Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70

Chemistry and Biology

Volumn 21, Issue 12, 2014, Pages 1648-1659

  Howe, Matthew K ^a   Bodoor, Khaldon ^b   Carlson, David A ^a   Hughes, Philip F ^a   Alwarawrah, Yazan ^a   Loiselle, David R ^a   Jaeger, Alex M ^a   Darr, David B ^c   Jordan, Jamie L ^c   Hunter, Lucas M ^c   Molzberger, Eileen T ^a   Gobillot, Theodore A ^d   Thiele, Dennis J ^a   Brodsky, Jeffrey L ^d   Spector, Neil L ^a   Haystead, Timothy A J ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 70; HS 72; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; BENZIMIDAZOLE DERIVATIVE; CASPASE; HS-72 COMPOUND; NIPECOTIC ACID DERIVATIVE; PIPERIDINE DERIVATIVE; PROTEIN AGGREGATE;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG TOLERABILITY; FLUORESCENCE LINKED ENZYME CHEMOPROTEOMIC STRATEGY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEOMICS; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOAVAILABILITY; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; HEK293 CELL LINE; HUMAN; METABOLISM; PERMEABILITY; PRECLINICAL STUDY; PROTEIN TERTIARY STRUCTURE;

ALLOSTERIC REGULATION; ANIMALS; BENZIMIDAZOLES; BIOLOGICAL AVAILABILITY; CASPASES; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; HEK293 CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MICE; MODELS, MOLECULAR; NIPECOTIC ACIDS; PERMEABILITY; PIPERIDINES; PROTEIN AGGREGATES; PROTEIN STRUCTURE, TERTIARY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84919927940     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.10.016     Document Type: Article

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