999, 70(4):248-260.
    • (1999) Int J Hematol , vol.70 , Issue.4 , pp. 248-260
    • Hu, J.1    Shen, Z.X.2    Sun, G.L.3
  • 70
    • 0025134930 scopus 로고
    • The unique aspects of acute promyelocytic leukemia
    • Stone R.M., Mayer R.J. The unique aspects of acute promyelocytic leukemia. JClin Oncol 1990, 8(11):1913-1921.
    • (1990) JClin Oncol , vol.8 , Issue.11 , pp. 1913-1921
    • Stone, R.M.1    Mayer, R.J.2
  • 71
    • 0028557482 scopus 로고
    • Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience
    • Warrell R.P., Maslak P., Eardley A., et al. Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience. Leukemia 1994, 8(6):929-933.
    • (1994) Leukemia , vol.8 , Issue.6 , pp. 929-933
    • Warrell, R.P.1    Maslak, P.2    Eardley, A.3
  • 72
    • 0030610687 scopus 로고    scopus 로고
    • Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients
    • Shen Z.X., Chen G.Q., Ni J.H., et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 1997, 89(9):3354-3360.
    • (1997) Blood , vol.89 , Issue.9 , pp. 3354-3360
    • Shen, Z.X.1    Chen, G.Q.2    Ni, J.H.3
  • 73
    • 0035884639 scopus 로고    scopus 로고
    • United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia
    • Soignet S.L., Frankel S.R., Douer D., et al. United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. JClin Oncol 2001, 19(18):3852-3860.
    • (2001) JClin Oncol , vol.19 , Issue.18 , pp. 3852-3860
    • Soignet, S.L.1    Frankel, S.R.2    Douer, D.3
  • 74
    • 0032487923 scopus 로고    scopus 로고
    • Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide
    • Soignet S.L., Maslak P., Wang Z.G., et al. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. NEngl J Med 1998, 339(19):1341-1348.
    • (1998) NEngl J Med , vol.339 , Issue.19 , pp. 1341-1348
    • Soignet, S.L.1    Maslak, P.2    Wang, Z.G.3
  • 75
    • 0006004416 scopus 로고
    • The electrocardiogram in acute arsenic poisoning
    • Weinberg S.L. The electrocardiogram in acute arsenic poisoning. Am Heart J 1960, 60:971-975.
    • (1960) Am Heart J , vol.60 , pp. 971-975
    • Weinberg, S.L.1
  • 76
    • 0033570955 scopus 로고    scopus 로고
    • Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients
    • Niu C., Yan H., Yu T., et al. Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. Blood 1999, 94(10):3315-3324.
    • (1999) Blood , vol.94 , Issue.10 , pp. 3315-3324
    • Niu, C.1    Yan, H.2    Yu, T.3
  • 77
    • 0035283137 scopus 로고    scopus 로고
    • Torsades de pointes in 3 patients with leukemia treated with arsenic trioxide
    • Unnikrishnan D., Dutcher J.P., Varshneya N., et al. Torsades de pointes in 3 patients with leukemia treated with arsenic trioxide. Blood 2001, 97(5):1514-1516.
    • (2001) Blood , vol.97 , Issue.5 , pp. 1514-1516
    • Unnikrishnan, D.1    Dutcher, J.P.2    Varshneya, N.3
  • 78
    • 0034610263 scopus 로고    scopus 로고
    • Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia
    • Ohnishi K., Yoshida H., Shigeno K., et al. Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Ann Intern Med 2000, 133(11):881-885.
    • (2000) Ann Intern Med , vol.133 , Issue.11 , pp. 881-885
    • Ohnishi, K.1    Yoshida, H.2    Shigeno, K.3
  • 79
    • 0141939058 scopus 로고    scopus 로고
    • Effect of arsenic trioxide on QT interval in patients with advanced malignancies
    • Barbey J.T., Pezzullo J.C., Soignet S.L. Effect of arsenic trioxide on QT interval in patients with advanced malignancies. JClin Oncol 2003, 21(19):3609-3615.
    • (2003) JClin Oncol , vol.21 , Issue.19 , pp. 3609-3615
    • Barbey, J.T.1    Pezzullo, J.C.2    Soignet, S.L.3
  • 80
    • 84911420075 scopus 로고    scopus 로고
    • Prevalence, management, and clinical consequences of qt interval prolongation during treatment with arsenic trioxide
    • Roboz G.J., Ritchie E.K., Carlin R.F., et al. Prevalence, management, and clinical consequences of qt interval prolongation during treatment with arsenic trioxide. JClin Oncol 2014, 32(33):3723-3728.
    • (2014) JClin Oncol , vol.32 , Issue.33 , pp. 3723-3728
    • Roboz, G.J.1    Ritchie, E.K.2    Carlin, R.F.3
  • 81
    • 0035462726 scopus 로고    scopus 로고
    • Cardiac toxicity of arsenic trioxide
    • [author reply: 1633-4]
    • Barbey J.T. Cardiac toxicity of arsenic trioxide. Blood 2001, 98(5):1632. [author reply: 1633-4].
    • (2001) Blood , vol.98 , Issue.5 , pp. 1632
    • Barbey, J.T.1
  • 82
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • Krause D.S., Van Etten R.A. Tyrosine kinases as targets for cancer therapy. NEngl J Med 2005, 353(2):172-187.
    • (2005) NEngl J Med , vol.353 , Issue.2 , pp. 172-187
    • Krause, D.S.1    Van Etten, R.A.2
  • 83
    • 50949132320 scopus 로고    scopus 로고
    • Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics
    • Chen M.H., Kerkela R., Force T. Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation 2008, 118(1):84-95.
    • (2008) Circulation , vol.118 , Issue.1 , pp. 84-95
    • Chen, M.H.1    Kerkela, R.2    Force, T.3
  • 84
    • 84877769909 scopus 로고    scopus 로고
    • Cardiovascular safety of tyrosine kinase inhibitors: with a special focus on cardiac repolarisation (QT interval)
    • Shah R.R., Morganroth J., Shah D.R. Cardiovascular safety of tyrosine kinase inhibitors: with a special focus on cardiac repolarisation (QT interval). Drug Saf 2013, 36(5):295-316.
    • (2013) Drug Saf , vol.36 , Issue.5 , pp. 295-316
    • Shah, R.R.1    Morganroth, J.2    Shah, D.R.3
  • 85
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker B.J., Talpaz M., Resta D.J., et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. NEngl J Med 2001, 344(14):1031-1037.
    • (2001) NEngl J Med , vol.344 , Issue.14 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 86
    • 84883592712 scopus 로고    scopus 로고
    • Emerging paradigms in cardiomyopathies associated with cancer therapies
    • Ky B., Vejpongsa P., Yeh E.T., et al. Emerging paradigms in cardiomyopathies associated with cancer therapies. Circ Res 2013, 113(6):754-764.
    • (2013) Circ Res , vol.113 , Issue.6 , pp. 754-764
    • Ky, B.1    Vejpongsa, P.2    Yeh, E.T.3
  • 87
    • 84875886935 scopus 로고    scopus 로고
    • Cardiovascular complications associated with novel angiogenesis inhibitors: emerging evidence and evolving perspectives
    • Bair S.M., Choueiri T.K., Moslehi J. Cardiovascular complications associated with novel angiogenesis inhibitors: emerging evidence and evolving perspectives. Trends Cardiovasc Med 2013, 23(4):104-113.
    • (2013) Trends Cardiovasc Med , vol.23 , Issue.4 , pp. 104-113
    • Bair, S.M.1    Choueiri, T.K.2    Moslehi, J.3
  • 88
    • 84887076805 scopus 로고    scopus 로고
    • Cancer-drug discovery and cardiovascular surveillance
    • Groarke J.D., Cheng S., Moslehi J. Cancer-drug discovery and cardiovascular surveillance. NEngl J Med 2013, 369(19):1779-1781.
    • (2013) NEngl J Med , vol.369 , Issue.19 , pp. 1779-1781
    • Groarke, J.D.1    Cheng, S.2    Moslehi, J.3
  • 89
    • 79959340971 scopus 로고    scopus 로고
    • Nilotinib treatment-associated peripheral artery disease and sudden death: yet another reason to stick to imatinib as front-line therapy for chronic myelogenous leukemia
    • Tefferi A., Letendre L. Nilotinib treatment-associated peripheral artery disease and sudden death: yet another reason to stick to imatinib as front-line therapy for chronic myelogenous leukemia. Am J Hematol 2011, 86(7):610-611.
    • (2011) Am J Hematol , vol.86 , Issue.7 , pp. 610-611
    • Tefferi, A.1    Letendre, L.2
  • 90
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H., Giles F., Wunderle L., et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. NEngl J Med 2006, 354(24):2542-2551.
    • (2006) NEngl J Med , vol.354 , Issue.24 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 91
    • 0027025790 scopus 로고
    • An overview of class III electrophysiological agents: a new generation of antiarrhythmic therapy
    • Morgan T.K., Sullivan M.E. An overview of class III electrophysiological agents: a new generation of antiarrhythmic therapy. Prog Med Chem 1992, 29:65-108.
    • (1992) Prog Med Chem , vol.29 , pp. 65-108
    • Morgan, T.K.1    Sullivan, M.E.2
  • 92
    • 84930271424 scopus 로고    scopus 로고
    • Submission control no 102788, Pfizer Canada Inc, Kirkland (WA); Quebec (Canada)
    • Product monograph: sutent, sunitimib malate capsules 2006, Submission control no 102788, Pfizer Canada Inc, Kirkland (WA); Quebec (Canada).
    • (2006) Product monograph: sutent, sunitimib malate capsules
  • 93
    • 34548276036 scopus 로고    scopus 로고
    • Molecularly targeted oncology therapeutics and prolongation of the QT interval
    • Strevel E.L., Ing D.J., Siu L.L. Molecularly targeted oncology therapeutics and prolongation of the QT interval. JClin Oncol 2007, 25(22):3362-3371.
    • (2007) JClin Oncol , vol.25 , Issue.22 , pp. 3362-3371
    • Strevel, E.L.1    Ing, D.J.2    Siu, L.L.3
  • 94
    • 18244387980 scopus 로고    scopus 로고
    • Amulticenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer
    • Miller K.D., Trigo J.M., Wheeler C., et al. Amulticenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer. Clin Cancer Res 2005, 11(9):3369-3376.
    • (2005) Clin Cancer Res , vol.11 , Issue.9 , pp. 3369-3376
    • Miller, K.D.1    Trigo, J.M.2    Wheeler, C.3
  • 95
    • 23844544081 scopus 로고    scopus 로고
    • Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors
    • Holden S.N., Eckhardt S.G., Basser R., et al. Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol 2005, 16(8):1391-1397.
    • (2005) Ann Oncol , vol.16 , Issue.8 , pp. 1391-1397
    • Holden, S.N.1    Eckhardt, S.G.2    Basser, R.3
  • 96
    • 33846844387 scopus 로고    scopus 로고
    • Aphase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors
    • Tamura T., Minami H., Yamada Y., et al. Aphase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors. JThorac Oncol 2006, 1(9):1002-1009.
    • (2006) JThorac Oncol , vol.1 , Issue.9 , pp. 1002-1009
    • Tamura, T.1    Minami, H.2    Yamada, Y.3
  • 97
    • 34948838898 scopus 로고    scopus 로고
    • Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer
    • Heymach J.V., Johnson B.E., Prager D., et al. Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. JClin Oncol 2007, 25(27):4270-4277.
    • (2007) JClin Oncol , vol.25 , Issue.27 , pp. 4270-4277
    • Heymach, J.V.1    Johnson, B.E.2    Prager, D.3
  • 98
    • 41749097667 scopus 로고    scopus 로고
    • Arandomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer
    • Kiura K., Nakagawa K., Shinkai T., et al. Arandomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer. JThorac Oncol 2008, 3(4):386-393.
    • (2008) JThorac Oncol , vol.3 , Issue.4 , pp. 386-393
    • Kiura, K.1    Nakagawa, K.2    Shinkai, T.3
  • 99
    • 33747644424 scopus 로고    scopus 로고
    • Aphase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma-NCIC CTG IND.145
    • Kovacs M.J., Reece D.E., Marcellus D., et al. Aphase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma-NCIC CTG IND.145. Invest New Drugs 2006, 24(6):529-535.
    • (2006) Invest New Drugs , vol.24 , Issue.6 , pp. 529-535
    • Kovacs, M.J.1    Reece, D.E.2    Marcellus, D.3
  • 100
    • 77649214078 scopus 로고    scopus 로고
    • Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Wells S.A., Gosnell J.E., Gagel R.F., et al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. JClin Oncol 2010, 28(5):767-772.
    • (2010) JClin Oncol , vol.28 , Issue.5 , pp. 767-772
    • Wells, S.A.1    Gosnell, J.E.2    Gagel, R.F.3
  • 101
    • 79952748468 scopus 로고    scopus 로고
    • Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer
    • Natale R.B., Thongprasert S., Greco F.A., et al. Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer. JClin Oncol 2011, 29(8):1059-1066.
    • (2011) JClin Oncol , vol.29 , Issue.8 , pp. 1059-1066
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3
  • 102
    • 84857158314 scopus 로고    scopus 로고
    • Incidence and risk of QTc interval prolongation among cancer patients treated with vandetanib: a systematic review and meta-analysis
    • Zang J., Wu S., Tang L., et al. Incidence and risk of QTc interval prolongation among cancer patients treated with vandetanib: a systematic review and meta-analysis. PLoS One 2012, 7(2):e30353.
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e30353
    • Zang, J.1    Wu, S.2    Tang, L.3
  • 103
    • 50949119729 scopus 로고    scopus 로고
    • Failure to achieve a major cytogenetic response by 12 months defines inadequate response in patients receiving nilotinib or dasatinib as second or subsequent line therapy for chronic myeloid leukemia
    • Tam C.S., Kantarjian H., Garcia-Manero G., et al. Failure to achieve a major cytogenetic response by 12 months defines inadequate response in patients receiving nilotinib or dasatinib as second or subsequent line therapy for chronic myeloid leukemia. Blood 2008, 112(3):516-518.
    • (2008) Blood , vol.112 , Issue.3 , pp. 516-518
    • Tam, C.S.1    Kantarjian, H.2    Garcia-Manero, G.3
  • 104
    • 84930274360 scopus 로고    scopus 로고
    • Accessed November 17, 2014.
    • US Food and Drug Administration. Safety information: tasigna (nilotinib) capsule. 2014. Available at: Accessed November 17, 2014. http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm218929.htm.
    • (2014)
  • 105
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
    • Johnstone R.W. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 2002, 1(4):287-299.
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.4 , pp. 287-299
    • Johnstone, R.W.1
  • 106
    • 79960188498 scopus 로고    scopus 로고
    • Optimization of the invitro cardiac safety of hydroxamate-based histone deacetylase inhibitors
    • Shultz M.D., Cao X., Chen C.H., et al. Optimization of the invitro cardiac safety of hydroxamate-based histone deacetylase inhibitors. JMed Chem 2011, 54(13):4752-4772.
    • (2011) JMed Chem , vol.54 , Issue.13 , pp. 4752-4772
    • Shultz, M.D.1    Cao, X.2    Chen, C.H.3
  • 107
    • 34547683194 scopus 로고    scopus 로고
    • Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
    • Olsen E.A., Kim Y.H., Kuzel T.M., et al. Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. JClin Oncol 2007, 25(21):3109-3115.
    • (2007) JClin Oncol , vol.25 , Issue.21 , pp. 3109-3115
    • Olsen, E.A.1    Kim, Y.H.2    Kuzel, T.M.3
  • 108
    • 84864069212 scopus 로고    scopus 로고
    • QT interval prolongation and torsades de pointes in a patient undergoing treatment with vorinostat: a case report and review of the literature
    • Lynch D.R., Washam J.B., Newby L.K. QT interval prolongation and torsades de pointes in a patient undergoing treatment with vorinostat: a case report and review of the literature. Cardiol J 2012, 19(4):434-438.
    • (2012) Cardiol J , vol.19 , Issue.4 , pp. 434-438
    • Lynch, D.R.1    Washam, J.B.2    Newby, L.K.3
  • 109
    • 29244472088 scopus 로고    scopus 로고
    • Effect of epirubicin-based chemotherapy and dexrazoxane supplementation on QT dispersion in non-Hodgkin lymphoma patients
    • Galetta F., Franzoni F., Cervetti G., et al. Effect of epirubicin-based chemotherapy and dexrazoxane supplementation on QT dispersion in non-Hodgkin lymphoma patients. Biomed Pharmacother 2005, 59(10):541-544.
    • (2005) Biomed Pharmacother , vol.59 , Issue.10 , pp. 541-544
    • Galetta, F.1    Franzoni, F.2    Cervetti, G.3
  • 110
    • 0032905116 scopus 로고    scopus 로고
    • QT dispersion and late potentials during doxorubicin therapy for non-Hodgkin's lymphoma
    • Nousiainen T., Vanninen E., Rantala A., et al. QT dispersion and late potentials during doxorubicin therapy for non-Hodgkin's lymphoma. JIntern Med 1999, 245(4):359-364.
    • (1999) JIntern Med , vol.245 , Issue.4 , pp. 359-364
    • Nousiainen, T.1    Vanninen, E.2    Rantala, A.3
  • 111
    • 0032238699 scopus 로고    scopus 로고
    • The antiestrogen tamoxifen blocks the delayed rectifier potassium current, IKr, in rabbit ventricular myocytes
    • Liu X.K., Katchman A., Ebert S.N., et al. The antiestrogen tamoxifen blocks the delayed rectifier potassium current, IKr, in rabbit ventricular myocytes. JPharmacol Exp Ther 1998, 287(3):877-883.
    • (1998) JPharmacol Exp Ther , vol.287 , Issue.3 , pp. 877-883
    • Liu, X.K.1    Katchman, A.2    Ebert, S.N.3
  • 112
    • 0037096814 scopus 로고    scopus 로고
    • Aphase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
    • Dowlati A., Robertson K., Cooney M., et al. Aphase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res 2002, 62(12):3408-3416.
    • (2002) Cancer Res , vol.62 , Issue.12 , pp. 3408-3416
    • Dowlati, A.1    Robertson, K.2    Cooney, M.3
  • 113
    • 0035678051 scopus 로고    scopus 로고
    • Aphase I and pharmacological study of the farnesyl protein transferase inhibitor L-778,123 in patients with solid malignancies
    • Britten C.D., Rowinsky E.K., Soignet S., et al. Aphase I and pharmacological study of the farnesyl protein transferase inhibitor L-778,123 in patients with solid malignancies. Clin Cancer Res 2001, 7(12):3894-3903.
    • (2001) Clin Cancer Res , vol.7 , Issue.12 , pp. 3894-3903
    • Britten, C.D.1    Rowinsky, E.K.2    Soignet, S.3
  • 114
    • 0036097103 scopus 로고    scopus 로고
    • APhase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer
    • Hahn S.M., Bernhard E.J., Regine W., et al. APhase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer. Clin Cancer Res 2002, 8(5):1065-1072.
    • (2002) Clin Cancer Res , vol.8 , Issue.5 , pp. 1065-1072
    • Hahn, S.M.1    Bernhard, E.J.2    Regine, W.3
  • 115
    • 4143060341 scopus 로고    scopus 로고
    • Aphase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer
    • Martin N.E., Brunner T.B., Kiel K.D., et al. Aphase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer. Clin Cancer Res 2004, 10(16):5447-5454.
    • (2004) Clin Cancer Res , vol.10 , Issue.16 , pp. 5447-5454
    • Martin, N.E.1    Brunner, T.B.2    Kiel, K.D.3
  • 116
    • 34249075706 scopus 로고    scopus 로고
    • Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma
    • Robertson M.J., Kahl B.S., Vose J.M., et al. Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. JClin Oncol 2007, 25(13):1741-1746.
    • (2007) JClin Oncol , vol.25 , Issue.13 , pp. 1741-1746
    • Robertson, M.J.1    Kahl, B.S.2    Vose, J.M.3
  • 117
    • 33748670455 scopus 로고    scopus 로고
    • Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer
    • Carducci M.A., Musib L., Kies M.S., et al. Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer. JClin Oncol 2006, 24(25):4092-4099.
    • (2006) JClin Oncol , vol.24 , Issue.25 , pp. 4092-4099
    • Carducci, M.A.1    Musib, L.2    Kies, M.S.3


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