Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis

Journal of Biological Chemistry

Volumn 286, Issue 25, 2011, Pages 22186-22194

  Wu, Zhi Yuan ^a   Yu, De Jie ^a   Soong, Tuck Wah ^a   Dawe, Gavin S ^a   Bian, Jin Song ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC MYOCYTES; CELL LINES; CHANNEL FOLDING; CHANNEL PROTEINS; ENDOPLASMIC RETICULUM; ER STRESS; GLYCOSYLATED; GOLGI COMPLEX; HOMOLOGOUS PROTEINS; IMMUNOFLUORESCENCE MICROSCOPY; INDUCED PROTEINS; INTRACELLULAR CHOLESTEROL; ION CHANNEL; MOLECULAR MECHANISM; OVER-EXPRESSION; POTASSIUM CHANNELS; PROTEIN EXPRESSIONS; QT PROLONGATION; SIMVASTATIN; UNDERLYING MECHANISM; WESTERN-BLOT ANALYSIS;

CELL CULTURE; CELL MEMBRANES; ETHERS; GENES; OBSTETRICS; ORGANIC COMPOUNDS; PHYSIOLOGY; PROTEINS;

CHOLESTEROL;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CHOLESTEROL; IMIPRAMINE; POTASSIUM CHANNEL HERG; PROGESTERONE; SIMVASTATIN; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL DISRUPTION; CELL MIGRATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GOLGI COMPLEX; HOMEOSTASIS; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOLECULAR MECHANICS; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; QT PROLONGATION; RAT;

ANIMALS; CELL MEMBRANE; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; ELECTRIC CONDUCTIVITY; ETHER-A-GO-GO POTASSIUM CHANNELS; GENE EXPRESSION REGULATION; HEK293 CELLS; HOMEOSTASIS; HUMANS; INTRACELLULAR SPACE; MYOCYTES, CARDIAC; POTASSIUM CHANNEL BLOCKERS; PROGESTERONE; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY; TEMPERATURE;

RATTUS;

EID: 79959330417     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.198853     Document Type: Article

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