Mesenchymal stem cells and haematopoietic stem cell culture

Mesenchymal Stem Cell Therapy

Volumn , Issue , 2013, Pages 161-172

  Cook, Matthew M ^a,b,c  

^a MATER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Bioreactors; Ex vivo expansion; Haematopoietic stem cells (HSC); Mesenchymal stem stromal cells (MSC); Osteoblasts; Umbilical cord blood

Indexed keywords

EID: 84929992400     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-62703-200-1_9     Document Type: Chapter

References (101)

1. Appelbaum FR (2003) The current status of hematopoietic cell transplantation. Annu Rev Med 54:491-512
2. Copelan EA (2006) Hematopoietic stem-cell transplantation. N Engl J Med 354(17):1813-1826
3. Gratwohl A, Baldomero H, Aljurf M, Pasquini MC, Bouzas LF, Yoshimi A et al (2010) Hematopoietic stem cell transplantation: a global perspective. JAMA 303(16):1617-1624
4. Mielcarek M, Storb R (2003) Non-myeloablative hematopoietic cell transplantation as immunotherapy for hematologic malignancies. Cancer Treat Rev 29(4):283-290
5. Sullivan MJ (2008) Banking on cord blood stem cells. Nat Rev Cancer 8(7):555-563
6. Appelbaum FR (2007) Hematopoietic-cell transplantation at 50. N Engl J Med 357(15): 1472-1475
7. Frey MA, Guess C, Allison J, Kurtzberg J (2009) Umbilical cord stem cell transplantation. Semin Oncol Nurs 25(2):115-119
8. McNiece I (2007) Delivering cellular therapies: lessons learned from ex vivo culture and clinical applications of hematopoietic cells. Semin Cell Dev Biol 18(6):839-845
9. Klingemann HG, Shepherd JD, Reece DE, Barnett MJ, Nantel SH, Sutherland HJ et al (1994) Regimen-related acute toxicities: pathophysiology, risk factors, clinical evaluation and preventive strategies. Bone Marrow Transplant 14(Suppl 4):S14-S18
10. Paczesny S, Choi SW, Ferrara JL (2009) Acute graft-versus-host disease: new treatment strategies. Curr Opin Hematol 16(6):427-436
11. Eapen M, Rubinstein P, Zhang MJ, Stevens C, Kurtzberg J, Scaradavou A et al (2007) Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet 369(9577):1947-1954
12. Hwang WY, Samuel M, Tan D, Koh LP, Lim W, Linn YC (2007) A meta-analysis of unrelated donor umbilical cord blood transplantation versus unrelated donor bone marrow transplantation in adult and pediatric patients. Biol Blood Marrow Transplant 13(4):444-453
13. Rocha V, Cornish J, Sievers EL, Filipovich A, Locatelli F, Peters C et al (2001) Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood 97(10):2962-2971
14. Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, Bosi A et al (2004) Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 351(22):2276-2285
15. Rocha V, Wagner JE Jr, Sobocinski KA, Klein JP, Zhang MJ, Horowitz MM et al (2000) Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources. N Engl J Med 342(25): 1846-1854
16. Smith AR, Wagner JE (2009) Alternative haematopoietic stem cell sources for transplantation: place of umbilical cord blood. Br J Haematol 147(2):246-261
17. Takahashi S, Ooi J, Tomonari A, Konuma T, Tsukada N, Oiwa-Monna M et al (2007) Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen. Blood 109(3): 1322-1330
18. Gluckman E (2009) History of cord blood transplantation. Bone Marrow Transplant 44(10): 621-626
19. Brown JA, Boussiotis VA (2008) Umbilical cord blood transplantation: basic biology and clinical challenges to immune reconstitution. Clin Immunol 127(3):286-297
20. Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K et al (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118(2): 149-161
21. Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y et al (2007) Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 1(6):685-697
22. Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, Habler L et al (2002) G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 3(7):687-694
23. Majumdar MK, Thiede MA, Haynesworth SE, Bruder SP, Gerson SL (2000) Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res 9(6):841-848
24. Miyazawa K, Williams DA, Gotoh A, Nishimaki J, Broxmeyer HE, Toyama K (1995) Membrane-bound steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood 85(3):641-649
25. Nilsson SK, Johnston HM, Whitty GA, Williams B, Webb RJ, Denhardt DT et al (2005) Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood 106(4):1232-1239
26. Fleming HE, Janzen V, Lo Celso L, Guo J, Leahy KM, Kronenberg HM et al (2008) Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2(3):274-283
27. Titushkin IA, Shin J, Cho M (2010) A new perspective for stem-cell mechanobiology: biomechanical control of stem-cell behavior and fate. Crit Rev Biomed Eng 38(5):393-433
28. Weber JM, Calvi LM (2010) Notch signaling and the bone marrow hematopoietic stem cell niche. Bone 46(2):281-285
29. Robinson S, Niu T, de Lima M, Ng J, Yang H, McMannis J et al (2005) Ex vivo expansion of umbilical cord blood. Cytotherapy 7(3):243-250
30. Dexter TM, Allen TD, Lajtha LG (1977) Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 91(3):335-344
31. Dexter TM, Wright EG, Krizsa F, Lajtha LG (1977) Regulation of haemopoietic stem cell proliferation in long term bone marrow cultures. Biomedicine 27(9-10):344-349
32. Dexter TM, Allen TD, Lajtha LG, Schofield R, Lord BI (1973) Stimulation of differentiation and proliferation of haemopoietic cells in vitro. J Cell Physiol 82(3):461-473
33. Dexter TM, Lajtha LG (1974) Proliferation of haemopoietic stem cells in vitro. Br J Haematol 28(4):525-530
34. Gartner S, Kaplan HS (1980) Long-term culture of human bone marrow cells. Proc Natl Acad Sci U S A 77(8):4756-4759
35. Greenberg HM, Newburger PE, Parker LM, Novak T, Greenberger JS (1981) Human granulocytes generated in continuous bone marrow culture are physiologically normal. Blood 58(4):724-732
36. Eaves AC, Cashman JD, Gaboury LA, Eaves CJ (1987) Clinical significance of long-term cultures of myeloid blood cells. Crit Rev Oncol Hematol 7(2):125-138
37. Eaves CJ, Eaves AC (1987) Cell culture studies in CML. Baillieres Clin Haematol 1(4):931-961
38. Landreth KS, Dorshkind K (1988) Pre-B cell generation potentiated by soluble factors from a bone marrow stromal cell line. J Immunol 140(3):845-852
39. Quesenberry P, Song ZX, McGrath E, McNiece I, Shadduck R, Waheed A et al (1987) Multilineage synergistic activity produced by a murine adherent marrow cell line. Blood 69(3):827-835
40. Zipori D (1986) Self-renewal is modulated by the composition and density of hemopoietic cell populations. Leuk Res 10(12):1485-1486
41. Zipori D, Tamir M, Toledo J, Oren T (1986) Differentiation stage and lineage-specific inhibitor from the stroma of mouse bone marrow that restricts lymphoma cell growth. Proc Natl Acad Sci U S A 83(12):4547-4551
42. Ploemacher RE, van der Sluijs JP, Voerman JS, Brons NH (1989) An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse. Blood 74(8): 2755-2763
43. Sutherland HJ, Eaves CJ, Eaves AC, Dragowska W, Lansdorp PM (1989) Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 74(5):1563-1570
44. Chung NG, Jeong DC, Park SJ, Choi BO, Cho B, Kim HK et al (2004) Cotransplantation of marrow stromal cells may prevent lethal graft-versus-host disease in major histocompatibility complex mismatched murine hematopoietic stem cell transplantation. Int J Hematol 80(4):370-376
45. Dazzi F, Ramasamy R, Glennie S, Jones SP, Roberts I (2006) The role of mesenchymal stem cells in haemopoiesis. Blood Rev 20(3):161-171
46. Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M et al (2004) Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363(9419):1439-1441
47. Zhang Y, Li C, Jiang X, Zhang S, Wu Y, Liu B et al (2004) Human placenta-derived mesenchymal progenitor cells support culture expansion of long-term culture-initiating cells from cord blood CD34+ cells. Exp Hematol 32(7):657-664
48. Bakhshi T, Zabriskie RC, Bodie S, Kidd S, Ramin S, Paganessi LA et al (2008) Mesenchymal stem cells from the Wharton's jelly of umbilical cord segments provide stromal support for the maintenance of cord blood hematopoietic stem cells during long-term ex vivo culture. Transfusion 48(12):2638-2644
49. Huang GP, Pan ZJ, Jia BB, Zheng Q, Xie CG, Gu JH et al (2007) Ex vivo expansion and transplantation of hematopoietic stem/progenitor cells supported by mesenchymal stem cells from human umbilical cord blood. Cell Transplant 16(6):579-585
50. Wang JF, Wang LJ, Wu YF, Xiang Y, Xie CG, Jia BB et al (2004) Mesenchymal stem/progeni-tor cells in human umbilical cord blood as support for ex vivo expansion of CD34(+) hematopoietic stem cells and for chondrogenic differentiation. Haematologica 89(7):837-844
51. Nakao N, Nakayama T, Yahata T, Muguruma Y, Saito S, Miyata Y et al (2010) Adipose tissue-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo. advantages over bone marrow-derived mesenchymal stem cells. Am J Pathol 177(2):547-554
52. Steiner D, Gelovani J, Savoldo B, Robinson SN, Decker WK, Brouard N et al (2009) Noninvasive bioluminescent imaging demonstrates long-term multilineage engraftment of ex vivo-expanded CD34-selected umbilical cord blood cells. Stem Cells 27(8):1932-1940
53. Jing D, Fonseca AV, Alakel N, Fierro FA, Muller K, Bornhauser M et al (2010) Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modelling the niche compartments in vitro. Haematologica 95(4):542-550
54. Song Y, Bahnson A, Hall N, Yu H, Shen H, Koebler D et al (2010) Stem cell traits in longterm co-culture revealed by time-lapse imaging. Leukemia 24(1):153-161
55. Wagner W, Wein F, Roderburg C, Saffrich R, Diehlmann A, Eckstein V et al (2008) Adhesion of human hematopoietic progenitor cells to mesenchymal stromal cells involves CD44. Cells Tissues Organs 188(1-2):160-169
56. Wagner W, Wein F, Roderburg C, Saffrich R, Faber A, Krause U et al (2007) Adhesion of hematopoietic progenitor cells to human mesenchymal stem cells as a model for cell-cell interaction. Exp Hematol 35(2):314-325
57. Wein F, Pietsch L, Saffrich R, Wuchter P, Walenda T, Bork S et al (2010) N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells. Stem Cell Res 4(2):129-139
58. Zhang Y, Chai C, Jiang XS, Teoh SH, Leong KW (2006) Co-culture of umbilical cord blood CD34+ cells with human mesenchymal stem cells. Tissue Eng 12(8):2161-2170
59. Andrade PZ, dos Santos F, Almeida-Porada G, da Silva CL, Cabral JMS (2010) Systematic delineation of optimal cytokine concentrations to expand hematopoietic stem/progenitor cells in co-culture with mesenchymal stem cells. Mol Biosyst 6(7):1207-1215
60. da Silva CL, Goncalves R, Crapnell KB, Cabral JM, Zanjani ED, Almeida-Porada G (2005) A human stromal-based serum-free culture system supports the ex vivo expansion/mainte-nance of bone marrow and cord blood hematopoietic stem/progenitor cells. Exp Hematol 33(7):828-835
61. McNiece I, Harrington J, Turney J, Kellner J, Shpall EJ (2004) Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells. Cytotherapy 6(4):311-317
62. Taichman RS, Emerson SG (1994) Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor. J Exp Med 179(5):1677-1682
63. Chitteti BR, Cheng YH, Poteat B, Rodriguez-Rodriguez S, Goebel WS, Carlesso N et al (2010) Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function. Blood 115(16):3239-3248
64. Mishima S, Nagai A, Abdullah S, Matsuda C, Taketani T, Kumakura S et al (2010) Effective ex vivo expansion of hematopoietic stem cells using osteoblast-differentiated mesenchymal stem cells is CXCL12 dependent. Eur J Haematol 84(6):538-546
65. Nakamura Y, Arai F, Iwasaki H, Hosokawa K, Kobayashi I, Gomei Y et al (2010) Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells. Blood 116(9):1422-1432
66. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC et al (2003) Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425(6960):841-846
67. Gong JK (1978) Endosteal marrow: a rich source of hematopoietic stem cells. Science 199(4336): 1443-1445
68. Haylock DN, Williams B, Johnston HM, Liu MC, Rutherford KE, Whitty GA et al (2007) Hemopoietic stem cells with higher hemopoietic potential reside at the bone marrow endosteum. Stem Cells 25(4):1062-1069
69. Zhang J, Niu C, Ye L, Huang H, He X, Tong WG et al (2003) Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425(6960):836-841
70. Jaroscak J, Goltry K, Smith A, Waters-Pick B, Martin PL, Driscoll TA et al (2003) Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase 1 trial using the AastromReplicell System. Blood 101(12):5061-5067
71. Pecora AL, Stiff P, LeMaistre CF, Bayer R, Bachier C, Goldberg SL et al (2001) A phase II trial evaluating the safety and effectiveness of the AastromReplicell system for augmentation of low-dose blood stem cell transplantation. Bone Marrow Transplant 28(3):295-303
72. Stiff P, Chen B, Franklin W, Oldenberg D, Hsi E, Bayer R et al (2000) Autologous transplantation of ex vivo expanded bone marrow cells grown from small aliquots after high-dose chemotherapy for breast cancer. Blood 95(6):2169-2174
73. Mesoblast ASX announcement Melbourne, Australia: Mesoblast, 6 November 2009, http:// www.mesoblast.com/download/163/
74. Kelly SS, Sola CB, de Lima M, Shpall E (2009) Ex vivo expansion of cord blood. Bone Marrow Transplant 44(10):673-681
75. Kirouac DC, Zandstra PW (2006) Understanding cellular networks to improve hematopoietic stem cell expansion cultures. Curr Opin Biotechnol 17(5):538-547
76. Koller MR, Palsson MA, Manchel I, Palsson BO (1995) Long-term culture-initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects. Blood 86(5):1784-1793
77. Madlambayan GJ, Rogers I, Kirouac DC, Yamanaka N, Mazurier F, Doedens M et al (2005) Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. Exp Hematol 33(10):1229-1239
78. Madlambayan GJ, Rogers I, Purpura KA, Ito C, Yu M, Kirouac D et al (2006) Clinically relevant expansion of hematopoietic stem cells with conserved function in a single-use, closed-system bioprocess. Biol Blood Marrow Transplant 12(10):1020-1030
79. Majka M, Janowska-Wieczorek A, Ratajczak J, Ehrenman K, Pietrzkowski Z, Kowalska MA et al (2001) Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. Blood 97(10):3075-3085
80. Cho CH, Eliason JF, Matthew HW (2008) Application of porous glycosaminoglycan-based scaffolds for expansion of human cord blood stem cells in perfusion culture. J Biomed Mater Res A 86(1):98-107
81. Koller MR, Bender JG, Miller WM, Papoutsakis ET (1993) Expansion of primitive human hematopoietic progenitors in a perfusion bioreactor system with IL-3, IL-6, and stem cell factor. Biotechnology (N Y) 11(3):358-363
82. Koller MR, Emerson SG, Palsson BO (1993) Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures. Blood 82(2):378-384
83. Kresnowati MT, Forde GM, Chen XD (2010) Model-based analysis and optimization of bioreactor for hematopoietic stem cell cultivation. Bioprocess Biosyst Eng 34(1):81-93
84. Sandstrom CE, Bender JG, Miller WM, Papoutsakis ET (1996) Development of novel perfusion chamber to retain nonadherent cells and its use for comparison of human "mobilized" peripheral blood mononuclear cell cultures with and without irradiated bone marrow stroma. Biotechnol Bioeng 50(5):493-504
85. Pecora AL, Stiff P, Jennis A, Goldberg S, Rosenbluth R, Price P et al (2000) Prompt and durable engraftment in two older adult patients with high risk chronic myelogenous leukemia (CML) using ex vivo expanded and unmanipulated unrelated umbilical cord blood. Bone Marrow Transplant 25(7):797-799
86. Andrade-Zaldivar H, Santos L, Leon Rodriguez A de (2008) Expansion ofhuman hematopoietic stem cells for transplantation: trends and perspectives. Cytotechnology 56(3):151-160
87. Takagi M (2005) Cell processing engineering for ex-vivo expansion of hematopoietic cells. J Biosci Bioeng 99(3):189-196
88. Markway BD, Tan GK, Brooke G, Hudson JE, Cooper-White JJ, Doran MR (2010) Enhanced chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in low oxygen environment micropellet cultures. Cell Transplant 19(1):29-42
89. Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA et al (2010) Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466(7308):829-834
90. Jahn K, Richards RG, Archer CW, Stoddart MJ (2010) Pellet culture model for human primary osteoblasts. Eur Cell Mater 20:149-161
91. Kelm JM, Fussenegger M (2004) Microscale tissue engineering using gravity-enforced cell assembly. Trends Biotechnol 22(4):195-202
92. Timmins NE, Nielsen LK (2007) Generation of multicellular tumor spheroids by the hanging-drop method. Methods Mol Med 140:141-151
93. Wang W, Itaka K, Ohba S, Nishiyama N, Chung UI, Yamasaki Y et al (2009) 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials 30(14):2705-2715
94. Bagley J, Rosenzweig M, Marks DF, Pykett MJ (1999) Extended culture of multipotent hematopoietic progenitors without cytokine augmentation in a novel three-dimensional device. Exp Hematol 27(3):496-504
95. Ehring B, Biber K, Upton TM, Plosky D, Pykett M, Rosenzweig M (2003) Expansion of HPCs from cord blood in a novel 3D matrix. Cytotherapy 5(6):490-499
96. Feng Q, Chai C, Jiang XS, Leong KW, Mao HQ (2006) Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin. J Biomed Mater Res A 78(4):781-791
97. Li Y, Ma T, Kniss DA, Yang ST, Lasky LC (2001) Human cord cell hematopoiesis in threedimensional nonwoven fibrous matrices: in vitro simulation of the marrow microenvironment. J Hematother Stem Cell Res 10(3):355-368
98. Schubert H, Garrn I, Berthold A, Knauf WU, Reufi B, Fietz T et al (2004) Culture of haematopoietic cells in a 3-D bioreactor made of Al2O3 or apatite foam. J Mater Sci Mater Med 15(4):331-334
99. Sasaki T, Takagi M, Soma T, Yoshida T (2002) 3D culture of murine hematopoietic cells with spatial development of stromal cells in nonwoven fabrics. Cytotherapy 4(3):285-291
100. Takagi M, Iemoto N, Yoshida T (2002) Effect of concentrations of murine stromal and hematopoietic cells on the progenitors expansion in their three-dimensional coculture in non-woven fabrics. J Biosci Bioeng 94(4):365-367
101. de Barros AP, Takiya CM, Garzoni LR, Leal-Ferreira ML, Dutra HS, Chiarini LB et al (2010) Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model. PLoS One 5(2):e9093