Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Xiao, Chuan Xing ^a   Xiao, Jing Jing ^b   Xu, Hong Zhi ^a   Wang, Huan Huan ^a   Chen, Xu ^a   Liu, Yuan Sheng ^a   Li, Ping ^a   Shi, Ying ^a   Nie, Yong Zhan ^d   Li, Shao ^e   Wu, Kai Chun ^d   Liu, Zhan Ju ^c   Ren, Jian Lin ^a   Guleng, Bayasi ^a  

^a XIAMEN UNIVERSITY   (China)

^b BGI SHENZHEN   (China)

^c TONGJI UNIVERSITY   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^e TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD4 ANTIGEN; CHEMOKINE; CYTOKINE; IFNA10 PROTEIN, HUMAN; IFNA4 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ACUTE DISEASE; ADOLESCENT; ADULT; ANIMAL; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; C57BL MOUSE; CASE CONTROL STUDY; CELL LINE; CHEMICALLY INDUCED; CHILD; CHINA; COLITIS; CROHN DISEASE; CYTOLOGY; DISEASE MODEL; DISEASE PREDISPOSITION; DNA MUTATIONAL ANALYSIS; EXOME; FEMALE; GENETICS; HEPACIVIRUS; HETEROZYGOTE; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; MOUSE; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; PLASMID; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; RNA INTERFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS REPLICATION; YOUNG ADULT;

ACUTE DISEASE; ADOLESCENT; ADULT; ANIMALS; ANTIGENS, CD4; ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; CASE-CONTROL STUDIES; CELL LINE; CHEMOKINES; CHILD; CHINA; COLITIS; CROHN DISEASE; CYTOKINES; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; DNA MUTATIONAL ANALYSIS; EXOME; FEMALE; HEPACIVIRUS; HETEROZYGOTE; HUMANS; INTERFERON-ALPHA; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PLASMIDS; POLYMORPHISM, SINGLE NUCLEOTIDE; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; T-LYMPHOCYTES, REGULATORY; VIRUS REPLICATION; YOUNG ADULT;

EID: 84930221753     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep10514     Document Type: Article

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