Noninvasive bioluminescent imaging demonstrates long-term multilineage engraftment of ex vivo-expanded CD34-selected umbilical cord blood cells

Stem Cells

Volumn 27, Issue 8, 2009, Pages 1932-1940

  Steiner, David ^a   Gelovani, Juri ^a   Savoldo, Barbara ^b   Robinson, Simon N ^a   Decker, William K ^a   Brouard, Nathalie ^c   Najjar, Amer ^a   Xing, Dongxia ^a   Yang, Hong ^a   Li, Sufang ^a   Marini, Frank ^a   Zweidler Mckay, Patrick A ^a   Bollard, Catherine M ^b   Shpall, Elizabeth J ^a   Dotti, Gianpietro ^b   Simmons, Paul J ^c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b CENTER FOR CELL AND GENE THERAPY   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Bioluminescent imaging; Calvarium; Engraftment; Hematopoiesis; Luciferase; Transplantation; Umbilical cord blood

Indexed keywords

HLA ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CD34 SELECTION; CONTROLLED STUDY; DIAGNOSTIC IMAGING; EX VIVO STUDY; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA MATCHING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LONG TERM CARE; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; UMBILICAL CORD BLOOD;

ANIMALS; ANTIGENS, CD34; CELL LINEAGE; CORD BLOOD STEM CELL TRANSPLANTATION; FETAL BLOOD; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; LUCIFERASES, FIREFLY; LUMINESCENT AGENTS; LUMINESCENT MEASUREMENTS; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED NOD; MICE, SCID; TRANSDUCTION, GENETIC;

MUS;

EID: 69249126245     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.111     Document Type: Article

References (47)

1. Barker JN, Davies SM, DeFor T et al. Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: Results of a matched-pair analysis. Blood 2001;97:2957-2961.
2. Barker JN, Weisdorf DJ, DeFor TE et al. Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning. Blood 2003;102:1915-1919.
3. Brunstein CG, Barker JN, Weisdorf DJ et al. Umbilical cord blood transplantation after nonmyeloablative conditioning: Impact on transplantation outcomes in 110 adults with hematologic disease. Blood 2007;110:3064-3070.
4. Gluckman E, Rocha V, Boyer-Chammard A et al. Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med 1997;337:373-381.
5. Gluckman E, Rocha V, Chevret S. Results of unrelated umbilical cord blood hematopoietic stem cell transplantation. Rev Clin Exp Hematol 2001;5:87-99.
6. Gluckman E, Rocha V, Arcese W et al. Factors associated with outcomes of unrelated cord blood transplant: Guidelines for donor choice. Exp Hematol 2004;32:397-407.
7. Kurtzberg J, Laughlin M, Graham ML et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med 1996;335:157-166.
8. Laughlin MJ, Barker J, Bambach B et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001;344:1815-1822.
9. Laughlin MJ, Eapen M, Rubinstein P et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004;351:2265-2275.
10. Rubinstein P, Carrier C, Scaradavou A et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 1998;339:1565-1577.
11. Wagner JE, Barker JN, DeFor TE et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and non-malignant diseases: Influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002;100:1611-1618.
12. Migliaccio AR, Adamson JW, Stevens CE et al. Cell dose and speed of engraftment in placental/umbilical cord blood transplantation: Graft progenitor cell content is a better predictor than nucleated cell quantity. Blood 2000;96:2717-2722.
13. Barker JN, Weisdorf DJ, Wagner JE. Creation of a double chimera after the transplantation of umbilical-cord blood from two partially matched unrelated donors. N Engl J Med 2001;344:1870-1871.
14. Barker JN, Weisdorf DJ, DeFor TE et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005;105:1343-1347.
15. De Lima M, St Johns LS, Wieder ED et al. Double-chimaerism after transplantation of two human leucocyte antigen mismatched, unrelated cord blood units. Br J Haematol 2002;119:773-776.
16. McNiece IK, Almeida-Porada G, Shpall EJ et al. Ex vivo expanded cord blood cells provide rapid engraftment in fetal sheep but lack long-term engrafting potential. Exp Hematol 2002;30:612-616.
17. McNiece I, Harrington J, Turney J et al. Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells. Cytotherapy 2004;6:311-317.
18. McNiece I, Kubegov D, Kerzic P et al. Increased expansion and differentiation of cord blood products using a two-step expansion culture. Exp Hematol 2000;28:1181-1186.
19. Shpall EJ, Quinones R, Giller R et al. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant 2002;8:368-376.
20. Robinson SN, Ng J, Niu T et al. Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transplant 2006;37:359-366.
21. de Lima M, McMannis J, Gee A et al. Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: A phase I/II clinical trial. Bone Marrow Transplant 2008;41:771-778.
22. Xiao M, Broxmeyer HE, Horie M et al. Extensive proliferative capacity of single isolated CD34 human cord blood cells in suspension culture. Blood Cells 1994;20:455-466; discussion 466-467.
23. Traycoff CM, Abboud MR, Laver J et al. Ex vivo expansion of CD34+ cells from purified adult human bone marrow and umbilical cord blood hematopoietic progenitor cells. Prog Clin Biol Res 1994;389:385-391.
24. Moore MA, Hoskins I. Ex vivo expansion of cord blood-derived stem cells and progenitors. Blood Cells 1994;20:468-479; discussion 479-481.
25. Broxmeyer HE, Hangoc G, Cooper S et al. Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults. Proc Natl Acad Sci U S A 1992;89:4109-4113.
26. Zhang CC, Kaba M, Iizuka S et al. Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood 2008;111:3415-3423.
27. Zhang CC, Kaba M, Ge G et al. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med 2006;12:240-245.
28. Zhang CC, Lodish HF. Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion. Blood 2005;105:4314-4320.
29. Zhang CC, Lodish HF. Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells. Blood 2004;103:2513-2521.
30. Abkowitz JL, Taboada MR, Sabo KM et al. The ex vivo expansion of feline marrow cells leads to increased numbers of BFU-E and CFU-GM but a loss of reconstituting ability. Stem Cells 1998;16:288-293.
31. Guenechea G, Segovia JC, Albella B et al. Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex vivo-expanded human CD34(+) cord blood cells. Blood 1999;93:1097-1105.
32. Holyoake TL, Alcorn MJ, Richmond L et al. CD34 positive PBPC expanded ex vivo may not provide durable engraftment following myeloablative chemoradiotherapy regimens. Bone Marrow Transplant 1997;19:1095-1101.
33. Peters SO, Kittler EL, Ramshaw HS et al. Murine marrow cells expanded in culture with IL-3, IL-6, IL-11, and SCF acquire an engraftment defect in normal hosts. Exp Hematol 1995;23:461-469.
34. Peters SO, Kittler EL, Ramshaw HS et al. Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL-6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts. Blood 1996;87:30-37.
35. Tisdale JF, Hanazono Y, Sellers SE et al. Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability. Blood 1998;92:1131-1141.
36. Traycoff CM, Cornetta K, Yoder MC et al. Ex vivo expansion of murine hematopoietic progenitor cells generates classes of expanded cells possessing different levels of bone marrow repopulating potential. Exp Hematol 1996;24:299-306.
37. Von Drygalski A, Alespeiti G, Ren L et al. Murine bone marrow cells cultured ex vivo in the presence of multiple cytokine combinations lose radioprotective and long-term engraftment potential. Stem Cells Dev 2004;13:101-111.
38. Williams DA. Ex vivo expansion of hematopoietic stem and progenitor cells-robbing Peter to pay Paul?Blood 1993;81:3169-3172.
39. De A, Lewis XZ, Gambhir SS.Noninvasive imaging of lentiviral-mediated reporter gene expression in living mice. Mol Ther 2003;7(suppl 5):681-691.
40. Lin Y, Molter J, Lee Z et al. Bioluminescence imaging of hematopoietic stem cell repopulation in murine models. Methods Mol Biol 2008;430:295-306.
41. Ishikawa F, Yasukawa M, Lyons B et al. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chain (null) mice. Blood 2005;106:1565-1573.
42. King M, Pearson T, Shultz LD et al. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol 2008;126:303-314.
43. Shultz LD, Pearson T, King M et al. Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research. Ann N Y Acad Sci 2007;1103:77-89.
44. Kelly PF, Vandergriff J, Nathwani A et al. Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency repopulating cells by oncoretroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein. Blood 2000;96:1206-1214.
45. + human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rγ (null) mice. Exp Biol Med 2008;233:997-1012.
46. Liu Y, Hangoc G, Campbell TB et al. Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells. Exp Hematol 2008;36:947-956.
47. Lo Celso C, Fleming HE, Wu JW et al. Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature 2009;457:92-96.