Endogenous Docosahexaenoic Acid (DHA) Prevents Aβ1–42 Oligomer-Induced Neuronal Injury

Molecular Neurobiology

Volumn 53, Issue 5, 2016, Pages 3146-3153

  Tan, Yuan ^a   Ren, Huixia ^a   Shi, Zhe ^a   Yao, Xiaoli ^b   He, Chengwei ^a   Kang, Jing X ^c   Wan, Jian Bo ^a   Li, Peng ^a   Yuan, Ti Fei ^d   Su, Huanxing ^a  

^a University of Macau   (Macao)

^b SUN YAT SEN UNIVERSITY   (China)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d NANJING NORMAL UNIVERSITY   (China)

Author keywords

Alzheimer s disease; A oligomers; DHA; Fat 1 mice; Omega 3

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; DOCOSAHEXAENOIC ACID; OMEGA 3 FATTY ACID; AMYLOID BETA PROTEIN; CADHERIN; FATH PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LOSS; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM STRESS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL LESION; NONHUMAN; TRANSGENIC MOUSE; ANIMAL; BRAIN CORTEX; C57BL MOUSE; CELL DEATH; DRUG EFFECTS; GENETICS; METABOLISM; NERVE CELL; PATHOLOGY; PROTEIN MULTIMERIZATION;

AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CADHERINS; CELL DEATH; CEREBRAL CORTEX; DOCOSAHEXAENOIC ACIDS; ENDOPLASMIC RETICULUM STRESS; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; PROTEIN MULTIMERIZATION;

EID: 84930159597     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9224-0     Document Type: Article

References (29)

1. Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid beta-peptide. Nat Rev Mol Cell Biol 8(2):101–112
2. Krafft GA, Klein WL (2010) ADDLs and the signaling web that leads to Alzheimer’s disease. Neuropharmacology 59(4-5):230–242
3. Kuo YM, Emmerling MR, Vigo-Pelfrey C, Kasunic TC, Kirkpatrick JB, Murdoch GH et al (1996) Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. J Biol Chem 271(8):4077–4081
4. Roher AE, Chaney MO, Kuo YM, Webster SD, Stine WB, Haverkamp LJ et al (1996) Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer’s disease. J Biol Chem 271(34):20631–20635
5. Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ (2000) The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry 39(35):10831–10839
6. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS et al (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416(6880):535–539
7. Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE et al (2003) Alzheimer’s disease-affected brain: presence of oligomeric a beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci U S A 100(18):10417–10422
8. Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A et al (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440(7082):352–357
9. Kalmijn S, Feskens EJ, Launer LJ, Kromhout D (1997) Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol 145(1):33–41
10. Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam study. Ann Neurol 42(5):776–782
11. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS et al (2003) Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 60(7):940–946
12. Barberger-Gateau P, Letenneur L, Deschamps V, Peres K, Dartigues JF, Renaud S (2002) Fish, meat, and risk of dementia: cohort study. BMJ 325(7370):932–933
13. Lim WS, Gammack JK, Van Niekerk J, Dangour AD (2006) Omega 3 fatty acid for the prevention of dementia. Cochrane Database Syst Rev. 2006 (1):Cd005379
14. Fotuhi M, Mohassel P, Yaffe K (2009) Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association. Nat Clin Pract Neurol 5(3):140–152
15. Kang ZB, Ge Y, Chen Z, Cluette-Brown J, Laposata M, Leaf A et al (2001) Adenoviral gene transfer of Caenorhabditis elegans n--3 fatty acid desaturase optimizes fatty acid composition in mammalian cells. Proc Natl Acad Sci U S A 98(7):4050–4054
16. Kang JX, Wang J, Wu L, Kang ZB (2004) Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature 427(6974):504
17. Fa M, Orozco IJ, Francis YI, Saeed F, Gong Y, Arancio O (2010) Preparation of oligomeric beta-amyloid 1-42 and induction of synaptic plasticity impairment on hippocampal slices. J Vis Exp 14:(41). doi:10.3791/1884
18. Klein WL (2002) ADDLs & protofibrils—the missing links? Neurobiol Aging 23(2):231–235
19. Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K et al (1999) Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models. Proc Natl Acad Sci U S A 96(6):3228–3233
20. Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, Forsell C et al (2001) The ‘Arctic’ APP mutation (E693G) causes Alzheimer’s disease by enhanced Abeta protofibril formation. Nat Neurosci 4(9):887–893
21. Prasad MR, Lovell MA, Yatin M, Dhillon H, Markesbery WR (1998) Regional membrane phospholipid alterations in Alzheimer’s disease. Neurochem Res 23(1):81–88
22. Soderberg M, Edlund C, Kristensson K, Dallner G (1991) Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease. Lipids 26(6):421–425
23. Song JH, Miyazawa T (2001) Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. Atherosclerosis 155(1):9–18
24. Johnson EJ, McDonald K, Caldarella SM, Chung HY, Troen AM, Snodderly DM (2008) Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. Nutr Neurosci 11(2):75–83
25. Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, Basun H, Faxen-Irving G, Garlind A et al (2006) Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch Neurol 63(10):1402–1408
26. Kotani S, Sakaguchi E, Warashina S, Matsukawa N, Ishikura Y, Kiso Y et al (2006) Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neurosci Res 56(2):159–164
27. Chiu CC, Su KP, Cheng TC, Liu HC, Chang CJ, Dewey ME et al (2008) The effects of omega-3 fatty acids monotherapy in Alzheimer’s disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study. Prog Neuropsychopharmacol Biol Psychiatry 32(6):1538–1544
28. van de Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Dullemeijer C, Olderikkert MG et al (2008) Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial. Neurology 71(6):430–438
29. Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C et al (2010) Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA 304(17):1903–1911