Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats

Journal of Ethnopharmacology

Volumn 170, Issue , 2015, Pages 106-116

  Fong, Sophia Yui Kau ^a   Wong, Yin Cheong ^a   Xie, Chen ^a   Zuo, Zhong ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Herb drug interaction; NSAIDs; Pharmacodynamics; Pharmacokinetics; Scutellariae Radix; Traditional Chinese medicine

Indexed keywords

BAICALEIN; BAICALIN; CYCLOOXYGENASE 2; MEFENAMIC ACID; OROXYLIN A; OROXYLOSIDE; PROSTAGLANDIN E2; SCUTELLARIAE RADIX; UNCLASSIFIED DRUG; WOGONIN; WOGONOSIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; SCUTELLARIA BAICALENSIS EXTRACT;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; EX VIVO STUDY; FOOD INTAKE; GENE EXPRESSION; HERB DRUG INTERACTION; LIQUID CHROMATOGRAPHY; MACROPHAGE; MALE; MAXIMUM PLASMA CONCENTRATION; MONOCYTE; NONHUMAN; RAT; STOMACH INJURY; STOMACH ULCER; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; CELL LINE; DRUG EFFECTS; GASTRIC MUCOSA; INFLAMMATION; METABOLISM; MOUSE; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS; SCUTELLARIA RADIX;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; CELL LINE; CHROMATOGRAPHY, LIQUID; GASTRIC MUCOSA; HERB-DRUG INTERACTIONS; INFLAMMATION; MACROPHAGES; MALE; MEFENAMIC ACID; MICE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 84930226737     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.04.036     Document Type: Article

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