Isoform-selective genetic inhibition of constitutive cytosolic Hsp70 activity promotes client Tau degradation using an altered co-chaperone complement

Journal of Biological Chemistry

Volumn 290, Issue 21, 2015, Pages 13115-13127

  Fontaine, Sarah N ^a,b   Rauch, Jennifer N ^d,e   Nordhues, Bryce A ^a,b   Assimon, Victoria A ^e   Stothert, Andrew R ^a   Jinwal, Umesh K ^c   Sabbagh, Jonathan J ^a,b   Chang, Lyra ^e   Stevens, Stanley M ^d   Zuiderweg, Erik R P ^f   Gestwicki, Jason E ^e   Dickey, Chad A ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDES;

BIOCHEMICAL CHARACTERIZATION; DOMINANT NEGATIVE; GENETIC INHIBITION; HEAT SHOCK PROTEIN 70; NUCLEOTIDE-BINDING DOMAIN; SELECTIVE INHIBITION; SINGLE-POINT MUTATION; THERAPEUTIC STRATEGY;

PROTEINS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; HEAT SHOCK PROTEIN 70; NUCLEOTIDE; PROTEASOME; PROTEIN DNAJ; TAU PROTEIN; HEAT SHOCK COGNATE PROTEIN 70; ISOPROTEIN; MAPT PROTEIN, HUMAN; MESSENGER RNA; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN REFOLDING; PROTEIN STABILITY; PROTEIN TARGETING; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOSOL; FLUORESCENCE POLARIZATION; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; PROTEIN FOLDING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATASES; BLOTTING, WESTERN; CELLS, CULTURED; CYTOSOL; FLUORESCENCE POLARIZATION; FLUORESCENT ANTIBODY TECHNIQUE; HSC70 HEAT-SHOCK PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN ISOFORMS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TAU PROTEINS;

EID: 84929994763     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.637595     Document Type: Article

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