Gastric mucosal changes induced by polyethylene glycol 400 administered by gavage in rats

Journal of Toxicological Sciences

Volumn 36, Issue 6, 2011, Pages 811-815

  Ueda, Yoshihide ^a   Tsuboi, Masaru ^a   Ota, Yasufumi ^a   Makita, Maki ^a   Aoshima, Takuya ^a   Nakajima, Madoka ^a   Narama, Isao ^a  

^a Biosafety Research Center Foods Drugs and Pesticides   (Japan)

Author keywords

Eosinophil; Gastric mucosa; Globule leukocyte; PEG 400; Repeated oral dosing

Indexed keywords

MACROGOL 400;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AUTOPSY; BODY WEIGHT; CELL INFILTRATION; EOSINOPHIL; FEMALE; FOOD INTAKE; FORESTOMACH; HEMATOLOGY; HISTOPATHOLOGY; LETTER; LEUKOCYTE; MALE; NONHUMAN; RAT; SQUAMOUS EPITHELIUM; STOMACH MUCOSA;

EID: 82855179525     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.36.811     Document Type: Letter

References (21)

1. Akpavie, S.O. and Pirie, H.M. (1989): The globule leucocyte: morphology, origin, function and fate, a review. Anat. Histol. Embryol., 18, 87-95.
2. Baert, J. and Frederix, M. (1985): Globule leukocytes in the respiratory epithelium of human upper airways: an ultrastructural study. Anat. Rec., 212, 143-152.
3. Bartsch, W., Sponer, G., Dietmann, K. and Fuchs, G. (1976): Acute toxicity of various solvents in the mouse and rat. LD50 of ethanol, diethylacetamide, dimethylformamide, dimethylsulfoxide, glycerine, N-methylpyrrolidone, polyethylene glycol 400, 1,2-propanediol and Tween 20. Arzneimittelforschung, 26, 1581-1583.
4. Carr, K.E. and Whur, P (1986): Ultrastructure of globule leucocyte inclusions in the rat and mouse. Z. Zellforsch Mikrosk. Anat., 86, 153-162.
5. Cho, C.H., Hui, W.M., Liao, N.X., Liu, X.G., Lam, S.K. and Ogle, C.W. (1992): Polyethylene glycol: its adverse gastric effects in rats. J. Pharm. Pharmacol., 44, 518-520.
6. Fan, L. and Iseki, S. (1999): Immunohistochemical localization of vascular endothelial growth factor in the globule leukocyte/ mucosal mast cell of the rat respiratory and digestive tracts. Histochem. Cell Biol., 111, 13-21.
7. Hermansky, S.J., Neptun, D.A., Loughran, K.A. and Leung, H.W. (1995): Effects of polyethylene glycol 400 (PEG 400) following 13 weeks of gavage treatment in Fischer-344 rats. Food Chem. Toxicol., 33, 139-149.
8. nd ed. (Hollander M. and Wolfe D.A., ed.), pp.473-477, John Wiley & Sons, Inc., New York.
9. Ikeda, Y. and Yamashina, S. (1993): Developmental changes in intestinal globule leukocytes of normal rats. Cell Tissue Res., 273, 447-455.
10. Ishida, S., Shimoyama, Y., Hatayama, K., Kusuoka, O., Noda, T. and Katsumata, T. (2004): Combined Repeated Dose and Reproductive/ Developmental Toxicity Screening Test of 2-Amino-2-ethyl-1,3-propanediol by Oral Administration in Rats. Japan Existing Chemical Data Base (JECDB)., http://dra4.nihs.go.jp/ mhlw_data/home/paper/paper115-70-8d.html. (in Japanese). [19 April, 2011]
11. Kent, J.F. (1966): Distribution and fine structure of globule leucocytes in respiratory and digestive tracts of the laboratory rat. Anat. Rec., 156, 439-453.
12. Kirkman, H. (1950): A comparative morphological and cytochemical study of globule leucocytes (Schollenleukocyten) of the urinary tract and of possibly related cells. Am. J. Anat., 86, 91-131.
13. Konno, A., Hashimoto, Y., Kon, Y. and Sugimura, M. (1994): Perforin-like immunoreactivity in feline globule leukocytes and their distribution. J. Vet. Med. Sci., 56, 1101-1105.
14. Narama, I., Ozaki, K., Matsushima, S. and Matsuura, T. (1999): Eosinophilic gastroenterocolitis in iron lactate-overloaded rats. Toxicol. Pathol., 27, 318-324.
15. Shaffer, C.B., Critchfield F.H. and Nair J.H. III (1950): The absorption and excretion of a liquid polyethylene glycol. J. Am. Pharm. Assoc., 39, 340-344.
16. Sheftel, V.O. (1990): Toxic Properties of Polymers and Additives. (Sheftel, V.O. ed.), pp.222, Papra Technology Ltd., Shropshire, UK.
17. Sheftel, V.O. (2000): Indirect Food Additives and Polymers: Migration and Toxicology. (Sheftel, V.O. ed.), pp.1114-1116, Lewis Publishers, Boca Raton, FL, US.
18. Smyth, H.F. Jr., Carpenter, C.P. and Weil, C.S. (1955): The chronic oral toxicology of the polyethylene glycols. J. Am. Pharm. Assoc., 44, 27-30.
19. Sudo, M., Shinobu, M., Doi, T., Toyota, N. and Kinomoto, K. (2003): Twenty-eight-day Repeat Dose Oral Toxicity Test of 3, 3'-Thiobispropanoic acid in Rats. Japan Existing Chemical Data Base (JECDB)., http://dra4.nihs.go.jp/mhlw_data/home/paper/ paper111-17-1b.html. (In Japanese). [19 April, 2011]
20. Taliaferro, W.H. and Sarles M.P. (1939): The cellular reactions in the skin, lungs and intestine of normal and immune rats after infection with Nippostrongylus muris. J. Infec. Dis., 64, 157-192.
21. Whur, P. (1966): Relationship of globule leucocytes to gastrointestinal nematodes in the sheep, and Nippostrongylus brasiliensis and Hymenolepis nana infections in rats. J. Comp. Pathol., 76, 57-65.