Loss of PTEN expression by mouse fibroblasts results in lung fibrosis through a CCN2-dependent mechanism

Matrix Biology

Volumn 43, Issue , 2015, Pages 35-41

  Parapuram, Sunil K ^a,b   Thompson, Katherine ^a   Tsang, Matthew ^a   Hutchenreuther, James ^a   Bekking, Christian ^a   Liu, Shangxi ^a   Leask, Andrew ^a  

^a WESTERN UNIVERSITY   (Canada)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

CCN family; CCN2; Ctgf; Lung fibrosis; Matricellular proteins; PTEN; Scleroderma

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; CRE RECOMBINASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TAMOXIFEN; ALPHA 2(I) COLLAGEN; CTGF PROTEIN, MOUSE; PTEN PROTEIN, MOUSE;

ALLELE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENHANCER REGION; GENE LOSS; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG FIBROBLAST; LUNG FIBROSIS; LUNG PARENCHYMA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; CELL CULTURE; CYTOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; LUNG; METABOLISM; MOUSE; PATHOLOGY;

MUS;

ANIMALS; CELLS, CULTURED; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; FIBROBLASTS; GENE EXPRESSION REGULATION; LUNG; MICE; PTEN PHOSPHOHYDROLASE; PULMONARY FIBROSIS;

EID: 84930180458     PISSN: 0945053X     EISSN: 15691802     Source Type: Journal    
DOI: 10.1016/j.matbio.2015.01.017     Document Type: Article

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